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Dietary supplement

Cubeb Berry 450 mg Ingredients & Drug Interactions

by TerraVita Premium Collection

Cubeb Berry 450 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Cubeb Berry 450 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Cubeb Berry 450 mg is a dietary supplement by TerraVita Premium Collection with 1 active ingredient. Its ingredients are commonly taken for coughs and bronchitis, indigestion and gas, urinary tract complaints.Based on those ingredients, 665 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Cubeb. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Cubeb Berry 450 mg by TerraVita Premium Collection

Ask about any prescription or over-the-counter medication and we check it for interactions with Cubeb Berry 450 mg by TerraVita Premium Collection — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Cubeb Berry 450 mg by TerraVita Premium Collection

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: cubeb, a peppery spice from a climbing vine, supplied as 450 mg per capsule. It's often used as a culinary seasoning and in traditional medicine.

The capsule itself is made from gelatin and water, which are inactive ingredients that hold the cubeb powder.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Cubebs product and its label doesn't state a use — see Cubebs's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The product facts we hold do not include effectiveness ratings for cubeb. We don't have evidence data on file for what this supplement is intended to do.

The evidence, ingredient by ingredient Cubebs

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cubeb in small culinary amounts is likely fine, but safety data for medicinal doses — the strength in this supplement — is limited. The essential oil form is also not well studied at medicinal levels.

The product should be avoided in medicinal amounts during pregnancy, because there isn't enough safety information. Breastfeeding is not recommended while taking medicinal cubeb, as reliable safety data are lacking.

Side effects, ingredient by ingredient Cubebs

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Cubebs.
  • The most serious interaction on file is rated Moderate.
  • For scale: 666 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check your medications with a pharmacist if you take any drugs processed through CYP3A4, including lovastatin, clarithromycin, cyclosporine, or diltiazem — cubeb may raise their levels (Moderate severity). Also flag any H2-blockers, antacids, or acid-reflux medications (PPIs), as cubeb may reduce their effectiveness (Minor severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you use cubeb as a culinary spice in tiny amounts, this probably isn't a concern. But if you're considering this 450 mg supplement and take any prescription medications — especially ones for cholesterol, heart problems, infections, or acid reflux — check with your pharmacist first.

Pregnant and breastfeeding people should skip medicinal cubeb.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Cubeb Berry 450 mg, straight from the product label.

Brand TerraVita Premium Collection
Barcode (UPC) 064435147617
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 287000
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Cubeb Berry 450 mg by TerraVita Premium Collection, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
100
UPC/BARCODE
064435147617
IngredientAmount% DV
Cubeb450 mg--

Other ingredients: Gelatin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

A Dietary Supplement

Brand IP Statement(s)

Copyright 2005 TerraVita - Distributed by ZooScape LLC, All Rights Reserved.

Suggested/Recommended/Usage/Directions

Directions Take 1 capsule, 3 times daily, with meals.

General Statements

TerraVita is an exclusive line of premium natural products that use the finest, purest and most potent ingredients in the world. TerraVita's hallmarks are the highest possible standards of purity, potency, stability and freshness. All products are prepared with the greatest quality control, from raw materials through the entire manufacturing process, right up to the moment your product is sealed for freshness and shipped to you.

Please recycle!

FDA Disclaimer Statement

Statements not evaluated by FDA. Product not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Cubeb Berry 450 mg by TerraVita Premium Collection label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Cubeb Berry 450 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Cubeb Berry 450 mg by TerraVita Premium Collection

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Cubeb

Interacts with
665 drugs
450 mg per serving

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary...

Cubeb monograph & interactions

Other (inactive) ingredients: Gelatin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Cubeb Berry 450 mg by TerraVita Premium Collection Drug Interactions

Want to check YOUR meds against Cubeb Berry 450 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
665Drugs
643 Moderate 22 Minor

Ingredients driving the most interactions

Cubeb 665

Individual Drug Interactions

The ingredients in Cubeb Berry 450 mg interact with 665 drugs. Click any drug to see the details.

1 of the 1 ingredient in Cubeb Berry 450 mg interact with drugs. Each result below shows which ingredient is responsible. Cubeb

Each ingredient & the kinds of drugs it affects

For each ingredient in Cubeb Berry 450 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Cubeb4 drug types · 665 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Several compounds isolated from cubebs can inhibit cytochrome P450 3A4 (CYP3A4) in vitro. So far, this effect has not been reported in humans. Theoretically, cubebs might increase the effects and side effects of drugs metabolized by CYP3A4. These include lovastatin (Mevacor), clarithromycin (Biaxin), cyclosporine (Neoral, Sandimmune), diltiazem (Cardizem), estrogens, indinavir (Crixivan), triazolam (Halcion), and numerous others.

Likelihood Possible Evidence D
Antacids

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of antacids.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of H2-blockers. The H2 blockers include cimetidine (Tagamet), ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid).

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, due to reports that cubebs increases stomach acid, cubebs might decrease the effectiveness of PPIs. PPIs include omeprazole (Prilosec), lansoprazole (Prevacid), rabeprazole (Aciphex), pantoprazole (Protonix), and esomeprazole (Nexium).

Likelihood Possible Evidence D
Cubeb full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Cubeb Berry 450 mg, from the product label.

TerraVita Premium Collection

See all TerraVita Premium Collection products
Name
TerraVita Fine Whole Herbs
City
Brampton
State
Ontario
Pharmacist Counseling Corner

Cubeb Berry 450 mg by TerraVita Premium Collection: Common Questions

Does Cubeb Berry 450 mg by TerraVita Premium Collection interact with any medications?
Yes. Based on its ingredients, Cubeb Berry 450 mg has a known interaction with 665 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Cubeb Berry 450 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is cubeb safe during pregnancy?
No. There isn't enough safety information for medicinal amounts of cubeb in pregnancy, so it's best avoided. Talk with your doctor or pharmacist about whether you need a supplement right now.
Can I take cubeb if I'm breastfeeding?
The safety data aren't reliable for breastfeeding, so medicinal cubeb is not recommended. A conversation with your pharmacist or doctor can help you decide what's right for you and your baby.
What's the difference between culinary cubeb and this supplement?
Cubeb as a culinary spice is used in tiny amounts and is likely fine. This 450 mg capsule is a medicinal dose, and safety at this level hasn't been well studied — especially the essential oil form.
Does cubeb have any side effects?
The product facts don't list common side effects from cubeb. The main concern is how it might interact with certain medications, not direct side effects from the herb itself.
Why might cubeb interfere with stomach acid medications?
Cubeb is reported to increase stomach acid production. Medications like antacids and PPIs work by lowering acid, so theoretically cubeb could work against them and make them less effective — though this hasn't been proven in people.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Cubeb Berry 450 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Cubeb Berry 450 mg label
Go deeper

The Full Monographs Behind Cubeb Berry 450 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cubebs

Interacts with 665 drugs

Cubebs are spicy, peppery berries from a vine in the pepper family that have long been used in traditional medicine for coughs, digestion, and urinary problems. Modern human studies are very...

Read the full Cubebs monograph →
Sources

Sources & How We Checked

Cubeb Berry 450 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cubebs 2 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Usia T, Watabe T, Kadota S, Tezuka Y. Potent CYP3A4 inhibitory constituents of Piper cubeba. J Nat Prod 2005;68(1):64-8.

See these in context on the Cubebs monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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