Major interaction on record — check this product against your medications before combining. Based on 6 of 8 ingredients. Check your meds →
Dietary supplement

DDR Prime Ingredients & Drug Interactions

by doTERRA

DDR Prime label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DDR Prime against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

DDR Prime is a dietary supplement by doTERRA with 8 active ingredients. Its ingredients are commonly taken for joint pain and osteoarthritis, inflammation, digestive complaints.Based on those ingredients, 1,218 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Clove (Eugenia caryophyllata) bud Oil, wild Orange (Citrus aurantium dulcis) peel Oil, Lemongrass (Cymbopogon flexuosus) leaf Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against DDR Prime by doTERRA

Ask about any prescription or over-the-counter medication and we check it for interactions with DDR Prime by doTERRA — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of DDR Prime by doTERRA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (180 mg) without saying how much of each component you get.

DDR Prime contains eight active ingredients, all essential oils and plant extracts. The product lists them in a proprietary blend — frankincense resin oil, wild orange peel oil, litsea fruit oil, thyme leaf oil, clove bud oil, summer savory plant oil, niaouli leaf oil, and lemongrass leaf oil.

Each is included for its traditional aromatic or wellness properties. The product contains no inactive ingredients listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Ventilator-associated pneumonia (VAP) — rated "Possibly Effective" (Clove) (Natural Medicines).

The evidence for effectiveness is limited. Frankincense, wild orange, thyme, clove, summer savory, niaouli, and lemongrass all carry ratings of insufficient reliable evidence for the conditions they're traditionally used for — meaning we don't hold clinical data strong enough to confirm they work.

Clove is rated possibly effective for ventilator-associated pneumonia (a serious lung infection in hospitalized patients on mechanical breathing support), but that's a narrow clinical use far from typical home wellness use. For common conditions like acne, skin aging, cough, colds, or general fatigue, the data simply isn't established in our records.

The evidence, ingredient by ingredient Frankincense Bitter Orange Thyme Clove Summer Savory Lemongrass

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these oils are generally well tolerated when inhaled or applied topically in small amounts, but oral use and concentrated doses raise concerns. Frankincense may cause skin irritation, dermatitis, or rarely allergic skin reactions; it should be avoided during pregnancy and breastfeeding due to insufficient safety data.

Wild orange contains stimulant compounds (synephrine and octopamine) that can raise heart rate and blood pressure, and serious but rare side effects — including heart attack, stroke, and seizure — have been reported; it should be avoided in pregnancy and during breastfeeding. Thyme is likely safe in food amounts but can cause allergic reactions, diarrhea, dizziness, headache, heartburn, nausea, or vomiting; it's safe in pregnancy.

Clove is well tolerated as a spice but can be toxic in concentrated doses; it's likely safe in pregnancy. Summer savory is likely safe as food seasoning but should be avoided in medicinal amounts during pregnancy.

Lemongrass lacks sufficient pregnancy safety data; medicinal amounts should be avoided. Litsea and niaouli have no adverse-effect or pregnancy/breastfeeding data on file.

Side effects, ingredient by ingredient Frankincense Bitter Orange Thyme Clove Summer Savory Lemongrass

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 6 matched ingredients can interact with medications — Clove, Summer Savory, Lemongrass, Thyme, Bitter Orange.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking DDR Prime, double-check these medication types: MAOIs and midazolam (the highest-risk interactions), then QT-prolonging drugs, CYP3A4 substrate drugs, blood sugar medications, stimulants, dextromethorphan, caffeine, blood thinners, estrogen therapy, acetylcholine-affecting drugs, and pentobarbital. Use the medication checker on this page with your specific prescription names.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.

DDR Prime is a blend of aromatic plant oils with limited clinical evidence for specific health claims. If you take any prescription medications — especially antidepressants, sedatives, blood thinners, blood pressure drugs, diabetes medications, or stimulants — check this product against your exact medications using the tool on this page before starting.

Pregnant or breastfeeding individuals should talk with their doctor or pharmacist first, since safety data is sparse or absent for several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 28, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DDR Prime, straight from the product label.

Brand doTERRA
Net contents 30 mL; 1 fl. Oz.
Market status On market
Date entered into DSLD May 28, 2019
DSLD ID 202895
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DDR Prime by doTERRA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Drop(s)
Maximum serving Sizes:
4 Drop(s)
Servings per container
160
IngredientAmount% DV
Proprietary Blend180 mg--
Frankincense (Boswellia carterii) resin Oil0 NP--
wild Orange (Citrus aurantium dulcis) peel Oil0 NP--
Litsea (Litsea cubeba) fruit Oil0 NP--
Thyme (Thymus vulgaris) leaf Oil0 NP--
Clove (Eugenia caryophyllata) bud Oil0 NP--
Summer Savory (Satureja hortensis) plant Oil0 NP--
Niaouli (Melaleuca quinquenervia) leaf Oil0 NP--
Lemongrass (Cymbopogon flexuosus) leaf Oil0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions for use: Take four (4) drops, two (2) times per day with food.

General

v5 41510001

Brand IP Statement(s)

CPTG Certified Pure Therapeutic Grade

General Statements

Essential oil cellular complex

60-day supply

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DDR Prime by doTERRA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DDR Prime label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DDR Prime by doTERRA

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Drop(s) Dosage formLiquid Servings per container160 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Interaction report

DDR Prime by doTERRA Drug Interactions

Want to check YOUR meds against DDR Prime?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,218Drugs
10 Major 1,208 Moderate

Ingredients driving the most interactions

Clove (Eugenia caryophyllata) bud Oil 977
wild Orange (Citrus aurantium dulcis) peel Oil 957
Lemongrass (Cymbopogon flexuosus) leaf Oil 708
Thyme (Thymus vulgaris) leaf Oil 379
Summer Savory (Satureja hortensis) plant Oil 122

Individual Drug Interactions

The ingredients in DDR Prime interact with 1,218 drugs. Click any drug to see the details.

5 of the 8 ingredients in DDR Prime interact with drugs. Each result below shows which ingredient is responsible. Clove (Eugenia caryophyllata) bud Oil wild Orange (Citrus aurantium dulcis) peel Oil Lemongrass (Cymbopogon flexuosus) leaf Oil Thyme (Thymus vulgaris) leaf Oil Summer Savory (Satureja hortensis) plant Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in DDR Prime with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Clove (Eugenia caryophyllata) bud Oil7 drug types · 977 drugs

Antidiabetes Drugs

Theoretically, concomitant use of clove extracts with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical and laboratory research suggest that polyphenol extracts from clove flower buds might lower blood glucose levels. Dosing adjustments for insulin or oral hypoglycemic agents may be necessary when taken with clove. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP1A2.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP1A2 in a dose-dependent manner,. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2C9.
In vitro research shows that eugenol, the principal constituent of clove, inhibits CYP2C9 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP2D6.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP2D6 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, concomitant use of clove may increase levels of drugs metabolized by CYP3A4.
In vitro research shows that eugenol, the principal constituent of clove, can inhibit CYP3A4 in a dose-dependent manner. This effect has not been reported in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, clove oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that eugenol, a constituent of clove, has antiplatelet activity. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Ibuprofen (Advil, Others)

Theoretically, topical application of clove oil with ibuprofen might increase the absorption and side effects of topical ibuprofen.
Laboratory research shows that topical application of clove oil increases the absorption of topical ibuprofen. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Clove (Eugenia caryophyllata) bud Oil full monograph & interactions

wild Orange (Citrus aurantium dulcis) peel Oil13 drug types · 957 drugs

Midazolam (Versed)

Bitter orange might increase blood levels of midazolam.
One small clinical study shows that bitter orange juice can increase midazolam levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4). Theoretically, bitter orange might increase the risk of midazolam-related adverse effects.

Likelihood Probable Evidence B
Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking MAOIs with synephrine-containing bitter orange preparations might increase the hypertensive effects of synephrine, potentially leading to hypertensive crisis.
Bitter orange contains tyramine, octopamine, and synephrine, which are MAO substrates.

Likelihood Probable Evidence D
Antidiabetes Drugs

Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Some clinical research shows that drinking a tea containing bitter orange and Indian snakeroot reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are using antidiabetes drugs. However, it is unclear if these effects are due to bitter orange, Indian snakeroot, or the combination. An animal study also shows that p-synephrine in combination with gliclazide , a sulfonylurea, causes an additional 20% to 44% decrease in glucose levels when compared with gliclazide alone.

Likelihood Possible Evidence B
Caffeine

Bitter orange might increase blood pressure and heart rate when taken with caffeine.
Small clinical studies show that taking bitter orange in combination with caffeine can increase blood pressure and heart rate in otherwise healthy normotensive adults. Theoretically, this might increase the risk of serious cardiovascular adverse effects.

Likelihood Possible Evidence B
Colchicine

Bitter orange might affect colchicine levels.
Colchicine is a substrate of P-glycoprotein and cytochrome P450 3A4 (CYP3A4). Bitter orange has been reported to inhibit CYP3A4 and increase levels of CYP3A4 substrates. However, one small clinical study in healthy adults shows that drinking bitter orange juice 240 mL twice daily for 4 days and taking a single dose of colchicine 0.6 mg on the 4th day decreases colchicine peak serum levels by 24%, time to peak serum level by 1 hour, and overall exposure to colchicine by 20%. The clinical significance of this finding is unclear.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Bitter orange might increase levels of drugs metabolized by CYP3A4.
Small clinical studies suggest that single or multiple doses of freshly squeezed bitter orange juice 200-240 mL can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. However, the extent of the effect of bitter orange on CYP3A4-mediated drug interactions is unknown. Some evidence suggests that bitter orange selectively inhibits intestinal CYP3A4, but not hepatic CYP3A4. Its effect on P-glycoprotein, which strongly overlaps with CYP3A4 interactions, is unclear. One small clinical study shows that drinking 8 ounces of freshly squeezed bitter orange juice has no effect on cyclosporine, which seems to be more dependent on hepatic CYP3A4 and P-glycoprotein than intestinal CYP3A4.

Likelihood Possible Evidence B
Dextromethorphan (Robitussin Dm, Others)

Bitter orange might increase blood levels of dextromethorphan.
One small clinical study shows that bitter orange juice increases dextromethorphan levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for dextromethorphan-related adverse effects.

Likelihood Possible Evidence B
Felodipine (Plendil)

Bitter orange might increase blood levels of felodipine.
One small clinical study shows that bitter orange juice increases felodipine levels, likely through cytochrome P450 3A4 (CYP3A4) inhibition. Theoretically, bitter orange might increase the risk for felodipine-related adverse effects.

Likelihood Probable Evidence B
Indinavir (Crixivan)

Bitter orange might increase blood levels of indinavir.
One small clinical study shows that bitter orange juice slightly increases indinavir levels, but this effect is likely to be clinically insignificant. Bitter orange selectively inhibits intestinal cytochrome P450 3A4 (CYP3A4); however, the metabolism of indinavir seems to be more dependent on hepatic CYP3A4. The effect of bitter orange on other protease inhibitors has not been studied.

Likelihood Possible Evidence B
Qt Interval-Prolonging Drugs

Theoretically, bitter orange might have an additive effect when combined with drugs that prolong the QT interval, potentially increasing the risk of ventricular arrhythmias.
One case report suggests that taking bitter orange in combination with other stimulants such as caffeine might prolong the QT interval in some patients.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Bitter orange juice might increase blood levels of sildenafil.
A small clinical study in healthy adult males shows that drinking freshly squeezed bitter orange juice 250 mL daily for 3 days and taking a single dose of sildenafil 50 mg on the 3rd day increases the peak plasma concentration of sildenafil by 18% and the overall exposure to sildenafil by 44%. Theoretically, this may be due to inhibition of cytochrome P450 3A4 by bitter orange.

Likelihood Probable Evidence B
Stimulant Drugs

Theoretically, bitter orange might increase the risk of hypertension and adverse cardiovascular effects when taken with stimulant drugs.
Bitter orange appears to have stimulant effects.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, bitter orange might increase levels of drug metabolized by CYP2D6.
In vitro research shows that octopamine, a constituent of bitter orange, weakly inhibits CYP2D6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
wild Orange (Citrus aurantium dulcis) peel Oil full monograph & interactions

Lemongrass (Cymbopogon flexuosus) leaf Oil3 drug types · 708 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, lemongrass might decrease the metabolism of CYP3A4 substrates.
Animal research shows that lemongrass and its constituent citral inhibit CYP3A4.

Likelihood Possible Evidence D
Glucuronidated Drugs

Theoretically, lemongrass might increase the clearance and decrease the levels of glucuronidated drugs.
Animal research shows that lemongrass and its constituent citral induce uridine diphosphoglucuronosyl transferase (UGT), the major phase 2 enzyme that is responsible for glucuronidation.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, lemongrass might increase the effects and adverse effects of pentobarbital.
Animal research shows that high doses of lemongrass essential oil increases sleep time and decreases time to fall asleep in animals administered pentobarbital.

Likelihood Possible Evidence D
Lemongrass (Cymbopogon flexuosus) leaf Oil full monograph & interactions

Thyme (Thymus vulgaris) leaf Oil4 drug types · 379 drugs

Anticholinergic Drugs

Theoretically, concurrent use of anticholinergic drugs and thyme essential oil might reduce the effects of anticholinergic drugs.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, thyme leaf extract might have additive effects with anticoagulant or antiplatelet drugs.
In vitro and animal research suggests that thyme leaf extract has antiplatelet effects. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of cholinergic drugs and thyme essential oil might cause additive cholinergic effects.
In vitro evidence suggests that thyme essential oil and specific essential oil constituents like thymohydroquinone and carvacrol can inhibit acetylcholinesterase (AChE). However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, thyme might competitively inhibit the effects of estrogen replacement therapy.
In vitro research shows that thyme has estrogen receptor-binding activity and phytoestrogen content. However, this effect has not been observed in humans.

Likelihood Possible Evidence D
Thyme (Thymus vulgaris) leaf Oil full monograph & interactions

Summer Savory (Satureja hortensis) plant Oil1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

In vitro research suggests that summer savory extract inhibits platelet aggregation and adhesion. Theoretically, summer savory might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs. Some anticoagulant or antiplatelet drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Likelihood Possible Evidence D
Summer Savory (Satureja hortensis) plant Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DDR Prime, from the product label.

doTERRA

See all doTERRA products
Name
doTERRA Intl, LLC
Street Address
389 S 1300 W
City
Pleasant Grove
State
UT
ZipCode
84062
Phone Number
1-800-411-8151
Pharmacist Counseling Corner

DDR Prime by doTERRA: Common Questions

Does DDR Prime by doTERRA interact with any medications?
Yes. Based on its ingredients, DDR Prime has a known interaction with 1,218 medications, including 10 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DDR Prime contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is DDR Prime safe to use if I'm pregnant or breastfeeding?
No — or not safely without talking to your doctor first. Frankincense should be avoided in pregnancy and breastfeeding because there isn't enough safety data. Summer savory is not recommended in pregnancy. Lemongrass lacks reliable pregnancy safety information. Other ingredients have better data (thyme and clove are likely safe, wild orange is possibly unsafe during breastfeeding), but the mix as a whole makes it worth a conversation with your pharmacist or OB/GYN.
Can I take this if I'm on a blood thinner like warfarin?
Not without checking with your pharmacist first. Three ingredients — thyme, clove, and summer savory — theoretically increase bleeding risk when combined with anticoagulants or antiplatelets. The interaction hasn't been seen in humans, but we can't rule it out. Your pharmacist can assess whether the risk applies to your specific dose and use pattern.
What does this supplement actually do? Does it work?
The evidence we hold doesn't establish that it works for the conditions it's traditionally used for — acne, skin health, cough, colds, or fatigue all carry ratings of insufficient reliable evidence. Clove is possibly effective for a serious lung infection in hospitalized patients, but that's not what most people use this product for. You're mainly paying for the aroma and tradition here, not proven effectiveness.
Are there any fillers or inactive ingredients in this?
No inactive ingredients are listed in the product facts we hold. This is a liquid blend of active essential oils and plant extracts only — no binders, capsule materials, or other additives on record.
Can I inhale or apply this topically, or do I have to swallow it?
The facts don't specify the intended route of use. As a liquid from doTERRA, it's typically designed for aromatherapy (inhaled via diffusion) or topical application, not ingestion. Swallowing concentrated essential oils can be toxic — frankincense, thyme, and clove are all noted as potentially unsafe when taken by mouth in medicinal amounts. If you're considering ingesting it, ask your pharmacist or doTERRA customer service for guidance on safe use.
Will this interact with my stimulant ADHD medication?
Possibly — and you need to check before taking it. Wild orange has stimulant properties itself and theoretically increases risk of high blood pressure and heart issues when combined with stimulant drugs. Your pharmacist can review your specific ADHD medicine and this product together to assess the risk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DDR Prime label
Go deeper

The Full Monographs Behind DDR Prime’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Frankincense

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for condition...

Read the full Frankincense monograph → Herb & supplement monograph

Bitter Orange

Interacts with 957 drugs

Bitter orange is a citrus fruit whose extracts contain synephrine, a mild stimulant often added to weight-loss and energy supplements. Evidence that it works for weight loss or performance i...

Read the full Bitter Orange monograph → Herb & supplement monograph

Thyme

Interacts with 379 drugs

Thyme is a common kitchen herb that has long been used for coughs, sore throats, and digestive complaints. It is generally safe in the amounts found in food, and some cough products that com...

Read the full Thyme monograph → Herb & supplement monograph

Clove

Interacts with 977 drugs

Clove is a common cooking spice that is also used in traditional medicine, especially as a topical numbing agent for tooth pain thanks to its main compound, eugenol. Food amounts are general...

Read the full Clove monograph → Herb & supplement monograph

Summer Savory

Interacts with 122 drugs

Summer savory is a common kitchen herb that has long been used as a tea or remedy for digestive complaints and minor infections. Food amounts are generally considered safe, but human studies...

Read the full Summer Savory monograph → Herb & supplement monograph

Lemongrass

Interacts with 708 drugs

Lemongrass is a fragrant tropical grass widely used as a cooking herb, a tea, and an aromatherapy oil. It is generally considered safe in the small amounts used in food, but most of its clai...

Read the full Lemongrass monograph →
Sources

Sources & How We Checked

DDR Prime's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 96 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Frankincense 2 references
  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

See these in context on the Frankincense monograph →

Bitter Orange 47 references
  1. Penzak SR, Jann MW, Cold JA, et al. Seville (sour) orange juice: synephrine content and cardiovascular effects in normotensive adults. J Clin Pharmacol 2001;41:1059-63. PubMed
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Calapai G, Firenzuoli F, Saitta A, et al. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: A preliminary report. Fitoterapia 1999;70:586-92. DOI
  4. Keogh AM, Baron DW. Sympathomimetic abuse and coronary artery spasm. Br Med J 1985;291:940.
  5. Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther 2001;69:14-23. PubMed
  6. Pellati F, Benvenuti S, Melegari M, Firenzuoli F. Determination of adrenergic agonists from extracts and herbal products of Citrus aurantium L. var. amara by LC. J Pharm Biomed Anal 2002;29:1113-9. . PubMed
  7. Colker CM, Kalman DS, Torina GC, et al. Effects of Citrus aurantium extract, caffeine, and St. John's wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res 1999;60:145-153. DOI
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Thyme 18 references
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Clove 26 references
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Summer Savory 1 reference
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Lemongrass 2 references
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