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Dietary supplement

Clinical Strength Lutein & Zeaxanthin Ingredients & Drug Interactions

by Member's Mark

Clinical Strength Lutein & Zeaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Clinical Strength Lutein & Zeaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Clinical Strength Lutein & Zeaxanthin is a dietary supplement by Member's Mark with 2 active ingredients. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Clinical Strength Lutein & Zeaxanthin by Member's Mark

Ask about any prescription or over-the-counter medication and we check it for interactions with Clinical Strength Lutein & Zeaxanthin by Member's Mark — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Clinical Strength Lutein & Zeaxanthin by Member's Mark

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains two active carotenoid ingredients: zeaxanthin and lutein. Both are plant pigments your body absorbs and deposits in the eye; they're the same compounds found in leafy greens and other colorful vegetables.

There are no inactive fillers or binding agents in this formulation.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: improve visual clarity and eye health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Zeaxanthin is possibly effective for age-related macular degeneration (AMD), a common cause of vision loss as you get older. Lutein is possibly effective for both AMD and cataracts.

For other conditions — including age-related cognitive decline, Alzheimer disease, asthma, and several others — the evidence we hold is insufficient to rate either ingredient. If you're taking this for eye health, the data supports its use; if you have a different goal in mind, talk with your doctor about whether the science backs it up.

The evidence, ingredient by ingredient Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both zeaxanthin and lutein are generally well tolerated at typical supplement doses. Lutein studies have shown doses up to 20 mg daily without adverse effects.

Since these carotenoids come from food naturally, dietary amounts are safe during pregnancy and breastfeeding — however, the safety data for concentrated supplements at higher doses during pregnancy and lactation isn't fully established, so use caution and check with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs, double-check them before starting this product — zeaxanthin may raise the risk of low blood sugar (hypoglycemia). No other major medication interactions are documented for lutein.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking to support eye health, especially for age-related macular degeneration, this product combines two ingredients with decent evidence. If you take antidiabetes medications, check your exact drugs before starting — there's a moderate-level concern about blood sugar dips.

For pregnancy, breastfeeding, or any other health condition, have a quick conversation with your doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Clinical Strength Lutein & Zeaxanthin, straight from the product label.

Brand Member's Mark
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Oct 25, 2013
DSLD ID 26111
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Clinical Strength Lutein & Zeaxanthin by Member's Mark, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Not Present
Maximum serving Sizes:
1 Not Present
IngredientAmount% DV
Zeaxanthin5 mg--
Lutein25 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Formulated with a 5:1 ratio of Lutein and Zeaxanthin to match the body's natural

Lutein and Zeaxanthin are natural pigments also known as "carotenoids", fat-soluble antioxidants found in fruits, vegetables and plants, including marigolds and sunflowers. Antioxidants protect the body from cellular and tissue damage caused by harmful molecules called free radicals, which cause "biological rusting" (oxidation) and may enhance the negative effects of aging. The retina (or "macula") is a light-sensitive tissue that lines the inner surface of the eye. The macula contains the highest concentration of Lutein and Zeaxanthin. In the healthy body, Lutein and Zeaxanthin are naturally present in a 5:1 ratio. Research has shown that adding Lutein and Zeaxanthin to a healthy diet may support eye health and overall vision health. The healthy human body has a natural 5:1 ratio of Lutein and Zeaxanthin, essential nutrients for healthy vision, particularly as the body ages. Simply Right Clinical Strength formula creates a natural, harmonized formula for eye health with 23mg of Lutein and 5mg Zeaxanthin in each softgel. These key nutrients may help improve visual clarity, protect against harmful UV light and promote eye and overall vision health.

~Scientifically formulated to match the body's natural 5:1 ratio of Lutein & Zeaxanthin ~Clinical Strength ~Helps improve visual clarity

Model: SAM644783 Item #:325613

Promotes Eye Health

Brand IP Statement(s)

Formulated by Mother Nature(TM)

Seals/Symbols

M(R)

Suggested/Recommended/Usage/Directions

1 Softgel Daily

Formula

25mg of Lutein - 5mg of Zeaxanthin per Softgel

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Clinical Strength Lutein & Zeaxanthin by Member's Mark label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Clinical Strength Lutein & Zeaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Clinical Strength Lutein & Zeaxanthin by Member's Mark

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Not Present Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zeaxanthin

Interacts with
86 drugs
5 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Lutein

No known
interactions
25 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions
Interaction report

Clinical Strength Lutein & Zeaxanthin by Member's Mark Drug Interactions

Want to check YOUR meds against Clinical Strength Lutein & Zeaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Clinical Strength Lutein & Zeaxanthin interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Clinical Strength Lutein & Zeaxanthin interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Clinical Strength Lutein & Zeaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Clinical Strength Lutein & Zeaxanthin, from the product label.

Member's Mark

Name
Member's Mark
Pharmacist Counseling Corner

Clinical Strength Lutein & Zeaxanthin by Member's Mark: Common Questions

Does Clinical Strength Lutein & Zeaxanthin by Member's Mark interact with any medications?
Yes. Based on its ingredients, Clinical Strength Lutein & Zeaxanthin has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Clinical Strength Lutein & Zeaxanthin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually work for dry eyes or presbyopia (reading vision)?
The evidence we hold shows lutein and zeaxanthin are possibly effective for age-related macular degeneration and lutein for cataracts, but not for dry eyes or presbyopia. If you're trying to address a different eye concern, ask your eye doctor whether this combo is the right fit.
Can I take this if I'm pregnant or breastfeeding?
Both ingredients are rated likely safe during pregnancy and lactation. However, the safety data on concentrated supplement doses — rather than food sources — isn't complete, so talk with your doctor or pharmacist to make sure the dose in this product is appropriate for you.
What are zeaxanthin and lutein, exactly?
They're carotenoids — plant pigments that give vegetables like spinach and kale their color. Your body absorbs them and stores them in your eyes, where they may protect against age-related damage.
Are there any side effects I should know about?
Lutein at supplement doses has been well tolerated with no adverse effects reported in our data. Zeaxanthin is generally well tolerated too. The only caution is a moderate risk of low blood sugar if you take antidiabetes medication.
How much lutein is in a typical dose?
That detail isn't in the product facts we have — check the label on your bottle for the exact amount per softgel, and compare it to the 20 mg daily dose that's been studied without adverse effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Clinical Strength Lutein & Zeaxanthin is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Clinical Strength Lutein & Zeaxanthin label
Go deeper

The Full Monographs Behind Clinical Strength Lutein & Zeaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Clinical Strength Lutein & Zeaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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