Interactions on record — worth a quick check against your medications. Based on 3 of 8 ingredients. Check your meds →
Dietary supplement

Dual Protection Ingredients & Drug Interactions

by AZO

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Dual Protection is a dietary supplement by AZO with 8 active ingredients. Its ingredients are commonly taken for vaginal health support, preventing recurrent bacterial vaginosis, reducing recurrent urinary tract infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus crispatus LBV 88, Lactobacillus gasseri LBV 150N, Lactobacillus jensenii LBV 116. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Dual Protection by AZO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Intelliflora Blend” is a proprietary blend — the label gives one combined amount (150 mg) without saying how much of each component you get.
  • “PreforPro Blend” is a proprietary blend — the label gives one combined amount (15 mg) without saying how much of each component you get.

AZO Dual Protection is a capsule containing eight ingredients: four bacteriophages (viral particles that may support healthy bacteria), a probiotic blend, and four Lactobacillus species — L. crispatus, L. gasseri, L. jensenii, and L. rhamnosus — which are live beneficial bacteria. The product also includes inactive ingredients such as cellulose, fructooligosaccharides (a fiber), and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support healthy feminine microbiome and urinary tract health.
  • We looked for evidence on: Bacterial vaginosis, Urinary tract infections (UTIs), Recurrent yeast infections, Vaginal flora imbalance.
  • The strongest evidence on file: Lactobacillus Crispatus is rated "Possibly Effective" for Bacterial vaginosis (Natural Medicines).
  • Also on file: Lactobacillus Crispatus is rated "Insufficient Reliable Evidence To Rate" for Urinary tract infections (UTIs).
  • Also on file: Lactobacillus Gasseri is rated "Insufficient Reliable Evidence To Rate" for Bacterial vaginosis.

The effectiveness data we hold covers only Lactobacillus crispatus and L. gasseri. L. crispatus is rated possibly effective for bacterial vaginosis; for other conditions in its profile (HIV/AIDS, periodontitis, UTIs, and preterm labor), the evidence is insufficient to rate.

L. gasseri shows insufficient evidence across all conditions we have on file — allergic rhinitis, aspirin-related stomach damage, asthma, bacterial vaginosis, common cold, and diarrhea. We have no effectiveness ratings for the bacteriophages, L. jensenii, or L. rhamnosus in our data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The three Lactobacillus species in this product are generally well tolerated in healthy adults, though quality and evidence vary by brand and product. Rarely, they have caused mild side effects such as nausea, gas, and flatulence.

One rare case of swollen tongue and epiglottis was reported. Because these are live organisms, there is a small theoretical risk of infection in vulnerable patients — cases of bacteremia (bacteria in the bloodstream), sepsis, abscess, heart infection, and severe tissue damage have been documented in the medical literature, though these appear to occur mainly in people with weakened immunity or serious underlying illness.

For pregnancy and breastfeeding, safety data is limited; check with your doctor before using.

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Lactobacillus Crispatus, Lactobacillus Gasseri, Lactobacillus Jensenii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check the timing with your doctor or pharmacist — these probiotics work best when separated from antibiotics by a few hours. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a probiotic supplement aimed at vaginal and urinary health, with the strongest evidence for bacterial vaginosis support from one of its ingredients. The main interaction to watch for is antibiotic timing — space them apart to preserve the supplement's live organisms.

If you take antibiotics, are pregnant or breastfeeding, or have a weakened immune system, talk with your doctor or pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dual Protection, straight from the product label.

Brand AZO
Barcode (UPC) 787651760285
Net contents 30 Once daily capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 243440
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dual Protection by AZO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
787651760285
IngredientAmount% DV
Calories0 Calorie(s)--
Total Carbohydrates0 Gram(s)--
Added Sugars0 Gram(s)--
Total Sugars0 Gram(s)--
Myoviridae LH010 NP--
Siphoviridae LL50 NP--
Myoviridae T4D0 NP--
Myoviridae LL120 NP--
Intelliflora Blend150 mg--
Lactobacillus crispatus LBV 880 NP--
Lactobacillus rhamnosus LBV 960 NP--
Lactobacillus gasseri LBV 150N0 NP--
Lactobacillus jensenii LBV 1160 NP--
PreforPro Blend15 mg--

Other ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Fructooligosaccharide, Magnesium Stearate, Titanium Dioxide, Carmine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Uniquely formulated to support a healthy feminine microbiome-the foundation for women's wellness.

This synergistic blend provides extra protection from the common cycle of urinary and vaginal issues many women face.

Feminie Health Prebiotic First of It's Kind Feminine Health Prebiotic

Helps guard the urinary tract and fight unfriendly bacteria and is scientifically demonstrated to support growth of the Intelliflora probiotic blend

Helps Protect Urinary Health

A Clinically Proven Women's Probiotic Restores good bacteria, helps fight yeast growth and supports a healthy pH Supports Vaginal Health

Starts Working Within 24 Hours. Trust AZO Dual Protection, a once daily oral capsule that helps maintain your natural defenses.

The Feminine Health Prebiotic and Intelliflora Probiotic Blend work together to help maintain your feminine wellness and support a healthy you.

AZO Dual Protection is designed to help restore your bacterial balance to support urinary and vaginal health.

Urinary + Vaginal Support

AZO Dual Protection Helps: Guard the urinary tract and fight unfriendly bacteria Fight yeast growth to support vaginal health Maintain optimal vaginal pH

Protects Urinary & Vaginal Health

Starts working within 24 hours

Made in the USA with US and imported materials.

Formula

With the Power of Intelliflora 4 Unique Strains

Stress, your cycle, sex, aging and medications like antibiotics or the pill can disrupt your feminine microbiome, leaving you feeling anything but balanced.

Prebiotic & Clinically Proven Probiotic

Precautions

For questions, concerns or to report an adverse event, call (800) 722-3476.

Caution: As with any dietary supplement, please inform your healthcare professional before taking.

Keep out of reach of children.

Tamper Evident: Do not use this product if safety seal bearing "sealed for your protection" under cap is missing.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Azo Values: We believe in helping you take charge of your health by delivering the best urinary, vaginal and bladder health products available. From the no. 1 Most Trusted Brand AZO #1 Most Trusted Brand based on Total AZO Brand Nielsen data through 10/03/20 and the 2020 Pharmacy Times Survey (Urinary Pain Relief and Cranberry Supplement categories).

Brand IP Statement(s)

AZO Dual Protection and Intelliflora are trademarks of DSM. PreforPro is a trademark of Deerland Probiotics & Enzymes Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take orally. One (1) capsule daily. May be taken at anytime of day, with or without food.

Storage

Storage instructions: Store in a cool, dry place away from direct sunlight.

See for yourself

Dual Protection by AZO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Dual Protection by AZO

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Intelliflora Blend

150 mg per serving

PreforPro Blend

15 mg per serving
  • › Myoviridae LH01
  • › Siphoviridae LL5
  • › Myoviridae T4D
  • › Myoviridae LL12

Other (inactive) ingredients: Microcrystalline Cellulose, Hydroxypropyl Methylcellulose, Fructooligosaccharide, Magnesium Stearate, Titanium Dioxide, Carmine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dual Protection by AZO Drug Interactions

Want to check YOUR meds against Dual Protection?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Each ingredient & the kinds of drugs it affects

For each ingredient in Dual Protection with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus crispatus LBV 881 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus crispatus with antibiotic drugs might decrease the effectiveness of L. crispatus.
Lactobacillus crispatus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. crispatus preparations by at least two hours.

Likelihood Probable Evidence D

Lactobacillus gasseri LBV 150N1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus gasseri with antibiotic drugs might decrease the effectiveness of L. gasseri.
Lactobacillus gasseri preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. gasseri preparations by at least two hours.

Likelihood Probable Evidence D

Lactobacillus jensenii LBV 1161 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus jensenii with antibiotic drugs might decrease the effectiveness of L. jensenii.
Lactobacillus jensenii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. jensenii preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Dual Protection, from the product label.

AZO

See all AZO products
Name
i-Health Inc.
Street Address
55 Sebethe Drive
City
Cromwell
State
CT
ZipCode
06416
Phone Number
(800) 722-3476
Web Address
www.azoproducts.com
Pharmacist Counseling Corner

Dual Protection by AZO: Common Questions

Does Dual Protection by AZO interact with any medications?
Yes. Based on its ingredients, Dual Protection has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dual Protection contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. The antibiotic will kill the live bacteria in this supplement, making it less effective. Ask your doctor or pharmacist how many hours to wait between doses — usually a few hours apart is recommended.
Is this safe during pregnancy or breastfeeding?
Safety data is limited for both. The facts we hold don't show enough information to know either way. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
What are the live bacteria in this for?
The Lactobacillus species are probiotics meant to support vaginal and urinary health. One ingredient, L. crispatus, has some evidence behind it for bacterial vaginosis, but the others need more research.
What are the bacteriophages in this product?
The four bacteriophages (Myoviridae and Siphoviridae species) are viral particles thought to support the growth of healthy bacteria, but we have no effectiveness or safety data on file for them specifically.
Are there any common side effects?
Mild side effects are rare but can include nausea, gas, and flatulence. A very rare case of swollen tongue was reported. Because these are live organisms, there is a small theoretical risk of infection in people with weakened immunity, though serious cases are uncommon.
Does it contain fillers?
Yes — inactive ingredients include cellulose, fiber, magnesium stearate, and colorants to make the capsule. These are standard excipients used in supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Dual Protection is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dual Protection label
Sources

Sources & How We Checked

Dual Protection's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Crispatus 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  7. DI Pierro F, Criscuolo AA, Dei Giudici A, et al. Oral administration of Lactobacillus crispatus M247 to papillomavirus-infected women: results of a preliminary, uncontrolled, open trial. Minerva Obstet Gynecol 2021;73(5):621-631. PubMed
  8. DE Leo V, Lazzeri E, Governini L, et al. Vaginal colonization of women after oral administration of Lactobacillus crispatus strain NTCVAG04 from the human microbiota. Minerva Obstet Gynecol 2022. PubMed
  9. Dellino M, Cascardi E, Laganà AS, et al. Lactobacillus crispatus M247 oral administration: Is it really an effective strategy in the management of papillomavirus-infected women?. Infect Agent Cancer 2022;17(1):53. PubMed

See these in context on the Lactobacillus Crispatus monograph →

Lactobacillus Gasseri 12 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Ramachandran L, Dontaraju VS, Patel K. Lactobacillus-associated spontaneous bacterial peritonitis in a liver cirrhosis patient on probiotics. Cureus. 2020;12(12):e11896. PubMed
  3. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  4. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  5. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  6. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  7. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.
  8. Ramos-Coria D, Canto-Losa J, Carrillo-Vázquez D, Carbajal-Morelos L, Estrada-León R, Corona-Rodarte E. Lactobacillus gasseri liver abscess and bacteremia: a case report. BMC Infect Dis 2021;21(1):518. PubMed
  9. Elikowski W, Malek-Elikowska M, Lisiecka M, Bodora A, Wisniewska K, Oko-Sarnowska Z. Lactobacillus gasseri endocarditis on the aortic valve bioprosthesis - a case report. Pol Merkur Lekarski 2017;43(257):220-223.
  10. Esquibel A, Dababneh AS, Palraj BR. Lactobacillus gasseri causing bilateral empyema. Case Rep Infect Dis 2017;2017:4895619.
  11. Tleyjeh IM, Routh J, Qutub MO, Lischer G, Liang KV, Baddour LM. Lactobacillus gasseri causing Fournier's gangrene. Scand J Infect Dis 2004;36(6-7):501-3. PubMed
  12. Dickgiesser U, Weiss N, Fritsche D. Lactobacillus gasseri as the cause of septic urinary infection. Infection 1984;12(1):14-6. PubMed

See these in context on the Lactobacillus Gasseri monograph →

Lactobacillus Jensenii 6 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
  5. Toprak NU, Bozan T, Yilmaz S, Buyukbayrak EE, Tigen ET. Polymicrobial bacteremia due to Lactobacillus jensenii and Veillonella montpellierensis in a pregnant patient; case report and review of literature. Anaerobe 2022;75:102576. PubMed
  6. Chazan B, Raz R, Shental Y, Sprecher H, Colodner R. Bacteremia and pyelonephritis caused by Lactobacillus jensenii in a patient with urolithiasis. Isr Med Assoc J 2008;10(2):164-5.

See these in context on the Lactobacillus Jensenii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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