Citrimax+ Ingredients & Drug Interactions
by The Vitamin Shoppe Next Step
What is this page for?
First and foremost: checking Citrimax+ against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Citrimax+ is a dietary supplement by The Vitamin Shoppe Next Step with 2 active ingredients. Its ingredients are commonly taken for weight loss, appetite suppression, curbing sugar and carb cravings.Based on those ingredients, 704 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Citrimax. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Citrimax+ by The Vitamin Shoppe Next Step
Ask about any prescription or over-the-counter medication and we check it for interactions with Citrimax+ by The Vitamin Shoppe Next Step — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Citrimax+ by The Vitamin Shoppe Next Step
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Citrimax+ contains 2 active ingredients. Citrimax is garcinia, a tropical fruit extract that supplies hydroxycitric acid (HCA), its main active compound.
The second ingredient is Chromax Chromium, a form of the mineral chromium. The product also includes inactive ingredients — gelatin, microcrystalline cellulose, silicon dioxide, and magnesium stearate — which serve as the capsule and binders.
Does it work?
Not established
The evidence for garcinia in Citrimax+ isn't established. Our data shows insufficient reliable evidence to rate it for athletic performance, fatty liver disease (NAFLD), high cholesterol (hyperlipidemia), or obesity.
While animal studies suggest garcinia might affect blood sugar and cholesterol, these effects haven't been proven in people. The effectiveness rating for Chromax Chromium isn't on file here.
How safe is it?
Well-documented data
Garcinia is generally well tolerated in short-term use, but you should know the rare risks. The most common side effects reported in studies are diarrhea, stomach discomfort, headache, and nausea.
Rarely, garcinia has been linked to liver injury and liver failure. There are also isolated case reports of mania (with symptoms like reduced need for sleep, increased spending, and agitation) developing weeks after starting it — especially concerning if you have bipolar disorder — and one case of severe heart muscle inflammation.
The safety data advises against use during pregnancy and while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Citrimax+, check with your doctor or pharmacist if you're on serotonergic drugs (antidepressants like SSRIs, SNRIs, or others used for mood or anxiety), blood thinners (anticoagulants or antiplatelet drugs), diabetes medications, or any drug that stresses the liver. Moderate-severity interactions are documented for all four of these types.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Citrimax+ may appeal to someone looking to support weight management or blood sugar control, but the evidence for garcinia's effectiveness in these areas isn't solid yet. If you take an antidepressant, blood thinner, diabetes medication, or any drug that affects your liver, talk with your doctor or pharmacist before starting it — the interaction risks are real.
Same goes if you have bipolar disorder or are pregnant or nursing. Your own healthcare provider can weigh whether this product makes sense for you.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Citrimax+, straight from the product label.
| Brand | The Vitamin Shoppe Next Step |
|---|---|
| Barcode (UPC) | 766536028931 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 25, 2016 |
| DSLD ID | 55214 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Citrimax+ by The Vitamin Shoppe Next Step, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Chromax Chromium | 200 mcg | 167% |
| Citrimax | 1500 mg | -- |
Other ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
I want to eat less
Helps control appetite & support glucose metabolism
This product may support a weight management or diet program that includes regular exercise and a calorie restricted diet.*
Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.
Brand IP Statement(s)
Powered by Citrimax garcinia cambogia and Chromax
Chromax is a registered trademark of Nutrition 21. CitriMax is a trademark of InterHealth N.I.
CITRIMAX
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement take two (2) capsules, 30 minutes before meals.
Formulation
Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Soy, Dairy, Citrus, Fish, Preservatives, Artificial Colors or Flavors.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Warning: Do not use if you are pregnant or nursing. Consult your physician prior to use if you are diabetic, under medical care or are taking any medication.
Not intended for use by children.
Keep out of reach of children.
Tamper Evident: Do not use if outer seal is broken or missing.
Storage
Store in a cool, dry place.
General
Item No. VS-2893 1972363 BP 52
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Citrimax+ by The Vitamin Shoppe Next Step label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Citrimax+ by The Vitamin Shoppe Next Step
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Chromax Chromium
Citrimax
Interacts with704 drugs
Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific eviden...
Citrimax monograph & interactionsOther (inactive) ingredients: Gelatin, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Citrimax+ by The Vitamin Shoppe Next Step Drug Interactions
HelloPharmacist Interaction Report
Citrimax+ by The Vitamin Shoppe Next Step contains garcinia, which interacts with several medication types.
The most serious concern is with serotonergic drugs (antidepressants and certain other psychiatric medications) — there's a documented case of serotonin syndrome in someone taking garcinia with escitalopram. The combination theoretically raises the risk of serotonergic side effects like agitation, confusion, and rapid heart rate.
Read the full breakdown — every affected drug type, severity by severity
Garcinia also carries Moderate-severity interactions with blood thinners (anticoagulants and antiplatelet drugs), drugs that affect the liver (hepatotoxic medications), and diabetes medications. With blood thinners, the main ingredient in garcinia may increase bleeding risk.
With liver-affecting drugs, there's a theoretical risk of compounded liver damage — and garcinia itself has rare reports of liver injury. With diabetes drugs, garcinia might lower blood sugar further, raising the risk of low blood sugar (hypoglycemia).
We could not check the interaction profile of Chromax Chromium — we hold no data for that ingredient. Altogether, these interactions span 705 individual medications.
Before you start Citrimax+, run your exact prescriptions through the search tool on this page, and talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Citrimax+?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Citrimax+ interact with 704 drugs. Click any drug to see the details.
1 of the 2 ingredients in Citrimax+ interact with drugs. Each result below shows which ingredient is responsible. Citrimax
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + 6-mercaptopurine interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Citrimax + Abciximab interactionAbiraterone
How Abiraterone interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Citrimax + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxAntidiabetes Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Read the full Citrimax + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Citrimax + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxAnticoagulant/antiplatelet Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Citrimax + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Citrimax + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Citrimax + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxHepatotoxic Drugs, Serotonergic Drugs Moderate
Interaction Summary
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Citrimax + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Citrimax+ — through 1 ingredient. Tap an ingredient for the detail:
CitrimaxSerotonergic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
Read the full Citrimax + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Citrimax+ with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Citrimax
Anticoagulant/Antiplatelet Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.
Antidiabetes Drugs
Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.
Hepatotoxic Drugs
Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.
Serotonergic Drugs
Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.
Brand information
Manufacturer and brand details for Citrimax+, from the product label.
The Vitamin Shoppe Next Step
See all The Vitamin Shoppe Next Step products- Name
- Vitamin Shoppe, Inc.
- City
- Secaucus
- State
- NJ
- ZipCode
- 07094
- Phone Number
- 1-800-223-1216
- Web Address
- www.vitaminshoppe.com
Citrimax+ by The Vitamin Shoppe Next Step: Common Questions
Does Citrimax+ by The Vitamin Shoppe Next Step interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Citrimax+ if I'm on an antidepressant?
What are the most common side effects?
Is Citrimax+ safe during pregnancy or breastfeeding?
Can this help me lose weight or manage my blood sugar?
What if I'm on a blood thinner — is that a problem?
Does Citrimax+ have any fillers?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Citrimax+ is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Citrimax+’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Citrimax+'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 44 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garcinia 44 references
- Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
- Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
- Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
- Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
- Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
- Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
- Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
- Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism 2004;53(1):66-72. PubMed
- Asghar M, Monjok E, Kouamou G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 2007;304(1-2):93-99. PubMed
- Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol 2005;288(6):G1144-G1149. PubMed
- Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition 2004;20(10):911-915. PubMed
- Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. PubMed
- Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91.
- Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94.
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