D-Mannose Ingredients & Drug Interactions
by AZO
What is this page for?
First and foremost: checking D-Mannose against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mannose is a dietary supplement by AZO with 1 active ingredient. Its ingredients are commonly taken for preventing urinary tract infections (utis), treating mild utis, urinary tract health.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of D-Mannose by AZO
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: D-mannose, a naturally occurring sugar. It's meant to support urinary tract health.
The capsule itself is made from hydroxypropyl methylcellulose (a plant-based capsule material) and magnesium stearate (a binder and anti-caking agent).
Does it work?
Leans against
The evidence here is mixed. D-mannose is likely effective for carbohydrate-deficient glycoprotein syndrome type 1b, a rare metabolic disorder — but that's not a common reason someone takes this product.
For urinary tract infections (UTIs), the data we hold rates it as possibly ineffective. If you're taking it hoping it'll prevent or treat a UTI, the evidence doesn't support that use.
How safe is it?
Well-documented data
D-mannose is generally well tolerated in the short term, but we don't have high-quality safety data for long-term use, so caution is advised if you're thinking of taking it for months on end. The most common side effects are bloating, diarrhea, and nausea.
Diarrhea is more likely if you take a single dose over 200 mg per kilogram of body weight. During pregnancy, there isn't enough reliable safety data, so it's best to avoid it unless your doctor says otherwise.
Safety while breastfeeding is not well studied, so caution is advised — talk it over with your doctor or pharmacist before you use it.
Meds to double-check
No known interactions
No interactions are documented in our data for this ingredient. That absence of data isn't a guarantee no interactions exist — check your specific medications with the search tool on this page or with your own doctor or pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with graded evidence leaning against its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
D-mannose is generally well tolerated short-term and has no documented interactions with medications. That said, the evidence for UTI prevention or treatment is weak.
If you're pregnant or breastfeeding, or thinking of taking it long-term, check with your own doctor or pharmacist first — the safety data just isn't there yet.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mannose, straight from the product label.
| Brand | AZO |
|---|---|
| Barcode (UPC) | 787651760261 |
| Net contents | 120 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2021 |
| DSLD ID | 243441 |
| Product type | Fiber And Other Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mannose by AZO, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 10 Calorie(s) | -- |
| Total Carbohydrates | 2 Gram(s) | 1% |
| Added Sugars | 2 Gram(s) | 4% |
| Total Sugars | 2 Gram(s) | -- |
| D-Mannose | 2000 mg | -- |
Other ingredients: Hydroxypropyl Methylcellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Clinical Strength Solution for Urinary Health.
Drug free Gluten free Dairy free Non-GMO
Clinical Strength Urinary Tract Health
Helps cleanse, flush & protect the urinary tract
Country of Origin: China
Formula
AZO D-Mannose is a drug-free solution to help maintain a healthy urinary tract. D-Mannose helps cleanse, flush & protect from bacteria adhering to the urinary tract. D-Mannose is naturally found in small amounts in many fruits such as oranges, apples & peaches.
General Statements
#1 Most Trusted Brand based on Total AZO Brand Nielsen data through 10/3/20 and the 2020 Pharmacy Times Survey (Urinary Pain Relief and Cranberry Supplement categories).
From the #1 Most Trusted Brand
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For clinical strength support, take 4 capsules with or without food once daily.
Precautions
As with any dietary supplement, please inform your healthcare provider before using.
Keep out of reach of children.
Tamper resistant: Do not use if seal under cap is broken or missing.
For questions, concerns, or to report an adverse event, please call (800) 722-3476
Storage
Store in a dry place and avoid excessive heat.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mannose by AZO label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mannose by AZO
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
D-Mannose
No knowninteractions
D-mannose is a natural sugar most often used to help prevent urinary tract infections, especially those caused by E. coli. Early research is promising...
D-Mannose monograph & interactionsOther (inactive) ingredients: Hydroxypropyl Methylcellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
D-Mannose by AZO Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in D-Mannose. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for D-Mannose, from the product label.
AZO
See all AZO products- Name
- i-Health Inc.
- Street Address
- 55 Sebethe Drive
- City
- Cromwell
- State
- CT
- ZipCode
- 06416
- Phone Number
- (800) 722-3476
D-Mannose by AZO: Common Questions
Does D-Mannose by AZO interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will D-mannose prevent or treat a UTI?
What side effects should I watch for?
Can I take this while pregnant?
Is it safe while breastfeeding?
How long can I safely take D-mannose?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mannose is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mannose’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mannose's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 6 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
D-mannose 6 references
- Westphal V, Kjaergaard S, Davis JA, et al. Genetic and metabolic analysis of the first adult with congenital disorder of glycosylation type Ib: long-term outcome and effects of mannose supplementation. Mol Genet Metab 2001;73:77-85. PubMed
- Kranjcec B, Papes D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World J Urol. 2014 Feb;32(1):79-84.
- de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841-3. PubMed
- Harms HK, Zimmer KP, Kurnik K, Bertele-Harms RM, Weidinger S, Reiter K. Oral mannose therapy persistently corrects the severe clinical symptoms and biochemical abnormalities of phosphomannose isomerase deficiency. Acta Paediatr. 2002;91(10):1065-72. DOI
- . Damen G, de Klerk H, Huijmans J, den Hollander J, Sinaasappel M. Gastrointestinal and other clinical manifestations in 17 children with congenital disorders of glycosylation type Ia, Ib, and Ic. J Pediatr Gastroenterol Nutr. 2004;38(3):282-7. DOI
- Lenger SM, Bradley MS, Thomas DA, Bertolet MH, Lowder JL, Sutcliffe S. D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis. Am J Obstet Gynecol. 2020;223(2):265.e1-265.e13. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC