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Dietary supplement

D3 1000 Chewable Natural Spearmint Flavor Ingredients & Drug Interactions

by Genestra Brands

D3 1000 Chewable Natural Spearmint Flavor label
See full label image
Liquid Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking D3 1000 Chewable Natural Spearmint Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

D3 1000 Chewable Natural Spearmint Flavor is a dietary supplement by Genestra Brands with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 717 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands

Ask about any prescription or over-the-counter medication and we check it for interactions with D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: vitamin D (in a liquid form you chew). The inactive ingredients are purified water, cellulose, spearmint flavoring, xanthan gum, olive oil, stevia leaf extract, potassium sorbate, and citric acid.

It's a straightforward single-ingredient supplement — the rest is just what holds it together and flavors it.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Vitamin D's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Vitamin D supplementation.
  • We looked for evidence on: Muscle strength.
  • The closest evidence on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Muscle strength (Natural Medicines).

Vitamin D at this dose is effective for several medical conditions: familial hypophosphatemia (a genetic disorder affecting phosphate balance), osteomalacia (soft bones from vitamin D deficiency), renal osteodystrophy (bone disease from kidney failure), rickets (childhood bone disease), and hypoparathyroidism (low parathyroid hormone). If you're taking it for general bone health or immune support, the evidence we hold doesn't speak to those uses — talk with your pharmacist or doctor about what the science actually shows for your reason.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is well tolerated at recommended doses, but very high doses over time can cause toxicity with symptoms of high blood calcium — including bone loss in adults and poor growth in children. Eye irritation and sensitivity to light have also been reported with excessive intake.

The safety notes say it's often used in pregnancy at recommended amounts, but only under your doctor's guidance. For breastfeeding, there isn't enough data on file to say either way — check with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 718 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, check with your pharmacist if you take thiazide diuretics (water pills for blood pressure), digoxin or other heart medications like verapamil or diltiazem, atorvastatin or other cholesterol drugs, or calcipotriene (a vitamin D-like cream for psoriasis). Altogether, these interactions span 705 individual medications.

Use the interaction tool on this page with your exact prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This 1000 IU dose of vitamin D is appropriate if your doctor prescribed it for rickets, osteomalacia, or other bone and mineral disorders, or if you're supplementing a documented deficiency. If you take a water pill, heart medication, cholesterol drug, or anything metabolized by your liver, run it through the interaction checker on this page before you start — and stick to the 4000 IU daily limit if you're on digoxin or thiazide diuretics.

Talk to your pharmacist about your specific situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D3 1000 Chewable Natural Spearmint Flavor, straight from the product label.

Brand Genestra Brands
Barcode (UPC) 88319612660
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Jan 25, 2016
DSLD ID 55549
Product type Vitamin
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Children (All)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.0225 mL
Maximum serving Sizes:
0.0225 mL
Servings per container
1333
UPC/BARCODE
88319612660
IngredientAmount% DV
Vitamin D1000 IU250%

Other ingredients: purified Water, Cellulose, natural Spearmint flavor, Xanthan Gum, extra virgin Olive Oil, organic Stevia leaf extract, Potassium Sorbate, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended Dose (All Ages): Take one drop (0.0225 ml) daily or as recommended by your healthcare practitioner.

Formulation

Guaranteed to contain no added wheat, yeast, gluten, soy, sodium, sugar, artificial coloring or flavoring or dairy products.

Ideal for vegetarians.

Precautions

Quality Assurance: Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Seals/Symbols

Seroyal

FDA Statement of Identity

VITAMIN SUPPLEMENT

General

V1.0 159

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

D3 1000 Chewable Natural Spearmint Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.0225 mL Dosage formLiquid Servings per container1333 Amounts shown are per serving.

Vitamin D

Interacts with
717 drugs
1000 IU per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Other (inactive) ingredients: Purified Water, Cellulose, Natural Spearmint flavor, Xanthan Gum, Extra virgin Olive Oil, Organic Stevia leaf extract, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands Drug Interactions

Want to check YOUR meds against D3 1000 Chewable Natural Spearmint Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
717Drugs
80 Moderate 637 Minor

Ingredients driving the most interactions

Vitamin D 717

Individual Drug Interactions

The ingredients in D3 1000 Chewable Natural Spearmint Flavor interact with 717 drugs. Click any drug to see the details.

1 of the 1 ingredient in D3 1000 Chewable Natural Spearmint Flavor interact with drugs. Each result below shows which ingredient is responsible. Vitamin D

Each ingredient & the kinds of drugs it affects

For each ingredient in D3 1000 Chewable Natural Spearmint Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 717 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
Vitamin D full monograph & interactions
The maker

Brand information

Manufacturer and brand details for D3 1000 Chewable Natural Spearmint Flavor, from the product label.

Genestra Brands

Name
Seroyal USA
City
Pittsburgh
State
PA
ZipCode
15275
Phone Number
1-888-737-6925
Web Address
seroyal.com
Pharmacist Counseling Corner

D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands: Common Questions

Does D3 1000 Chewable Natural Spearmint Flavor by Genestra Brands interact with any medications?
Yes. Based on its ingredients, D3 1000 Chewable Natural Spearmint Flavor has a known interaction with 717 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D3 1000 Chewable Natural Spearmint Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy or while breastfeeding?
It's often used during pregnancy at recommended doses, but only under your doctor's guidance — don't start it on your own. For breastfeeding, we don't have enough safety data on file to say either way. Talk with your doctor or pharmacist about what's right for you.
What are the side effects?
At recommended doses, vitamin D is well tolerated. Very high doses over time can cause toxicity with symptoms like high blood calcium, bone loss, or poor growth in children. Eye irritation and light sensitivity have also been reported with excessive intake. Stick to the dose your doctor recommends.
Can I take this if I have kidney disease?
The interaction data shows a concern about aluminum absorption in people with kidney failure who take vitamin D. If you have kidney disease, talk with your doctor or pharmacist before starting — they may need to monitor your calcium and adjust your dose.
Does it really work for bone health?
Vitamin D is proven effective for rickets, osteomalacia (soft bones from deficiency), familial hypophosphatemia, renal osteodystrophy, and hypoparathyroidism. For general bone health or immune support in otherwise healthy people, the evidence we hold doesn't establish that — ask your pharmacist what the science shows for your specific reason.
What's in this besides vitamin D?
The rest is inactive ingredients: water, cellulose, spearmint flavor, xanthan gum, olive oil, stevia extract, potassium sorbate, and citric acid. These are binders, thickeners, flavoring, and preservatives — standard stuff that holds a liquid chewable together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if D3 1000 Chewable Natural Spearmint Flavor is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D3 1000 Chewable Natural Spearmint Flavor label
Go deeper

The Full Monographs Behind D3 1000 Chewable Natural Spearmint Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin D

Interacts with 717 drugs

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people, especially those with low sun exposure,...

Read the full Vitamin D monograph →
Sources

Sources & How We Checked

D3 1000 Chewable Natural Spearmint Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 25 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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