No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

D-Mannose 500 mg Ingredients & Drug Interactions

by BulkSupplements.com

D-Mannose 500 mg label
See full label image
Capsule Category: Fiber And Other Nutrients
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D-Mannose 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

D-Mannose 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of D-Mannose 500 mg by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: D-mannose, a simple sugar that your body can metabolize. The capsule itself is made from hypromellose, a plant-derived material that holds the ingredient together.

That's it — no fillers, binders, or dyes beyond the capsule material.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded D-mannose's overall clinical evidence instead.

Strong

Strong clinical evidence supports D-mannose for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Carbohydrate-deficient glycoprotein syndrome type 1b — rated "Likely Effective" (Natural Medicines).

D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare genetic condition. For urinary tract infections (UTIs), the evidence rates it as possibly ineffective — meaning current data don't support its use for that purpose, even though it's marketed for it.

The evidence, ingredient by ingredient D-mannose

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

D-mannose is generally well tolerated in the short term, but high-quality long-term safety data are limited, so we don't have a clear picture of what happens if you take it for months or years. The most common side effects are bloating, diarrhea, and nausea.

Higher doses — especially more than 200 mg/kg in one dose — are more likely to cause osmotic diarrhea (watery stool). There isn't enough reliable safety data to use it during pregnancy unless your doctor advises you to, and safety while breastfeeding hasn't been well studied, so caution is advised if you're nursing.

Side effects, ingredient by ingredient D-mannose

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented for D-mannose in our data. Still, check with your own doctor or pharmacist if you're on any medications and want to add this product to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.

D-mannose may be worth considering if you have carbohydrate-deficient glycoprotein syndrome type 1b and your doctor recommends it. If you're taking it for UTIs, the evidence doesn't support that use.

Stick to the dosing on the label to minimize bloating and diarrhea, and talk with your doctor or pharmacist before starting, especially if you're pregnant, breastfeeding, or planning to take it long-term.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D-Mannose 500 mg, straight from the product label.

Brand BulkSupplements.com
Net contents 100 Vegetarian Capsules
Market status On market
Date entered into DSLD Aug 23, 2021
DSLD ID 253639
Product type Fiber And Other Nutrients
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D-Mannose 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
25
IngredientAmount% DV
D-Mannose2000 mg--

Other ingredients: Hypromellose Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Clean & Pure Bulk Supplements

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Free of: Sugar, soy, dairy, yeast, gluten or additives

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 4 capsules (2000 mg) daily or as directed by a physician.

Storage

Storage: Keep dry, cool & dark

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D-Mannose 500 mg by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D-Mannose 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D-Mannose 500 mg by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container25 Amounts shown are per serving.

D-Mannose

No known
interactions
2000 mg per serving

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...

D-Mannose monograph & interactions

Other (inactive) ingredients: Hypromellose Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

D-Mannose 500 mg by BulkSupplements.com Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for D-Mannose 500 mg, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Road
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

D-Mannose 500 mg by BulkSupplements.com: Common Questions

Does D-Mannose 500 mg by BulkSupplements.com interact with any medications?
We do not currently list a known interaction for the mapped ingredients in D-Mannose 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
D-Mannose 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take D-mannose if I'm pregnant?
There isn't enough reliable safety data to know, so it's best to avoid it unless your doctor advises otherwise. Talk with your doctor about whether it's appropriate for you.
Is D-mannose safe while breastfeeding?
Safety while breastfeeding hasn't been well studied, so caution is advised. Check with your pharmacist or doctor before taking it if you're nursing.
Does D-mannose really help with UTIs?
The evidence rates it as possibly ineffective for urinary tract infections, which means current data don't support using it for that purpose.
What are the side effects?
The most common ones are bloating, diarrhea, and nausea. Higher doses — especially more than 200 mg/kg in one dose — are more likely to cause watery stool. Taking it as directed on the label helps minimize these.
Is it safe to take long-term?
D-mannose is well tolerated short-term, but high-quality long-term safety data are limited, so we don't know much about safety beyond a few weeks or months. Talk with your doctor if you're planning to take it long-term.
What exactly is D-mannose?
It's a simple sugar your body can use for energy. It's found naturally in some fruits, but this supplement is a concentrated dose in capsule form.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D-Mannose 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D-Mannose 500 mg label
Go deeper

The Full Monographs Behind D-Mannose 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

D-mannose

D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising for prevention, but the evidence is sti...

Read the full D-mannose monograph →
Sources

Sources & How We Checked

D-Mannose 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

D-mannose 6 references
  1. Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
  2. Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
  3. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
  4. Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
  5. . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
  6. Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed

See these in context on the D-mannose monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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