Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

CoComelon Toddler Probiotic Liquid Drops Unflavored Ingredients & Drug Interactions

by Mary Ruth’s

CoComelon Toddler Probiotic Liquid Drops Unflavored label
See full label image
Liquid Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CoComelon Toddler Probiotic Liquid Drops Unflavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CoComelon Toddler Probiotic Liquid Drops Unflavored is a dietary supplement by Mary Ruth’s with 5 active ingredients. Its ingredients are commonly taken for digestive health and regularity, diarrhea (including antibiotic-related), irritable bowel syndrome (ibs) symptoms.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are B. bifidum, B. coagulans Unique IS-2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s

Ask about any prescription or over-the-counter medication and we check it for interactions with CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (5.75 mg) without saying how much of each component you get.

This product has 5 active probiotic ingredients: a proprietary blend containing Bifidobacterium bifidum, B. longum infantis, B. animalis lactis, Bacillus coagulans Unique IS-2, and Lactobacillus reuteri. These are live beneficial bacteria designed to support digestive and immune health.

The liquid also contains medium-chain triglyceride oil and alfalfa grass as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Digestive health and immune support for toddlers.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Diarrhea, Flatulence, Irritable bowel syndrome (IBS) — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

B. bifidum is possibly effective for irritable bowel syndrome (IBS) and respiratory tract infections; the evidence for allergic rhinitis (hay fever) and anxiety is not yet established. B. coagulans is possibly effective for constipation and IBS, but evidence for antibiotic-associated diarrhea, athletic performance, cancer, and fatty liver disease is not yet established.

We hold no effectiveness data for the other three strains in this blend.

The evidence, ingredient by ingredient Bifidobacterium Bifidum Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both B. bifidum and B. coagulans are generally well tolerated in healthy children, but evidence is limited. Those with weakened immune systems should be cautious and speak with their doctor first.

Bloating and flatulence are general risks with probiotics, though not specifically reported from B. bifidum. One case of vomiting and fever was reported in a child taking B. bifidum with another probiotic strain, but it's unclear if the probiotics caused it.

Rare cases of serious infection (sepsis) have been reported in critically ill patients using probiotics, but these are not tied to B. bifidum specifically. We hold no pregnancy or breastfeeding safety data for any ingredient in this product — discuss use with your pediatrician or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Bifidobacterium Bifidum Bacillus Coagulans

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bacillus Coagulans, Bifidobacterium Bifidum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Separate antibiotic drugs from this supplement by a few hours — antibiotics can kill the live bacteria and reduce the supplement's benefit. If your child takes any antibiotics, check with your pharmacist about timing before using this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-strain probiotic aimed at toddlers, with some evidence for IBS and constipation support. The main caution is separating doses from antibiotics.

We couldn't check three of the five strains for interactions, and safety data in young children is limited — talk to your pediatrician or pharmacist before starting, especially if your child has a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CoComelon Toddler Probiotic Liquid Drops Unflavored, straight from the product label.

Brand Mary Ruth’s
Barcode (UPC) 810104621052
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 327714
Product type Non-nutrient/non-botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Organic, Dairy Free, Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Children less than 4 years of age
Minimum serving Sizes:
1.5 mL
Maximum serving Sizes:
1.5 mL
Servings per container
20
UPC/BARCODE
810104621052
IngredientAmount% DV
Calories15 Calorie(s)--
Total Fat1.5 Gram(s)4%
Saturated Fat1.5 Gram(s)15%
Proprietary Probiotic Blend5.75 mg--
B. bifidum0 NP--
B. longum infantis0 NP--
B. animalis lactis0 NP--
L. reuteri0 NP--
B. coagulans Unique IS-20 NP--

Other ingredients: Medium Chain Triglyceride Oil, Alfalfa Grass

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Product naturally settles. Shake gently before use. Ages 1-3, take up to 1.5 mL daily or as recommended by a physician or healthcare professional.

Precautions

Please avoid direct dropper contact to the skin or mouth in order to prevent product contamination and damage to the dropper. Do not exceed the recommended dose.

Keep out of reach of children.

Please consult with a physician or healthcare professional before starting any health supplement, especially if pregnant or lactating, taking medication, or if you have a medical diagnosis.

Discontinue use if any negative reaction occurs.

General Statements

We genuinely care about all our customers.

Learn more Contact us We love to hear from our customers. Questions? Feedback? Please feel free to call or email us! [email protected] (310) 955-1353

Storage

Store in a cool, dry place No refrigeration necessary

Formulation

Gut health

Vegan

Non GMO

Certified organic by Organic Certifiers

All ingredients are vegan and non-GMO

All ingredients are vegan and non-GMO

Formula

150 million CFU

For ages 1-3 years

Seals/Symbols

USDA Organic Vegan

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

CoComelon & copyright 2023 Moonbug Entertainment. All Rights Reserved.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CoComelon Toddler Probiotic Liquid Drops Unflavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1.5 mL Dosage formLiquid Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

5.75 mg per serving

Other (inactive) ingredients: Medium Chain Triglyceride Oil, Alfalfa Grass. These complete the product’s ingredient list but are not active constituents.

Interaction report

CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s Drug Interactions

Want to check YOUR meds against CoComelon Toddler Probiotic Liquid Drops Unflavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

B. bifidum 182
B. coagulans Unique IS-2 182

Individual Drug Interactions

The ingredients in CoComelon Toddler Probiotic Liquid Drops Unflavored interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in CoComelon Toddler Probiotic Liquid Drops Unflavored interact with drugs. Each result below shows which ingredient is responsible. B. bifidum B. coagulans Unique IS-2

Each ingredient & the kinds of drugs it affects

For each ingredient in CoComelon Toddler Probiotic Liquid Drops Unflavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

B. bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
B. bifidum full monograph & interactions

B. coagulans Unique IS-21 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
B. coagulans Unique IS-2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CoComelon Toddler Probiotic Liquid Drops Unflavored, from the product label.

Mary Ruth’s

See all Mary Ruth’s products
Name
MRO MaryRuth, LLC
City
Los Angeles
State
CA
ZipCode
90035
Phone Number
(310) 955-1353
Web Address
www.maryruthorganics.com
Pharmacist Counseling Corner

CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s: Common Questions

Does CoComelon Toddler Probiotic Liquid Drops Unflavored by Mary Ruth’s interact with any medications?
Yes. Based on its ingredients, CoComelon Toddler Probiotic Liquid Drops Unflavored has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CoComelon Toddler Probiotic Liquid Drops Unflavored contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I give this to my toddler if they're on an antibiotic?
You can, but timing matters. Antibiotics can kill the live probiotics in this supplement, making it less effective. Ask your pharmacist or doctor how many hours to space them apart. Don't stop the antibiotic — just separate the doses.
What does each probiotic strain do?
B. bifidum and B. coagulans have evidence for irritable bowel syndrome. B. coagulans also shows promise for constipation. We don't have established effectiveness data for B. longum infantis, B. animalis lactis, or L. reuteri in the facts we hold.
Are there any side effects I should watch for?
Bloating and gas are possible with probiotics, though not specifically reported from B. bifidum. One case of vomiting and fever in a child taking B. bifidum with another probiotic was reported, but it's unclear if the probiotics caused it. Serious infection is very rare and mostly seen in critically ill patients.
Is it safe to use while pregnant or breastfeeding?
We don't have safety data on file for any ingredient in this product during pregnancy or breastfeeding. Talk to your doctor or pharmacist for personalized advice.
What are the inactive ingredients?
Medium-chain triglyceride oil and alfalfa grass. These are not the active probiotics but are included in the formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CoComelon Toddler Probiotic Liquid Drops Unflavored is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CoComelon Toddler Probiotic Liquid Drops Unflavored label
Go deeper

The Full Monographs Behind CoComelon Toddler Probiotic Liquid Drops Unflavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

CoComelon Toddler Probiotic Liquid Drops Unflavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Bifidum 7 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Rerksuppaphol S, Rerksuppaphol L. Randomized controlled trial of probiotics to reduce common cold in schoolchildren. Pediatr Int. 2012;54(5):682-7. PubMed
  4. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  5. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team