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Dietary supplement

Clinical Strength Lutein & Zeaxanthin Ingredients & Drug Interactions

by Simply Right

Clinical Strength Lutein & Zeaxanthin label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Clinical Strength Lutein & Zeaxanthin against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Clinical Strength Lutein & Zeaxanthin is a dietary supplement by Simply Right with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin Isomers. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Clinical Strength Lutein & Zeaxanthin by Simply Right

Ask about any prescription or over-the-counter medication and we check it for interactions with Clinical Strength Lutein & Zeaxanthin by Simply Right — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Clinical Strength Lutein & Zeaxanthin by Simply Right

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Clinical Strength Lutein & Zeaxanthin, straight from the product label.

Brand Simply Right
Net contents 120 Softgel(s)
Market status Off market
Date entered into DSLD Mar 25, 2013
DSLD ID 20061
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Clinical Strength Lutein & Zeaxanthin by Simply Right, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
IngredientAmount% DV
Lutein25 mg--
Zeaxanthin Isomers5 mg--

Other ingredients: Sunflower Oil, Lutein, Gelatin, Glycerin, yellow Beeswax, Purified Water, Lecithin, Annatto Oil, Titanium Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Warning: Pregnant or nursing women, individuals taking medication(s) or persons who have a health condition should consult their physician before using this product.

Keep out of the reach of children.

SAFETY - SEALED. DO NOT USE IF PRINTED SEAL UNDER CAP IS CUT, TORN, OR MISSING.

General Statements

Lutein and Zeaxanthin are carotenoids found in vegetables and fruits. They act as antioxidants, protecting cells against the damaging effects of free radicals and help support healthy eyes and vision.*

We would like to hear from you with any comments or suggestions. In the continental U.S. or Canada, you can call us toll-free at 1.888.698.5034 from 8:30 a.m. to 5 p.m. EST Monday-Friday.

Scientifically formulated to match the body's natural 5:1 ratio of Lutein & Zeaxanthin* Helps improve visual clairty* Protects against harmful UV light*

{Softgel} actual size

FRESHNESS & POTENCY GUARANTEED THROUGH:

Wellness & Nutrition

Herbs have a distinct natural odor and may vary in color.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

THE SIMPLY RIGHT(TM) PROMISE Simply Right is dedicated to providing healthful, gentle, and safe personal care products for the entire family. We continuously strive to be your trusted partner in wellness and exceed your expectations.

Promotes eye and vision health*

Seals/Symbols

LABORATORY TESTED QUALITY ASSURED

GLUTEN FREE

Formula

25mg of Lutein + 5mg of Zeaxanthin per softgel

Contains: Soy.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults - One softgel daily, preferably with a meal, as a dietary supplement.

Storage

Store at 15(0) - 30(0) C (59(0) - 86(0) F).

Formulation

- NO ARTIFICIAL DYES OR FLAVORS - NO SALT - NO CHEMICAL SOLVENTS - NO SUGAR - NO GLUTEN - NO PRESERVATIVES - NO STARCH - NO WHEAT - NO LACTOSE - NO TRANS FAT

General

518265 134599 SAM644943

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Clinical Strength Lutein & Zeaxanthin by Simply Right label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Clinical Strength Lutein & Zeaxanthin label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Clinical Strength Lutein & Zeaxanthin by Simply Right

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
25 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin Isomers

Interacts with
86 drugs
5 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin Isomers monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Lutein, Gelatin, Glycerin, Yellow Beeswax, Purified Water, Lecithin, Annatto Oil, Titanium Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Clinical Strength Lutein & Zeaxanthin by Simply Right Drug Interactions

Clinical Strength Lutein & Zeaxanthin contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 86 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Clinical Strength Lutein & Zeaxanthin?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin Isomers 86

Individual Drug Interactions

The ingredients in Clinical Strength Lutein & Zeaxanthin interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Clinical Strength Lutein & Zeaxanthin interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin Isomers

Each ingredient & the kinds of drugs it affects

For each ingredient in Clinical Strength Lutein & Zeaxanthin with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin Isomers1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin Isomers full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Clinical Strength Lutein & Zeaxanthin, from the product label.

Simply Right

See all Simply Right products
Name
Sam's West, Inc.
City
Bentonville
State
AR
ZipCode
72716
Phone Number
1-888-698-5034
Web Address
SamsClub.com
Pharmacist Counseling Corner

Clinical Strength Lutein & Zeaxanthin by Simply Right: Common Questions

Does Clinical Strength Lutein & Zeaxanthin by Simply Right interact with any medications?
Yes. Based on its ingredients, Clinical Strength Lutein & Zeaxanthin has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Clinical Strength Lutein & Zeaxanthin contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Clinical Strength Lutein & Zeaxanthin is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Clinical Strength Lutein & Zeaxanthin label
Go deeper

The Full Monographs Behind Clinical Strength Lutein & Zeaxanthin’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Clinical Strength Lutein & Zeaxanthin's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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