Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Counter Cravings Ingredients & Drug Interactions

by HUM

Counter Cravings label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Counter Cravings against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Counter Cravings is a dietary supplement by HUM with 4 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,237 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Coleus forskohlii extract powder, L-Theanine, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Counter Cravings by HUM

Ask about any prescription or over-the-counter medication and we check it for interactions with Counter Cravings by HUM — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Counter Cravings by HUM

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • “Chromax” is listed as a grouped ingredient — the label gives one combined amount (800 mcg) without saying how much of each component you get.
  • “Coleus forskohlii extract powder” is listed as a grouped ingredient — the label gives one combined amount (250 mg) without saying how much of each component you get.
  • “Brown Seaweed (Laminaria japonica) extract” is listed as a grouped ingredient — the label gives one combined amount (15 mg) without saying how much of each component you get.

Counter Cravings contains 4 active ingredients. L-theanine is an amino acid that supports calm focus without drowsiness.

Chromium (from Chromax, a chromium blend) is a mineral that plays a role in blood sugar balance. Forskolin comes from Coleus forskohlii extract and supports metabolic function.

The product also contains brown seaweed extract for its fucoxanthin content, though we have no interaction data on fucoxanthin itself. The capsule also holds inactive fillers: cellulose, ascorbyl palmitate (a form of vitamin C for stability), and rice flour.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Reduces stress-induced cravings and maintains healthy weight.
  • We looked for evidence on: Stress, Binge eating disorder, Obesity, Generalized anxiety disorder (GAD), Emotional eating, Appetite control.
  • The closest evidence on file: Chromium is rated "Insufficient Reliable Evidence To Rate" for Obesity (Natural Medicines).
  • Also on file: Chromium is rated "Insufficient Reliable Evidence To Rate" for Binge eating disorder.
  • Also on file: Coleus is rated "Insufficient Reliable Evidence To Rate" for Obesity.

L-theanine is possibly effective for cognitive function, but evidence is insufficient to rate it for age-related cognitive decline, Alzheimer disease, or anxiety disorders like GAD and OCD. Chromium is likely effective for chromium deficiency and possibly effective for type 2 diabetes, but possibly ineffective for prediabetes, schizophrenia, and high blood pressure.

Forskolin's evidence is insufficient to rate it for any of its proposed uses—angina, asthma, heart failure, eczema, or dry eye. We hold no effectiveness data for fucoxanthin.

The evidence, ingredient by ingredient Theanine Chromium Coleus Laminaria

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated for short-term use in healthy adults, but long-term safety isn't well studied. Common side effects include headaches, drowsiness, and vivid dreams.

The safety data advises against L-theanine during pregnancy and while breastfeeding. Chromium is usually well tolerated at typical supplement doses; at high or prolonged doses, gastrointestinal upset, headaches, insomnia, and mood changes may occur, and rare cases of kidney damage and blood cell problems have been reported.

Small amounts from food or prenatal vitamins are generally acceptable, but extra supplement doses should be avoided unless your doctor recommends them. Forskolin appears well tolerated, with most common side effects being constipation, diarrhea, nausea, and vomiting.

The safety data advises against forskolin during pregnancy and breastfeeding. No safety data are on file for fucoxanthin.

Side effects, ingredient by ingredient Theanine Chromium Coleus Laminaria

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Chromium, Coleus, Theanine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 1,212 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take nitrates or calcium channel blockers (Major severity), any blood pressure medication, diabetes or insulin therapy, levothyroxine or thyroid hormone, blood thinners like warfarin, drugs that work through the liver's CYP2C9 or CYP3A4 pathways, NSAIDs or aspirin, or sedating medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

Counter Cravings may help with focus and cognition if you take no blood pressure or heart medications, diabetes drugs, thyroid medication, blood thinners, or certain sedating drugs. If you take nitrates, calcium channel blockers, or any antihypertensive drug, this product is not for you.

Before starting, check your medications with your doctor or pharmacist — the interaction list is long and includes common drugs.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Counter Cravings, straight from the product label.

Brand HUM
Barcode (UPC) 850008331305
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 241681
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Counter Cravings by HUM, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
850008331305
IngredientAmount% DV
L-Theanine200 mg--
Chromax800 mcg--
Chromium100 mcg286%
Coleus forskohlii extract powder250 mg--
Forskolin25 mg--
Brown Seaweed (Laminaria japonica) extract15 mg--
Fucoxanthin1.5 mg--

Other ingredients: Cellulose, Ascorbyl Palmitate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

HUM Beauty starts from within

Formulation

Manages stress-eating and boosts metabolism

Non-GMO Gluten-free No artificial colors or preservatives

Sustainably sourced

Contains No: Wheat, gluten, soy, milk, egg, fish, crustacean shellfish, peanuts, artificial colors, flavors or preservatives.

Vegan produtct.

Made in the USA

Formula

forskolin, chromium, L-theanine

Snacking as a stress response? Counter Cravings contains a combination of plant extracts including forskolin from the coleus plant and fucoxanthin, a seaweed extract to help reduce stress-induced cravings and maintain a healthy weight. Chromium boosts metabolism and balances blood sugar levels while L-theanine helps to boost mood. Pure & potent nutrients

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended by leading nutritionists Take 1 capsule twice a day

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Keep out of reach of children.

Consult your healthcare professional prior to use if you have or suspect a medical condition, are taking prescription drugs, or are pregnant or lactating.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Counter Cravings by HUM label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Counter Cravings label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Counter Cravings by HUM

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Chromax

800 mcg per serving

Coleus forskohlii extract powder

Interacts with
915 drugs
250 mg per serving Form: Forskohlin

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...

Coleus forskohlii extract powder monograph & interactions

Brown Seaweed (Laminaria japonica) extract

Interacts with
69 drugs
15 mg per serving Form: Fucoxanthin

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because it...

Brown Seaweed (Laminaria japonica) extract monograph & interactions
  • › Fucoxanthin

Other (inactive) ingredients: Cellulose, Ascorbyl Palmitate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Counter Cravings by HUM Drug Interactions

Want to check YOUR meds against Counter Cravings?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,237Drugs
29 Major 984 Moderate 224 Minor

Ingredients driving the most interactions

Coleus forskohlii extract powder 915
L-Theanine 565
Chromium 178
Brown Seaweed (Laminaria japonica) extract 69

Individual Drug Interactions

The ingredients in Counter Cravings interact with 1,237 drugs. Click any drug to see the details.

4 of the 4 ingredients in Counter Cravings interact with drugs. Each result below shows which ingredient is responsible. Coleus forskohlii extract powder L-Theanine Chromium Brown Seaweed (Laminaria japonica) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Counter Cravings with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Coleus forskohlii extract powder7 drug types · 915 drugs

Calcium Channel Blockers

Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Nitrates

Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.

Likelihood Probable Evidence B
Anticoagulant/Antiplatelet Drugs

Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.

Likelihood Possible Evidence D
Coleus forskohlii extract powder full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Brown Seaweed (Laminaria japonica) extract6 drug types · 69 drugs

Ace Inhibitors (Aceis)

Theoretically, laminaria might increase the risk of hyperkalemia when taken with ACEIs.
Laminaria contains potassium.

Likelihood Possible Evidence D
Amiodarone (Cordarone)

Theoretically, combining laminaria with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with laminaria supplements, some of which may contain as much as 1000 mcg iodine, might increase the risk of adverse effects from iodine, including altered thyroid function.

Likelihood Possible Evidence D
Antithyroid Drugs

Due to its iodine content, laminaria might alter the effects of antithyroid drugs.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of antithyroid drugs.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, laminaria might increase the risk of hyperkalemia, which could increase the effects and adverse effects of digoxin.
Laminaria contains potassium.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, laminaria might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Laminaria contains potassium.

Likelihood Possible Evidence D
Thyroid Hormone

Due to its iodine content, laminaria might alter the effects of thyroid hormone.
Some laminaria supplements contain up to 1000 mcg of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking laminaria could theoretically alter the effects of thyroid hormone.

Likelihood Possible Evidence D
Brown Seaweed (Laminaria japonica) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Counter Cravings, from the product label.

HUM

See all HUM products
Name
HUM Nutrition
City
Los Angeles
State
CA
ZipCode
90069
Phone Number
888-647-8880
Web Address
HUMNutrition.com
Pharmacist Counseling Corner

Counter Cravings by HUM: Common Questions

Does Counter Cravings by HUM interact with any medications?
Yes. Based on its ingredients, Counter Cravings has a known interaction with 1,237 medications, including 29 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Counter Cravings contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
The safety data advises against L-theanine and forskolin during pregnancy and while breastfeeding — there isn't enough data to know either way. Chromium in small amounts from food or prenatal vitamins is generally acceptable, but extra supplement doses should be avoided unless your doctor recommends them. Talk with your doctor or pharmacist about what's right for you.
What does L-theanine actually do?
L-theanine is an amino acid that appears to support focus and cognitive function — the evidence rates it as possibly effective for that. It's generally well tolerated and doesn't usually cause drowsiness, though some people report vivid dreams or headaches.
Will this help with my blood sugar?
Chromium in this product is possibly effective for type 2 diabetes, but the evidence rates it possibly ineffective for prediabetes. If you're already taking diabetes or insulin medication, chromium can increase the blood-sugar-lowering effect and raise your hypoglycemia risk — don't add it without talking to your doctor first.
What are the common side effects?
L-theanine may cause headaches, drowsiness, and vivid dreams. Chromium can cause stomach upset, insomnia, headaches, and mood changes at typical doses. Forskolin may cause constipation, diarrhea, nausea, or vomiting. If you notice any of these, stop and talk with your pharmacist.
Is it safe for long-term use?
Long-term safety for L-theanine and forskolin isn't well studied, so use with care and professional guidance. Chromium at high or prolonged doses carries theoretical risks — stick to typical supplement doses and talk with your doctor if you plan to use it long-term.
What is fucoxanthin?
Fucoxanthin is a compound from brown seaweed in this product. We don't hold any interaction data for it, so we can't tell you about its safety or effectiveness profile.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Counter Cravings label
Go deeper

The Full Monographs Behind Counter Cravings’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Coleus

Interacts with 915 drugs

Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...

Read the full Coleus monograph → Herb & supplement monograph

Laminaria

Interacts with 69 drugs

Laminaria is a type of brown seaweed (kelp) that is very rich in iodine and is also used in medical settings as a natural cervical dilator. Because its iodine content can be high and variabl...

Read the full Laminaria monograph →
Sources

Sources & How We Checked

Counter Cravings's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 84 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
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Coleus 16 references
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Laminaria 9 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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