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Dietary supplement

Cinnamon 500 mg Ingredients & Drug Interactions

by up&up

Cinnamon 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cinnamon 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cinnamon 500 mg is a dietary supplement by up&up with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, digestive upset, antioxidant support.Based on those ingredients, 442 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cinnamon. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cinnamon 500 mg by up&up

Ask about any prescription or over-the-counter medication and we check it for interactions with Cinnamon 500 mg by up&up — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cinnamon 500 mg by up&up

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cassia cinnamon, 500 mg per capsule. The remaining ingredients are inactive — gelatin (the capsule shell), magnesium stearate, silicon dioxide, sodium lauryl sulfate, and polysorbate 80 (all fillers, binders, and processing aids).

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cassia Cinnamon's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: promote healthy glucose metabolism.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Dyslipidemia, Obesity, Blood sugar control, Metabolic health.
  • The closest evidence on file: Cassia Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Cassia Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Dyslipidemia, Obesity, Impaired glucose tolerance (prediabetes).

The evidence isn't established for what cinnamon might do. Our data shows insufficient reliable evidence to rate it for amenorrhea, angina, common cold, diabetes, diarrhea, or dyslipidemia (high cholesterol).

That doesn't mean it doesn't work — it means the research so far hasn't been conclusive enough to say.

The evidence, ingredient by ingredient Cassia Cinnamon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cinnamon is generally well tolerated in food amounts. At supplement doses — especially high doses or over a long time — there's concern about liver damage from coumarin, the compound cinnamon contains.

In clinical trials using 360 mg to 12 grams daily for three months, liver enzyme levels didn't change significantly, but very high coumarin intake (50 to 7,000 mg/day) has caused reversible liver damage in humans. Rare side effects in trials include rash and, in one case, a hypoglycemic seizure (low blood sugar episode), though it's unclear whether cinnamon caused it.

One person also developed eyelid dermatitis (a rash) from systemic contact dermatitis to cinnamon in food — symptoms cleared within five days of stopping.

Side effects, ingredient by ingredient Cassia Cinnamon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cassia Cinnamon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 443 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before taking this if you use any diabetes or blood sugar drugs (insulin, metformin, sulfonylureas, etc.) — cinnamon may lower blood sugar and you might need a dose change. Also flag any medications that can damage the liver; cinnamon may add to that risk at high doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you're curious about cinnamon for general wellness and don't take diabetes drugs or liver-harming medications, this supplement is likely okay at this dose. If you take insulin, blood sugar medications, or drugs that stress your liver, talk to your pharmacist before starting — you may need monitoring or dose adjustments.

Food-amount cinnamon is safe; this is a supplement dose, so discuss it first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cinnamon 500 mg, straight from the product label.

Brand up&up
Barcode (UPC) 070030625160
Net contents 200 Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2013
DSLD ID 20002
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cinnamon 500 mg by up&up, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
100
UPC/BARCODE
070030625160
IngredientAmount% DV
Total Carbohydrates1 g1%
Cinnamon1 g--

Other ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Sodium Lauryl Sulfate, Polysorbate 80

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

GLUTEN FREE

General

094 02 0738 : 4T382 UW F1

Brand IP Statement(s)

(C) 2012 Target Brands, Inc.

General Statements

EXP12/13 2HN1347

ENERGY METABOLISM This ancient herb has been referenced in Chinese scripts dating back thousands of years. As an herbal supplement to the diet, cinnamon helps promote healthy glucose metabolism.

{Capsule} ACTUAL SIZE

helps promote health glucose metabolism

ENERGY METABOLISM

ID482463

Suggested/Recommended/Usage/Directions

Directions: For adults, take two capsules per day preferably with a meal.

Precautions

WARNING: Not intended for use by pregnant or nursing women. If you are taking any medications or have a medical condition, including diabetes or hypoglycemia, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Seals/Symbols

{Arrow} up&up(R)

FDA Statement of Identity

DIETARY SUPPLEMENT

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store at room temperature (59(0)-86(0)F).

Formula

Cinnamon 500 mg per capsule

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cinnamon 500 mg by up&up label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cinnamon 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cinnamon 500 mg by up&up

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Cinnamon

Interacts with
442 drugs
1 g per serving

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...

Cinnamon monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Silicon Dioxide, Sodium Lauryl Sulfate, Polysorbate 80. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cinnamon 500 mg by up&up Drug Interactions

Want to check YOUR meds against Cinnamon 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
442Drugs
442 Moderate

Ingredients driving the most interactions

Cinnamon 442

Individual Drug Interactions

The ingredients in Cinnamon 500 mg interact with 442 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cinnamon 500 mg interact with drugs. Each result below shows which ingredient is responsible. Cinnamon

Each ingredient & the kinds of drugs it affects

For each ingredient in Cinnamon 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cinnamon2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cinnamon full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cinnamon 500 mg, from the product label.

up&up

See all up&up products
Name
Target Corporation
City
Minneapolis
State
MN
ZipCode
55403
Pharmacist Counseling Corner

Cinnamon 500 mg by up&up: Common Questions

Does Cinnamon 500 mg by up&up interact with any medications?
Yes. Based on its ingredients, Cinnamon 500 mg has a known interaction with 442 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cinnamon 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe during pregnancy or while breastfeeding?
Food amounts of cinnamon are likely safe in pregnancy and lactation. The data rates cassia cinnamon as likely safe overall. However, the facts advise against medicinal or high-dose supplement amounts during pregnancy because safety data in that setting is limited. Talk with your doctor or pharmacist about whether this 500 mg supplement dose is right for you.
Does cinnamon actually help with blood sugar or diabetes?
The evidence isn't established. Our data shows insufficient reliable evidence to rate cinnamon for diabetes. That said, cinnamon may lower blood glucose, which is why it can interact with diabetes medications.
What's coumarin and why does it matter?
Coumarin is a naturally occurring compound in cassia cinnamon. In animal studies, it can damage the liver. Very high doses of coumarin (50 to 7,000 mg/day) have caused liver damage in humans, though it reversed when people stopped. This supplement has 500 mg of cinnamon, so the coumarin dose is much lower — but it's a reason to avoid very high intakes or long-term use without checking with your pharmacist.
Can this cause side effects?
Most people tolerate it well. In clinical trials, a rash was reported in one person taking 1 gram daily, and one case of eyelid dermatitis cleared within five days of stopping cinnamon in food. One person had a low blood sugar episode, though it's unclear if cinnamon caused it.
Does this have any fillers or other ingredients?
Yes. Besides the 500 mg of cinnamon, the capsule contains gelatin, magnesium stearate, silicon dioxide, sodium lauryl sulfate, and polysorbate 80 — all inactive ingredients used to make the capsule and help it dissolve.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cinnamon 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cinnamon 500 mg label
Go deeper

The Full Monographs Behind Cinnamon 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph →
Sources

Sources & How We Checked

Cinnamon 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 20 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cassia Cinnamon 20 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. Khan A, Safdar M, Ali Khan M, et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26:3215-8. PubMed
  3. De Benito V, Alzaga R. Occupational allergic contact dermatitis from cassia (Chinese cinnamon) as a flavouring agent in coffee. Contact Dermatitis 1999;40:165. PubMed
  4. Drake TE, Maibach HI. Allergic contact dermatitis and stomatitis caused by a cinnamic aldehyde-flavored toothpaste. Arch Dermatol 1976;112:202-3.
  5. Press release. Cinnamon capsules to reduce blood sugar are medicinal products! Efficacy has not been scientifically proven - some products contain high levels of coumarin. Federal Institute of Risk Assessment (BfM), Germany, November 11, 2006. Available a
  6. Felter SP, Vassallo JD, Carlton BD, Daston GP. A safety assessment of coumarin taking into account species-specificity of toxicokinetics. Food Chem Toxicol 2006;44:462-75. PubMed
  7. Crawford P. Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial. J Am Board Fam Med 2009;22:507-12. PubMed
  8. Akilen, R., Tsiami, A., Devendra, D., and Robinson, N. Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet.Med. 2010; PubMed
  9. Lu T, Sheng H Wu J Cheng Y Zhu J Chen Y. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res. 2012;32(6):408-412. PubMed
  10. Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.
  11. Altschuler JA, Casella SJ, MacKenzie TA, Curtis KM. The effect of cinnamon on A1C among adolescents with type 1 diabetes. Diabetes Care 2007;30(4):813-6. PubMed
  12. Stoecker BR, Zhan Z, Luo R, et al. Cinnamon extract lowers blood glucose in hyperglycemic subjects. FASEB J. 2010;22:722.1 (Abstract only). DOI
  13. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  14. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  15. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  16. Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J 2014 Sep 24;13:96. PubMed
  17. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  18. Shekarchizadeh-Esfahani P, Heydarpour F, Izadi F, Jalili C. The effect of cinnamon supplementation on liver enzymes in adults: A systematic review and meta-analysis of randomized controlled trials. Complement Ther Med 2021;58:102699. PubMed
  19. Bernaola J, Valverde-Monge M, Otal-Buesa M, Cullen D, Heras-Mendaza F. Cinnamon allergic contact cheilitis. Contact Dermatitis 2023;88(5):418-419. PubMed
  20. Patel K, Howard M, Tate B. Cheilitis caused by allergic contact dermatitis to cinnamon in chai tea: A case report. Contact Dermatitis 2023;88(3):239-240. PubMed

See these in context on the Cassia Cinnamon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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