Interactions on record — worth a quick check against your medications. Based on 3 of 7 ingredients. Check your meds →
Dietary supplement

Creakic Hardcore Ingredients & Drug Interactions

by MuscleTech

Creakic Hardcore label
See full label image
Other (e.g. Tea Bag) Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Creakic Hardcore against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Creakic Hardcore is a dietary supplement by MuscleTech with 7 active ingredients. Its ingredients are commonly taken for improving high-intensity exercise performance, building muscle strength and size, sports and athletic training.Based on those ingredients, 263 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 6-8-Thioctic Acid, L-Carnosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Creakic Hardcore by MuscleTech

Ask about any prescription or over-the-counter medication and we check it for interactions with Creakic Hardcore by MuscleTech — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Creakic Hardcore by MuscleTech

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 7 active ingredients.
  • “CREAKIC Hardcore Proprietary Blend” is a proprietary blend — the label gives one combined amount (6,208 mg) without saying how much of each component you get.

Creakic Hardcore contains seven active ingredients. Creatine Monohydrate and Creatine Pyruvate are two forms of creatine, a compound that helps your muscles produce energy during intense exercise.

L-Carnosine is a dipeptide — a small chain of amino acids — that plays roles in muscle and nerve function. Alpha-Ketoglutarate, Ketoisocaproic Acid Calcium, and N Omega-Phosphocreatine are additional compounds meant to support muscle metabolism.

The product also includes 6-8-Thioctic Acid (alpha-lipoic acid), an antioxidant. The remaining ingredients are inactive — cellulose, binders, flow agents, coating materials, and flavoring to make the product palatable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Diabetic neuropathy — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).
  • On file: Hyperlipidemia — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).
  • On file: Obesity — rated "Possibly Effective" (Alpha-lipoic Acid) (Natural Medicines).
  • On file: Athletic performance — rated "Possibly Effective" (Creatine) (Natural Medicines).
  • On file: Muscle strength — rated "Possibly Effective" (Creatine) (Natural Medicines).

Creatine Monohydrate and Creatine Pyruvate are rated Possibly Effective for sarcopenia (age-related muscle loss), cerebral creatine deficiency syndromes, muscle strength, and athletic performance. They are rated Possibly Ineffective for Huntington disease and osteopenia (low bone density).

Alpha-lipoic acid (6-8-Thioctic Acid) is rated Possibly Effective for diabetic neuropathy (nerve damage from diabetes), high cholesterol (hyperlipidemia), and obesity. For L-Carnosine, the evidence isn't established — it's rated Insufficient Reliable Evidence for age-related cognitive decline, Alzheimer disease, athletic performance, cataracts, and cognitive impairment, and Possibly Ineffective for autism spectrum disorder.

We hold no effectiveness data for Alpha-Ketoglutarate, Ketoisocaproic Acid Calcium, or N Omega-Phosphocreatine.

The evidence, ingredient by ingredient Creatine Carnosine Alpha-lipoic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Creatine (both forms) is generally well tolerated in healthy adults but warrants caution if you have kidney problems. Common side effects include dehydration, diarrhea, stomach upset, muscle cramps, and water retention.

Rare serious concerns from case reports include kidney inflammation, kidney insufficiency, muscle breakdown (rhabdomyolysis), and blood clots — though these are uncommon. Some people taking creatine at high doses have reported water retention and swelling.

L-Carnosine is generally well tolerated short-term, though long-term safety data are limited. Reported side effects include decreased appetite, dry mouth, weight changes, foot and joint pain, and rarely pneumonia.

Alpha-lipoic acid is generally well tolerated but commonly causes headache, heartburn, nausea, and vomiting; rarely, it may cause a serious skin rash or autoimmune reaction. Alpha-lipoic acid can lower blood sugar, so it's best used under medical guidance if you're diabetic.

Side effects, ingredient by ingredient Creatine Carnosine Alpha-lipoic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Alpha-lipoic Acid, Carnosine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications.
  • For scale: 263 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Creakic Hardcore, double-check with your pharmacist if you take anticoagulant or antiplatelet drugs (blood thinners like warfarin or aspirin) — alpha-lipoic acid may increase bleeding risk. Also check if you take thyroid hormone replacement, chemotherapy drugs (alkylating agents or antitumor antibiotics), or antidiabetes medications — all three drug types have documented interactions at Moderate or Minor severity with ingredients in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is aimed at people seeking to support muscle strength and athletic performance through creatine supplementation paired with other metabolic compounds. If you have kidney disease, are on blood thinners or clotting medications, take thyroid hormone, use chemotherapy, or take diabetes medication, talk to your pharmacist or doctor before starting — the interactions and safety concerns are real.

Pregnant or nursing women should avoid it based on insufficient safety data.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 10, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Creakic Hardcore, straight from the product label.

Brand MuscleTech
Net contents 180 Caplet(s)
Market status On market
Date entered into DSLD Oct 10, 2014
DSLD ID 37128
Product type Non-nutrient/non-botanical
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Creakic Hardcore by MuscleTech, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
6 Caplet(s)
Maximum serving Sizes:
6 Caplet(s)
Servings per container
30
IngredientAmount% DV
Creatine Monohydrate0 NP--
L-Carnosine0 NP--
Alpha-Ketoglutarate0 NP--
Creatine Pyruvate0 NP--
CREAKIC Hardcore Proprietary Blend6208 mg--
6-8-Thioctic Acid0 NP--
Ketoisocaproic Acid Calcium0 NP--
N Omega-Phosphocreatine0 NP--

Other ingredients: Microcrystalline Cellulose, Hydroxypropylcellulose, Coating, Povidone, Croscarmellose Sodium, Crospovidone, Stearic Acid, Magnesium Stearate, Silica, Natural flavor, Acesulfame-Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

For best results, stack with LEUKIC(R) Hardcore and GAKIC(R) Hardcore.

Sure, there are a lot of creatine pills you can choose from, but when compared to other leading creatine pills on the market, CREAKIC(R) Hardcore is mega-dosed with more creatine per serving- up to a massive 330 percent more! The new CREAKIC(R) Hardcore formula is also protected by a U.S.patent.

The new CREAKIC(R) hardcore formula is powered by the most scientifically validated form of creatine on the planet.

Team Muscle Tech(TM) researchers examined countless studies spanning the globe on creatine and muscle physiology. New CREAKIC(R) Hardcore is engineered with Micro-Dispersion Technology(TM) for rapid release and it's loaded with 100 percent more creatine per serving than the previous formula. Get CREAKIC(R) Hardcore now for rapid and dramatic results.

The Muscle Tech(R) brand of supplements is America's #1 selling sports supplement brand.

(C) 2010

Rapidly and Dramatically Builds Lean Muscle Mass CREAKIC(C) Hardcore is scientifically engineered to deliver rapid and dramatic gains in both muscle size and strength when combined with you hardcore training program.

Test Subjects Increased Muscle Fiber Protein Content by 58% In a 12-week study, test subjects taking the key ingredient in CREAKIC(R) Hardcore and following a hardcore training program increased muscle fiber protein content by 58 percent.

In a 12-week study on 22 untrained subjects randomly assigned to one of three groups, subjects taking the key ingredient in CREAKIC(R) Hardcore built over 4 times more muscle (7.1 vs. 1.3 lbs.) compared to the placebo.

SCIENTIFICALLY ADVANCED MUSCLEBUILDING CREATINE PILL(TM)

For rapid gains in muscle size and strength, CREAKIC(R) Hardcore is mega-dosed with up to 330 percent more creatine per serving than other leading creatine pills.

In fact, in a study on 31 weight-trained subjects randomly assigned to one of three groups, test subjects consuming the key ingredient in CREAKIC(R) Hardcore increased their strength capacity by 18.6 percent in 10 days!

Precautions

WARNING: Not intended for use by persons under 18.

Do not use if pregnant or nursing.

Discontinue use and consult a medical doctor if you experience unusual symptoms.

If you experience a skin rash or any other allergic reaction, discontinue use and consult a medical doctor.

Consult a medical doctor before use if you have been treated for or diagnosed with, or have a family history of, any medical condition, or if you are using any prescription or over-the-counter drugs(s), including blood thinners.

Improper use of this product will not improve results and is not advised. Use only as directed. Do not use if packaging has been tampered with.

KEEP OUT OF REACH OF CHILDREN.

CONTAINS SOY INGREDIENTS

Do not exceed 6 caplets in a 24-hour period.

General Statements

SCIENTIFICALLY DEVELOPED BASED ON RESEARCH AT: ST. FRANCIS XAVIER UNIVERSITY

NEW FORMULA

1 MONTH SUPPLY

TEST SUBJECTS BUILT OVER 4x MORE MUSCLE

Delivers up to 330% More Creatine per Serving Than Other Leading Creatine Pill Formula

This study was published in the Journal of Strength and Conditioning Research.

SCIENTIFICALLY ENGINEERED WITH MORE CREATINE THAN THE COMPETITION

Consult a medical doctor before starting any diet or exercise program.

Protected by U.S. patent #6,136,339.

Made in the U.S.A. from international and domestic ingredients.

In this same university study later documented and published in the journal Medicine & Science of Sports & Exercise, test subjects also built over 4 times more muscle compared to the placebo group (7.1 vs. 1.3 lbs.). That's right-over 4 times more lean, rock-hard muscle!

SCIENTIFICALLY VALIDATED & DOCUMENTED MUSCLEBUILING RESULTS

{GRAPH} MUSCEL GAINED (LBS) 0 1 2 3 4 5 6 7 OVER 4X MORE MUSCLE KEY INGREDIENT IN CREAKIC(R) HARDCORE PLACEBO

Rapidly and Dramatically Builds Lean Muscle & Strength~Delivers up to 330% More Creatine per Serving than Other Leading Creatine Pill Formulas, ~Formulated with the Most Scientifically-Validated Form of Creatine in Existence

{Graph} CREATINE PER SERVING UP TO 330% MORE CREATINE CREAKIC(R) HARDCORE OTHER CREATINE PILL

This key musclebuilding agent is supported by countless university and independent studies to build muscle size and strength, fast.

Its powerful formula is designed to saturate your muscle cells with its advanced creatine blend, which is powered by the most scientifically validated form of creatine in existence.

Research and development

Seals/Symbols

AMERICA'S SPORTS SUPPLEMENT BRAND #1 SELLING

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

Fromulated with the Most Scientifically Validated For of Creatine in Existence

New Formula with 100% More Creatine

CONTAINS SOY INGREDIENTS

Storage

Store in a cool, dry place (60(0) to 80(0)F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 serving (6 Caplets) of CREAKIC(R) Hardcore with a glass of water daily. On workout days, take 1 serving immediately after your workout. On non-workout days, take 1 serving in the morning upon awakening.

Consume 10 glasses of water daily to help enhance creatine absorption, to maintain an adequate state of hydration and for general good health. Read the entire label before use and follow directions.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Creakic Hardcore by MuscleTech label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Creakic Hardcore label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Creakic Hardcore by MuscleTech

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size6 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

CREAKIC Hardcore Proprietary Blend

6208 mg per serving

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropylcellulose, Coating, Povidone, Croscarmellose Sodium, Crospovidone, Stearic Acid, Magnesium Stearate, Silica, Natural flavor, Acesulfame-Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Creakic Hardcore by MuscleTech Drug Interactions

Want to check YOUR meds against Creakic Hardcore?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
263Drugs
263 Moderate

Ingredients driving the most interactions

6-8-Thioctic Acid 263
L-Carnosine 86

Individual Drug Interactions

The ingredients in Creakic Hardcore interact with 263 drugs. Click any drug to see the details.

2 of the 7 ingredients in Creakic Hardcore interact with drugs. Each result below shows which ingredient is responsible. 6-8-Thioctic Acid L-Carnosine

Each ingredient & the kinds of drugs it affects

For each ingredient in Creakic Hardcore with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

6-8-Thioctic Acid5 drug types · 263 drugs

Alkylating Agents

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of alkylating agents.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, alpha-lipoic acid may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro, alpha-lipoic acid inhibits platelet aggregation.

Likelihood Possible Evidence D
Antitumor Antibiotics

Theoretically, the antioxidant effects of alpha-lipoic acid might alter the effectiveness of antitumor antibiotics.
The use of antioxidants like alpha-lipoic acid during chemotherapy is controversial. There are concerns that antioxidants could reduce the activity of antitumor antibiotic drugs, which work by generating free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as alpha-lipoic acid have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using alpha-lipoic acid.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, alpha-lipoic acid might decrease the effects of thyroid hormone drugs.
Animal research suggests that co-administration of thyroxine with alpha-lipoic acid reduces conversion into the active T3 form.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking alpha-lipoic acid with antidiabetes drugs might increase the risk of hypoglycemia.
Although some small clinical studies have suggested that alpha-lipoic acid can lower blood glucose levels, larger clinical studies in patients with diabetes have shown no clinically meaningful effect. Additionally, co-administration of single doses of alpha-lipoic acid and glyburide or acarbose did not cause detectable drug interactions in healthy volunteers.

Likelihood Unlikely Evidence B
6-8-Thioctic Acid full monograph & interactions

L-Carnosine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking carnosine with antidiabetes drugs might increase the risk of hypoglycemia.
Some, but not all, preliminary clinical research shows that carnosine might reduce fasting blood glucose levels.

Likelihood Possible Evidence D
L-Carnosine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Creakic Hardcore, from the product label.

MuscleTech

See all MuscleTech products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
3880 Jeffrey Blvd
City
Blasdell
State
NY
ZipCode
14219
Pharmacist Counseling Corner

Creakic Hardcore by MuscleTech: Common Questions

Does Creakic Hardcore by MuscleTech interact with any medications?
Yes. Based on its ingredients, Creakic Hardcore has a known interaction with 263 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Creakic Hardcore contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Creakic Hardcore if I'm pregnant or nursing?
No — there isn't enough safety information for either. The facts advise against creatine, carnosine, and alpha-lipoic acid during pregnancy and lactation. Talk with your doctor or pharmacist about alternatives while you're expecting or breastfeeding.
What's the most common side effect I might notice?
The creatine in this product commonly causes dehydration, diarrhea, stomach upset, muscle cramps, and water retention — that last one is why some people notice a bit of bloating or weight gain early on. Headache, heartburn, nausea, and dry mouth are also possible from the alpha-lipoic acid.
Does this product actually work for muscle strength?
The creatine in it is rated Possibly Effective for muscle strength and athletic performance, so the evidence supports its use for those goals. We don't have solid evidence yet for the other active ingredients' effects on athletic performance.
I have kidney problems — is this safe for me?
No — caution is advised. Both forms of creatine in this product warrant careful consideration if you have kidney disease, since rare case reports have raised concerns about kidney injury. Check with your doctor or pharmacist before taking it.
What does creatine actually do in my muscles?
Creatine helps your muscles produce energy during intense, short bursts of activity like weightlifting or sprinting. Your body makes a little naturally, and this supplement tops it up to support strength and performance.
Can alpha-lipoic acid lower my blood sugar?
It might — some small studies suggest it can lower blood glucose. If you take diabetes medication, that's another reason to talk with your pharmacist before starting this product, since the combination could theoretically increase your risk of low blood sugar.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Creakic Hardcore is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Creakic Hardcore label
Go deeper

The Full Monographs Behind Creakic Hardcore’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Carnosine

Interacts with 86 drugs

Carnosine is a naturally occurring dipeptide (made of beta-alanine and histidine) that acts as an antioxidant and buffer in muscle and brain. It is sold as an anti-aging and performance supp...

Read the full Carnosine monograph → Herb & supplement monograph

Alpha-lipoic Acid

Interacts with 263 drugs

Alpha-lipoic acid (ALA) is an antioxidant made naturally by the body and found in small amounts in foods. It is most studied for diabetic nerve pain, where some evidence suggests it may help...

Read the full Alpha-lipoic Acid monograph →
Sources

Sources & How We Checked

Creakic Hardcore's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 139 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Creatine 86 references
  1. Koshy KM, Griswold E, Schneeberger EE. Interstitial nephritis in a patient taking creatine. N Engl J Med 1999;340:814-5. PubMed
  2. Vahedi K, Domingo V, Amarenco P, Bousser MG. Ischemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for bodybuilding. J Neurol Neurosurg Psychiatr 2000;68:112-3.
  3. Greenhaff P. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;352:233-4. PubMed
  4. Vandenberghe K, Goris M, Van Hecke P, et al. Long-term creatine intake is beneficial to muscle performance during resistance training (abstract). J Appl Physiol 1997;83:2055-63. PubMed
  5. Hultman E, Soderlund K, Timmons JA, et al. Muscle creatine loading in men. J Appl Physiol 1996;81:232-7. PubMed
  6. Pritchard NR, Kalra PA. Renal dysfunction accompanying oral creatine supplements. Lancet 1998;351:1252-3. PubMed
  7. Poortmans JR, Auquier H, Renaut V, et al. Effect of short-term creatine supplementation on renal responses in men (abstract). Eur J Appl Physiol Occup Physiol 1997;76:566-7. PubMed
  8. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10. PubMed
  9. Mihic S, MacDonald JR, McKenzie S, Tarnopolsky MA. Acute creatine loading increases fat-free mass, but does not affect blood pressure, plasma creatinine, or CK activity in men and women. Med Sci Sports Exerc 2000;32:291-6. PubMed
  10. Rawson ES, Wehnert ML, Clarkson PM. Effects of 30 days of creatine ingestion in older men. Eur J Appl Physiol Occup Physiol 1999;80:139-44. PubMed
  11. Earnest CP, Almada AL, Mitchell TL. High-performance capillary electrophoresis-pure creatine monohydrate reduces blood lipids in men and women. Clin Sci (Colch) 1996;91:113-8. PubMed
  12. Juhn MS. Oral creatine supplementation. Separating fact from hype. Phys Sportsmed 1999;27:47-50,53-54,56,61,89. PubMed
  13. Juhn MS, O'Kane JW, Vinci DM. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am Diet Assoc 1999;99:593-5.
  14. Green AL, Hultman E, Macdonald IA, et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996;271:E821-6. PubMed
  15. Balsom PD, Soderlund K, Sjodin B, Ekblom B. Skeletal muscle metabolism during short duration high-intensity exercise: influence of creatine supplementation. Acta Physiol Scand 1995;154:303-10. PubMed
  16. Snow RJ, McKenna MJ, Selig SE, et al. Effect of creatine supplementation on sprint exercise performance and muscle metabolism. (abstract) J Appl Physiol 1998;84:1667-73. PubMed
  17. McNaughton LR, Dalton B, Tarr J. The effects of creatine supplementation on high-intensity exercise performance in elite performers. (abstract) Eur J Appl Physiol Occup Physiol 1998;78:236-40. PubMed
  18. Groeneveld GJ, Veldink JH, van der Tweel I, et al. A randomized sequential trial of creatine in amyotrophic lateral sclerosis. Ann Neurol 2003;53:437-45. . PubMed
  19. Robinson SJ. Acute quadriceps compartment syndrome and rhabdomyolysis in a weight lifter using high-dose creatine supplementation. J Am Board Fam Pract 2000;13:134-7. PubMed
  20. Kammer RT. Lone atrial fibrillation associated with creatine monohydrate supplementation. Pharmacotherapy 2005;25:762-4. PubMed
  21. Gualano B, Ugrinowitsch C, Novaes RB, et al. Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial. Eur J Appl Physiol 2008;103:33-40. PubMed
  22. Pfeffer, G., Majamaa, K., Turnbull, D. M., Thorburn, D., and Chinnery, P. F. Treatment for mitochondrial disorders. Cochrane Database.Syst.Rev. 2012;4:CD004426. PubMed
  23. Boos, C. J., White, S. H., Bland, S. A., and McAllister, P. D. Dietary supplements and military operations: caution is advised. J R.Army Med Corps 2010;156(1):41-43. PubMed
  24. Kreider, R. B. Dietary supplements and the promotion of muscle growth with resistance exercise. Sports Med 1999;27(2):97-110. PubMed
  25. Juhn, M. S., O'Kane, J. W., and Vinci, D. M. Oral creatine supplementation in male collegiate athletes: a survey of dosing habits and side effects. J Am.Diet.Assoc 1999;99(5):593-595.
  26. Volek, J. S., Duncan, N. D., Mazzetti, S. A., Putukian, M., Gomez, A. L., and Kraemer, W. J. No effect of heavy resistance training and creatine supplementation on blood lipids. Int J Sport Nutr.Exerc.Metab 2000;10(2):144-156. PubMed
  27. Robinson, T. M., Sewell, D. A., Casey, A., Steenge, G., and Greenhaff, P. L. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function. Br.J Sports Med 2000;34(4):284-288. PubMed
  28. Tarnopolsky, M. A. Potential benefits of creatine monohydrate supplementation in the elderly. Curr.Opin.Clin Nutr.Metab Care 2000;3(6):497-502. PubMed
  29. Tarnopolsky, M. A. and MacLennan, D. P. Creatine monohydrate supplementation enhances high-intensity exercise performance in males and females. Int J Sport Nutr.Exerc.Metab 2000;10(4):452-463. PubMed
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Alpha-lipoic Acid 48 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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