Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Happy Cycle Ingredients & Drug Interactions

by AZO

Happy Cycle label
See full label image
Other (e.g. Tea Bag) Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Happy Cycle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Happy Cycle is a dietary supplement by AZO with 2 active ingredients. Its ingredients are commonly taken for premenstrual syndrome (pms), irregular or absent menstrual periods, cyclical breast pain (mastalgia).Based on those ingredients, 1,563 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sensoril Ashwagandha root & leaf extract, Chasteberry & Nutrient Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Happy Cycle by AZO

Ask about any prescription or over-the-counter medication and we check it for interactions with Happy Cycle by AZO — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Happy Cycle by AZO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 6, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Chasteberry & Nutrient Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

Happy Cycle contains six active ingredients formulated for menstrual cycle support. Vitamin B6 supports red blood cell formation and is effective for deficiency and certain types of anemia; thiamine (vitamin B1) is effective for deficiency and Wernicke-Korsakoff syndrome; calcium supports bone health and is effective for low calcium levels; magnesium aids muscle and nerve function and is effective for low magnesium and pre-eclampsia prevention; chastetree berry extract is possibly effective for premenstrual syndrome and breast tenderness; and ashwagandha is possibly effective for anxiety, stress, and insomnia.

The product also contains inactive ingredients such as microcrystalline cellulose, croscarmellose sodium, and magnesium stearate, which serve as binders and flow agents in the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support hormonal health and menstrual cycle symptoms.
  • We looked for evidence on: Amenorrhea, Anxiety, Menstrual irregularity, Cyclical breast pain, Mood support.
  • The strongest evidence on file: Ashwagandha is rated "Possibly Effective" for Anxiety (Natural Medicines).
  • Also on file: Ashwagandha is rated "Possibly Effective" for Generalized anxiety disorder (GAD).
  • Also on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

Evidence for this product's ingredients is mixed. Vitamin B6 is effective for deficiency and sideroblastic anemia, and possibly effective for pregnancy-related nausea.

Thiamine is effective for deficiency and Wernicke-Korsakoff syndrome, and possibly effective for menstrual pain (dysmenorrhea). Calcium is effective for low calcium levels and likely effective for osteoporosis.

Magnesium is effective for low magnesium, constipation, and indigestion, and effective for preventing pre-eclampsia in pregnancy. Chastetree berry extract is possibly effective for premenstrual syndrome and breast tenderness.

Ashwagandha is possibly effective for anxiety, stress, and insomnia. The evidence isn't established in our data for some other proposed uses like treating fractures or skin aging.

The evidence, ingredient by ingredient Vitex Agnus-castus Vitamin B6 Thiamine Calcium Magnesium Ashwagandha

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These ingredients are generally well tolerated at recommended doses. Vitamin B6 is safe at normal amounts, but high doses over time can damage nerves (a rare but serious effect).

Thiamine is very safe orally at standard doses. Calcium is safe at recommended amounts, though high doses can increase kidney stone risk.

Magnesium is safe at recommended amounts and commonly causes mild digestive effects like diarrhea or constipation. Chastetree berry extract is generally well tolerated short-term but may affect hormones.

Ashwagandha is generally well tolerated short-term, though rare cases of liver injury have been reported. The safety notes advise caution with high-dose vitamin B6 and magnesium in pregnancy, and recommend avoiding chastetree berry extract and ashwagandha during pregnancy and breastfeeding due to limited safety data and possible hormonal effects.

Side effects, ingredient by ingredient Vitex Agnus-castus Vitamin B6 Thiamine Calcium Magnesium Ashwagandha

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Calcium, Vitamin B6, Ashwagandha, Thiamine, Vitex Agnus-castus, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,564 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Happy Cycle, check with your doctor or pharmacist if you take any of the following: blood pressure medications (calcium and vitamin B6 may lower blood pressure further), seizure drugs like phenytoin or phenobarbital (vitamin B6 may reduce their levels), HIV integrase inhibitors like dolutegravir or elvitegravir (calcium significantly reduces their absorption), oral contraceptives or estrogen therapy (chastetree berry may interfere), diabetes medications (magnesium and ashwagandha may increase low blood sugar risk), Parkinson's medications containing levodopa/carbidopa (magnesium reduces absorption), thyroid medications (ashwagandha may boost effects), sedatives or benzodiazepines (ashwagandha may increase drowsiness), or immunosuppressants (ashwagandha may reduce their effectiveness). Altogether, these interactions span 1,526 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Happy Cycle may be worth considering if you're interested in menstrual cycle support and you don't take medications that interact with these ingredients—especially blood pressure drugs, seizure medications, HIV drugs, oral contraceptives, diabetes medications, or certain antibiotics. If you take any regular medication or have a condition like thyroid disease, liver problems, or low blood pressure, talk it over with your doctor or pharmacist before starting.

They can review whether this product is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Happy Cycle, straight from the product label.

Brand AZO
Barcode (UPC) 787651760193
Net contents 30 Once Daily Caplet(s)
Market status On market
Date entered into DSLD Jan 22, 2021
DSLD ID 242650
Product type Botanical With Nutrients
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Happy Cycle by AZO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Caplet(s)
Maximum serving Sizes:
1 Caplet(s)
Servings per container
30
UPC/BARCODE
787651760193
IngredientAmount% DV
Vitamin B650 mg2941%
Thiamine100 mg8333%
Calcium50 mg4%
Magnesium50 mg12%
Chastetree berry extract40 mg--
Chasteberry & Nutrient Blend0 NP--
Sensoril Ashwagandha root & leaf extract125 mg--

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Hydroxypropyl Cellulose, Stearic Acid, Spirulina extract color, Magnesium Stearate, Coating, Natural flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

The proactive way to address those annoying symptoms that occur before and during your period, that can leave you feeling less than your best. Be on your way to a happier cycle with a drug-free foundation to support hormonal health and help manage the symptoms brought on by your monthly cycle.

Your hormones naturally fluctuate all through the month, not just during your period. These ebbs and flows can contribute to both physical and emotional symptoms occurring for up to ¾ of your cycle! Let’s be honest, who wants to feel less than their best for that long each month? Your monthly cycle Pre-menstrual Period Best days

Own your cycle

From No. 1 most trusted brand AZO visit us online at: www.azoproducts.com

#1 Most trusted brand based on total AZO Brand Nielsen data through 3/14/20 and the 2019 Pharmacy Times Survey (Urinary Pain Relief and Cranberry Supplement categories)

Formulation

AZO Happy Cycle is specially formulated with a Chasteberry and Nutrient Blend plus Ashwagandha. When taken daily, AZO Happy Cycle helps support: Positive mood Daily stress relief Cramping & bloating relief A regular & consistent cycle Plus helps boost & sustain energy

AZO Happy Cycle is a proactive approach to hormonal health. When taken daily, AZO Happy Cycle formula works naturally with your body to help deal with those hormonal fluctuations, so you can feel your best, more days of the month.

Gluten-free Drug free No artificial dyes Non-GMO Dairy Free

Doctor Formulated

Vegan

Hormonal health A daily approach to support: Positive mood all month long Plus helps relieve irritability, bloating & cramping

Made in USA with US and imported materials.

Slight variations in bilayer caplet may occur due to the naturally sourced colorants.

Formula

Chastetree Berry This naturally sourced plant from the Mediterranean has been used by women for thousands of years to support hormonal health. Ashwagandha, an Ayurvedic herb that provides mood support and reduces stress, to help you stay happy and upbeat anytime of the month.

Chasteberry blend+ Ashwagandha

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Daily Supplement

Suggested/Recommended/Usage/Directions

Directions for use and Storage: Take (1) caplet daily at any time of day with food. When taken daily, results seen in as little as one cycle. For best results, a minimum of 90 days is important.

Storage

Store at room temperature. Do not expose to excessive heat, humidity or direct sunlight.

Precautions

Caution: As with any dietary supplement, please inform your healthcare professional before taking.

Do not take if pregnant, breastfeeding or intending to become pregnant.

Keep out of reach of children.

Tamper Evident: Do not sue this product if safety seal bearing "Sealed for your protection" under cap is missing.

For questions, concerns or to report an adverse event, please call: 1-800-722-3476

Brand IP Statement(s)

AZO and AZO Happy Cycle are trademarks of DSM. Sensoril is protected under U.S. Patent No. 7,318,938 and CA Patent No. 2,508,478, and is a registered trademark of Natreon, Inc.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Happy Cycle by AZO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Happy Cycle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Happy Cycle by AZO

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Chasteberry & Nutrient Blend

Interacts with
121 drugs
0 NP per serving

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS sympto...

Chasteberry & Nutrient Blend monograph & interactions

Sensoril Ashwagandha root & leaf extract

Interacts with
1,372 drugs
125 mg per serving

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...

Sensoril Ashwagandha root & leaf extract monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Hydroxypropyl Cellulose, Stearic Acid, Spirulina extract color, Magnesium Stearate, Coating, Natural flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

Happy Cycle by AZO Drug Interactions

Want to check YOUR meds against Happy Cycle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,563Drugs
13 Major 1,090 Moderate 460 Minor

Ingredients driving the most interactions

Sensoril Ashwagandha root & leaf extract 1,372
Chasteberry & Nutrient Blend 121

Individual Drug Interactions

The ingredients in Happy Cycle interact with 1,563 drugs. Click any drug to see the details.

2 of the 2 ingredients in Happy Cycle interact with drugs. Each result below shows which ingredient is responsible. Sensoril Ashwagandha root & leaf extract Chasteberry & Nutrient Blend

Each ingredient & the kinds of drugs it affects

For each ingredient in Happy Cycle with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sensoril Ashwagandha root & leaf extract10 drug types · 1,372 drugs

Antidiabetes Drugs

Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.

Likelihood Possible Evidence D
Benzodiazepines

Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.

Likelihood Possible Evidence D
Thyroid Hormone

Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Serotonergic Drugs

Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]

Likelihood Possible Evidence C
Sensoril Ashwagandha root & leaf extract full monograph & interactions

Chasteberry & Nutrient Blend5 drug types · 121 drugs

Antipsychotic Drugs

Theoretically, vitex agnus-castus could interfere with the activity of antipsychotic drugs.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as antipsychotic drugs due to its dopamine agonist effects.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, vitex agnus-castus could interfere with oral contraceptives.
Vitex agnus-castus might interfere with the efficacy of oral contraceptives due to possible hormone modulating activity.

Likelihood Possible Evidence B
Dopamine Agonists

Theoretically, vitex agnus-castus could interfere with dopamine agonists.
Vitex agnus-castus might potentiate the actions of dopaminergic agonists due to possible dopaminergic effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, vitex agnus-castus could interfere with the activity of estrogens.
Vitex agnus-castus has hormone modulating activity that can interfere with the efficacy of hormone replacement therapy.

Likelihood Probable Evidence D
Metoclopramide (Reglan)

Theoretically, dopaminergic effects of vitex agnus-castus could interfere with metoclopramide.
Vitex agnus-castus might interfere with the action of dopamine antagonists such as metoclopramide due to its possible dopaminergic effects.

Likelihood Possible Evidence D
Chasteberry & Nutrient Blend full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Happy Cycle, from the product label.

AZO

See all AZO products
Name
i-Health, Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
1-800-722-3476
Web Address
www.azoproducts.com
Pharmacist Counseling Corner

Happy Cycle by AZO: Common Questions

Does Happy Cycle by AZO interact with any medications?
Yes. Based on its ingredients, Happy Cycle has a known interaction with 1,563 medications, including 13 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Happy Cycle contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Happy Cycle if I'm pregnant or breastfeeding?
The safety data advises against taking chastetree berry extract and ashwagandha during pregnancy and breastfeeding. Vitamin B6 is possibly unsafe in pregnancy depending on dose, so check with your doctor. Calcium, magnesium, and thiamine are needed during pregnancy and breastfeeding, but use supplement doses only as your doctor advises. Talk with your healthcare provider before starting this product.
What's chastetree berry extract and what does it do?
Chastetree berry extract, also called vitex, is possibly effective for relieving premenstrual syndrome symptoms and breast tenderness. It's thought to work through hormone and dopamine activity in the body, but it may interact with certain medications.
Is ashwagandha safe to take long-term?
Ashwagandha is generally well tolerated short-term in healthy adults, but long-term safety data are limited. Rare cases of liver injury have been reported. If you're considering long-term use, talk with your doctor, especially if you have liver disease or take other medications.
Can high doses of the vitamins in this product cause problems?
Yes. High doses of vitamin B6 over time can damage nerves; the safety notes caution against high-dose use without medical guidance. Magnesium at very high doses may cause bone loss. Stick to recommended doses unless your doctor advises otherwise.
What are the most common side effects I might experience?
The most common side effects from these ingredients are mild and digestive: stomach upset, nausea, diarrhea, constipation, headache, or irregular menstruation. These typically don't happen at recommended doses.
Does this product have any fillers or other ingredients?
Yes. In addition to the six active ingredients, Happy Cycle contains inactive ingredients including microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and others that serve as binders and flow agents in the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Happy Cycle label
Go deeper

The Full Monographs Behind Happy Cycle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitex Agnus-castus

Interacts with 121 drugs

Vitex (chasteberry) is an herbal remedy most often used for PMS and menstrual cycle problems, and the strongest evidence is for easing some PMS symptoms. It is generally well tolerated by ma...

Read the full Vitex Agnus-castus monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Thiamine

Interacts with 3 drugs

Thiamine (vitamin B1) is an essential nutrient your body needs to turn food into energy and to keep your nerves and heart healthy. Most people get enough from food, but supplements are clear...

Read the full Thiamine monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Ashwagandha

Interacts with 1,372 drugs

Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...

Read the full Ashwagandha monograph →
Sources

Sources & How We Checked

Happy Cycle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 238 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
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  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
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Ashwagandha 32 references
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