Interactions on record — worth a quick check against your medications. Based on 6 of 15 ingredients. Check your meds →
Dietary supplement

Digest Extra Ingredients & Drug Interactions

by The Vitamin Shoppe

Digest Extra label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest Extra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digest Extra is a dietary supplement by The Vitamin Shoppe with 15 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.Based on those ingredients, 333 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Legume and Grain Digesting Enzymes, Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digest Extra by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest Extra by The Vitamin Shoppe — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digest Extra by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 16 active ingredients.
  • “Fat Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Protein and Gluten Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Starch Digesting Enzymes” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Digest Extra contains 16 ingredients, most of them digestive enzymes. The active ones are protease, bromelain, amylase, cellulase, hemicellulase, xylanase, beta-glucanase, alpha-galactosidase, lactase, lipase, diastase, peptidase, acid protease, papain, and invertase — each one breaks down a different component of food (proteins, carbs, fats, fiber, sugars, or lactose).

Lactase is the enzyme that helps you digest lactose in milk and dairy products. The product also contains inactive ingredients like hypromellose, maltodextrin, microcrystalline cellulose, magnesium stearate, and medium-chain triglycerides, which are fillers and binders that hold the capsule together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Complete digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, Bloating and gas, Fat maldigestion.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for most of these enzymes hasn't been fully established in the data we hold. Lactase is effective for lactose intolerance — if you have trouble digesting dairy, this ingredient should help.

For the other digestive enzymes in this blend, effectiveness for conditions like inflammatory bowel disease, gas, bloating, or general poor digestion is rated as insufficient reliable evidence — meaning we don't have enough solid research to know whether they work for those purposes. If you're considering this for a specific digestive issue, talk it over with your doctor or pharmacist.

The evidence, ingredient by ingredient Lipase Proteolytic Enzymes (proteases) Bromelain Papain Calabar Bean Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These digestive enzymes are generally well tolerated in adults, though some may cause mild digestive upset like diarrhea, gas, or stomach discomfort — especially if you're new to enzyme supplements. Bromelain may rarely cause allergic reactions, including rash or itching, and occupational exposure to airborne bromelain or protease dust has triggered asthma or allergic rhinitis in sensitive people.

Papain can cause allergic reactions and digestive irritation, and high doses may be unsafe. For pregnancy, bromelain and concentrated papain are best avoided unless your doctor prescribes them — safety data is limited.

Protease safety hasn't been established in pregnancy, so it's best avoided unless prescribed. Lactase is likely safe in pregnancy if your doctor advises it.

For breastfeeding, there isn't enough safety data for bromelain, protease, or papain — check with your doctor or pharmacist before using if you're nursing. Lipase and lactase have limited breastfeeding data as well; ask your healthcare provider first.

Side effects, ingredient by ingredient Lipase Proteolytic Enzymes (proteases) Bromelain Papain Calabar Bean Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Digest Extra, double-check your medications with your doctor or pharmacist if you take warfarin (Coumadin) or other blood thinners, since papain may increase bleeding risk — this is the most serious concern. If you take antiplatelet drugs like aspirin or clopidogrel, or tetracycline antibiotics, bromelain may affect how they work.

No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is a blend of digestive enzymes meant to help break down food; lactase clearly works for lactose intolerance, but evidence for the others is thin. If you take warfarin or blood thinners, or tetracycline antibiotics, check your exact medications with your doctor or pharmacist before starting.

Mild digestive upset is the most common side effect, but allergic reactions are rare. Talk it over with your own healthcare provider to see if it's right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 16 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest Extra, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536025718
Net contents 30 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2019
DSLD ID 208825
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest Extra by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
UPC/BARCODE
766536025718
IngredientAmount% DV
Fat Digesting Enzymes0 NP--
Protease0 NP--
Bromelain0 NP--
Amylase I0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Xylanase0 NP--
Beta-Glucanase0 NP--
Alpha-Galactosidase0 NP--
Lactase0 NP--
Lipase0 NP--
Diastase0 NP--
Peptidase0 NP--
Acid Protease0 NP--
Amylase II0 NP--
Protein and Gluten Digesting Enzymes0 NP--
Starch Digesting Enzymes0 NP--
Fiber and Complex Carbohydrate Digesting Enzymes0 NP--
Legume and Grain Digesting Enzymes0 NP--
Lactose Digesting Enzyme0 NP--
Papain0 NP--
Invertase0 NP--

Other ingredients: Hypromellose, Maltodextrin, Microcrystalline Cellulose, Magnesium Stearate, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Complete Digestive Enzyme Formula

Formulation

Supports gluten and lactose digestion

Gluten-free Soy-free Dairy-free Nut-free

General Statements

Specialty

FDA Statement of Identity

Dietary Supplement

Precautions

Wheat, soy and dairy are used in the fermentation process, but are not present in the finished product.

Warning: Consult your healthcare provider prior to use if you are pregnant, nursing, taking any medication or have any medical conditions.

Keep out of reach of children.

Tamper evident Do not use if outer seal is broken or missing.

Suggested/Recommended/Usage/Directions

Directions: Take one (1) vegetable capsule with each meal.

Storage

Store in a cool, dry place.

Seals/Symbols

Quality promise Tested & trusted

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest Extra by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest Extra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest Extra by The Vitamin Shoppe

These are the 15 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fat Digesting Enzymes

0 NP per serving

Protein and Gluten Digesting Enzymes

0 NP per serving

Starch Digesting Enzymes

0 NP per serving
  • › Amylase I
  • › Diastase
  • › Amylase II
  • › Invertase

Fiber and Complex Carbohydrate Digesting Enzymes

0 NP per serving
  • › Cellulase
  • › Hemicellulase
  • › Xylanase

Legume and Grain Digesting Enzymes

Interacts with
195 drugs
0 NP per serving

Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supple...

Legume and Grain Digesting Enzymes monograph & interactions
  • › Beta-Glucanase
  • › Alpha-Galactosidase

Lactose Digesting Enzyme

0 NP per serving

Other (inactive) ingredients: Hypromellose, Maltodextrin, Microcrystalline Cellulose, Magnesium Stearate, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest Extra by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Digest Extra?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
333Drugs
122 Moderate 211 Minor

Ingredients driving the most interactions

Legume and Grain Digesting Enzymes 195
Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Digest Extra interact with 333 drugs. Click any drug to see the details.

3 of the 15 ingredients in Digest Extra interact with drugs. Each result below shows which ingredient is responsible. Legume and Grain Digesting Enzymes Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest Extra with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Legume and Grain Digesting Enzymes1 drug type · 195 drugs

Anticholinergic Drugs

Theoretically, taking calabar bean might reduce the effects of anticholinergic drugs.
Physostigmine, a constituent of calabar bean, reverses the effects of belladonna and other drugs with anticholinergic activity.

Likelihood Unlikely Evidence D
Legume and Grain Digesting Enzymes full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digest Extra, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-866-293-3367
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Digest Extra by The Vitamin Shoppe: Common Questions

Does Digest Extra by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Digest Extra has a known interaction with 333 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest Extra contains 15 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help with bloating and gas?
These enzymes are designed to break down food, but we don't have enough solid evidence to know whether they actually reduce bloating or gas. If you want to try it, you may notice results, but don't expect a guaranteed fix. If symptoms persist, see your doctor to rule out an underlying condition.
Is it safe to take during pregnancy?
No — bromelain and papain are best avoided in pregnancy because safety data is limited. Protease safety hasn't been established either. Lactase is likely safe if your doctor recommends it, but the others need a green light from your healthcare provider first.
Can I breastfeed while taking this?
There isn't enough safety data on bromelain, protease, papain, or lipase during breastfeeding. Lactase has limited data but is probably okay — talk with your doctor or pharmacist before using any of these while nursing to make sure it's right for you and your baby.
What's the difference between all these enzyme names?
Each enzyme breaks down a different part of food — protease and papain handle proteins, amylase handles starches, lipase handles fats, lactase handles milk sugar, and the others target fiber and complex carbs. Together, they're meant to give your digestive system a full toolkit.
Are there any common side effects?
Most people tolerate these enzymes well. Some experience mild diarrhea, gas, stomach upset, or headache — especially when starting out. Allergic reactions like rash or itching are rare but can happen if you're sensitive to any of the enzymes.
Can I take this if I'm on blood thinners?
Not without checking first — this product contains papain, which may strengthen warfarin's effects and raise bleeding risk, and bromelain, which may also thin your blood. Talk to your doctor or pharmacist before adding it to your routine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest Extra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest Extra label
Go deeper

The Full Monographs Behind Digest Extra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Calabar Bean

Interacts with 195 drugs

Calabar bean is a highly poisonous West African seed that contains physostigmine, a powerful cholinesterase inhibitor. It is not a safe dietary supplement, and eating the bean can cause seri...

Read the full Calabar Bean monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digest Extra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 37 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Calabar Bean 2 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.

See these in context on the Calabar Bean monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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