D-Mannose 500 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking D-Mannose 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose 500 mg is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose 500 mg by BulkSupplements.com
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a naturally occurring sugar. Each capsule delivers 500 mg of D-mannose.
The capsule itself is made from hypromellose, an inactive ingredient that forms the capsule shell.
Does it work?
Strong evidence
D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare inherited metabolic disorder. For urinary tract infections (UTIs), the evidence suggests it is possibly ineffective — meaning it may not reliably prevent or treat UTIs the way antibiotics do.
Talk with your doctor about whether D-mannose makes sense for your specific health goal.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, though long-term safety data are limited. The most common side effects are bloating, diarrhea, loose stools, and nausea — especially at higher doses.
Diarrhea has been reported in adults taking 2 grams daily for 6 months; doses greater than 200 mg per kilogram of body weight are more likely to cause osmotic diarrhea (watery stools). Not enough reliable safety data exist to recommend D-mannose in pregnancy unless your doctor advises it.
Safety while breastfeeding is not well studied, so caution is advised — talk with your doctor or pharmacist before taking it if you're nursing.
Meds to double-check
No known interactions
No interactions are documented for D-mannose in our data. That said, check your exact medications with the search tool on this page or ask your pharmacist before starting.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is worth considering if your doctor has recommended it for carbohydrate-deficient glycoprotein syndrome type 1b. If you're thinking about it for UTI prevention, know the evidence doesn't strongly support that use.
Before you start, especially if you're pregnant, breastfeeding, or take regular medications, check in with your doctor or pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose 500 mg, straight from the product label.
| Brand | BulkSupplements.com |
|---|---|
| Net contents | 300 Vegetarian Capsules |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2021 |
| DSLD ID | 253625 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose 500 mg by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Clean & Pure Bulk Supplements
Precautions
Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.
Consult your physician before use.
Keep out of reach of children!
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Free of: Sugar, soy, dairy, yeast, gluten or additives
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take 4 capsules (2000 mg) daily or as directed by a physician.
Storage
Storage: Keep dry, cool & dark
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose 500 mg by BulkSupplements.com label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose 500 mg by BulkSupplements.com
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container75 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Hypromellose Capsules. These complete the product’s ingredient list but are not active constituents.
D-Mannose 500 mg by BulkSupplements.com Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose 500 mg, from the product label.
BulkSupplements.com
See all BulkSupplements.com products- Name
- BulkSupplements.com
- Street Address
- 7511 Eastgate Road
- City
- Henderson
- State
- NV
- ZipCode
- 89011
- Web Address
- BulkSupplements.com
D-Mannose 500 mg by BulkSupplements.com: Common Questions
Does D-Mannose 500 mg by BulkSupplements.com interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take D-mannose if I'm pregnant?
Can I take D-mannose if I'm breastfeeding?
Does D-mannose really prevent UTIs?
What side effects should I watch for?
Is D-mannose safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose 500 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose 500 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC