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Dietary supplement

Dulse Ingredients & Drug Interactions

by Pure Herbs

Dulse label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Dulse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Dulse is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for nutritional supplement (iodine, minerals), source of plant protein, general wellness.Based on those ingredients, 85 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dulse Leaf Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Dulse by Pure Herbs

Ask about any prescription or over-the-counter medication and we check it for interactions with Dulse by Pure Herbs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Dulse by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pure Herbs Dulse is a one-ingredient liquid supplement made from dulse leaf extract. Dulse is a type of edible seaweed, and this extract concentrates its natural compounds — chiefly potassium and iodine — into supplement form.

There are no inactive ingredients listed.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Dulse's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: help maintain healthy thyroid function.
  • We looked for evidence on: Iodine deficiency, Hypothyroidism, Thyroid hormone synthesis, Goiter.
  • The closest evidence on file: Dulse is rated "Insufficient Reliable Evidence To Rate" for Iodine deficiency (Natural Medicines).

The evidence we hold doesn't establish that dulse works for any particular health goal. Studies haven't produced reliable evidence for its use with high cholesterol or iodine deficiency, so we can't say whether it actually delivers on those fronts.

The evidence, ingredient by ingredient Dulse

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Dulse is generally well tolerated as a food, but supplements are a different story. Concentrated supplements can deliver unpredictably high levels of iodine and potassium, and safety data for these doses is limited.

If you're pregnant, food amounts are likely okay, but supplement doses aren't well studied — talk with your doctor or pharmacist before taking this. If you're breastfeeding, excess iodine can pass into your milk, so avoid supplement doses and check with your healthcare provider first.

The safety notes don't report common adverse effects from trials.

Side effects, ingredient by ingredient Dulse

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Dulse.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 85 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your pharmacist if you take digoxin (a heart medication), any thyroid hormone or antithyroid drugs, amiodarone (Cordarone) for heart rhythm, or blood pressure medications like ACE inhibitors, ARBs, or potassium-sparing diuretics. Dulse's potassium and iodine content can theoretically affect all of these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Dulse leaf extract might be worth considering if you're looking to boost iodine or potassium intake and have no thyroid condition or heart medications. But if you take digoxin, thyroid drugs, amiodarone, blood pressure medications (especially ACEIs, ARBs, or potassium-sparing diuretics), you need to check with your doctor or pharmacist before adding this — the potassium and iodine could interfere with how your medications work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Dulse, straight from the product label.

Brand Pure Herbs
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 279316
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Dulse by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
60
IngredientAmount% DV
Dulse Leaf Extract2026 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial to help maintain healthy thyroid function.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Dulse by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Dulse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Dulse by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Dulse Leaf Extract

Interacts with
85 drugs
2026 mg per serving

Dulse is a red seaweed eaten as a food in many coastal cultures and is a natural source of iodine, potassium, protein, and antioxidant compounds. As a...

Dulse Leaf Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Dulse by Pure Herbs Drug Interactions

Want to check YOUR meds against Dulse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
85Drugs
23 Moderate 62 Minor

Ingredients driving the most interactions

Dulse Leaf Extract 85

Individual Drug Interactions

The ingredients in Dulse interact with 85 drugs. Click any drug to see the details.

1 of the 1 ingredient in Dulse interact with drugs. Each result below shows which ingredient is responsible. Dulse Leaf Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Dulse with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Dulse Leaf Extract7 drug types · 85 drugs

Amiodarine (Cordarone)

Theoretically, combining dulse with amiodarone might cause excessively high iodine levels.
Dulse is rich in iodine, and amiodarone contains 37.3% iodine and can increase iodine levels.

Likelihood Possible Evidence D
Antithyroid Drugs

Theoretically, due to its iodine content, dulse might alter the effects of antithyroid drugs.
Dulse is rich in iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, dulse might increase the risk of hyperkalemia when taken with digoxin.
Dulse is rich in potassium, and digoxin can increase potassium levels in the blood. This interaction has not been demonstrated in humans.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, due to its iodine content, dulse might alter the effects of thyroid hormone.
Dulse is rich in iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Although dulse has been associated with a statistically significant increase in thyroid stimulating hormone (TSH) levels in clinical research, clinically significant increases have not been documented.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, dulse might increase the risk of hyperkalemia when taken with ACEIs.
Dulse is rich in potassium. ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels. However, using these drugs while consuming dulse in quantities that provide larger amounts of potassium daily might increase the risk of hyperkalemia. Additionally, in vitro research suggests that dulse protein hydrolysates inhibit the activity of ACE. However, these effects have not been demonstrated in humans.

Likelihood Possible Evidence D
Angiotensin Receptor Blockers (Arbs)

Theoretically, dulse might increase the risk of hyperkalemia when taken with ARBs.
Dulse is rich in potassium. ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels. However, using these drugs while consuming dulse in quantities that provide higher amounts of potassium daily might increase the risk of hyperkalemia. Additionally, in vitro research suggests that dulse protein hydrolysates inhibit the activity of angiotensin converting enzyme (ACE). However, these effects have not been demonstrated in humans.

Likelihood Possible Evidence D
Potassium-Sparing Diuretics

Theoretically, dulse might increase the risk of hyperkalemia when taken with potassium-sparing diuretics.
Dulse is rich in potassium, and potassium-sparing diuretics can increase potassium levels in the blood. This interaction has not been shown in humans.

Likelihood Possible Evidence D
Dulse Leaf Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Dulse, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Dulse by Pure Herbs: Common Questions

Does Dulse by Pure Herbs interact with any medications?
Yes. Based on its ingredients, Dulse has a known interaction with 85 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Dulse contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is dulse safe if I'm pregnant or breastfeeding?
Food amounts of dulse are likely fine in pregnancy, but we don't have enough safety data on supplement doses to recommend them. If you're breastfeeding, excess iodine from supplements can pass into breast milk. Talk with your doctor or pharmacist before taking this supplement in either case.
What is dulse, and why is it in this supplement?
Dulse is an edible seaweed rich in potassium and iodine. This extract concentrates those compounds, making it a source of both minerals. The evidence we hold doesn't show it reliably helps with high cholesterol or iodine deficiency, though.
Can I take this if I have a thyroid condition?
Dulse's high iodine content can theoretically alter how thyroid hormones and antithyroid medications work, depending on your history. If you take any thyroid drug or have a thyroid condition, check with your doctor or pharmacist before starting this supplement.
Are there any side effects listed for this product?
The data we hold doesn't report common adverse effects from trials. That said, supplements with high potassium and iodine can cause problems in certain people — especially those on heart or blood pressure medications — so it's worth confirming your medications first.
Can this replace my iodine supplements or thyroid medication?
No. This supplement's iodine content isn't reliably measured, and the evidence doesn't show it works for iodine deficiency or thyroid health. Never stop or replace prescribed thyroid medication with this — talk with your doctor if you're thinking about any changes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Dulse label
Go deeper

The Full Monographs Behind Dulse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dulse

Interacts with 85 drugs

Dulse is a red seaweed eaten as a food in many coastal cultures and is a natural source of iodine, potassium, protein, and antioxidant compounds. As a food it is generally considered safe fo...

Read the full Dulse monograph →
Sources

Sources & How We Checked

Dulse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dulse 5 references
  1. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  2. Allsopp P, Crowe W, Bahar B, et al. The effect of consuming Palmaria palmata-enriched bread on inflammatory markers, antioxidant status, lipid profile and thyroid function in a randomised placebo-controlled intervention trial in healthy adults. Eur J Nutr PubMed
  3. McGrath BM, Harmon JP, Bishop G. Palmaria palmata (Dulse) as an unusual maritime aetiology of hyperkalemia in a patient with chronic renal failure: a case report. J Med Case Rep. 2010;4:301. PubMed
  4. Furuta T, Miyabe Y, Yasui H, Kinoshita Y, Kishimura H. Angiotensin I converting enzyme inhibitory peptides derived from phycobiliproteins of dulse Palmaria palmata. Mar Drugs. 2016;14(2):32. PubMed
  5. Takase T, Nakamura A, Miyoshi H, et al. Effects of Palmaria palmata on lipid metabolism and glycemic control in participants with hypercholesterolemia in a randomized double-blind placebo-controlled trial. Phytother Res. 2020.

See these in context on the Dulse monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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