DHEA 10 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking DHEA 10 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
DHEA 10 mg is a dietary supplement by Pure Encapsulations with 1 active ingredient. Its ingredients are commonly taken for anti-aging and low dhea levels, mood and depression, vaginal dryness and sexual health.Based on those ingredients, 776 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dehydroepiandrosterone, Micronized. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against DHEA 10 mg by Pure Encapsulations
Ask about any prescription or over-the-counter medication and we check it for interactions with DHEA 10 mg by Pure Encapsulations — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of DHEA 10 mg by Pure Encapsulations
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: dehydroepiandrosterone (DHEA), a hormone your body makes naturally. The 10 mg dose is micronized — ground into tiny particles to help your body absorb it.
The capsule also contains inactive ingredients: plant fiber, cellulose, water, rice husk, and ascorbyl palmitate (a form of vitamin C used as a preservative).
Does it work?
Moderate evidence
DHEA is likely effective for vaginal atrophy — thinning and drying of vaginal tissue, often during menopause. It's possibly effective for certain types of infertility, aging skin, and depression, though the evidence for these uses is less robust.
The data we hold doesn't establish effectiveness for other common DHEA uses.
How safe is it?
Well-documented data
DHEA is a hormone and should be used only under medical guidance because it can shift your hormone levels and trigger hormonal side effects. Short-term use in typical doses is generally well tolerated, but there's concern that long-term oral DHEA may raise cancer risk — this hasn't been proven but is why caution matters.
The most common side effects are acne (especially in women, usually mild and dose-dependent), headache, insomnia, mood changes, and nausea. Women may experience masculinization — voice deepening, irregular periods, excess hair growth, and oily skin.
Men may have aggression or breast changes. DHEA can also trigger mood swings, anxiety, irritability, or mania, particularly in people on antidepressants.
Avoid DHEA during pregnancy — it's rated possibly unsafe. There isn't enough safety data to use it while breastfeeding, so don't take it then either.
Meds to double-check
Moderate interaction found
Before taking DHEA, check with your pharmacist if you're on antidepressants (especially SSRIs), blood thinners or antiplatelet drugs, triazolam or other sedatives, or estrogen-blocking cancer medications like aromatase inhibitors, tamoxifen, or fulvestrant. DHEA may also interact with other drugs your liver breaks down through the CYP3A4 pathway.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
DHEA is a hormone supplement best suited for people with vaginal atrophy or certain fertility concerns, under a doctor's care. If you take antidepressants, blood thinners, sedatives, cancer medications that block estrogen, or have had cancer, talk to your pharmacist or doctor before starting — DHEA interacts with these.
You'll want to discuss long-term use and cancer risk, and avoid it in pregnancy and while nursing.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about DHEA 10 mg, straight from the product label.
| Brand | Pure Encapsulations |
|---|---|
| Barcode (UPC) | 766298000985 |
| Net contents | 180 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2025 |
| DSLD ID | 323055 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for DHEA 10 mg by Pure Encapsulations, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Dehydroepiandrosterone, Micronized | 10 mg | -- |
Other ingredients: Plant Fiber, Cellulose, Water, Rice Husk, Ascorbyl Palmitate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Storage
Store in a cool, dry place.
Suggested/Recommended/Usage/Directions
Recommendations: As a dietary supplement, take 1 capsule daily, with a meal.
Precautions
Warning: See side panel. Use only if safety seal is intact.
Keep out of the reach of children.
Warning: Not for use by individuals under the age of 18 years. Keep out of reach of children.
Do not use if pregnant or nursing. Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of, breast cancer, prostate cancer, prostate enlargement, heart disease, low “good” cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.
Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen. Discontinue use and call a physician or licensed qualified healthcare professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms. To report any adverse event call 1-800-332-1088.
Caution athletes: DHEA is classified as a prohibited substance by certain sports organizations, as well as the World Anti-Doping Association (WADA). Please consult the rules of your specific organization to determine if DHEA is prohibited.
General Statements
Contents may not fill package in order to accommodate required labeling. Please rely on stated quantity. Scan to learn about our hypoallergenic supplements
Formulation
Micronized; Supports healthy DHEA levels Gluten-free, Non-GMO & Hypoallergenic
Gluten-free, Non-GMO & Hypoallergenic
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
DHEA 10 mg by Pure Encapsulations label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in DHEA 10 mg by Pure Encapsulations
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.
Dehydroepiandrosterone, Micronized
Interacts with776 drugs
DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...
Dehydroepiandrosterone, Micronized monograph & interactionsOther (inactive) ingredients: Plant Fiber, Cellulose, Water, Rice Husk, Ascorbyl Palmitate. These complete the product’s ingredient list but are not active constituents.
DHEA 10 mg by Pure Encapsulations Drug Interactions
HelloPharmacist Interaction Report
Pure Encapsulations DHEA 10 mg contains dehydroepiandrosterone, a hormone that interacts with several medication types.
The most serious concern is with antidepressants (particularly SSRIs like sertraline or paroxetine), where DHEA has triggered manic episodes in case reports and may raise the risk of psychiatric side effects — a risk that may be higher in younger people. This is a Moderate severity interaction.
Read the full breakdown — every affected drug type, severity by severity
DHEA also interacts with blood thinners and antiplatelet drugs (aspirin, warfarin, clopidogrel) — it can increase bleeding risk by interfering with how platelets clump. It may raise blood levels of certain sedatives, especially triazolam (Halcion), by slowing how your liver breaks them down.
If you take cancer medications that block estrogen — aromatase inhibitors, tamoxifen, or fulvestrant — DHEA may work against them, since DHEA itself acts like estrogen in your body. Additionally, DHEA may reduce how well the tuberculosis vaccine works.
Finally, DHEA can theoretically increase levels of drugs broken down by a liver enzyme called CYP3A4, though we don't yet know how often this matters in practice.
Altogether, these interactions span 766 individual medications.
Use the medication checker on this page to look up your exact drugs before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against DHEA 10 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in DHEA 10 mg interact with 776 drugs. Click any drug to see the details.
1 of the 1 ingredient in DHEA 10 mg interact with drugs. Each result below shows which ingredient is responsible. Dehydroepiandrosterone, Micronized
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone, Micronized + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Abemaciclib interactionAbiraterone
How Abiraterone interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone, Micronized + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone, Micronized + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with DHEA 10 mg — through 1 ingredient. Tap an ingredient for the detail:
Dehydroepiandrosterone, MicronizedCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Read the full Dehydroepiandrosterone, Micronized + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in DHEA 10 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Dehydroepiandrosterone, Micronized
Anticoagulant/Antiplatelet Drugs
Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.
Antidepressant Drugs
Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.
Aromatase Inhibitors
Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.
Fulvestrant (Faslodex)
Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.
Tamoxifen (Nolvadex)
Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.
Triazolam (Halcion)
DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.
Tuberculosis Vaccine
DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.
Estrogens
Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.
Testosterone
Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.
Brand information
Manufacturer and brand details for DHEA 10 mg, from the product label.
Pure Encapsulations
See all Pure Encapsulations products- Name
- Pure Encapsulations
- Street Address
- 490 Boston Post Road
- City
- Sudbury
- State
- MA
- Phone Number
- 1-800-753-2277
- Web Address
- www.PureEncapsulations.com
DHEA 10 mg by Pure Encapsulations: Common Questions
Does DHEA 10 mg by Pure Encapsulations interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
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The Full Monographs Behind DHEA 10 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
DHEA 10 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 98 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Dhea 98 references
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- Panjari, M., Bell, R. J., Jane, F., Wolfe, R., Adams, J., Morrow, C., Davis, S. R. A randomized trial of oral DHEA treatment for sexual function, well-being, and menopausal symptoms in postmenopausal women with low libido. J Sex Med 2009;6(9):2579-90. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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