Interactions on record — worth a quick check against your medications. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Collagen Peptides Powder Ingredients & Drug Interactions

by NATURELO Premium Supplements

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Collagen Peptides Powder is a dietary supplement by NATURELO Premium Supplements with 6 active ingredients. Its ingredients are commonly taken for general nutrition and energy, antioxidant support, cholesterol and metabolic health.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Spirulina powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Collagen Peptides Powder by NATURELO Premium Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Digestive Enzymes Blend” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.

This product has 6 active ingredients. The main one is hydrolyzed collagen peptides — basically collagen protein broken down into smaller pieces your body can absorb more easily.

It also contains a blend of digestive enzymes: lipase, protease, cellulase, and amylase, which help break down fats, proteins, and carbohydrates. Spirulina powder (a blue-green algae) rounds out the formula.

There are no inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Support for skin, hair, and joint health.
  • We looked for evidence on: Aging skin, Brittle nails, Cellulite, Dermatoporosis, Dry skin, Exercise-induced muscle damage — and 4 related terms.
  • The strongest evidence on file: Collagen Peptides is rated "Possibly Effective" for Aging skin (Natural Medicines).
  • Also on file: Collagen Peptides is rated "Possibly Effective" for Dry skin.
  • Also on file: Blue-green Algae is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness.

The collagen peptides themselves are possibly effective for aging skin and dry skin, based on the data we have. For muscle strength, the evidence suggests it's probably not effective.

We don't have enough reliable evidence yet to rate how well the enzymes work for their stated purposes — lipase and protease for digestion, or spirulina for other uses. The evidence for spirulina is mixed: it's possibly effective for high blood pressure, but for allergies, acne, anemia, and arsenic poisoning, we don't have enough solid data to say either way.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Collagen peptides and the digestive enzymes are generally well tolerated, though some people report nausea, indigestion, diarrhea, or bloating — these are rare. Spirulina is also generally well tolerated by mouth, but may cause abdominal cramps, bloating, diarrhea, dizziness, fatigue, flatulence, headache, nausea, or vomiting.

Rarely, allergic reactions including rash, swelling, and even anaphylaxis have been reported. Quality varies — some spirulina products can be contaminated with toxins or heavy metals, so sourcing matters.

For pregnancy, there isn't enough safety data on lipase or protease to know either way; talk with your doctor before using. Collagen peptides also haven't been well studied in pregnancy — check first.

Spirulina should be avoided in pregnancy because safety data is insufficient and contamination is a concern. For breastfeeding, safety data is limited for lipase, protease, and collagen peptides — ask your healthcare provider.

Spirulina should also be avoided while breastfeeding.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 4 matched ingredients can interact with medications — Blue-green Algae.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take blood thinners or antiplatelet drugs (like aspirin or warfarin), diabetes medications, or immunosuppressants. Spirulina in this product has moderate-severity interactions documented with all three drug types.

No interactions are documented for the other ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with skin aging and dryness, thanks to the collagen peptides. If you take blood thinners, diabetes medications, or immunosuppressants, you'll want to double-check with your pharmacist before adding the spirulina in here — it could theoretically affect how those drugs work.

If you're pregnant or breastfeeding, talk with your doctor first, especially about the spirulina component.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Peptides Powder, straight from the product label.

Brand NATURELO Premium Supplements
Barcode (UPC) 628110628701
Net contents 8 Ounce(s); 228 Gram(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 262631
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Peptides Powder by NATURELO Premium Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7.6 Gram(s)
Maximum serving Sizes:
7.6 Gram(s)
Servings per container
30
UPC/BARCODE
628110628701
IngredientAmount% DV
Lipase0 NP--
Protease0 NP--
Cellulase0 NP--
Amylase0 NP--
Spirulina powder50 mg--
Digestive Enzymes Blend50 mg--
hydrolyzed Collagen Peptides7500 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

The NATURELO Difference Our Hydrolyzed Collagen contains Digestive Enzymes such as Amylase, Cellulase Lipase and Protease for improved absorption. We've also added Organic Spirulina to further boost the amount of important Protein Amino Acids such as Glycine and Proline Spirulina is also a good source of Copper which is critical for the formation of Collagen.

Formulation

Taken with your favorite drink our Collagen Peptides Powder provides natural support for your skin hair and joint health.

Variations in aroma, color, taste and solubility may occur.

No GMOs No soy No gluten No sugar added

Collagen peptides powder with organic spirulina

Provides natural support for skin, hair, & joint health

Suggested/Recommended/Usage/Directions

Helpful Tip: Collagen Peptides may clump in cold water. To enjoy Collagen Peptides in cold liquid, simply mix into room temperature liquid first and then add ice.

Suggested Use: Combine one (1) scoop into your favorite beverage or meal once daily and mix thoroughly.

Storage

Storage Information: Store in a cool (<77 degrees F), dry place. Keep lid tightly sealed. Do not expose product to excessive light, heat, or moisture.

Precautions

Caution: Keep out of the reach of children.

As with any dietary supplement consult a healthcare practitioner prior to use. Do not exceed recommended daily intake. Do not use if seal is damaged or missing.

General Statements

Note: The daily serving of 7.5 grams per scoop is an average Individual scooping technique may yield slightly less or slightly more than 7.5 grams. This product is packaged by weight, not by volume. Settling of the powder occurs over time which may reduce volume, but weight remains the same.

30 Servings

Amino Acid Profile Amount Per Serving (mg) Alanine 710 Arginine 607 Aspartic Acid 472 Glutamic Acid 787 Glycine 1,904 Isoleucine 122 Leucine 227 Lysine 325 Phenylalanine 163 Proline 1,197 Serine 246 Threonine 154 Tyrosine 47 Valine 185

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Made In USA GMP Good Manufacturing Practice Consistent Quality

See for yourself

Collagen Peptides Powder by NATURELO Premium Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Collagen Peptides Powder by NATURELO Premium Supplements

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size7.6 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Spirulina powder

Interacts with
327 drugs
50 mg per serving

Blue-green algae are nutrient-rich aquatic microorganisms (such as spirulina and Klamath Lake algae) taken as a supplement for energy, nutrition, and...

Spirulina powder monograph & interactions

Digestive Enzymes Blend

50 mg per serving

Hydrolyzed Collagen Peptides

No known
interactions
7500 mg per serving

Collagen peptides are a well-absorbed form of protein that may modestly improve skin elasticity and joint comfort for some people, though evidence is...

Hydrolyzed Collagen Peptides monograph & interactions
Interaction report

Collagen Peptides Powder by NATURELO Premium Supplements Drug Interactions

Want to check YOUR meds against Collagen Peptides Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Peptides Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Spirulina powder3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, spirulina blue-green algae might increase the risk of bleeding if used with other anticoagulant or antiplatelet drugs. However, this is unlikely.
Spirulina blue-green algae have shown antiplatelet and anticoagulant effects in vitro. However, one preliminary study in 24 patients receiving spirulina blue-green algae 2.3 grams daily for 2 weeks showed no effect on platelet activation or measures of clotting time.

Likelihood Unlikely Evidence D
Antidiabetes Drugs

Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.
Human research shows that spirulina blue-green algae can have hypoglycemic effects in patients with diabetes, at least some of whom were using antidiabetes drugs. However, blue-green algae does not seem to improve glycated hemoglobin (HbA1c) levels in patients with diabetes. A meta-analysis of animal studies also suggests that spirulina blue-green algae have hypoglycemic effects.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, concurrent use of blue-green algae might interfere with immunosuppressive therapy.
Blue-green algae have been shown to stimulate the immune system.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Collagen Peptides Powder, from the product label.

NATURELO Premium Supplements

See all NATURELO Premium Supplements products
Name
NATURELO Premium Supplements
City
Seattle
State
WA
ZipCode
98104
Web Address
www.naturelo.com
Pharmacist Counseling Corner

Collagen Peptides Powder by NATURELO Premium Supplements: Common Questions

Does Collagen Peptides Powder by NATURELO Premium Supplements interact with any medications?
Yes. Based on its ingredients, Collagen Peptides Powder has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Peptides Powder contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my skin?
The collagen peptides are possibly effective for aging skin and dry skin, so there's evidence backing that use. The enzymes and spirulina aren't well studied for skin, though.
What are these digestive enzymes supposed to do?
Lipase breaks down fats, protease breaks down proteins, and amylase breaks down carbohydrates. Cellulase helps break down fiber. Together they're meant to support digestion, but we don't have enough reliable evidence yet to rate how well they actually work in supplement form.
Are there any fillers in this?
No inactive ingredients are listed, so there are no added fillers or binders — just the active components.
Could this cause digestive upset?
It's possible. Collagen peptides, the enzymes, and spirulina can all cause nausea, bloating, diarrhea, or flatulence in some people, though these side effects are generally rare or mild.
Is spirulina safe, and where does it come from?
Spirulina is generally well tolerated, but quality varies widely between products — some can be contaminated with toxins or heavy metals. Ask the brand about their sourcing and testing.
Is this safe during pregnancy or while breastfeeding?
The data isn't there yet for most of these ingredients, and spirulina should be avoided because of contamination risk and insufficient safety data. Talk with your doctor before using if you're pregnant or nursing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Collagen Peptides Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Peptides Powder label
Sources

Sources & How We Checked

Collagen Peptides Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Blue-green Algae 22 references
  1. Jensen GS, Ginsberg DJ, Huerta P, et al. Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans. A novel approach to nutritional mobilization of the immune system. JANA 2000;2:50-6.
  2. Iwasa M, Yamamoto M, Tanaka Y, et al. Spirulina-associated hepatotoxicity. Am J Gastroenterol 2002;97:3212-13. PubMed
  3. Hayashi O, Katoh T, Okuwaki Y. Enhancement of antibody production in mice by dietary Spirulina platensis. J Nutr Sci Vitaminol (Tokyo) 1994;40:431-41.. PubMed
  4. Vitale S, Miller NR, Mejico LJ, et al. A randomized, placebo-controlled, crossover clinical trial of super blue-green algae in patients with essential blepharospasm or Meige syndrome. Am J Ophthalmol 2004;138:18-32. PubMed
  5. Mani UV, Desai S, Iyer U. Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients. J Nutraceut 2000;2(3):25-32. DOI
  6. Chiu HF, Yang SP, Kuo YL, et al. Mechanisms involved in the antiplatelet effect of C-phycocyanin. Br J Nutr 2006;95:435-40. PubMed
  7. Hsiao G, Chou PH, Shen MY, et al. C-phycocyanin, a very potent and novel platelet aggregation inhibitor from Spirulina platensis. J Agric Food Chem 2005;53:7734-40.
  8. Katz M, Levine AA, Kol-Degani H, Kav-Venaki L. A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial. J Atten Disord 2010;14:281-91. PubMed
  9. Madhyastha, H. K., Radha, K. S., Sugiki, M., Omura, S., and Maruyama, M. Purification of c-phycocyanin from Spirulina fusiformis and its effect on the induction of urokinase-type plasminogen activator from calf pulmonary endothelial cells. Phytomedicine PubMed
  10. Mazokopakis, E. E., Karefilakis, C. M., Tsartsalis, A. N., Milkas, A. N., and Ganotakis, E. S. Acute rhabdomyolysis caused by Spirulina (Arthrospira platensis). Phytomedicine. 2008;15(6-7):525-527. PubMed
  11. Halidou, Doudou M., Degbey, H., Daouda, H., Leveque, A., Donnen, P., Hennart, P., and Dramaix-Wilmet, M. [The effect of spiruline during nutritional rehabilitation: systematic review]. Rev.Epidemiol.Sante Publique 2008;56(6):425-431.
  12. Konno, T., Umeda, Y., Umeda, M., Kawachi, I., Oyake, M., and Fujita, N. [A case of inflammatory myopathy with widely skin rash following use of supplements containing Spirulina]. Rinsho Shinkeigaku 2011;51(5):330-333. PubMed
  13. Le TM, Knulst AC, Röckmann H. Anaphylaxis to Spirulina confirmed by skin prick test with ingredients of Spirulina tablets. Food Chem Toxicol 2014;74:309-10. PubMed
  14. Rzymski P, Niedzielski P, Kaczmarek N, Jurczak T, Klimaszyk P. The multidisciplinary approach to safety and toxicity assessment of microalgae-based food supplements following clinical cases of poisoning. Harmful Algae 2015;46:34-42. DOI
  15. Petrus M, Culerrier R, Campistron M, et al. First case report of anaphylaxis to spirulin: identification of phycocyanin as responsible allergen. Allergy 2010;65(7):924-5. PubMed
  16. Marles RJ, Barrett ML, Barnes J, et al. United States Pharmacopeia safety evaluation of spirulina. Crit Rev Food Sci Nutr 2011;51(7):593-604. PubMed
  17. Majdoub H, Ben Mansour M, Chaubet F, et al. Anticoagulant activity of a sulfated polysaccharide from the green alga Arthrospira platensis. Biochim Biophys Acta 2009;1790(10):1377-81. PubMed
  18. Cha BG, Kwak HW, Park AR, et al. Structural characteristics and biological performance of silk fibroin nanofiber containing microalgae spirulina extract. Biopolymers 2014;101(4):307-18. PubMed
  19. Jensen GS, Drapeau C, Lenninger M, Benson KF. Clinical safety of a high dose of phycocyanin-enriched aqueous extract from Arthrospira (Spirulina) platensis: results from a randomized, double-Blind, placebo-controlled study with a focus on anticoagulant ac
  20. Hamedifard Z, Milajerdi A, Reiner Z, Taghizadeh M, Kolahdooz F, Asemi Z. The effects of spirulina on glycemic control and serum lipoproteins in patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized con
  21. Moradi S, Zobeiri M, Feizi A, Clark CCT, Entezari MH. The effects of spirulina (Arthrospira platensis) supplementation on anthropometric indices, blood pressure, sleep quality, mental health, fatigue status and quality of life in patients with ulcerative
  22. Ghanbari F, Amerizadeh A, Behshood P, Moradi S, Asgary S. Effect of microalgae arthrospira on biomarkers of glycemic control and glucose metabolism: a systematic Review and meta-analysis. Curr Probl Cardiol 2022;47(10):100942. PubMed

See these in context on the Blue-green Algae monograph →

Collagen Peptides 2 references
  1. Trc T, Bohmová J. Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). Int Orthop. 2011;35(3):341-8. PubMed
  2. Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. PubMed

See these in context on the Collagen Peptides monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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