Cranberry Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Cranberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Cranberry is a dietary supplement by Eclectic Institute with 3 active ingredients. Its ingredients are commonly taken for urinary tract infection prevention, bladder health, antioxidant support.Based on those ingredients, 712 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are ORGANIC Cranberry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Cranberry by Eclectic Institute
Ask about any prescription or over-the-counter medication and we check it for interactions with Cranberry by Eclectic Institute — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Cranberry by Eclectic Institute
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains three ingredients. The active one is organic cranberry, a concentrated source of compounds traditionally used for urinary tract health.
The other two listed ingredients — procyanidin oligomers and anthocyanosides — are naturally occurring compounds in cranberry that contribute to its activity. There are no inactive fillers listed for this product.
Does it work?
Moderate evidence
Cranberry is possibly effective for urinary tract infections (UTIs) based on available evidence. For other uses — including age-related cognitive decline, benign prostatic hyperplasia, cancer prevention, fatty liver disease, and chronic fatigue — the evidence is insufficient to rate whether it works.
If you're taking this for a UTI or to help prevent one, it may help; for any other condition, the science hasn't yet shown a clear benefit.
How safe is it?
Well-documented data
Cranberry is generally well tolerated when taken by mouth, but the most common side effects are diarrhea and gastrointestinal discomfort. In very large doses — several liters of juice daily — it can cause more severe stomach upset, especially in young children.
Some people have reported nausea, vomiting, and skin redness. Concentrated supplement doses like this one haven't been studied as thoroughly as whole cranberry in food amounts, so it's wise to check with your provider before starting, especially if you have a sensitive stomach.
Cranberry is considered likely safe in pregnancy and while breastfeeding.
Meds to double-check
Moderate interaction found
Check your medications if you take blood thinners like warfarin, cholesterol-lowering drugs like atorvastatin, or blood pressure medications like nifedipine — cranberry may increase their levels and side effects (Moderate severity). Also mention any pain relievers like diclofenac or other medications that go through your liver's CYP3A4 or CYP2C9 pathways.
Use the medication checker below to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
If you're looking to support urinary tract health, cranberry may help. However, if you take blood thinners, cholesterol drugs, or blood pressure medications, talk to your pharmacist or doctor first — cranberry can alter how these work.
Even if you don't take those medications, a quick medication check on this page is smart before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Cranberry, straight from the product label.
| Brand | Eclectic Institute |
|---|---|
| Barcode (UPC) | 023363305384 |
| Net contents | 50 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | May 23, 2014 |
| DSLD ID | 32976 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Cranberry by Eclectic Institute, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| ORGANIC Cranberry | 300 mg | -- |
| 0.75-1.5% procyanidin oligomers | 0 NP | -- |
| 0.35-1% Total anthocyanosides | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General
3053800
General Statements
Fresh Raw Freeze-Dried
300 mg per capsule
RAW: No heat, No Extraction, No Solvents WHOLE: Delivers the complete complex of ingredients found in the fresh, whole berry. Only the water has been removed. Nothing has been added. COMPLEX: In addition to procyanidins and anthocyanins, scores of other constituents from fresh berries remain intact including polyphenols, phytosterols, polysaccharides, vitamins, minerals and enzymes. Each Capsule Contains:
Established Oct. 1982
Lot# 14508/11 - Exp. 12/13
We start but most importantly also end with fresh whole raw foods.
Formula
Vaccinium macrocarpon Berry
0.75-1.5% Procyanidins 0.5-1.0% Anthocyanins
100% Kosher
FDA Statement of Identity
A Dietary Supplement
Seals/Symbols
Vegan
Gluten free
Brand IP Statement(s)
FRESH UPGRADE(TM)
CONSISTENCY WITHOUT CHEMICALS(TM)
The FRESH UPGRADE(TM) Exclusive Guarantee
Suggested/Recommended/Usage/Directions
Suggested Use: 1-3 capsules, 1-4 times per day.
Precautions
Discontinue use if unusual symptoms occur.
Consult your health care advisor regarding the use of herbs during pregnancy, with infants or with prescription drugs.
Consult your health care advisor regarding the use of herbs during pregnancy, with infants or with prescription drugs.
Keep out of reach of children
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Cranberry by Eclectic Institute label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Cranberry by Eclectic Institute
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
ORGANIC Cranberry
Interacts with712 drugs
Cranberry is best known for helping to prevent repeated urinary tract infections (UTIs) in some people, and the evidence here is moderate but mixed. I...
ORGANIC Cranberry monograph & interactions0.75-1.5% procyanidin oligomers
0.35-1% Total anthocyanosides
Cranberry by Eclectic Institute Drug Interactions
HelloPharmacist Interaction Report
Eclectic Institute's Cranberry product contains an active ingredient, organic cranberry, that does interact with medications.
The most serious concern is with blood thinners (anticoagulants) like warfarin — cranberry may increase how much warfarin stays in your body and raise your bleeding risk, though the research is conflicting on this point.
Read the full breakdown — every affected drug type, severity by severity
Cranberry also interacts moderately with cholesterol-lowering drugs like atorvastatin and with certain blood pressure medications like nifedipine. There's a documented case of a patient on atorvastatin who developed severe muscle breakdown and liver problems after drinking large amounts of cranberry juice daily for two weeks.
Additionally, cranberry may affect how your body processes pain relievers like diclofenac, though human evidence for this is weak.
Altogether, these interactions span 702 individual medications. The other two listed ingredients — the procyanidin oligomers and anthocyanosides — could not be checked against medication databases, so we have no interaction data for them.
Before starting this supplement, run your exact medications through the checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Cranberry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Cranberry interact with 712 drugs. Click any drug to see the details.
1 of the 3 ingredients in Cranberry interact with drugs. Each result below shows which ingredient is responsible. ORGANIC Cranberry
Buproprion, DextromethorphanAuvelity
How Buproprion, Dextromethorphan interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Buproprion, Dextromethorphan interactionBuspironeBuSpar
How Buspirone interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Buspirone interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Busulfan interactionCabazitaxelCabazitaxel, Jetvana
How Cabazitaxel interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cabazitaxel interactionCabotegravir, RilpivirineCabenuva
How Cabotegravir, Rilpivirine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cabotegravir, Rilpivirine interactionCabozantinibCometriq
How Cabozantinib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cabozantinib interactionCabozantinib S-malateCabometyx
How Cabozantinib S-malate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cabozantinib S-malate interactionCaffeine (otc Drug)Molie, Overtime, Vivarin
How Caffeine (otc Drug) interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine (otc Drug) interactionCaffeine (prescription Drug)Caffeine, Dextrophin
How Caffeine (prescription Drug) interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine (prescription Drug) interactionCaffeine , Sodium BenzoateCaffeine and Sodium Benzoate
How Caffeine , Sodium Benzoate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine , Sodium Benzoate interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine (prescription Drug)Migergot
How Caffeine, Ergotamine (prescription Drug) interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine, Ergotamine (prescription Drug) interactionCaffeine, Ergotamine Tartrate (prescription Drug)Cafergot, Wigraine
How Caffeine, Ergotamine Tartrate (prescription Drug) interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine, Ergotamine Tartrate (prescription Drug) interactionCaffeine, Potassium Salicylate, SalicylamideTrim-Elim
How Caffeine, Potassium Salicylate, Salicylamide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Caffeine, Potassium Salicylate, Salicylamide interactionCalcifediolRayaldee
How Calcifediol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Calcifediol interactionCannabidiol (prescription Drug)Epidiolex
How Cannabidiol (prescription Drug) interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cannabidiol (prescription Drug) interactionCapivasertibTruqap
How Capivasertib interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Capivasertib interactionCapmatinib HydrochlorideTabrecta
How Capmatinib Hydrochloride interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Capmatinib Hydrochloride interactionCarbamazepineCarbatrol, Carnexiv, Equetro, Tegretol, Tegretol XR
How Carbamazepine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Carbamazepine interactionCarbetapentane Tannate, Chlorpheniramine TannateTussi-12
How Carbetapentane Tannate, Chlorpheniramine Tannate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Carbetapentane Tannate, Chlorpheniramine Tannate interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionCarbetapentane, Chlorpheniramine, PhenylephrineRicotuss
How Carbetapentane, Chlorpheniramine, Phenylephrine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Carbetapentane, Chlorpheniramine, Phenylephrine interactionCarbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium GuaiacolsulfonateCophene-X
How Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interactionCariprazine HydrochlorideVraylar
How Cariprazine Hydrochloride interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cariprazine Hydrochloride interactionCelecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 2c9 (cyp2c9) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates.
Read the full Organic Cranberry + Celecoxib, Tramadol interactionCevimelineEvoxac
How Cevimeline interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Cevimeline interactionChlorpheniramineChlor-Trimeton, Teldrin
How Chlorpheniramine interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Chlorpheniramine interactionChlorpheniramine Maleate, Dextromethorphan HydrobromideCoricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief
How Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Cranberry — through 1 ingredient. Tap an ingredient for the detail:
Organic CranberryCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
Read the full Organic Cranberry + Chlorpheniramine Polistirex, Codeine Polistirex interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Cranberry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
ORGANIC Cranberry
Atorvastatin (Lipitor)
Theoretically, cranberry might increase levels and adverse effects of atorvastatin.
In one case report, a patient taking atorvastatin experienced upper back pain, rhabdomyolysis, and abnormal liver function after drinking cranberry juice 16 ounces daily for 2 weeks. Theoretically, this may have been caused by inhibition of cytochrome P450 3A4 (CYP3A4) enzymes by cranberry juice, as atorvastatin is a CYP3A4 substrate. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Patients taking atorvastatin should avoid large quantities of cranberry juice.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP3A4 substrates.
A case of upper back pain, rhabdomyolysis, and abnormal liver function has been reported for a patient taking atorvastatin, a CYP3A4 substrate, in combination with cranberry juice 16 ounces daily for 2 weeks. Creatinine kinase and liver enzymes normalized within 2 weeks of stopping cranberry juice. Also, animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine, a CYP3A4 substrate, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control.
Nifedipine (Procardia)
Theoretically, cranberry might increase the levels and adverse effects of nifedipine.
Animal research suggests that cranberry juice, administered intraduodenally 30 minutes prior to nifedipine treatment, inhibits nifedipine metabolism and increases the area under the concentration-time curve by 1.6-fold compared to control. This interaction has not been reported in humans.
Warfarin (Coumadin)
Theoretically, cranberry might increase the levels and adverse effects of warfarin. However, research is conflicting.
There is contradictory evidence about the effect of cranberry juice on warfarin. Case reports have linked cranberry juice consumption to increases in the international normalized ratio (INR) in patients taking warfarin, resulting in severe spontaneous bleeding and excessive postoperative bleeding. Daily consumption of cranberry sauce for one week has also been linked to an increase in INR in one case report. In a small study in healthy young males, taking a high dose of 3 grams of cranberry juice concentrate capsules, equivalent to 57 grams of fruit daily, for 2 weeks produced a 30% increase in the area under the INR-time curve after a single 25-mg dose of warfarin. However, 3 very small clinical studies in patients stabilized on warfarin reported that cranberry juice 250 mL once or twice daily for 7 days (27% cranberry juice or pure cranberry juice) or 240 mL once daily for 14 days does not significantly increase INR or affect plasma warfarin levels. The reasons for these discrepant findings are unclear. It is possible that the form and dose of cranberry may play a role, as cranberry extracts and juices contain different constituents. Additionally, an in vitro study evaluating 5 different cranberry juices found varying effects, with only a cranberry concentrate, and not diluted cranberry juices, inhibiting CYP2C9. However, this concentrate did not inhibit CYP2C9 activity in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, cranberry might increase the levels and adverse effects of CYP2C9 substrates. However, research is conflicting.
There is contradictory evidence about the effect of cranberry on CYP2C9 enzymes. In vitro evidence suggests that flavonoids in cranberry inhibit CYP2C9 enzymes. However, clinical research shows that cranberry juice does not significantly affect the levels, metabolism, or elimination of the CYP2C9 substrates flurbiprofen or diclofenac. Also, in patients stabilized on warfarin, drinking cranberry juice 250 mL daily for 7 days does not significantly increase the anticoagulant activity of warfarin, a CYP2C9 substrate. Additional pharmacokinetic research shows that cranberry juice does not increase peak plasma concentrations or area under the concentration-time curve of warfarin.
Diclofenac (Voltaren, Others)
Theoretically, cranberry might modestly increase the levels and adverse effects of diclofenac.
In vitro evidence suggests that cranberry juice inhibits diclofenac metabolism by human liver microsomes. However, drinking cranberry juice does not seem to affect diclofenac metabolism in humans.
Brand information
Manufacturer and brand details for Cranberry, from the product label.
Eclectic Institute
See all Eclectic Institute products- Name
- Eclectic Institute Inc.
- City
- Sandy
- State
- Oregon
- ZipCode
- 97055
- Phone Number
- 503-668-4120
- Web Address
- www.eclecticherb.com
Cranberry by Eclectic Institute: Common Questions
Does Cranberry by Eclectic Institute interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Does cranberry actually work for urinary tract infections?
What are the side effects I might notice?
Is it safe to take while pregnant or breastfeeding?
Why does the label mention procyanidin oligomers and anthocyanosides?
I'm on a statin for my cholesterol — is this okay?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Cranberry is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Cranberry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Cranberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 33 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Cranberry 33 references
- Anon. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance 2003;29:8. PubMed
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. PubMed
- Hodek P, Trefil P, Stiborova M. Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450. Chem Biol Interact 2002;139:1-21.. PubMed
- Grant P. Warfarin and cranberry juice: An interaction? J Heart Valve Dis 2004;13:25-6.
- Suvarna R, Pirmohamed M, Henderson L. Possible interaction between warfarin and cranberry juice. BMJ 2003;327:1454. PubMed
- Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc 2006;106:2057-61. PubMed
- Lilja JJ, Backman JT, Neuvonen PJ. Effects of daily ingestion of cranberry juice on the pharmacokinetics of warfarin, tizanidine, and midazolam - probes of CYP2C9, CYP1A2 and CYP3A4. Clin Pharmacol The 2007:81:833-9. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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