Major interaction on record — check this product against your medications before combining. Based on 6 of 10 ingredients. Check your meds →
Dietary supplement

Digestive Enzymes with Probiotics Ingredients & Drug Interactions

by Isotonix

Digestive Enzymes with Probiotics label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Digestive Enzymes with Probiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Digestive Enzymes with Probiotics is a dietary supplement by Isotonix with 10 active ingredients. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 467 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, Bacillus coagulans, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Digestive Enzymes with Probiotics by Isotonix

Ask about any prescription or over-the-counter medication and we check it for interactions with Digestive Enzymes with Probiotics by Isotonix — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Digestive Enzymes with Probiotics by Isotonix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 10 active ingredients.

This product contains 10 active ingredients: the minerals potassium and magnesium; four digestive enzymes (amylase, protease, lipase, and cellulase); two enzyme complexes (lactase and sucrase); DigeZyme, a multi-enzyme blend; and Bacillus coagulans, a beneficial bacteria (probiotic). The enzymes are meant to help break down food — protein, fat, carbohydrates, dairy, and fiber — while the probiotic may support gut health.

The product also contains inactive ingredients like fructose, glucose, maltodextrin, and apple fiber, which make up the powder base and flavoring.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: promotes digestion and nutrient absorption.
  • We looked for evidence on: Constipation, Diarrhea, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Magnesium is rated "Effective" for Constipation, Dyspepsia.
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation, Irritable bowel syndrome (IBS).

Lactase has solid evidence behind it — it's effective for lactose intolerance. Magnesium has established effectiveness for dyspepsia (indigestion) and constipation.

Bacillus coagulans shows possibly effective evidence for constipation and irritable bowel syndrome (IBS), though the data is weaker. For the other ingredients and uses, the evidence in our data is insufficient — we don't have reliable ratings on whether the other enzymes work well as supplements, and probiotic benefits for other conditions like antibiotic-associated diarrhea are still being studied.

The evidence, ingredient by ingredient Potassium Proteolytic Enzymes (proteases) Lipase Lactase Magnesium Bacillus Coagulans

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium and magnesium are generally well tolerated at normal dietary amounts, but supplements carry real risks. Potassium from supplements can dangerously raise blood levels, especially in people with kidney disease — use only under medical guidance.

Magnesium's most common oral side effects are diarrhea, nausea, and gastrointestinal upset; serious effects like muscle weakness or cardiac arrhythmias are rare but possible at high doses. Protease may trigger allergic reactions in sensitive people.

Bacillus coagulans is generally well tolerated in healthy adults, but hasn't been well studied in people with severe illness or weak immune systems — there are rare reports of infection from probiotic bacteria in hospitalized or immunocompromised patients.

Side effects, ingredient by ingredient Potassium Proteolytic Enzymes (proteases) Lipase Lactase Magnesium Bacillus Coagulans

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 6 matched ingredients can interact with medications — Potassium, Magnesium, Bacillus Coagulans.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 467 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on levodopa/carbidopa (Sinemet) for Parkinson's disease — magnesium cuts its effectiveness significantly. Next, check for potassium-sparing diuretics, ACE inhibitors, or ARBs (blood-pressure drugs), which all raise the risk of dangerously high potassium levels.

Also watch for muscle relaxants, calcium channel blockers, quinolone antibiotics, bisphosphonates, sulfonylureas, and antacids — magnesium can change how these work. Finally, if you take antibiotics, separate them from this product because the live probiotic may be killed.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take blood-pressure medications, diabetes drugs, antibiotics, Parkinson's medication, or bone drugs, check with your pharmacist before starting this product — the mineral and probiotic content can interfere with how these work. Healthy people without these medications may find the enzymes and probiotics helpful for digestion and occasional constipation, but the evidence is stronger for some ingredients than others.

Talk to your pharmacist about whether this is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Digestive Enzymes with Probiotics, straight from the product label.

Brand Isotonix
Net contents 4.7 Oz(s); 133.4 Gram(s); 20 Packet(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 217849
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Digestive Enzymes with Probiotics by Isotonix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3.3 Gram(s)
Maximum serving Sizes:
3.3 Gram(s)
Servings per container
2
IngredientAmount% DV
Calories10 Calorie(s)--
Total Carbohydrates2 Gram(s)1%
Potassium90 mg2%
Amylase0 NP--
Protease0 NP--
Added Sugars2.1 Gram(s)4%
Lipase0 NP--
Total Sugars2 Gram(s)--
Lactase0 NP--
Cellulase0 NP--
Magnesium24 mg6%
Sucrase0 NP--
DigeZyme100 mg--
Bacillus coagulans0 NP--

Other ingredients: Fructose, Glucose, Citric Acid, Maltodextrin, Silicon Dioxide, Calcium Sulfate, Apple Fiber, Apple Cider, Lemon flavor, Lime flavor, Riboflavin 5-Phosphate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Provides enzymes and good bacteria that promote nutrient absorption from foods Promotes digestion May help ease occasional stomach upset Supports healthy immune functions

Gluten free

Isotonix Digestive Enzymes with Probiotics supplies enzymes that are not inactivated by the low pH found in stomach acid. This allows the Isotonix enzymes to mix with the body's own enzymes to promote the digestion and absorption of nutrients.

This vegetarian product contains no added wheat, soy, yeast, gluten, starch, salt, preservatives or milk.

This vegetarian product contains no added wheat, soy, yeast, gluten, starch, salt, preservatives or milk.

General Statements

The world's most advanced nutraceuticals

20 Packets: 0.23 oz (6.67 g)

FDA Statement of Identity

An Isotonic-Capable Dietary Supplement

Formula

This formula also contains Lactobacillus sporogenes, which helps support a healthy digestive tract.

Brand IP Statement(s)

DigeZyme and Lactospore are registered trademarks of the Sabinsa Corporation.

Suggested/Recommended/Usage/Directions

Directions for use: Pour 1/2 of packet contents into a glass. Add 2 fl oz/60 ml of water and stir. Maximum benefits occur when taken with or immediately following a meal. Additional servings may be taken if necessary.

Precautions

Keep out of the reach of children.

Do not use if safety seal is broken or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Digestive Enzymes with Probiotics by Isotonix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Digestive Enzymes with Probiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Digestive Enzymes with Probiotics by Isotonix

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size3.3 Gram(s) Dosage formPowder Servings per container2 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Potassium

Interacts with
62 drugs
90 mg per serving Form: Potassium Bicarbonate

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Amylase

0 NP per serving

Protease

No known
interactions
0 NP per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Lipase

No known
interactions
0 NP per serving

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...

Lipase monograph & interactions

Lactase

No known
interactions
0 NP per serving

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...

Lactase monograph & interactions

Cellulase

0 NP per serving

Magnesium

Interacts with
295 drugs
24 mg per serving Form: Magnesium Carbonate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Sucrase

0 NP per serving

DigeZyme

100 mg per serving

Bacillus coagulans

Interacts with
182 drugs
0 NP per serving Form: Lactospore

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, a...

Bacillus coagulans monograph & interactions

Other (inactive) ingredients: Fructose, Glucose, Citric Acid, Maltodextrin, Silicon Dioxide, Calcium Sulfate, Apple Fiber, Apple Cider, Lemon flavor, Lime flavor, Riboflavin 5-Phosphate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Digestive Enzymes with Probiotics by Isotonix Drug Interactions

Want to check YOUR meds against Digestive Enzymes with Probiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
467Drugs
6 Major 347 Moderate 114 Minor

Ingredients driving the most interactions

Magnesium 295
Bacillus coagulans 182
Potassium 62

Individual Drug Interactions

The ingredients in Digestive Enzymes with Probiotics interact with 467 drugs. Click any drug to see the details.

3 of the 10 ingredients in Digestive Enzymes with Probiotics interact with drugs. Each result below shows which ingredient is responsible. Magnesium Bacillus coagulans Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Digestive Enzymes with Probiotics with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Digestive Enzymes with Probiotics, from the product label.

Isotonix

See all Isotonix products
Name
Market America, Inc.
Street Address
1302 Pleasant Ridge Road
City
Greensboro
State
NC
ZipCode
27409
Pharmacist Counseling Corner

Digestive Enzymes with Probiotics by Isotonix: Common Questions

Does Digestive Enzymes with Probiotics by Isotonix interact with any medications?
Yes. Based on its ingredients, Digestive Enzymes with Probiotics has a known interaction with 467 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Digestive Enzymes with Probiotics contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant?
Potassium and lactase are rated likely safe in pregnancy. Magnesium is likely to possibly safe, though you should use supplements only under your doctor's guidance because magnesium is needed but the dose matters. Safety data on protease, lipase, and the probiotic during pregnancy isn't well established — talk with your doctor before using this product while pregnant.
Is it safe to breastfeed while taking this?
Potassium and lactase are fine; dietary amounts are appropriate and your doctor can guide supplement use. Lipase safety while breastfeeding hasn't been well studied, and there's little safety data on protease — check with your healthcare provider first. Bacillus coagulans has limited safety information during breastfeeding too, so ask your doctor or pharmacist.
What does lactase actually do in this product?
Lactase is an enzyme that breaks down lactose, the sugar in dairy. If you're lactose intolerant — meaning you have trouble digesting milk or cheese — this ingredient can help. It's effective for that specific purpose.
Will this help my IBS?
Bacillus coagulans, the probiotic in here, is possibly effective for IBS based on the research we have. That said, the evidence isn't strong, and probiotic products vary in quality. If you want to try it, talk to your doctor first — especially if you're on antibiotics, which would kill the live bacteria.
What are the most common side effects?
The minerals can cause digestive upset — diarrhea, nausea, gas, and abdominal discomfort are the most common complaints from magnesium and potassium supplements. Protease rarely causes allergic reactions. Most people tolerate this type of product without trouble, but if your stomach gets upset, scale back or stop and talk to your pharmacist.
Can I take this with my antibiotics?
You can, but it's better to separate them. Antibiotics kill the live Bacillus coagulans bacteria in this product, so you won't get the probiotic benefit if you take them together. Take your antibiotic as prescribed, and space out this supplement by a few hours if you can — your pharmacist can help you time them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Digestive Enzymes with Probiotics is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Digestive Enzymes with Probiotics label
Go deeper

The Full Monographs Behind Digestive Enzymes with Probiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph →
Sources

Sources & How We Checked

Digestive Enzymes with Probiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 119 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
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Proteolytic Enzymes (proteases) 3 references
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Lactase 1 reference
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Bacillus Coagulans 20 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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