D-Mannose 500 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose 500 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 500 is a dietary supplement by ProCaps Laboratories with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 500 by ProCaps Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This supplement contains one active ingredient: D-mannose, a naturally occurring sugar. The capsule itself is made from gelatin.
Does it work?
Leans against
The evidence picture is mixed. D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare metabolic disorder.
For urinary tract infections (UTIs), the data suggests it's possibly ineffective — meaning the evidence doesn't support it as a reliable option for prevention or treatment. If you're considering this for UTI relief, talk with your doctor or pharmacist about options with stronger evidence behind them.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but long-term safety data are limited. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea risk increases with higher doses — taking more than 200 mg per kilogram of body weight in a single dose is more likely to cause osmotic diarrhea (the kind triggered when too much sugar pulls water into your stool). There isn't enough safety data to know whether this supplement is safe in pregnancy; safety while breastfeeding is also not well studied.
If you're pregnant or breastfeeding, talk with your doctor or pharmacist before taking it.
Meds to double-check
No known interactions
No interactions are documented in our data for D-mannose. Even so, it's wise to review your full medication list with your own doctor or pharmacist before adding any new supplement.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-Mannose 500 is generally well tolerated short-term and may help with a specific rare metabolic disorder, but it's not reliable for UTI relief. If you're pregnant, breastfeeding, or taking any regular medications, check with your doctor or pharmacist before starting.
Stick to the dose on the label to minimize your risk of digestive side effects.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 500, straight from the product label.
| Brand | ProCaps Laboratories |
|---|---|
| Barcode (UPC) | 766861 |
| Net contents | 240 Easy-To-Swallow Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2022 |
| DSLD ID | 275206 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 500 by ProCaps Laboratories, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use Consume one or more capsules daily or as recommended by your physician. As with any dietary supplement, this product is most effective as part of a healthy diet and active lifestyle.
General Statements
For questions about the use of this product, call 800.332.7799. For over 40 years Unsurpassed purity, quality and efficacy 100% solar production Zero carbon footprint Andrew Lessman, Founder www.HSN.com 800.944.9999 www.QVC.com 800.345.1515
Formulation
Supports bladder and urinary tract health
Andrew Lessman's D-Mannose 500 delivers 500 mg of pure, non-GMO D-Mannose, a naturally occurring monosaccharide (simple sugar) that supports the health of the bladder, kidneys and urinary tract.
Research has shown that its benefits stem from its ability to promote a healthy environment and microbiome in the bladder and urinary tract. D-Mannose is not metabolized like a typical sugar, so it will not interfere with healthy blood sugar balance. D-Mannose delivers its benefits independently, but it is the perfect addition to the well established benefits of cranberry to support bladder, kidney and urinary tract health.
Contains no additives or common allergens Contains no milk, soy, yeast, corn, wheat, gluten, sodium, salt, fat, cholesterol, color, preservative, common allergens genetically modified ingredients (GMO) ingredients or manufacturing additives.
FDA Statement of Identity
Dietary Supplement
Formula
Andrew Lessman's D-Mannose 500 delivers 500 mg of pure, non-GMO D-Mannose, a naturally occurring monosaccharide (simple sugar) that supports the health of the bladder, kidneys and urinary tract. D-Mannose is not readily available from the diet, since it is only present in trace amounts in fruits and vegetables. D-Mannose has been the subject of extensive clinical study demonstrating its ability to support the health of the urinary tract and bladder.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 500 by ProCaps Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 500 by ProCaps Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container240 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.
D-Mannose 500 by ProCaps Laboratories Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 500, from the product label.
ProCaps Laboratories
See all ProCaps Laboratories products- Name
- ProCaps Labs
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Phone Number
- 800.800.1200
- Web Address
- www.ProCapsLabs.com
D-Mannose 500 by ProCaps Laboratories: Common Questions
Does D-Mannose 500 by ProCaps Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose help prevent or treat a UTI?
What are the most common side effects?
Is it safe to take long-term?
Can I take this while pregnant?
Is it safe while breastfeeding?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 500 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 500’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 500's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC