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Dietary supplement

Cissus Quadrangularis Ingredients & Drug Interactions

by NutraKey

Cissus Quadrangularis label
See full label image
Powder Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Quadrangularis against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Quadrangularis is a dietary supplement by NutraKey with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cissus quadrangularis Extract, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Quadrangularis by NutraKey

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Quadrangularis by NutraKey — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cissus Quadrangularis by NutraKey

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Cissus quadrangularis Extract in micronized form, which means it's been finely ground for better absorption. Cissus quadrangularis is a plant extract that has been studied for its effects on weight and metabolic health.

The product contains no other active ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Cissus Quadrangularis's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: joint health and inflammation support.
  • We looked for evidence on: Joint pain, Rheumatoid arthritis (RA), Osteoporosis, Osteopenia, Fractures, cartilage health — and 2 related terms.
  • The closest evidence on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Osteopenia (Natural Medicines).
  • Also on file: Cissus Quadrangularis is rated "Insufficient Reliable Evidence To Rate" for Fractures, Osteoporosis, Joint pain, Rheumatoid arthritis (RA).

Cissus quadrangularis is rated Possibly Effective for obesity. The evidence for other uses — high cholesterol (hyperlipidemia), low bone mineral density (osteopenia), cancer, and epilepsy — is insufficient to rate at this time, meaning we don't yet have reliable data showing whether it works for those conditions.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, though long-term safety hasn't been well studied. Trial participants reported headache and insomnia at rates similar to or lower than placebo, and the same was true for flatulence, diarrhea, gastritis (stomach inflammation), and dry mouth.

The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe in those situations. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or breastfeeding and considering this supplement.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any antidiabetes drugs — insulin, metformin, sulfonylureas, or others used to manage blood sugar — check with your doctor or pharmacist before adding this product. Cissus quadrangularis may lower blood sugar further, raising the risk of low blood sugar (hypoglycemia).

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This extract may help with weight management in people who are overweight or obese, but the main thing to watch is its potential effect on blood sugar — especially if you take antidiabetes medication. Before you start, check your medications with your doctor or pharmacist, and mention that you're considering Cissus quadrangularis.

Long-term safety isn't well established, so think of it as a short-term option for now.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Quadrangularis, straight from the product label.

Brand NutraKey
Barcode (UPC) 851090006126
Net contents 100 Gram(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 287393
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Quadrangularis by NutraKey, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
Servings per container
100
UPC/BARCODE
851090006126
IngredientAmount% DV
Cissus quadrangularis Extract, Micronized1000 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Cissus quadrangularis is a natural extract Cissus quadrangularis is a type of vine in the grape family. Extracts from this plant have been used in classical medicine for centuries. This succulent vine, which grows naturally in Africa and Asia, is still well regarded today for its unique healing and health benefits. Antioxidant joint support Cissus Quadrangularis contains severe unique saponins and antioxidants. It has been clinically studied for its support in joint, ligament, and tendon health. Studies suggest that Cissus Quadrangularis may provide a range of benefits for soft tissue health, while also contributing to a healthy anti-inflammatory response.

Formulation

Inflammation support Controlling inflammation is extremely important to overall health and wellness, especially for those who lead an active lifestyle.

Joint performance

Ultra pure No fillers

Max bioavailability Ultra micronized Healthy joints & cartilage Supports optimal joint health Improve joint comfort & recovery Pharmaceutical grade

Hypoallergenic: contains no yeast, dairy, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor, or fragrance

Hypoallergenic: contains no yeast, dairy, gluten, corn, soy, wheat, sugar, starch, salt, preservatives, or artificial color, flavor, or fragrance.

Seals/Symbols

Made in the USA

Brand IP Statement(s)

NutraKey Health Performance Inc

FDA Statement of Identity

Dietary Supplement

General Statements

#TEAMNUTRAKEY Follow us free giveaways Facebook Pinterest Instagram Twitter

Our commitment to you Integrity, quality, and hard work is the Nutrakey foundation. We've created a line of clean and pure products to support a lifestyle focused on health and wellness. Our customers are our priority and we will continue to create the best and most affordable supplements for your everyday needs. #MAKELIFEBETTER Pure nutrition go green

Suggested/Recommended/Usage/Directions

Recommended use: Take 1 level scoop (1000 mg) 30 minutes prior to a meal in the morning and 1 scoop 30 minutes prior to a meal 6-8 hours later.

Precautions

Warning: Pregnant or lactating women, diabetics, hypoglycemics, and people with known medical conditions and/or taking drugs should consult with a license physician and/or pharmacist prior to taking dietary supplements.

Do not take if safety seal is broken.

FDA Disclaimer Statement

These statements have not been reviewed by the Food and Drug Administration.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Quadrangularis by NutraKey label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Quadrangularis label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Quadrangularis by NutraKey

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

Cissus quadrangularis Extract, Micronized

Interacts with
86 drugs
1000 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Cissus quadrangularis Extract, Micronized monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Quadrangularis by NutraKey Drug Interactions

Want to check YOUR meds against Cissus Quadrangularis?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Cissus quadrangularis Extract, Micronized 86

Individual Drug Interactions

The ingredients in Cissus Quadrangularis interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Quadrangularis interact with drugs. Each result below shows which ingredient is responsible. Cissus quadrangularis Extract, Micronized

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Quadrangularis with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cissus quadrangularis Extract, Micronized1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Cissus quadrangularis Extract, Micronized full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Quadrangularis, from the product label.

NutraKey

See all NutraKey products
Name
NutraKey
Street Address
975 Bennett Drive
City
Longwood
State
FL
ZipCode
32750
Web Address
thenutrakey.com
Pharmacist Counseling Corner

Cissus Quadrangularis by NutraKey: Common Questions

Does Cissus Quadrangularis by NutraKey interact with any medications?
Yes. Based on its ingredients, Cissus Quadrangularis has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Quadrangularis contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does Cissus quadrangularis actually help with weight loss?
It's rated Possibly Effective for obesity based on available evidence. Small studies suggest it may help lower fasting blood sugar in people who are overweight or obese, which can be part of a weight management approach — but it's not a standalone solution. Talk with your doctor about how it might fit into your overall plan.
Can I take this if I'm on diabetes medication?
Not without checking first. Cissus quadrangularis can theoretically lower blood sugar further, which could push your levels too low (hypoglycemia). Your doctor or pharmacist needs to know you're considering it so they can decide whether it's safe for you and whether you need more frequent blood sugar monitoring.
What side effects should I watch for?
Headache, insomnia, flatulence, diarrhea, stomach upset, and dry mouth have been reported — but trials showed these happened at rates similar to or lower than placebo. Most people tolerate it well in short-term use.
Is it safe to take during pregnancy or while breastfeeding?
The safety data advises against it. There isn't enough information to know whether it's safe in pregnancy or while breastfeeding. If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before using this product.
How long can I safely take this?
Short-term use is generally well tolerated, but long-term safety hasn't been well studied. It's a good idea to discuss duration with your doctor or pharmacist — they can advise you on how long it makes sense for you to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Quadrangularis is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Quadrangularis label
Go deeper

The Full Monographs Behind Cissus Quadrangularis’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Quadrangularis's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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