D-Mulsion 1000 Citrus Flavour Ingredients & Drug Interactions
by Genestra Brands
What is this page for?
First and foremost: checking D-Mulsion 1000 Citrus Flavour against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
D-Mulsion 1000 Citrus Flavour is a dietary supplement by Genestra Brands with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against D-Mulsion 1000 Citrus Flavour by Genestra Brands
Ask about any prescription or over-the-counter medication and we check it for interactions with D-Mulsion 1000 Citrus Flavour by Genestra Brands — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of D-Mulsion 1000 Citrus Flavour by Genestra Brands
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
D-Mulsion 1000 Citrus Flavour is a liquid supplement containing one active ingredient: vitamin D. The inactive ingredients are purified water, maltodextrin, tapioca starch, extra virgin olive oil, lemon oil, citric acid, potassium sorbate, stevia leaf extract, and mixed tocopherols — these are fillers, preservatives, flavoring, and stabilizers that keep the product stable and palatable.
Does it work?
Strong evidence
Vitamin D is effective for treating rickets, osteomalacia (soft bones due to vitamin D deficiency), familial hypophosphatemia (a genetic disorder affecting phosphate handling), renal osteodystrophy (bone disease from kidney failure), and hypoparathyroidism (low parathyroid hormone). It's most useful when there's a documented deficiency or a specific condition your doctor is managing with vitamin D.
How safe is it?
Well-documented data
Vitamin D is generally well tolerated at recommended doses, but very high doses taken over time can cause toxicity. Symptoms of vitamin D toxicity include high blood calcium (hypercalcemia), low blood cell counts, weak bones in adults, poor growth in children, and rarely eye inflammation or light sensitivity.
During pregnancy, vitamin D at recommended amounts is likely safe, but the data also notes a possibly unsafe rating — talk with your doctor about what's right for you. During breastfeeding, recommended amounts are considered likely safe, though use under medical guidance.
Meds to double-check
Moderate interaction found
Before taking D-Mulsion 1000, double-check if you're on thiazide diuretics, verapamil, diltiazem, digoxin, atorvastatin, calcipotriene, or aluminum-containing antacids — these have Moderate-severity interactions. Vitamin D may also reduce the effectiveness of many other medications processed through your liver's CYP3A4 pathway (Minor severity).
Talk it over with your doctor or pharmacist if you're unsure.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is designed for people with vitamin D deficiency or specific conditions like rickets or hypoparathyroidism — not for routine daily use at high doses. If you take heart medications, blood pressure pills, cholesterol drugs, digoxin, or calcipotriene, or if you have kidney problems, check with your doctor or pharmacist before starting.
Stick to recommended doses and have your doctor monitor your blood calcium if you're on any interacting medication.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about D-Mulsion 1000 Citrus Flavour, straight from the product label.
| Brand | Genestra Brands |
|---|---|
| Barcode (UPC) | 88319610871 |
| Net contents | 30 mL Liquid |
| Market status | On market |
| Date entered into DSLD | Apr 25, 2018 |
| DSLD ID | 176569 |
| Product type | Vitamin |
| Supplement form | Liquid |
| Dietary claims / uses | All Other |
| Intended target group(s) | Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Children more than 1 but less than 4 |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for D-Mulsion 1000 Citrus Flavour by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D | 25 mcg | -- |
Other ingredients: purified Water, Maltodextrin, Tapioca Starch, extra virgin Olive Oil, Lemon Oil, Citric Acid, Potassium Sorbate, Stevia leaf extract, Mixed Tocopherols
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Recommended Dose (All Ages): Take one drop daily or as recommended by your healthcare practitioner.
Formulation
Guaranteed to contain no added wheat, yeast, gluten, corn, sugar, artificial colouring or flavouring or dairy products.
Ideal for vegetarians.
General Statements
Quality Assurance: Safety-sealed for your protection and for product freshness.
A factor in the maintenance of good health. Helps in the development and maintenance of bones and teeth; helps in the absorption and use of calcium and phosphorus; and helps to prevent vitamin D deficiency.
Precautions
Do not use if outer seal is missing or broken.
Keep out of reach of children.
Storage
Store in a cool, dry place.
FDA Statement of Identity
Vitamin Supplement
General
V2.0 154
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
D-Mulsion 1000 Citrus Flavour by Genestra Brands label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in D-Mulsion 1000 Citrus Flavour by Genestra Brands
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.027 mL Dosage formLiquid Amounts shown are per serving.
Vitamin D
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D monograph & interactionsOther (inactive) ingredients: Purified Water, Maltodextrin, Tapioca Starch, Extra virgin Olive Oil, Lemon Oil, Citric Acid, Potassium Sorbate, Stevia leaf extract, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.
D-Mulsion 1000 Citrus Flavour by Genestra Brands Drug Interactions
HelloPharmacist Interaction Report
D-Mulsion 1000 Citrus Flavour by Genestra Brands contains vitamin D, which has documented interactions with several medication types.
The most serious concern is with thiazide diuretics, verapamil, atorvastatin, aluminum-containing products, digoxin, diltiazem, and calcipotriene — all rated Moderate severity — because high-dose vitamin D can raise calcium levels in your blood (hypercalcemia), which interferes with how these drugs work or increases the risk of serious side effects like heart rhythm problems.
Read the full breakdown — every affected drug type, severity by severity
Thiazide diuretics (water pills for high blood pressure) reduce how much calcium your body excretes in urine, so adding vitamin D on top can push calcium too high. The same hypercalcemia risk applies to verapamil and diltiazem (heart rhythm medications) — high calcium can make them less effective or dangerous.
Vitamin D may also reduce how well your body absorbs atorvastatin (a cholesterol drug), and it can theoretically increase aluminum absorption, which matters mainly if you have kidney problems. Digoxin (a heart medication) becomes riskier in the presence of high blood calcium.
Calcipotriene, a vitamin D-like topical psoriasis treatment, adds to this hypercalcemia risk if combined.
Vitamin D may also induce CYP3A4 enzymes (Minor severity), which could reduce the effectiveness of many other medications that rely on this enzyme pathway — a large group of common drugs. Altogether, these interactions span 716 individual medications.
Before you start this product, run your exact medications through the interaction checker on this page, and talk with your doctor or pharmacist if you take any of these types of drugs.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against D-Mulsion 1000 Citrus Flavour?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in D-Mulsion 1000 Citrus Flavour interact with 715 drugs. Click any drug to see the details.
1 of the 1 ingredient in D-Mulsion 1000 Citrus Flavour interact with drugs. Each result below shows which ingredient is responsible. Vitamin D
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Alginic Acid, Aluminum Hydroxide interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Amiloride, Hydrochlorothiazide interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Atenolol, Chlorthalidone interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DAtorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D + Atorvastatin Calcium interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Benzthiazide interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCalcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D + Betamethasone Dipropionate, Calcipotriene interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Bisoprolol, Hydrochlorothiazide interactionCalcipotrieneDovonex
How Calcipotriene interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DCalcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D + Calcipotriene interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with D-Mulsion 1000 Citrus Flavour — through 1 ingredient. Tap an ingredient for the detail:
Vitamin DThiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D + Chlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in D-Mulsion 1000 Citrus Flavour with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for D-Mulsion 1000 Citrus Flavour, from the product label.
Genestra Brands
- Name
- Seroyal International
- Street Address
- 490 Elgin Mills Rd E
- City
- Richmond Hill
- State
- ON
- ZipCode
- L4C 0L8
D-Mulsion 1000 Citrus Flavour by Genestra Brands: Common Questions
Does D-Mulsion 1000 Citrus Flavour by Genestra Brands interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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Is it safe to take during pregnancy?
Can I take it while breastfeeding?
What happens if I take too much?
Does vitamin D interact with my heart medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if D-Mulsion 1000 Citrus Flavour is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind D-Mulsion 1000 Citrus Flavour’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
D-Mulsion 1000 Citrus Flavour's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
- Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
- Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
- Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
- Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
- Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
- Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
- Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
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