Interactions on record — worth a quick check against your medications. Based on 5 of 13 ingredients. Check your meds →
Dietary supplement

Digest HPE Ingredients & Drug Interactions

by American Health

Digest HPE label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digest HPE against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digest HPE is a dietary supplement by American Health with 13 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digest HPE by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Digest HPE by American Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digest HPE by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 13 active ingredients.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (520 mg) without saying how much of each component you get.

Digest HPE contains 13 active ingredients — a blend of digestive enzymes designed to break down different food components. Papain and bromelain are proteases (protein-digesting enzymes) from papaya and pineapple; the product also includes amylase (for starch), lipase (for fats), lactase (for milk sugar), and several others that target different carbohydrates and fibers.

The remaining inactive ingredients are rice flour, vegetable cellulose, silica, and vegetable magnesium stearate — standard fillers and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: aid thorough efficient digestion.
  • We looked for evidence on: Dyspepsia, Lactose intolerance, indigestion, bloating.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The data we hold shows insufficient evidence to establish whether papain works for cancer, dental cavities, radiation dermatitis, muscle soreness after exercise, shingles, or parasite infections. For bromelain, evidence is similarly insufficient for hay fever, burns, cancer, nerve damage from chemotherapy, poor circulation in the legs, and diabetes.

Lipase's effectiveness for inflammatory bowel disease and indigestion (dyspepsia) is also not established in the data we hold. Lactase, however, is rated effective for lactose intolerance — it helps people digest milk sugar.

For the other enzymes in the blend, we hold no effectiveness data.

The evidence, ingredient by ingredient Papain Bromelain Proteolytic Enzymes (proteases) Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food, but supplements may irritate your digestive tract and trigger allergic reactions in sensitive people — especially itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. High doses may be unsafe and have rarely caused severe stomach inflammation or esophageal perforation.

Avoid concentrated papain and unripe papaya products in pregnancy; don't use supplemental papain while breastfeeding unless your doctor advises it. Bromelain is generally well tolerated short-term, but long-term safety data is limited.

Common side effects include diarrhea, gas, stomach upset, and headache. It may cause allergic reactions, including asthma if inhaled.

Avoid bromelain in pregnancy and while breastfeeding — safety data is insufficient. Protease and lipase are generally tolerated but may cause digestive upset or allergic reactions; safety in pregnancy and breastfeeding is not well established, so check with your doctor.

Lactase is likely safe in pregnancy and is generally well tolerated.

Side effects, ingredient by ingredient Papain Bromelain Proteolytic Enzymes (proteases) Lipase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 5 matched ingredients can interact with medications — Papain, Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Digest HPE, double-check with your doctor or pharmacist if you take warfarin or other anticoagulants (blood thinners), or antiplatelet drugs like aspirin — papain and bromelain both may increase bleeding risk. Tetracycline antibiotics theoretically may have higher levels with bromelain, though study data are mixed.

No other interactions are documented for the enzymes we could check, but several ingredients in this blend we were unable to verify.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is an enzyme blend for general digestive support. If you take warfarin or other blood thinners, or any antiplatelet drugs like aspirin, check with your doctor or pharmacist before starting — papain and bromelain both interact with these medications.

Pregnant or breastfeeding people should talk with their healthcare provider first, especially given the safety concerns around papain and bromelain. Use the medication checker below to verify your exact drugs against this product.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digest HPE, straight from the product label.

Brand American Health
Barcode (UPC) 076630347112
Net contents 90 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 60828
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digest HPE by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetarian Capsule(s)
Maximum serving Sizes:
1 Vegetarian Capsule(s)
UPC/BARCODE
076630347112
IngredientAmount% DV
Amylase0 NP--
Papain0 NP--
Bromelain0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Cellulase0 NP--
Invertase0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Xylanase0 NP--
Beta-Glucanase0 NP--
Hemicellulase0 NP--
Proprietary Enzyme Blend520 mg--

Other ingredients: Rice Flour, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Digestive issues require a serious response, and supplementing your diet with Digest HPE may help. Digest HPE is an intensive strength complex of 13 bio-active, naturally derived enzymes that aid in more thorough and efficient digestion.

2016 American Health, Inc.

Digest HPE gives you the "enzyme edge" to feel better about the foods you enjoy...with every meal, every day.

Digest HPE provides an easy option to help support optimal digestive health, so you can feel good with every meal, everyday.

General Statements

This advanced formula was specifically developed to deliver a broad spectrum of enzymes of high activity levels, which help break down the foods we take in so we can feel better about what we eat.

Visit www.AmericanHealthUS.com for our complete line of products

Advanced Activity High performing enzyme delivery 13 Bio-Active naturally derived enzymes

Intensive strength complex

Formulated to support more efficient and thorough digestion Helps to naturally break down difficult-to-digest foods Promotes "Feel Better" benefit across multi-food groups

Digestive Health

Enzyme Importance Enzymes are vital not only for the digestive process, but for overall health.* They help protein break down into amino acids, carbohydrates into simple sugars and fat into fatty acids that your body absorbs as nutrients. However, we may not have all the essential enzymes we need for optimal digestion. In fact, enzyme production naturally decreases with age, which is why many individuals experience more frequent digestive issues as they get older.

Enzymes play a critical role in the digestive process and since we naturally produce enzymes at different levels, many of us can use some extra help. Because we digest our foods differently, it is common to experience digestive issues related to protein, carbohydrate, fat or fiber. Without proper digestion, undigested food simply passes through the gastrointestinal tract inefficiently, leaving your digestive system feeling unsettled and out of balance.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Contains milk, wheat and soy ingredients.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

34711 B34711 01A

Formulation

100% Vegetarian

No egg, no grapefruit, no sugar, no artificial color, no artificial flavor, no sodium.

Non-GMO.

Suitable for vegetarians.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) vegetarian capsule three times daily preferably with meals.

Formula

Contains milk, wheat and soy ingredients.

Advanced Enzyme Activity...Efficient digetstion Digest HPE contains 13 distinct, naturally derived protein, carbohydrate and fat-digesting enzymes including those not naturally produced by the body, such as Cellulase, Bromelain and Papain. Along with Amylase, Protease, Lipase and Lactase, these enzymes work at high-activity levels, providing advanced nutrient absorption benefits to the overall digestive process.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digest HPE by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digest HPE label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digest HPE by American Health

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Enzyme Blend

520 mg per serving
  • › Amylase
  • › Papain
  • › Bromelain
  • › Protease
  • › Lipase
  • › Lactase
  • › Cellulase
  • › Invertase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Xylanase
  • › Beta-Glucanase
  • › Hemicellulase

Other (inactive) ingredients: Rice Flour, Vegetable Cellulose, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digest HPE by American Health Drug Interactions

Want to check YOUR meds against Digest HPE?

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141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141
Papain 2

Individual Drug Interactions

The ingredients in Digest HPE interact with 141 drugs. Click any drug to see the details.

2 of the 13 ingredients in Digest HPE interact with drugs. Each result below shows which ingredient is responsible. Bromelain Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digest HPE with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digest HPE, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Web Address
www.AmericanHealthUS.com
Pharmacist Counseling Corner

Digest HPE by American Health: Common Questions

Does Digest HPE by American Health interact with any medications?
Yes. Based on its ingredients, Digest HPE has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digest HPE contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
Not enough safety data exists for most of the enzymes here. Papain specifically is possibly unsafe in pregnancy, and bromelain should be avoided. Talk with your doctor or pharmacist before using this product if you're pregnant — they can advise whether it's right for you.
Can I take this while breastfeeding?
Safety data for breastfeeding is limited or missing for papain, bromelain, protease, and lipase. Lactase is likely safe, but for the others, check with your doctor or pharmacist first to be sure.
What are the most common side effects?
The enzymes in this blend are generally well tolerated, but some people report diarrhea, gas, stomach upset, headache, or allergic reactions like itchy eyes, runny nose, or sneezing — especially if sensitive to papain or bromelain.
Does lactase in this product really help with lactose intolerance?
Yes — lactase is rated effective for lactose intolerance and helps your body digest milk sugar. However, it's just one ingredient in a 13-ingredient blend, so this product is formulated for broader digestive support, not solely for lactose.
What's papain, and why is it in a digestive enzyme blend?
Papain is a protein-digesting enzyme from papaya that breaks down proteins as part of your digestion. It's included to support the breakdown of protein-containing foods, alongside other enzymes that handle fats, starches, and different carbohydrates.
I'm on aspirin for my heart — is this product safe for me?
Bromelain in this product may increase bleeding risk if combined with aspirin or other antiplatelet drugs. Talk with your doctor or pharmacist before taking it — they'll help you decide if it's appropriate for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digest HPE is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digest HPE label
Go deeper

The Full Monographs Behind Digest HPE’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Digest HPE's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 35 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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