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Dietary supplement

CoQ10 with Tocotrienols 100 mg Ingredients & Drug Interactions

by Swanson

CoQ10 with Tocotrienols 100 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CoQ10 with Tocotrienols 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CoQ10 with Tocotrienols 100 mg is a dietary supplement by Swanson with 2 active ingredients. Its ingredients are commonly taken for heart and cholesterol support, antioxidant support, liver health (fatty liver).Based on those ingredients, 902 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are natural Coenzyme Q10, EVNol natural Full Spectrum Tocotrienol Complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against CoQ10 with Tocotrienols 100 mg by Swanson

Ask about any prescription or over-the-counter medication and we check it for interactions with CoQ10 with Tocotrienols 100 mg by Swanson — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CoQ10 with Tocotrienols 100 mg by Swanson

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “EVNol natural Full Spectrum Tocotrienol Complex” is a proprietary blend — the label gives one combined amount (10 mg) without saying how much of each component you get.

This product contains 5 active ingredients: four forms of vitamin E (D-beta tocotrienol, D-delta tocotrienol, D-gamma tocotrienol, and D-alpha tocotrienol), a full-spectrum tocotrienol complex, and coenzyme Q10 (CoQ10). The tocotrienols are fat-soluble antioxidants related to vitamin E, and CoQ10 is a naturally occurring compound your body uses for energy production in cells.

The softgel also contains several inactive ingredients — rice bran oil, gelatin, glycerin, yellow beeswax, purified water, annatto, palm oil, additional D-alpha tocopherol, plant squalene, and a sterol complex — which serve as carriers, binders, and capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: cellular energy production and cardiovascular health.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Congestive heart failure (CHF), Coronary artery bypass graft (CABG) surgery, Exercise-induced muscle damage, Hypercholesterolemia — and 4 related terms.
  • The strongest evidence on file: Coenzyme Q10 is rated "Likely Effective" for Coenzyme Q10 deficiency (Natural Medicines).
  • Also on file: Coenzyme Q10 is rated "Possibly Effective" for Congestive heart failure (CHF).
  • Also on file: Vitamin E is rated "Possibly Effective" for Exercise-induced muscle damage.

Vitamin E (the tocotrienols) is effective for treating vitamin E deficiency and ataxia with vitamin E deficiency (AVED), a rare neurological condition. It's possibly effective for Alzheimer disease, beta-thalassemia, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and intracranial hemorrhage, though the evidence is less established for these uses.

CoQ10 is likely effective for CoQ10 deficiency and possibly effective for fibromyalgia, migraine headache, congestive heart failure, and diabetic nerve damage. The effectiveness of the full combination for general wellness or other conditions is not established in our data.

The evidence, ingredient by ingredient Tocotrienols Vitamin E Coenzyme Q10

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin E is generally well tolerated at usual dietary amounts, but high-dose long-term supplementation may raise the risk of bleeding and other harms — including rare serious effects like bleeding, hemorrhagic stroke, and cardiovascular complications. There's particular concern about increased stroke risk in male smokers taking synthetic vitamin E long-term, though other studies have shown conflicting results.

CoQ10 is generally well tolerated; in clinical trials, serious adverse effects haven't been reported, but gastrointestinal side effects like nausea, diarrhea, heartburn, and appetite suppression occur in less than 1% of patients. A small number of people have reported headache, dizziness, insomnia, skin itching, and allergic rash.

For pregnancy, vitamin E is rated possibly safe, but high-dose supplements are best avoided unless your doctor directs otherwise — amounts from food and prenatal vitamins are appropriate. For breastfeeding, vitamin E is likely safe at normal dietary amounts, but check with your doctor before taking high-dose supplements.

CoQ10's pregnancy safety has not been well studied, and safety while breastfeeding has not been established — talk with your doctor or pharmacist for personalized guidance.

Side effects, ingredient by ingredient Tocotrienols Vitamin E Coenzyme Q10

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Coenzyme Q10, Vitamin E.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments.
  • For scale: 903 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel), chemotherapy drugs (particularly alkylating agents and antitumor antibiotics), cyclosporine, drugs metabolized by your liver's CYP3A4 system, selumetinib, niacin, or blood-pressure-lowering medications. Altogether, these interactions span 903 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take any blood-thinning medications, chemotherapy drugs, or drugs processed by your liver, you'll want to check this product with your pharmacist before starting. CoQ10 and vitamin E can be helpful for specific deficiencies and certain conditions, but the tocotrienol doses here are toward the supplement range, so discuss whether it's right for you, especially if you're pregnant, breastfeeding, or have bleeding concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CoQ10 with Tocotrienols 100 mg, straight from the product label.

Brand Swanson
Barcode (UPC) 087614023496
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 265063
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CoQ10 with Tocotrienols 100 mg by Swanson, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
087614023496
IngredientAmount% DV
D-Beta Tocotrienol0 NP--
D-Delta Tocotrienol0 NP--
EVNol natural Full Spectrum Tocotrienol Complex10 mg--
natural Coenzyme Q10100 mg--
D-Gamma Tocotrienol0 NP--
D-Alpha Tocotrienol0 NP--

Other ingredients: Rice Bran Oil, Gelatin, Glycerin, yellow Beeswax, purified Water, Annatto, Palm Oil, D-Alpha Tocopherol, Plant Squalene, Sterol Complex

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

swanson.com or call 1-800-437-4148

Science-Backed Quality Since 1969

Formulation

Enhances cellular energy production and physical performance Supports cardiovascular health Boosts antioxidant activity

Cardiovascular Health

Made in Canada

Body-preferred form

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one softgel per day with food and water.

Brand IP Statement(s)

EVNol is a trademark of ExcelVite Sdn Bhd.

Precautions

Warning: For adults only.

Consult your healthcare provider before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.

Keep out of reach of children.

Do not use if seal is broken.

Storage

Store in a cool, dry place. Do not refrigerate.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formula

100 mg CoQ10 per softgel

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CoQ10 with Tocotrienols 100 mg by Swanson label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CoQ10 with Tocotrienols 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CoQ10 with Tocotrienols 100 mg by Swanson

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

EVNol natural Full Spectrum Tocotrienol Complex

Interacts with
122 drugs
10 mg per serving Form: Palm

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

EVNol natural Full Spectrum Tocotrienol Complex monograph & interactions

Natural Coenzyme Q10

Interacts with
198 drugs
100 mg per serving Form: Ubiquinone

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...

Natural Coenzyme Q10 monograph & interactions

Other (inactive) ingredients: Rice Bran Oil, Gelatin, Glycerin, Yellow Beeswax, Purified Water, Annatto, Palm Oil, D-Alpha Tocopherol, Plant Squalene, Sterol Complex. These complete the product’s ingredient list but are not active constituents.

Interaction report

CoQ10 with Tocotrienols 100 mg by Swanson Drug Interactions

Want to check YOUR meds against CoQ10 with Tocotrienols 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
902Drugs
763 Moderate 139 Minor

Ingredients driving the most interactions

natural Coenzyme Q10 198
EVNol natural Full Spectrum Tocotrienol Complex 122

Individual Drug Interactions

The ingredients in CoQ10 with Tocotrienols 100 mg interact with 902 drugs. Click any drug to see the details.

2 of the 2 ingredients in CoQ10 with Tocotrienols 100 mg interact with drugs. Each result below shows which ingredient is responsible. natural Coenzyme Q10 EVNol natural Full Spectrum Tocotrienol Complex

Each ingredient & the kinds of drugs it affects

For each ingredient in CoQ10 with Tocotrienols 100 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

natural Coenzyme Q103 drug types · 198 drugs

Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.

Likelihood Possible Evidence B
natural Coenzyme Q10 full monograph & interactions

EVNol natural Full Spectrum Tocotrienol Complex1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
EVNol natural Full Spectrum Tocotrienol Complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CoQ10 with Tocotrienols 100 mg, from the product label.

Swanson

See all Swanson products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
swanson.com
Pharmacist Counseling Corner

CoQ10 with Tocotrienols 100 mg by Swanson: Common Questions

Does CoQ10 with Tocotrienols 100 mg by Swanson interact with any medications?
Yes. Based on its ingredients, CoQ10 with Tocotrienols 100 mg has a known interaction with 902 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CoQ10 with Tocotrienols 100 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this product safe to take if I'm pregnant?
Vitamin E is rated possibly safe in pregnancy, but high-dose supplements are best avoided unless your doctor directs you to take them — amounts from food and prenatal vitamins are fine. CoQ10's pregnancy safety data is incomplete. Talk with your doctor or pharmacist about whether this product is appropriate for you during pregnancy.
What does CoQ10 do in my body?
CoQ10 is a naturally occurring compound your cells use to produce energy. Your body makes some on its own, and you also get small amounts from food. In supplement form, it's likely effective for CoQ10 deficiency and possibly effective for conditions like migraine, heart failure, and nerve damage related to diabetes.
What are the tocotrienols in this product?
Tocotrienols are forms of vitamin E — fat-soluble antioxidants your body needs. This product contains four different types: D-beta, D-delta, D-gamma, and D-alpha tocotrienols, plus a full-spectrum blend. Vitamin E is effective for treating vitamin E deficiency and a rare neurological condition called AVED, and possibly effective for Alzheimer disease and a few other conditions.
Can this product lower my blood pressure?
CoQ10 has shown the ability to lower blood pressure in some clinical studies, though other research shows mixed results. If you already take blood-pressure-lowering drugs, check with your pharmacist before adding this product, since CoQ10 could theoretically have additive effects.
What side effects might I experience?
CoQ10 is generally well tolerated, with gastrointestinal effects like nausea, diarrhea, or heartburn occurring in less than 1% of people. Vitamin E at usual doses is also well tolerated orally, but high-dose supplementation may increase bleeding risk. Rare serious effects include bleeding, stroke, and cardiovascular complications, particularly with long-term high doses.
Is this safe to take while breastfeeding?
Vitamin E is likely safe while breastfeeding at normal dietary amounts, but check with your doctor before taking high-dose supplements. CoQ10's safety while breastfeeding has not been well studied — talk with your doctor or pharmacist for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CoQ10 with Tocotrienols 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CoQ10 with Tocotrienols 100 mg label
Go deeper

The Full Monographs Behind CoQ10 with Tocotrienols 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Coenzyme Q10

Interacts with 198 drugs

CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated and is most studied for heart condition...

Read the full Coenzyme Q10 monograph →
Sources

Sources & How We Checked

CoQ10 with Tocotrienols 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 108 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin E 64 references
  1. Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol 1996;77:545-6. PubMed
  2. Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982;393:361-8. PubMed
  3. Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol 1979;1:169-73.
  4. Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA 1974;230:1300-1. DOI
  5. Labriola D, Livingston R. Possible interactions between dietary antioxidants and chemotherapy. Oncology 1999;13:1003-8.
  6. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther 1996;59:297-303. PubMed
  7. Pan SH, Lopez RR Jr, Sher LS, et al. Enhanced oral cyclosporine absorption with water-soluble vitamin E early after liver transplantation. Pharmacother 1996;16:59-65. DOI
  8. Anon. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto miocardico. Lancet 1999;354:447-55. DOI
  9. Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet 1999;354:810-6. DOI
  10. Yusuf S, Dagenais G, Pogue J, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The heart outcomes prevention evaluation study investigators. N Engl J Med 2000;342:154-60. PubMed
  11. Stephens NG, Parsons A, Schofield PM, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study. Lancet 1996;347:781-6.
  12. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. PubMed
  13. Takahashi O. Haemorrhagic toxicity of a large dose of alpha-, beta-, gamma- and delta-tocopherols, ubiquinone, beta-carotene, retinol acetate and L-ascorbic acid in the rat. Food Chem Toxicol 1995;33:121-8.
  14. Briggs GB, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 5th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 1998.
  15. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med 1997;336:1216-22. PubMed
  16. Liede KE, Haukka JK, Saxen LM, Heinonen OP. Increased tendency towards gingival bleeding caused by joint effect of alpha-tocopherol supplementation and acetylsalicylic acid. Ann Med 1998;30:542-6.
  17. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
  18. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
  19. Liu M, Wallmon A, Olsson-Mortlock C, et al. Mixed tocopherols inhibit platelet aggregation in humans: potential mechanisms. Am J Clin Nutr 2003;77:700-6. PubMed
  20. Sokol RJ, Johnson KE, Karrer FM, et al. Improvement of cyclosporin absorption in children after liver transplantation by means of water-soluble vitamin E. Lancet 1991;338:212-4.. PubMed
  21. Stein JH, Carlsson CM, Papcke-Benson K, et al. The effects of lipid-lowering and antioxidant vitamin therapies on flow-mediated vasodilation of the brachial artery in older adults with hypercholesterolemia. J Am Coll Cardiol 2001;38:1806-13.. PubMed
  22. Carlsson CM, Papcke-Benson K, Carnes M, et al. Health-related quality of life and long-term therapy with pravastatin and tocopherol (vitamin E) in older adults. Drugs Aging 2002;19:793-805. . PubMed
  23. Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
  24. Schrogie JJ. Coagulopathy and fat-soluble vitamins (letter). JAMA 1975;232:19. DOI
  25. Celestini A, Pulcinelli FM, Pignatelli P, et al. Vitamin E potentiates the antiplatelet activity of aspirin in collagen-stimulated platelets. Haematologica 2002;87:420-6.
  26. Stampfer MJ, Jakubowski JA, Faigel D, et al. Vitamin E supplementation effect on human platelet function, arachidonic acid metabolism, and plasma prostacyclin levels. Am J Clin Nutr 1988;47:700-6. PubMed
  27. Jandak J, Steiner M, Richardson PD. Alpha-tocopherol, an effective inhibitor of platelet adhesion. Blood 1989;73:141-9. DOI
  28. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996;94:2434-40. PubMed
  29. Steiner M. Vitamin E, a modifier of platelet function: rationale and use in cardiovascular and cerebrovascular disease. Nutr Rev 1999;57:306-9. PubMed
  30. Brodkin RH, Bleiberg J. Sensitivity to topically applied vitamin E. Arch Dermatol 1965;92:76-7. DOI
  31. Booth SL, Golly I, Sacheck JM, et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr 2004;80:143-8. PubMed
  32. Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: High-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med 2005;142:60520-53. PubMed
  33. Lonn E, Bosch J, Yusuf S, et al. HOPE and HOPE-TOO Trial Investigators. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA 2005;293:1338-47. PubMed
  34. Landes N, Pfluger P, Kluth D, et al. Vitamin E activates gene expression via the pregnane X receptor. Biochem Pharmacol 2003;65:269-73. . PubMed
  35. Brigelius-Flohe R. Vitamin E and drug metabolism. Biochem Biophys Res Commun 2003;305:737-40. PubMed
  36. Prasad KN. Rationale for using high-dose multiple dietary antioxidants as an adjunct to radiation therapy and chemotherapy. J Nutr 2004;134:3182S-3S. PubMed
  37. Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
  38. Schurks M, Glynn RJ, Rist PM, et al. Effects of vitamin E on stroke subtypes: meta-analysis of randomized controlled trials. BMJ 2010;341: c5702. doi: 10.1136/bmj.c5702.
  39. Lawson KA, Wright ME, Subar A, et al. Multivitamin use and risk of prostate cancer in the National Institutes of Health-AARP Diet and Health Study. J Natl Cancer Inst 2007;99:754-64. PubMed
  40. Gaziano JM, Glynn RJ, Christen WG, et al. Vitamins E and C in the prevention of prostate total cancer in men: the physicians' health study II randomised controlled trial. JAMA 2009;301:52-62.
  41. Hayden KM, Welsh-Bohmer KA, Wengreen HJ, et al; Cache County Investigators. Risk of mortality with vitamin E supplements: the Cache County study. Am L Med 2007;120:180-4. PubMed
  42. Smedts HP, de Vries JH, Rakhshandehroo M, et al. High maternal vitamin E intake by diet or supplements is associated with congenital heart defects in the offspring. BJOG 2009;116:416-23. PubMed
  43. Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2011;306:1549-56. PubMed
  44. Huang, H. Y., Caballero, B., Chang, S., Alberg, A. J., Semba, R. D., Schneyer, C. R., Wilson, R. F., Cheng, T. Y., Vassy, J., Prokopowicz, G., Barnes, G. J., and Bass, E. B. The efficacy and safety of multivitamin and mineral supplement use to prevent ca
  45. Sesso, H. D., Buring, J. E., Christen, W. G., Kurth, T., Belanger, C., MacFadyen, J., Bubes, V., Manson, J. E., Glynn, R. J., and Gaziano, J. M. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians' Health Study II randomiz
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  47. Cooper, K., Squires, H., Carroll, C., Papaioannou, D., Booth, A., Logan, R. F., Maguire, C., Hind, D., and Tappenden, P. Chemoprevention of colorectal cancer: systematic review and economic evaluation. Health Technol.Assess. 2010;14(32):1-206. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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