Interactions on record — worth a quick check against your medications. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Chewable Papaya Enzyme with Chlorophyll Ingredients & Drug Interactions

by American Health

Chewable Papaya Enzyme with Chlorophyll label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Chewable Papaya Enzyme with Chlorophyll against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Chewable Papaya Enzyme with Chlorophyll is a dietary supplement by American Health with 5 active ingredients. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 297 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium Copper Chlorophyllin, Papaya, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Chewable Papaya Enzyme with Chlorophyll by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Chewable Papaya Enzyme with Chlorophyll by American Health — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Chewable Papaya Enzyme with Chlorophyll by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 5 active ingredients: papaya, papain (an enzyme from papaya), alpha-amylase, protease, and sodium copper chlorophyllin. Papaya and papain are digestive enzymes meant to help break down food proteins.

Alpha-amylase works on starches. Protease is another protein-digesting enzyme.

Sodium copper chlorophyllin (the chlorophyll component) is added for its green pigment. The rest of the tablet is made up of inactive ingredients — sweeteners, binders, and thickeners like sucrose, maltodextrin, and stearic acid.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: aid digestion of proteins and carbohydrates.
  • We looked for evidence on: Exercise-induced muscle soreness, Intestinal parasite infection, Wound healing, Indigestion, Bloating, Constipation.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection, Wound healing.
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection, Wound healing.

The evidence for what papaya and papain actually do is thin. For papaya, the data we hold rates aging skin, hair loss, and cancer prevention as having insufficient evidence — meaning studies haven't shown it works for these uses yet.

Papain has the same story for muscle soreness, dental cavities, shingles, and parasite infections. The chlorophyll ingredient does show some promise: it's rated likely effective for cystic fibrosis and possibly effective for kidney damage from the drug amphotericin B, but those uses are specialized and aren't what most people take this chewable for.

The evidence, ingredient by ingredient Papaya Papain Proteolytic Enzymes (proteases) Sodium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papaya and papain are well tolerated in food amounts, but concentrated supplements are less well studied. The main side effects reported with papaya extract are nausea and vomiting, and both ingredients can trigger allergic reactions — especially in people allergic to latex.

Unripe (green) papaya, papaya latex, and papaya seeds should be avoided; some sources warn against large amounts during pregnancy. Protease is generally well tolerated but may cause digestive upset or allergic reactions in sensitive people.

Sodium chlorophyllin is safe at normal dietary levels, but too much sodium is linked to high blood pressure and heart strain — something to keep in mind if you're taking this regularly.

Side effects, ingredient by ingredient Papaya Papain Proteolytic Enzymes (proteases) Sodium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Papain, Papaya, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 297 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist if you take warfarin or other blood thinners (moderate risk of increased bleeding), diabetes medications, amiodarone for heart rhythm, levothyroxine for thyroid function, blood-pressure pills, corticosteroids, lithium, didanosine, or any sodium-containing medication or supplement. These are the main drug types that interact with ingredients in this product at moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is digestive support, but its ingredients' real-world benefits aren't well proven. If you take blood thinners, diabetes meds, thyroid pills, blood-pressure drugs, or lithium, check with your pharmacist before using it — the interactions are real and could affect how your medications work.

Those with latex allergies should be cautious. For most people with no medications, a moderate amount of ripe papaya as food is fine, but supplement strength is less well studied.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Chewable Papaya Enzyme with Chlorophyll, straight from the product label.

Brand American Health
Barcode (UPC) 076630503044
Net contents 250 Chewable Tablet(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 317666
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Chewable Papaya Enzyme with Chlorophyll by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Tablet(s)
Maximum serving Sizes:
3 Tablet(s)
Servings per container
83
UPC/BARCODE
076630503044
IngredientAmount% DV
Calories5 Calorie(s)--
Total Carbohydrates1 Gram(s)1%
Added Sugars1 Gram(s)2%
Total Sugars1 Gram(s)--
Papaya3 mg--
Papain45 mg--
Alpha-Amylase6 mg--
Protease6 mg--
Sodium Copper Chlorophyllin3 mg--

Other ingredients: Sucrose, Calcium Carbonate, Maltodextrin, Corn Starch, Natural Flavors, Stearic Acid, Magnesium Stearate, Fructose, Date, Powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Our famous blend with Chlorophyll is the perfect "after meal" supplement. Our formula contains freshly ripened Papaya. The formula also has enzymes including papain, amylase and protease which aid in the digestion of proteins, carbohydrates and fats.

Plant and fermentation-based enzymes

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Warning: If you are pregnant, nursing, taking any medications or have any medical condition, including a known sensitivity to latex, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

Seals/Symbols

IGEN Non-GMO Tested

Formulation

IGEN Non-GMO Tested This product does not contain common GE Genes or proteins. Visit igenprogram.com

The "After Meal" Supplement Promotes the breakdown of food Digestive Aids

Vegan

Gluten Free

No gluten, no yeast, no wheat, no milk or milk derivatives, no lactose, no soy, no egg, no grapefruit, no sugar, no artificial color.

Suitable for Vegans

General Statements

Visit www.AmericanHealthUS.com for our complete line of products

Brand IP Statement(s)

Copyright 2022 American Health, Inc.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, chew three (3) tablets with a meal, up to three times daily, as needed.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Chewable Papaya Enzyme with Chlorophyll by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Chewable Papaya Enzyme with Chlorophyll label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Chewable Papaya Enzyme with Chlorophyll by American Health

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Tablet(s) Dosage formTablet Or Pill Servings per container83 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papaya

Interacts with
92 drugs
3 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya monograph & interactions

Papain

Interacts with
2 drugs
45 mg per serving Form: Carica papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Alpha-Amylase

6 mg per serving Form: Aspergillus oryzae

Protease

No known
interactions
6 mg per serving Form: Aspergillus oryzae

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Sodium Copper Chlorophyllin

Interacts with
205 drugs
3 mg per serving Form: Chlorophyll

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium Copper Chlorophyllin monograph & interactions

Other (inactive) ingredients: Sucrose, Calcium Carbonate, Maltodextrin, Corn Starch, Natural Flavors, Stearic Acid, Magnesium Stearate, Fructose, Date, Powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Chewable Papaya Enzyme with Chlorophyll by American Health Drug Interactions

Want to check YOUR meds against Chewable Papaya Enzyme with Chlorophyll?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
297Drugs
297 Moderate

Ingredients driving the most interactions

Sodium Copper Chlorophyllin 205
Papaya 92
Papain 2

Individual Drug Interactions

The ingredients in Chewable Papaya Enzyme with Chlorophyll interact with 297 drugs. Click any drug to see the details.

3 of the 5 ingredients in Chewable Papaya Enzyme with Chlorophyll interact with drugs. Each result below shows which ingredient is responsible. Sodium Copper Chlorophyllin Papaya Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Chewable Papaya Enzyme with Chlorophyll with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium Copper Chlorophyllin7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium Copper Chlorophyllin full monograph & interactions

Papaya4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Chewable Papaya Enzyme with Chlorophyll, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Web Address
www.AmericanHealthUS.com
Pharmacist Counseling Corner

Chewable Papaya Enzyme with Chlorophyll by American Health: Common Questions

Does Chewable Papaya Enzyme with Chlorophyll by American Health interact with any medications?
Yes. Based on its ingredients, Chewable Papaya Enzyme with Chlorophyll has a known interaction with 297 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Chewable Papaya Enzyme with Chlorophyll contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this really help with digestion?
Papaya and papain are digestive enzymes meant to help break down proteins, but the evidence that they actually improve digestion is insufficient — studies haven't proven it works yet. Eating ripe papaya as food is fine, but whether the supplement amount does anything extra isn't established in our data.
Can I take this if I'm on blood thinners?
No — not without checking with your pharmacist first. Papaya and papain have a moderate interaction with warfarin and other blood thinners. One case report showed a patient's blood clotting measure spiked dangerously after taking papaya. Your pharmacist needs to assess your specific situation.
Is this safe if I'm pregnant?
The data we hold doesn't include a safety rating for papaya or papain in pregnancy, so there isn't enough information to know either way. Some sources caution against large amounts during pregnancy, and unripe papaya should be avoided. Talk with your doctor or pharmacist for personalized advice before taking this while pregnant.
What are the side effects?
Papaya and papain are usually well tolerated in food amounts. The most common side effects reported with supplements are nausea and vomiting, especially with papaya leaf extract. Allergic reactions can occur, including itchy eyes, sneezing, and stomach cramps — and people allergic to latex are at higher risk. Serious allergic reactions are rare.
Can I take this with my diabetes medication?
Possibly not — there's a moderate interaction. A small study showed that fermented papaya lowered blood sugar further in people taking glibenclamide, which could cause low blood sugar. Check with your pharmacist or doctor before combining this product with your diabetes medication.
What's the chlorophyll in this for?
Chlorophyll is the green pigment in the product. The form used here, sodium copper chlorophyllin, does show promise for cystic fibrosis and kidney damage from certain chemotherapy drugs, but those are specialized uses. For general digestive support, its role isn't well established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Chewable Papaya Enzyme with Chlorophyll is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Chewable Papaya Enzyme with Chlorophyll label
Go deeper

The Full Monographs Behind Chewable Papaya Enzyme with Chlorophyll’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph →
Sources

Sources & How We Checked

Chewable Papaya Enzyme with Chlorophyll's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 66 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
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See these in context on the Proteolytic Enzymes (proteases) monograph →

Sodium 38 references
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See these in context on the Sodium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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