Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Digestive Aide Ingredients & Drug Interactions

by Get At The Roots Weight Loss

Digestive Aide label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Aide against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Digestive Aide is a dietary supplement by Get At The Roots Weight Loss with 6 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 38 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betain Hydrochloride, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Digestive Aide by Get At The Roots Weight Loss

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Aide by Get At The Roots Weight Loss — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Digestive Aide by Get At The Roots Weight Loss

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has six active ingredients designed to support digestion. Papain is an enzyme from papaya that breaks down proteins.

Pepsin is another protein-digesting enzyme. Ox bile helps the body digest and absorb fats.

Betaine hydrochloride boosts stomach acid to aid digestion. Pancreatin 4x is a concentrated mix of digestive enzymes from pancreas tissue.

The product also includes a blend — we don't have details on what's in it. The inactive ingredients are microcrystalline cellulose, vegetable magnesium stearate, soy polysaccharides, food glaze, and hydrated magnesium silicate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive support and enzyme supplementation.
  • We looked for evidence on: Dyspepsia, Exercise-induced muscle soreness, Wound healing, indigestion, bloating, protein digestion.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence we hold doesn't establish that papain works for cancer, dental cavities, radiation skin damage, exercise-related muscle soreness, shingles, or intestinal parasites — the data is simply insufficient. Betaine hydrochloride likewise lacks reliable evidence for indigestion, low thyroid function, diarrhea, rheumatoid arthritis, food allergies, or hay fever.

We have no effectiveness ratings on file for pepsin, ox bile, pancreatin 4x, or the blend.

The evidence, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food but may irritate your digestive tract or trigger allergic reactions in sensitive people — watch for itchy eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. High doses are unsafe and can rarely cause severe stomach inflammation or even a tear in your food tube.

Avoid concentrated papain and unripe papaya products during pregnancy; there isn't enough safety data to recommend papain supplements while breastfeeding, so talk with your doctor or pharmacist first. Pepsin is generally well tolerated but may cause digestive upset or allergic reactions; rarely, occupational exposure to pepsin dust has triggered nasal and eye allergies or asthma.

Safety hasn't been established in pregnancy, so avoid it unless prescribed. There's little data on breastfeeding — medical advice is needed.

Betaine hydrochloride can irritate the stomach and is unsafe if you have ulcers, gastritis, or true acid reflux — it may trigger heartburn. Avoid it during pregnancy and breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Papain, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 38 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Digestive Aide, check with your doctor or pharmacist if you're on warfarin (a blood thinner) — papain may boost its effects. Also check if you take H2-blockers, antacids, or proton pump inhibitors for stomach acid — betaine hydrochloride may reduce how well they work.

We couldn't verify interactions for three ingredients, so mention all your medications to your provider.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines digestive enzymes and acid support, but the evidence for what it actually does isn't established in the data we hold. If you take warfarin, an antacid, an H2-blocker, or a PPI, you need to check with your doctor or pharmacist before starting — the interactions could matter.

People with stomach ulcers or acid reflux should avoid it altogether. Talk it over with your own healthcare provider to decide if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Aide, straight from the product label.

Brand Get At The Roots Weight Loss
Net contents 150 Tablet(s)
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 21786
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Aide by Get At The Roots Weight Loss, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
150
IngredientAmount% DV
Papain32 mg--
Pepsin32 mg--
Ox Bile120 mg--
Betain Hydrochloride129 mg--
Pancreatin 4x69 mg--
Blend64 mg--

Other ingredients: Microcrystalline Cellulose, Veg. Magnesium Stearate, Soy Polysaccharides, Food Glaze, hydrated Magnesium Silicate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

MADE IN THE U.S.A.

Amino Acids, Vitamins & Minerals have been manufactured and analyzed in accordance with USP Standards.

CERTIFICATION OF QUALITY The ingredients contained in this product come from natural sources and are the finest quality food-grade materials available.**

CERTIFICATION OF POTENCY Guaranteed through date on this container.

General

Product No. 5089

Storage

KEEP IN A COOL, DRY PLACE

Formula

With Betaine Hydrochloride, Multiple Enzymes & Ox Bile

FDA Statement of Identity

Dietary Supplement

Formulation

Does not contain any other ingredients.

No genetically modified ingredients, citrus, color, corn, egg, gluten, milk, preservatives, salt, solvents, soy protein, starch, sugar, waxes, wheat, yeast or artificial flavors.

Suggested/Recommended/Usage/Directions

SUGGESTED USE 1 tablet with each meal or as directed by your health care professional.

FDA Disclaimer Statement

**This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Aide by Get At The Roots Weight Loss label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Aide label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Aide by Get At The Roots Weight Loss

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formOther (e.g. Tea Bag) Servings per container150 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
32 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Pepsin

No known
interactions
32 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Ox Bile

120 mg per serving

Betain Hydrochloride

Interacts with
36 drugs
129 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betain Hydrochloride monograph & interactions

Pancreatin 4x

69 mg per serving

Blend

64 mg per serving Form: Diastase, Invertase, Lipase, Maltase, Phosphatase, Protease, Sulfatase

Other (inactive) ingredients: Microcrystalline Cellulose, Veg. Magnesium Stearate, Soy Polysaccharides, Food Glaze, Hydrated Magnesium Silicate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Aide by Get At The Roots Weight Loss Drug Interactions

Want to check YOUR meds against Digestive Aide?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
38Drugs
2 Moderate 36 Minor

Ingredients driving the most interactions

Betain Hydrochloride 36
Papain 2

Individual Drug Interactions

The ingredients in Digestive Aide interact with 38 drugs. Click any drug to see the details.

2 of the 6 ingredients in Digestive Aide interact with drugs. Each result below shows which ingredient is responsible. Betain Hydrochloride Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Aide with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betain Hydrochloride3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betain Hydrochloride full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Aide, from the product label.

Get At The Roots Weight Loss

See all Get At The Roots Weight Loss products
Name
Get At The Roots Weight Loss, LLC
City
Brandford
State
CT
ZipCode
06405
Phone Number
(855) 467-3785
Web Address
www.GetAtTheRootsWeightLoss.com
Pharmacist Counseling Corner

Digestive Aide by Get At The Roots Weight Loss: Common Questions

Does Digestive Aide by Get At The Roots Weight Loss interact with any medications?
Yes. Based on its ingredients, Digestive Aide has a known interaction with 38 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Aide contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is papain safe during pregnancy?
No. Concentrated papain and unripe papaya products are possibly unsafe in pregnancy. Avoid supplemental papain during pregnancy due to safety concerns.
Can I take this while breastfeeding?
There isn't enough safety data to recommend papain or pepsin supplements while breastfeeding. Talk with your doctor or pharmacist before using this product if you're nursing.
What are the most common side effects?
Papain and pepsin may cause allergic reactions in sensitive people, including itchy watery eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea. Betaine hydrochloride may irritate your stomach or cause heartburn.
Can I take this if I have an ulcer?
No. Betaine hydrochloride increases stomach acid and is unsafe if you have ulcers, gastritis, or true acid reflux — it could make these conditions worse.
Does this product actually work for digestion?
The evidence we hold doesn't establish that the ingredients in this product work for their intended digestive purposes — the data is simply insufficient.
What's papain supposed to do?
Papain is an enzyme from papaya that breaks down proteins to aid digestion, but we don't have reliable evidence that it actually works for the conditions listed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Aide is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Aide label
Go deeper

The Full Monographs Behind Digestive Aide’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph →
Sources

Sources & How We Checked

Digestive Aide's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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