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Dietary supplement

D3 5000 IU (125 mcg) Mixed Berry Ingredients & Drug Interactions

by Nature Made

Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

D3 5000 IU (125 mcg) Mixed Berry is a dietary supplement by Nature Made with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 717 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of D3 5000 IU (125 mcg) Mixed Berry by Nature Made

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Nature Made D3 5000 IU contains one active ingredient: vitamin D3 (also called cholecalciferol), a fat-soluble vitamin your body makes from sunlight and also needs from food or supplements. This 5000 IU dose is higher than the standard daily recommendation, so it's meant for people who need extra — such as those with limited sun exposure, dark skin in northern climates, or certain bone or kidney conditions.

The tablet also contains inactive ingredients like mannitol, corn starch, citric acid, magnesium stearate, monk fruit extract for taste, and food colorings.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports immune, bone, teeth and muscle health.
  • We looked for evidence on: Muscle strength, Physical performance, Fall prevention, Fractures, Osteomalacia, Corticosteroid-induced osteoporosis — and 4 related terms.
  • The strongest evidence on file: Vitamin D is rated "Effective" for Osteomalacia (Natural Medicines).
  • Also on file: Vitamin D is rated "Likely Effective" for Corticosteroid-induced osteoporosis.
  • Also on file: Vitamin D is rated "Possibly Effective" for Dental caries, Hyperparathyroidism-related bone loss.

Vitamin D3 is effective for rickets, osteomalacia (soft bones), renal osteodystrophy (bone disease from kidney failure), hypoparathyroidism (low parathyroid hormone), and familial hypophosphatemia (a rare inherited condition). It's the form of vitamin D your body prefers and is well studied for these conditions.

For other uses — such as general bone health or immune support — the evidence we hold does not establish effectiveness.

The evidence, ingredient by ingredient Vitamin D

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D3 is generally well tolerated at recommended doses. However, very high doses over time can cause toxicity, with symptoms like high blood calcium, weak bones in adults, stunted growth in children, eye inflammation, and light sensitivity.

At this 5000 IU dose, toxicity is unlikely if you're not taking other vitamin D sources, but it's higher than the tolerable upper daily limit of 4000 IU for adults — so talk with your doctor about whether it's right for you. During pregnancy, vitamin D at recommended amounts is often used and likely safe, though the data also notes it's possibly unsafe — use only under your doctor's guidance.

During breastfeeding, recommended amounts are considered likely safe.

Side effects, ingredient by ingredient Vitamin D

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 718 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use thiazide diuretics, verapamil, digoxin, diltiazem, atorvastatin, calcipotriene, or any aluminum-containing antacids or binders — all carry Moderate risk. Also mention any other drugs you take, since vitamin D may affect how certain liver enzymes process them (Minor severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is useful if your doctor has confirmed you need extra vitamin D for rickets, weak bones, kidney bone disease, or low parathyroid hormone. Because the dose is at the upper limit for adults and interacts with several heart and blood pressure medications, talk with your doctor or pharmacist first — especially if you take a diuretic, digoxin, verapamil, diltiazem, atorvastatin, or an aluminum antacid.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about D3 5000 IU (125 mcg) Mixed Berry, straight from the product label.

Brand Nature Made
Barcode (UPC) 031604002749
Net contents 70 Tablet(s)
Market status On market
Date entered into DSLD May 23, 2024
DSLD ID 313827
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for D3 5000 IU (125 mcg) Mixed Berry by Nature Made, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
70
UPC/BARCODE
031604002749
IngredientAmount% DV
Vitamin D3125 mcg625%

Other ingredients: Mannitol, Corn Starch, Food Starch, Modified, Maltodextrin, Crospovidone, Silicon Dioxide, Colors added, Citric Acid, Magnesium Stearate, Monk Fruit Extract, Natural Flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#1 Pharmacist Recommended Vitamin & Supplement Brand Based on a survey of pharmacists who recommend branded vitamins and supplements.

Formulation

Fast dissolve Extra strength Supports immune, bone, teeth & muscle health

No synthetic dyes- colors derived from natural sources No artificial flavors Sugar free Lactose free

Tableted and quality tested in the USA. Made to our guaranteed purity and potency standards.

Formula

Mixed berry with other natural flavors

No synthetic dyes- colors derived from natural sources

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Use daily to help raise vitamin D levels if deficient. Suggested use: This product is designed for those with higher vitamin D needs and/or deficiency, as determined by a healthcare professional. Take one fast dissolve tablet daily. Dissolve in mouth or chew before swallowing. No water necessary. Approx 29% of the U.S. adults are vitamin D deficient (<50 nmol/L).

Storage

Store tightly closed, in a cool, dry place, out of reach of children.

Precautions

Store tightly closed, in a cool, dry place, out of reach of children.

Do not use if seal under cap is broken or missing.

Caution: Use only as directed by your healthcare professional. Do not exceed one tablet daily or take with other supplements containing vitamin D.

Consult with your healthcare professional before using if you are pregnant, nursing, taking any medications, or have any chronic medical conditions.

See for yourself

D3 5000 IU (125 mcg) Mixed Berry by Nature Made label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in D3 5000 IU (125 mcg) Mixed Berry by Nature Made

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container70 Amounts shown are per serving.

Vitamin D3

Interacts with
717 drugs
125 mcg per serving Form: Cholecalciferol

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D3 monograph & interactions

Other (inactive) ingredients: Mannitol, Corn Starch, Food Starch, Modified, Maltodextrin, Crospovidone, Silicon Dioxide, Colors added, Citric Acid, Magnesium Stearate, Monk Fruit Extract, Natural Flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

D3 5000 IU (125 mcg) Mixed Berry by Nature Made Drug Interactions

Want to check YOUR meds against D3 5000 IU (125 mcg) Mixed Berry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
717Drugs
80 Moderate 637 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in D3 5000 IU (125 mcg) Mixed Berry with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D38 drug types · 717 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for D3 5000 IU (125 mcg) Mixed Berry, from the product label.

Nature Made

See all Nature Made products
Name
Nature Made Nutritional Products
City
West Hills
State
CA
ZipCode
91309-9903
Phone Number
1-800-276-2878
Web Address
www.NatureMade.com
Pharmacist Counseling Corner

D3 5000 IU (125 mcg) Mixed Berry by Nature Made: Common Questions

Does D3 5000 IU (125 mcg) Mixed Berry by Nature Made interact with any medications?
Yes. Based on its ingredients, D3 5000 IU (125 mcg) Mixed Berry has a known interaction with 717 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
D3 5000 IU (125 mcg) Mixed Berry contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is 5000 IU safe for daily use?
At 5000 IU, you're at the upper limit set by the FDA for adults (4000 IU daily), so daily use should be monitored by your doctor. Vitamin D is well tolerated at recommended doses, but very high doses over time can cause toxicity with high blood calcium and weak bones.
Can I take this if I'm pregnant?
Vitamin D at recommended amounts is often used during pregnancy and is likely safe, though the data also notes it's possibly unsafe — so use it only under your doctor's guidance, not on your own.
Is this D3 or D2?
This is D3 (cholecalciferol), the form your body makes from sunlight and the one your body prefers. It's more effective than D2 (ergocalciferol) for raising and maintaining vitamin D levels.
What are the inactive ingredients?
This tablet contains mannitol, corn starch, citric acid, magnesium stearate, silicon dioxide, crospovidone, monk fruit extract, natural flavors, and food colorings — all are inactive fillers and binders.
Will this interact with my blood pressure medication?
If you take a thiazide diuretic (a water pill), yes — it's a Moderate interaction. High-dose vitamin D can raise your blood calcium, which makes the diuretic work less well. Check the medication checker below or ask your pharmacist to confirm your specific drug.
Does vitamin D help with immune function or general wellness?
The evidence we hold shows vitamin D is effective for specific bone and metabolic disorders — rickets, weak bones, kidney bone disease, and low parathyroid hormone. For other uses like immunity, the data doesn't establish effectiveness for this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

D3 5000 IU (125 mcg) Mixed Berry label
Go deeper

The Full Monographs Behind D3 5000 IU (125 mcg) Mixed Berry’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

D3 5000 IU (125 mcg) Mixed Berry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 25 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed

See these in context on the Vitamin D monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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