DHA Algae Oil Complex Capsules Ingredients & Drug Interactions
What is this page for?
First and foremost: checking DHA Algae Oil Complex Capsules against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
DHA Algae Oil Complex Capsules is a dietary supplement by Esmond Natural with 4 active ingredients. Its ingredients are commonly taken for common cold and immune support, antioxidant support, skin health and collagen formation.Based on those ingredients, 542 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are DHA Algal Oil, Vitamin C. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against DHA Algae Oil Complex Capsules by Esmond Natural
Ask about any prescription or over-the-counter medication and we check it for interactions with DHA Algae Oil Complex Capsules by Esmond Natural — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of DHA Algae Oil Complex Capsules by Esmond Natural
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This capsule contains 4 ingredients: vitamin C, lutein, monk fruit, and DHA algal oil. Vitamin C is a water-soluble antioxidant vitamin; lutein is a carotenoid pigment naturally found in leafy greens and the eye; and DHA algal oil is a plant-based source of docosahexaenoic acid (DHA), an omega-3 fatty acid.
The other ingredients are inactive — gelatin, dicalcium phosphate, silica, and vegetable magnesium stearate — which help form and stabilize the capsule.
Does it work?
Moderate evidence
Vitamin C is effective for vitamin C deficiency, and possibly effective for anemia related to chronic disease, atrial fibrillation, cataracts, and exercise-induced respiratory infections. Lutein is possibly effective for age-related macular degeneration and cataracts, though it was found possibly ineffective for retinitis pigmentosa, necrotizing enterocolitis, retinopathy of prematurity, and bronchopulmonary dysplasia.
DHA algal oil is possibly effective for preterm labor but possibly ineffective for fractures, cystic fibrosis, physical performance, and cognitive function; the evidence for nonalcoholic fatty liver disease is insufficient to rate. We hold no effectiveness data for monk fruit.
How safe is it?
Well-documented data
Vitamin C is well tolerated at normal dietary doses. Most adverse effects — like stomach cramps, heartburn, diarrhea, nausea, and headache — happen at very high doses above 2 grams daily; kidney stones are a risk for people prone to them.
Lutein from food and typical supplement doses is generally safe; doses up to 20 mg daily have not caused adverse effects in studies. DHA algal oil is generally well tolerated by healthy adults, though it may theoretically cause itching, rash, or warmth in the hands, and it can modestly raise LDL cholesterol by about 8% in some people.
Pregnancy and lactation: Vitamin C at normal prenatal doses is likely safe, but high-dose supplements should be avoided unless your doctor recommends them. Lutein during pregnancy is likely safe.
DHA is often recommended in pregnancy and is likely safe, but use only under your healthcare provider's guidance.
Meds to double-check
Moderate interaction found
Before taking this product, double-check if you're on estrogens (birth control or hormone therapy) — vitamin C can increase your estrogen levels significantly. Blood thinners like warfarin, blood pressure medications, and diabetes drugs should also be reviewed; the vitamin C and algal oil in this formula may affect how they work.
If you're on chemotherapy drugs or take levothyroxine (thyroid medication), aluminum-based antacids, or the HIV drug indinavir, talk to your pharmacist first.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is worth considering if you're looking for lutein for eye health or DHA for general omega-3 intake — but the vitamin C here interacts with many medications. If you take birth control, a blood thinner, a blood pressure or diabetes drug, chemotherapy, or a thyroid medication, check your exact drugs with the tool on this page before starting.
Talk to your pharmacist or doctor to make sure it fits your routine safely.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about DHA Algae Oil Complex Capsules, straight from the product label.
| Brand | Esmond Natural |
|---|---|
| Barcode (UPC) | 641399086802 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2024 |
| DSLD ID | 315878 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for DHA Algae Oil Complex Capsules by Esmond Natural, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin C | 50 mg | 83% |
| Lutein | 5 mg | -- |
| Monk Fruit | 50 mg | -- |
| DHA Algal Oil | 200 mg | -- |
Other ingredients: Gelatin, Dicalcium Phosphate, Silica, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Support optimal brain, eye, and nervous system function.
GMP
Maintain Health Regulate Physical Function
Precautions
Warning: If you are pregnant, nursing or taking any medications, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur. Tamper resistant: Do not use if imprinted seal under cap is broken or missing.
Keep out of reach of children.
Store in a dry place and avoid excessive heat.
Storage
Store in a dry place and avoid excessive heat.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Herbal health Since 1994
Esmondnatural Integrated health
FDA Statement of Identity
Dietary Supplement
Formula
DHA
Suggested/Recommended/Usage/Directions
Directions: For adults, take one to two (1-2) capsules daily, preferably with meals. As a reminder, discuss the supplements and medications you take with your health care providers.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
DHA Algae Oil Complex Capsules by Esmond Natural label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in DHA Algae Oil Complex Capsules by Esmond Natural
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Vitamin C
Interacts with207 drugs
Vitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for im...
Vitamin C monograph & interactionsLutein
No knowninteractions
Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...
Lutein monograph & interactionsMonk Fruit
DHA Algal Oil
Interacts with375 drugs
Algal oil is a plant-based source of the omega-3 fats DHA and (in some products) EPA, making it a popular alternative to fish oil for vegetarians, veg...
DHA Algal Oil monograph & interactionsOther (inactive) ingredients: Gelatin, Dicalcium Phosphate, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
DHA Algae Oil Complex Capsules by Esmond Natural Drug Interactions
HelloPharmacist Interaction Report
Esmond Natural DHA Algae Oil Complex Capsules contains vitamin C and algal oil, both of which interact with medications.
Vitamin C carries the most serious interactions — it's Moderate severity across multiple drug types. The biggest concern is with estrogens (including oral contraceptives and hormone replacement therapy); vitamin C can increase estrogen levels by up to 55%, which may affect how well your birth control or HRT works or how your body handles it.
Read the full breakdown — every affected drug type, severity by severity
Vitamin C also interacts Moderately with blood thinners like warfarin — high doses can reduce their effectiveness. It has Moderate interactions too with chemotherapy drugs (alkylating agents and antitumor antibiotics), where its antioxidant effect might blunt the drugs' action, and with several others: the thyroid medication levothyroxine, the HIV drug indinavir, the antipsychotic fluphenazine, and aluminum-based compounds.
Algal oil adds Moderate interactions with blood pressure medications and diabetes drugs, plus a Minor interaction with blood thinners if the product contains more than 2 grams daily of EPA (eicosapentaenoic acid). We couldn't check Monk Fruit — we hold no data for it.
Altogether, these interactions span 539 individual medications. Before you start this product, use the medication checker on this page to search your exact prescriptions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against DHA Algae Oil Complex Capsules?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in DHA Algae Oil Complex Capsules interact with 542 drugs. Click any drug to see the details.
2 of the 4 ingredients in DHA Algae Oil Complex Capsules interact with drugs. Each result below shows which ingredient is responsible. DHA Algal Oil Vitamin C
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Dha Algal Oil + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Dha Algal Oil + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Dha Algal Oil + Albiglutide interactionAlginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Alginic Acid, Aluminum Hydroxide interactionAliskirenTekturna
How Aliskiren interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Dha Algal Oil + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Dha Algal Oil + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Read the full Dha Algal Oil + Alogliptin, Pioglitazone interactionAltretamineHexalen
How Altretamine interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAlkylating Agents Moderate
Interaction Summary
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
Read the full Vitamin C + Altretamine interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with DHA Algae Oil Complex Capsules — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionDha Algal OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, algal oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dha Algal Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with DHA Algae Oil Complex Capsules — through 2 ingredients. Tap an ingredient for the detail:
Vitamin CAspirin, Aluminum Moderate
Interaction Summary
Acidification of the urine by vitamin C might increase aspirin levels.
Read the full Vitamin C + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionDha Algal OilAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, algal oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dha Algal Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Vitamin CAluminum Moderate
Interaction Summary
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Read the full Vitamin C + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with DHA Algae Oil Complex Capsules — through 1 ingredient. Tap an ingredient for the detail:
Dha Algal OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Read the full Dha Algal Oil + Amlodipine, Celecoxib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in DHA Algae Oil Complex Capsules with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
DHA Algal Oil
Antidiabetes Drugs
Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Most algal oil contains docosahexaenoic acid (DHA). Clinical research in people with type 2 diabetes, including those taking antidiabetes drugs, shows that taking DHA 4 grams daily for 6 weeks increases fasting blood glucose levels by about 18 mg/dL when compared with taking olive oil.
Antihypertensive Drugs
Theoretically, taking algal oil with antihypertensive drugs might increase the risk of hypotension.
Algal oil usually contains docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA). There is evidence that fish oil, which also contains DHA and EPA, can modestly lower blood pressure and might have additive effects in patients treated with antihypertensive drugs.
Anticoagulant/Antiplatelet Drugs
Theoretically, algal oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
The risk of interaction is highest for algal oil containing high amounts (> 2 grams daily) of eicosapentaenoic acid (EPA), or EPA and docosahexaenoic acid (DHA). High doses of EPA or oils containing EPA and DHA can reduce platelet aggregation in humans. However, most algal oil contains very little EPA and larger amounts of DHA. While some conflicting evidence exist, most research shows that DHA alone does not affect blood clotting.
Vitamin C
Alkylating Agents
Theoretically, antioxidant effects of vitamin C might reduce the effectiveness of alkylating agents.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs that generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin C have on chemotherapy.
Aluminum
Vitamin C can increase the amount of aluminum absorbed from aluminum compounds.
Research in animals and humans shows that vitamin C increases aluminum absorption, theoretically by chelating aluminum and keeping it in solution where it is available for absorption. In people with normal renal function, urinary excretion of aluminum will likely increase, making aluminum retention and toxicity unlikely. Patients with renal failure who take aluminum-containing compounds such as phosphate binders should avoid vitamin C supplements in doses above the recommended dietary allowances.
Antitumor Antibiotics
Theoretically, the antioxidant effects of vitamin C might reduce the effectiveness of antitumor antibiotics.
The use of antioxidants like vitamin C during chemotherapy is controversial. There is concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as doxorubicin. In contrast, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that could interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effects, if any, antioxidants such as vitamin C have on chemotherapy.
Estrogens
Vitamin C might increase blood levels of estrogens.
Increases in plasma estrogen levels of up to 55% occur under some circumstances when vitamin C is taken concurrently with oral contraceptives or hormone replacement therapy, including topical products. It is suggested that vitamin C prevents oxidation of estrogen in the tissues, regenerates oxidized estrogen, and reduces sulfate conjugation of estrogen in the gut wall. When tissue levels of vitamin C are high, these processes are already maximized and supplemental vitamin C does not have any effect on estrogen levels. Increases in plasma estrogen levels may occur when patients who are deficient in vitamin C take supplements. Monitor these patients for estrogen-related side effects.
Fluphenazine (Prolixin)
Theoretically, vitamin C might decrease levels of fluphenazine.
In one patient there was a clinically significant decrease in fluphenazine levels when vitamin C (500 mg twice daily) was started. The mechanism is not known, and there is no further data to confirm this interaction.
Indinavir (Crixivan)
Vitamin C can modestly reduce indinavir levels.
One pharmacokinetic study shows that taking vitamin C 1 gram orally once daily along with indinavir 800 mg orally three times daily reduces the area under the concentration-time curve of indinavir by 14%. The mechanism of this interaction is unknown, but it is unlikely to be clinically significant in most patients. The effect of higher doses of vitamin C on indinavir levels is unknown.
Levothyroxine (Synthroid, Others)
Vitamin C can increase levothyroxine absorption.
Two clinical studies in adults with poorly controlled hypothyroidism show that swallowing levothyroxine with a glass of water containing vitamin C 500-1000 mg in solution reduces thyroid stimulating hormone (TSH) levels and increases thyroxine (T4) levels when compared with taking levothyroxine alone. This suggests that vitamin C increases the oral absorption of levothyroxine, possibly due to a reduction in pH.
Warfarin (Coumadin)
High-dose vitamin C might reduce the levels and effectiveness of warfarin.
Vitamin C in high doses may cause diarrhea and possibly reduce warfarin absorption. There are reports of two people who took up to 16 grams daily of vitamin C and had a reduction in prothrombin time. Lower doses of 5-10 grams daily can also reduce warfarin absorption. In many cases, this does not seem to be clinically significant. However, a case of warfarin resistance has been reported for a patient who took vitamin C 500 mg twice daily. Cessation of vitamin C supplementation resulted in a rapid increase in international normalized ratio (INR). Tell patients taking warfarin to avoid taking vitamin C in excessively high doses (greater than 10 grams daily). Lower doses may be safe, but the anticoagulation activity of warfarin should be monitored. Patients who are stabilized on warfarin while taking vitamin C should avoid adjusting vitamin C dosage to prevent the possibility of warfarin resistance.
Acetaminophen (Tylenol, Others)
High-dose vitamin C might slightly prolong the clearance of acetaminophen.
A small pharmacokinetic study in healthy volunteers shows that taking high-dose vitamin C (3 grams) 1.5 hours after taking acetaminophen 1 gram slightly increases the apparent half-life of acetaminophen from around 2.3 hours to 3.1 hours. Ascorbic acid competitively inhibits sulfate conjugation of acetaminophen. However, to compensate, elimination of acetaminophen glucuronide and unconjugated acetaminophen increases. This effect is not likely to be clinically significant.
Aspirin
Acidification of the urine by vitamin C might increase aspirin levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction is not clinically significant.
Choline Magnesium Trisalicylate (Trilisate)
Acidification of the urine by vitamin C might increase choline magnesium trisalicylate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams daily of vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Niacin
Vitamin C might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as vitamin C, or to the combination. It also is not known whether it will occur in other patient populations.
Salsalate (Disalcid)
Acidification of the urine by vitamin C might increase salsalate levels.
It has been suggested that acidification of the urine by vitamin C could increase reabsorption of salicylates by the renal tubules, and increase plasma salicylate levels. However, short-term use of up to 6 grams/day vitamin C does not seem to affect urinary pH or salicylate excretion, suggesting this interaction probably is not clinically significant.
Brand information
Manufacturer and brand details for DHA Algae Oil Complex Capsules, from the product label.
Esmond Natural
See all Esmond Natural products- Name
- Esmond Natural Inc.
- City
- Irwindale
- State
- CA
- ZipCode
- 91706
- Web Address
- www.esmondnatural.com
DHA Algae Oil Complex Capsules by Esmond Natural: Common Questions
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The Full Monographs Behind DHA Algae Oil Complex Capsules’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Vitamin C
Interacts with 207 drugsVitamin C (ascorbic acid) is an essential nutrient your body needs but cannot make, so you must get it from food or supplements. It's important for immune function, collagen, and acts as an...
Read the full Vitamin C monograph → Herb & supplement monographLutein
Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...
Read the full Lutein monograph → Herb & supplement monographAlgal Oil
Interacts with 375 drugsAlgal oil is a plant-based source of the omega-3 fats DHA and (in some products) EPA, making it a popular alternative to fish oil for vegetarians, vegans, and people who dislike fish. There...
Read the full Algal Oil monograph →Sources & How We Checked
DHA Algae Oil Complex Capsules's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 96 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin C 51 references
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- Domingo JL, Gomez M, Llobet JM, Corbella J. Influence of some dietary constituents on aluminum absorption and retention in rats. Kidney Int 1991;39:598-601. PubMed
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- Slain D, Amsden JR, Khakoo RA, et al. Effect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers. Pharmacotherapy 2005;25:165-70. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
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- Conklin KA. Cancer chemotherapy and antioxidants. J Nutr 2004;134:3201S-3204S. PubMed
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- Gruenwald, J., Graubaum, H. J., Busch, R., and Bentley, C. Safety and tolerance of ester-C compared with regular ascorbic acid. Adv.Ther. 2006;23(1):171-178.
- Rahimi, R., Nikfar, S., Rezaie, A., and Abdollahi, M. A meta-analysis on the efficacy and safety of combined vitamin C and E supplementation in preeclamptic women. Hypertens.Pregnancy. 2009;28(4):417-434. PubMed
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- Li, G., Li, L., Yu, C., and Chen, L. Effect of vitamins C and E supplementation on Helicobacter pylori eradication: a meta-analysis. Br.J Nutr 2011;106(11):1632-1637.
- Chen X, Shen L, Gu X, et al. High-dose supplementation with vitamin C--induced pediatric urolithiasis: the first case report in a child and literature review. Urology. 2014;84(4):922-4. PubMed
- Sattar A, Willman JE, Kolluri R. Possible warfarin resistance due to interaction with ascorbic acid: case report and literature review. Am J Health Syst Pharm. 2013;70(9):782-6. PubMed
- Yaich S, Chaabouni Y, Charfeddine K, et al. Secondary oxalosis due to excess vitamin C intake: a cause of graft loss in a renal transplant recipient. Saudi J Kidney Dis Transpl. 2014;25(1):113-6. PubMed
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- Seo MS, Kim JK, Shim JY. High-dose vitamin C promotes regression of multiple pulmonary metastases originating from hepatocellular carcinoma. Yonsei Med J. 2015;56(5):1449-52. PubMed
- Skelin M, Lucijanic T, Amidzic Klaric D, et al. Factors Affecting Gastrointestinal Absorption of Levothyroxine: A Review. Clin Ther. 2017 Feb;39(2):378-403. PubMed
- Jiang K, Tang K, Liu H, Xu H, Ye Z, Chen Z. Ascorbic acid supplements and kidney stones incidence among men and women: a systematic review and meta-analysis. Urol J. 2019;16(2):115-120.
- Thomas S, Patel D, Bittel B, et al. Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs Usual Care on Symptom Length and Reduction Among Ambulatory Patients With SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial. JAMA Netw Open. 2 PubMed
- Giffen MA, McLemore JL. Hyperoxalosis Secondary to Intravenous Vitamin C Administration as a Non-Allopathic Treatment for Cancer. Acad Forensic Pathol 2019;9(1-2):118-126. PubMed
- Maike A, Sturgill D, Gallan A. Oxalate Nephropathy in a Renal Transplant Recipient After Receiving High Dose Ascorbic Acid. Am J Med Sci 2021. PubMed
- Shen ZY, Chen YR, Wang MC, Chang SS. High-dose vitamin C-induced acute oxalate nephropathy in a renal transplant recipient: a case report and literature review. Asian J Surg 2022. PubMed
- Yanase F, Spano S, Maeda A, et al. Mega-dose sodium ascorbate: a pilot, single-dose, physiological effect, double-blind, randomized, controlled trial. Crit Care 2023;27(1):371. PubMed
- Sharma Y, Sumanadasa S, Shahi R, et al. Efficacy and safety of vitamin C supplementation in the treatment of community-acquired pneumonia: a systematic review and meta-analysis with trial sequential analysis. Sci Rep 2024;14(1):11846. PubMed
- Pejcic AV, Petrovic NZ, Djordjic MD, Milosavljevic MN. Vitamin C Levels in Pregnant Women and the Efficacy of Vitamin C Supplements in Preventing Premature Rupture of Membranes: A Systematic Review and Meta-Analysis. Balkan Med J 2024;41(4):248-260. PubMed
Lutein 2 references
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- Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed
Algal Oil 43 references
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- Grimsgaard S, Bonaa KH, Hansen JB, Nordoy A. Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. Am J Clin Nutr 1997;66:649-59.
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- Sacks FM, Hebert P, Appel LJ, et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the trials of hypertension prevention. J Hypertens 1994;12:209-13.
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- FDA. Center for Food Safety and Applied Nutrition. Letter regarding dietary supplement health claim for omega-3 fatty acids and coronary heart disease. Available at: http://www.fda.gov/ohrms/dockets/dockets/95s0316/95s-0316-Rpt0272-38-Appendix-D-Reference
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC