Interactions on record — worth a quick check against your medications. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Collagen Refreshers Beauty Strawberry Lemon Flavor Ingredients & Drug Interactions

by Bluebonnet

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Collagen Refreshers Beauty Strawberry Lemon Flavor is a dietary supplement by Bluebonnet with 8 active ingredients. Its ingredients are commonly taken for skin hydration and aging, joint comfort and osteoarthritis, dry eyes.Based on those ingredients, 316 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Strawberry juice powder, Lemon fruit juice powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Beauty Blend” is a proprietary blend — the label gives one combined amount (2.35 Gram(s)) without saying how much of each component you get.

This powder contains 7 ingredients, with active ones being Hyaluronic Acid (a molecule that holds water in skin and eyes), strawberry juice powder and strawberry fruit powder (both rich in phenols and antioxidants), Collagen Peptides (hydrolyzed—broken-down collagen to help absorption), Keratin (a structural protein), L-Glutathione (an antioxidant), and Lemon fruit juice powder (for flavor and vitamin C). The inactive ingredients—Citric Acid, Maltodextrin, and Monk Fruit extract—are fillers, thickeners, and sweeteners that keep the powder stable and palatable.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Hair, skin and nails beauty support.
  • We looked for evidence on: Aging skin, Wound healing, Hair quality, Nail strength, Skin elasticity.
  • The closest evidence on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Aging skin (Natural Medicines).
  • Also on file: Hyaluronic Acid is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

Hyaluronic Acid is rated Possibly Effective for dry eye and venous leg ulcers (slow-healing wounds in the leg due to poor circulation), but the evidence for aging skin is Insufficient—we simply don't have enough reliable data to say whether it works for that. The strawberry and lemon components have Insufficient Reliable Evidence for conditions like heart disease, diabetes, high cholesterol, and high blood pressure, so we can't rate them.

Overall, reliable evidence for this product's beauty and skin claims isn't established in our data.

The evidence, ingredient by ingredient Hyaluronic Acid Strawberry Lemon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hyaluronic Acid is generally well tolerated orally and topically, but long-term safety of oral supplements hasn't been fully studied; avoid oral supplements unless your doctor advises otherwise. Strawberry is safe in normal food amounts but concentrated supplement doses haven't been well studied in pregnancy or while breastfeeding—talk to your doctor.

Strawberry rarely causes nausea and allergic reactions (oral allergy syndrome, skin reactions). At 50 grams daily, freeze-dried strawberry powder has caused nausea in some trial participants.

Lemon is safe as food but concentrated supplements or essential oils lack safety data; fresh lemon juice can cause heartburn and stomach pain—in one trial, 37% of people drinking lemon juice daily reported gastrointestinal disturbances versus 8% on placebo.

Side effects, ingredient by ingredient Hyaluronic Acid Strawberry Lemon

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Strawberry, Lemon.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 316 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check if you take blood thinners or antiplatelet drugs (Moderate concern)—strawberry may raise bleeding risk. Also check p-glycoprotein substrates like certain cancer drugs and immunosuppressants (Moderate)—strawberry might increase their levels.

If you take itraconazole (Sporanox) for fungal infection (Minor), lemon could boost its levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, antiplatelet drugs, or p-glycoprotein substrates, check your medications with our tool before using this product because strawberry may affect how they work. If you're pregnant, breastfeeding, or have a strawberry allergy, talk to your pharmacist first.

For everyone else, the main caution is that large amounts might cause stomach upset or nausea.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Collagen Refreshers Beauty Strawberry Lemon Flavor, straight from the product label.

Brand Bluebonnet
Barcode (UPC) 743715017504
Net contents 11.29 Ounce(s); 320 Gram(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 268568
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
16 Gram(s)
Maximum serving Sizes:
16 Gram(s)
Servings per container
20
UPC/BARCODE
743715017504
IngredientAmount% DV
Calories60 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Total Sugars1 Gram(s)--
Protein11 Gram(s)--
Keratin0 NP--
Hyaluronic Acid0 NP--
L-Glutathione, Reduced0 NP--
Strawberry juice powder0 NP--
Beauty Blend2.35 Gram(s)--
Strawberry fruit powder0 NP--
Collagen Peptides, Hydrolyzed12 Gram(s)--
Lemon fruit juice powder0 NP--

Other ingredients: Citric Acid, Maltodextrin, Monk Fruit extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, add one scoop (16 g) to 8 fl oz of water, or beverage of choice and then shake, mix or stir until smooth. Mixes instantly without the use of a blender.

Formula

Bluebonnet's Collagen Refreshers Beautry is carefully crafted to revive hair, skin and nails as part of a daily beauty regimen with hydrolyzed collagen peptides as well as hyaluronic acid, Cynatine HNS a patented form of soluble keratin, and L-glutathione in a base of hydrating organic strawberry and lemon powders. Mix and enjoy!

Keto & paleo

Collagen types I & III peptides

Formulation

Beauty lift Luscious hair Youthful skin Be beautiful Strong nails

Grass-fed cows Pasture raised

Made with Non GMO ingredients Gluten free Soy free

Hydrolyzed powder

Note: This product is sold by weight, not volume. This product requires aeration at the time of filling. Settling of contents may occur. Net weight and servings are clearly marked.

Made in USA from imported and domestic ingredients.

Free of Artificially-derived flavors Dairy Soy

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Mixes instantly

Servings per container are approximate.

Recycle bottle

BPA free

Stay connected

FDA Statement of Identity

Dietary Supplement

Precautions

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Caution: For adults only.

Consult a healthcare practitioner if pregnant/nursing, or if you have a medical condition.

Keep out of the reach of children.

Allergen Warning: Manufactured in a facility that processes products containing milk, eggs, soybeans, wheat, shellfish, fish oil, tree nuts and peanut flavor.

Storage

Keep tightly closed. To guarantee freshness. After opening, store in a cool, dry place away from heat, light and moisture.

Brand IP Statement(s)

Collagen Refreshers is a trademark of Bluebonnet Nutrition Corporation.

See for yourself

Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size16 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

11 Gram(s) per serving

Beauty Blend

2.35 Gram(s) per serving

Collagen Peptides, Hydrolyzed

12 Gram(s) per serving Form: Bovine Collagen Type I Peptide, Hydrolyzed, Bovine Collagen Type III Peptide, Hydrolyzed

Other (inactive) ingredients: Citric Acid, Maltodextrin, Monk Fruit extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet Drug Interactions

Want to check YOUR meds against Collagen Refreshers Beauty Strawberry Lemon Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
316Drugs
316 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Collagen Refreshers Beauty Strawberry Lemon Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Strawberry juice powder2 drug types · 316 drugs

Anticoagulant/Antiplatelet Drugs

In vitro and animal research suggests that strawberry extract can inhibit platelet aggregation due to its phenolic content. Theoretically, strawberry might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

In vitro research suggests that strawberry extract can inhibit p-glycoprotein efflux. Theoretically, strawberry might inhibit p-glycoprotein mediated drug efflux and potentially increase levels of drugs that are substrates of p-glycoprotein. Until more is known, strawberry should be used cautiously in people taking p-glycoprotein substrates.
Drugs that might be affected include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Likelihood Possible Evidence D

Lemon fruit juice powder1 drug type · 1 drug

Itraconazole (Sporanox)

Theoretically, taking itraconazole capsules or tablets with a beverage containing lemon might increase the levels and clinical effects of itraconazole.
In one case report, dissolving itraconazole tablets in a small amount of specific beverages containing lemon prior to administration increased the level of itraconazole in a lung transplant patient. In this case, the increased bioavailability was desirable and was likely due to improved tablet dissolution in the acidic beverage.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Collagen Refreshers Beauty Strawberry Lemon Flavor, from the product label.

Bluebonnet

Name
Bluebonnet Nutrition Corporation
Street Address
12915 Dairy Ashford
City
Sugar Land
State
TX
ZipCode
77478
Web Address
www.bluebonnetnutrition.com
Pharmacist Counseling Corner

Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet: Common Questions

Does Collagen Refreshers Beauty Strawberry Lemon Flavor by Bluebonnet interact with any medications?
Yes. Based on its ingredients, Collagen Refreshers Beauty Strawberry Lemon Flavor has a known interaction with 316 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Collagen Refreshers Beauty Strawberry Lemon Flavor contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this help with aging skin?
The Hyaluronic Acid in this product hasn't been tested enough to know whether it works for aging skin, so we don't have a reliable answer. It's Possibly Effective for dry eye and slow-healing leg wounds, but skin aging is different. You might try it and see if you notice a difference, but don't count on science backing it up yet.
Is it safe to take while I'm pregnant?
Strawberry as food is fine during pregnancy, but we don't have safety data on concentrated supplement doses. There isn't enough information on file for the other active ingredients either. Talk with your doctor or pharmacist before taking this—they can weigh the pros and cons for your situation.
Can strawberry make me bleed more easily?
In theory, yes. Strawberry extract can slow platelet clumping, which is how your blood clots. If you're already on a blood thinner or aspirin-like drug, adding strawberry could increase bleeding risk. That's why checking your exact medications is important before you start.
What are the strawberry powders in here for?
They're the active ingredient providing antioxidants and phenols—plant compounds thought to support skin health, though the evidence for aging skin specifically isn't strong yet. They're listed twice because the product includes both strawberry juice powder and strawberry fruit powder.
Will this upset my stomach?
Strawberry at this dose is generally well tolerated, but freeze-dried strawberry powder at 50 grams daily has caused nausea in some people in trials. Lemon juice can cause heartburn and stomach pain—in one study, about 37% of people drinking fresh lemon juice daily had gastrointestinal trouble. If you have a sensitive stomach, start small.
Is there anything in here I should worry about if I take other medications?
Yes—strawberry can interact with blood thinners, antiplatelet drugs, and certain other medications. Lemon also interacts with itraconazole (Sporanox) for fungal infections. Use the medication checker on this page to see if any of your prescriptions are affected.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Collagen Refreshers Beauty Strawberry Lemon Flavor is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Collagen Refreshers Beauty Strawberry Lemon Flavor label
Sources

Sources & How We Checked

Collagen Refreshers Beauty Strawberry Lemon Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hyaluronic Acid 4 references
  1. Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. PubMed
  2. U.S. Food and Drug Administration. Do Not Use Needle-Free Devices for Injection of Dermal Fillers - FDA Safety Communication. October 8, 2021. Available at: https://www.fda.gov/medical-devices/safety-communications/do-not-use-needle-free-devices-injection
  3. Disphanurat W, Srisantithum B. Efficacy and safety of 0.15% isobutylamido thiazolyl resorcinol combined with hyaluronic acid vs 0.15% isobutylamido thiazolyl resorcinol or hyaluronic acid alone in melasma treatment: A randomized evaluator-blind trial. J C PubMed
  4. Humbert P, Mikosinki J, Benchikhi H, Allaert FA. Efficacy and safety of a gauze pad containing hyaluronic acid in treatment of leg ulcers of venous or mixed origin: a double-blind, randomised, controlled trial. Int Wound J 2013;10(2):159-66. PubMed

See these in context on the Hyaluronic Acid monograph →

Strawberry 18 references
  1. Grattan CE, Harman RR. Contact urticaria to strawberry. Contact Dermatitis 1985;13:191-2. . PubMed
  2. Dutta-Roy, A. K., Crosbie, L., and Gordon, M. J. Effects of tomato extract on human platelet aggregation in vitro. Platelets. 2001;12(4):218-227. PubMed
  3. Van Gelder, J., Deferme, S., Naesens, L., De Clercq, E., van den, Mooter G., Kinget, R., and Augustijns, P. Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined este
  4. Deferme, S., Van Gelder, J., and Augustijns, P. Inhibitory effect of fruit extracts on P-glycoprotein-related efflux carriers: an in-vitro screening. J Pharm Pharmacol 2002;54(9):1213-1219.
  5. Naemura, A., Mitani, T., Ijiri, Y., Tamura, Y., Yamashita, T., Okimura, M., and Yamamoto, J. Anti-thrombotic effect of strawberries. Blood Coagul.Fibrinolysis 2005;16(7):501-509. PubMed
  6. Basu A, Betts NM, Nguyen A, Newman ED, Fu D, Lyons TJ. Freeze-dried strawberries lower serum cholesterol and lipid peroxidation in adults with abdominal adiposity and elevated serum lipids. J Nutr. 2014;144(6):830-7. PubMed
  7. Feresin RG, Johnson SA, Pourafshar S, et al. Impact of daily strawberry consumption on blood pressure and arterial stiffness in pre- and stage 1-hypertensive postmenopausal women: a randomized controlled trial. Food Funct. 2017;8(11):4139-4149. PubMed
  8. Moazen S, Amani R, Homayouni Rad A, Shahbazian H, Ahmadi K, Taha Jalali M. Effects of freeze-dried strawberry supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes: a randomized double-blind controlled trial. Ann Nutr PubMed
  9. Schell J, Scofield RH, Barrett JR, et al. Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis. Nutrients. 2017;9(9):949. PubMed
  10. Zunino SJ, Parelman MA, Freytag TL, et al. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br J Nutr. 2012;108(5):900-9. PubMed
  11. Amani R, Moazen S, Shahbazian H, Ahmadi K, Jalali MT. Flavonoid-rich beverage effects on lipid profile and blood pressure in diabetic patients. World J Diabetes. 2014;5(6):962-8. PubMed
  12. Cabrera-Freitag P, Bermejo Becerro A, Abreu Ramírez MG, et al. Allergy to strawberry in children from the Mediterranean area: is it really allergy? J Investig Allergol Clin Immunol 2020;30(4):283-5. PubMed
  13. Hadi A, Askarpour M, Miraghajani M, Symonds ME, Sheikhi A, Ghaedi E. Effects of strawberry supplementation on cardiovascular risk factors: a comprehensive systematic review and meta-analysis of randomized controlled trials. Food Funct 2019;10(11):6987-98. PubMed
  14. Gao Q, Qin LQ, Arafa A, Eshak ES, Dong JY. Effects of strawberry intervention on cardiovascular risk factors: a meta-analysis of randomised controlled trials. Br J Nutr 2020;124(3):241-6. PubMed
  15. Basu A, Izuora K, Hooyman A, Scofield HR, Ebersole JL. Dietary Strawberries Improve Serum Metabolites of Cardiometabolic Risks in Adults with Features of the Metabolic Syndrome in a Randomized Controlled Crossover Trial. Int J Mol Sci 2023;24(3):2051. PubMed
  16. Huang L, Xiao D, Zhang X, et al. Strawberry Consumption, Cardiometabolic Risk Factors, and Vascular Function: A Randomized Controlled Trial in Adults with Moderate Hypercholesterolemia. J Nutr 2021;151(6):1517-1526. PubMed
  17. Basu A, Izuora K, Betts NM, et al. Dietary Strawberries Improve Cardiometabolic Risks in Adults with Obesity and Elevated Serum LDL Cholesterol in a Randomized Controlled Crossover Trial. Nutrients 2021;13(5):1421. PubMed
  18. Wilken MR, Lambert MNT, Christensen CB, Jeppesen PB. Effects of Anthocyanin-rich Berries on the Risk of Metabolic Syndrome: A Systematic Review and Meta-analysis. Rev Diabet Stud 2022;18(1):42-57. PubMed

See these in context on the Strawberry monograph →

Lemon 2 references
  1. Ruggenenti P, Caruso MR, Cortinovis M, et al. Fresh lemon juice supplementation for the prevention of recurrent stones in calcium oxalate nephrolithiasis: A pragmatic, prospective, randomised, open, blinded endpoint (PROBE) trial. EClinicalMedicine 2021;4 PubMed
  2. Umemura K, Katada Y, Nakagawa S, et al. Improved absorption of itraconazole tablet by co-administration with lemon beverages in a lung transplant recipient: A case report. J Infect Chemother 2022;28(8):1203-1207. PubMed

See these in context on the Lemon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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