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Dietary supplement

Cissus Supreme 500 mg Ingredients & Drug Interactions

by Supreme Nutrition Products

Cissus Supreme 500 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cissus Supreme 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cissus Supreme 500 mg is a dietary supplement by Supreme Nutrition Products with 1 active ingredient. Its ingredients are commonly taken for bone fracture healing, joint pain and bone health, weight management.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Winged Treebine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cissus Supreme 500 mg by Supreme Nutrition Products

Ask about any prescription or over-the-counter medication and we check it for interactions with Cissus Supreme 500 mg by Supreme Nutrition Products — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cissus Supreme 500 mg by Supreme Nutrition Products

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Cissus Supreme contains one active ingredient: winged treebine (Cissus quadrangularis), supplied at 500 mg per capsule. The ingredient is encased in a vegetarian capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Cissus Quadrangularis's overall clinical evidence instead.

Moderate

Some clinical evidence supports Cissus Quadrangularis for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Obesity — rated "Possibly Effective" (Natural Medicines).

The evidence for Cissus quadrangularis is mixed. It's rated possibly effective for obesity — small clinical studies suggest it might help lower fasting blood glucose in people with overweight or obesity.

For high cholesterol (hyperlipidemia), weak bones (osteopenia), cancer, and epilepsy, the evidence isn't established well enough for us to rate it one way or the other.

The evidence, ingredient by ingredient Cissus Quadrangularis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cissus quadrangularis is generally well tolerated in short-term use, but we don't have good long-term safety data. Headache and insomnia have been reported, as have flatulence, diarrhea, gastritis, and dry mouth — but the rates of these side effects are similar to or lower than what's seen with placebo.

There isn't enough safety data to know whether this ingredient is safe during pregnancy or while breastfeeding. If you're pregnant, planning to become pregnant, or nursing, talk it over with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Cissus Quadrangularis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cissus Quadrangularis.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (insulin, metformin, sulfonylureas, or others that lower blood sugar), double-check with your doctor or pharmacist before adding this product — Cissus quadrangularis may increase the risk of low blood sugar when used together.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support healthy weight or blood glucose levels, Cissus Supreme may be worth considering — the evidence is modest but encouraging for obesity. The catch: if you're on antidiabetes medications, you'll need to check with your own doctor or pharmacist first, because the ingredient might lower your blood sugar further.

Long-term safety data is limited, so talk it over with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cissus Supreme 500 mg, straight from the product label.

Brand Supreme Nutrition Products
Barcode (UPC) 195893145003
Net contents 90 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 307915
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cissus Supreme 500 mg by Supreme Nutrition Products, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
30
UPC/BARCODE
195893145003
IngredientAmount% DV
Winged Treebine1500 mg--

Other ingredients: vegetarian capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 2-3 capsules 3 times per day.

Precautions

If pregnant or breast feeding consult with your doctor before using this product.

Keep out of reach of children.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cissus Supreme 500 mg by Supreme Nutrition Products label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cissus Supreme 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cissus Supreme 500 mg by Supreme Nutrition Products

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Winged Treebine

Interacts with
86 drugs
1500 mg per serving

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from...

Winged Treebine monograph & interactions

Other (inactive) ingredients: Vegetarian capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cissus Supreme 500 mg by Supreme Nutrition Products Drug Interactions

Want to check YOUR meds against Cissus Supreme 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Winged Treebine 86

Individual Drug Interactions

The ingredients in Cissus Supreme 500 mg interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cissus Supreme 500 mg interact with drugs. Each result below shows which ingredient is responsible. Winged Treebine

Each ingredient & the kinds of drugs it affects

For each ingredient in Cissus Supreme 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Winged Treebine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, Cissus quadrangularis might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Small clinical studies suggest that Cissus quadrangularis might reduce fasting blood glucose in individuals with overweight or obesity.

Likelihood Possible Evidence D
Winged Treebine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cissus Supreme 500 mg, from the product label.

Supreme Nutrition Products

See all Supreme Nutrition Products products
Name
Supreme Nutrition Products
Street Address
1019 Regents Blvd #203
City
Tacoma
State
WA
ZipCode
98466
Web Address
www.SupremeNutritionProducts.com
Pharmacist Counseling Corner

Cissus Supreme 500 mg by Supreme Nutrition Products: Common Questions

Does Cissus Supreme 500 mg by Supreme Nutrition Products interact with any medications?
Yes. Based on its ingredients, Cissus Supreme 500 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cissus Supreme 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is winged treebine, and what's it supposed to do?
Winged treebine is the plant also called Cissus quadrangularis. The evidence suggests it might help with weight management and blood glucose control in people who are overweight or obese. For other uses like high cholesterol or bone density, there just isn't enough reliable evidence yet.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data on Cissus quadrangularis during pregnancy or breastfeeding. The safety data advises against use in both situations. Talk it over with your doctor or pharmacist if you're in either of these situations — they can help you weigh the pros and cons for your individual circumstances.
What side effects should I expect?
Headache and insomnia have been reported, along with flatulence, diarrhea, stomach irritation, and dry mouth. The good news: the rates of these side effects in studies are the same as or lower than what people experienced taking placebo.
Is it safe to use long-term?
It's generally well tolerated in short-term use, but we don't have solid safety data for long-term use. If you're thinking about taking it regularly for months or longer, check with your doctor or pharmacist first.
Does this product have any fillers?
The capsule itself is vegetarian, which is the only inactive ingredient listed. There are no other fillers or binders in this formulation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cissus Supreme 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cissus Supreme 500 mg label
Go deeper

The Full Monographs Behind Cissus Supreme 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cissus Quadrangularis

Interacts with 86 drugs

Cissus quadrangularis is a traditional vine used mainly for bone health, joint pain, and weight management. Most of the supporting evidence comes from animal studies and a small number of hu...

Read the full Cissus Quadrangularis monograph →
Sources

Sources & How We Checked

Cissus Supreme 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cissus Quadrangularis 5 references
  1. Oben J, Kuate D, Agbor G, et al. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids Health Dis 2006, 5:24.
  2. Oben JE, Ngondi JL, Momo CN, et al. The use of Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double-blind placebo-controlled study. Lipids Health Dis 2008;7:12.
  3. Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai
  4. Nash R, Azantsa B, Kuate D, Singh H, Oben J. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants. J Altern Complement Med. 2019;25(1):98-106
  5. Benjawan S, Nimitphong H, Tragulpiankit P, Musigavong O, Prathanturarug S, Pathomwichaiwat T. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial. Phytomedicine 2022;1 PubMed

See these in context on the Cissus Quadrangularis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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