Interactions on record — worth a quick check against your medications. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

DuoZyme Ingredients & Drug Interactions

by Karuna

DuoZyme label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking DuoZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

DuoZyme is a dietary supplement by Karuna with 9 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 39 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Betaine HCl, Papain, Pancreatin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against DuoZyme by Karuna

Ask about any prescription or over-the-counter medication and we check it for interactions with DuoZyme by Karuna — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of DuoZyme by Karuna

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • “Providing at least the following” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

DuoZyme contains 9 ingredients total, most of them digestive enzymes. The active enzymes are amylase (breaks down starches), papain (from papaya, breaks down proteins), protease (protein-digesting enzymes), lipase (fat-digesting enzyme), pepsin (another protein-digesting enzyme), and pancreatin (a pancreatic enzyme blend).

The formula also includes betaine HCl and glutamic acid hydrochloride to support stomach acid, plus ox bile extract to aid fat digestion. The remaining ingredients—capsule, silica, stearic acid, vegetable stearate, and maltodextrin—are inactive fillers and binders that hold the capsule together.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Full range digestive enzyme support.
  • We looked for evidence on: Dyspepsia, Pancreatic insufficiency, indigestion, pancreatic enzyme insufficiency, fat malabsorption.
  • The strongest evidence on file: Pancreatic Enzyme Products is rated "Effective" for Pancreatic insufficiency (Natural Medicines).
  • Also on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for most of DuoZyme's ingredients is not well established. Pancreatin is effective for pancreatic insufficiency (when the pancreas doesn't make enough digestive enzymes), but for the other uses studied—including exercise soreness, shingles, intestinal parasites, and various digestive complaints—the evidence is insufficient to rate whether these ingredients actually work.

The data we hold does not establish effectiveness for the product as a whole digestive aid.

The evidence, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride Pancreatic Enzyme Products Lipase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papain is generally tolerated as a food but may irritate the digestive tract and can trigger allergic reactions in sensitive people—including itchy watery eyes, runny nose, sneezing, abdominal cramps, diarrhea, and in rare cases, severe gastritis or esophageal perforation at high doses. Protease, pepsin, and pancreatin are also generally well tolerated but may cause digestive upset or allergic reactions; occupational exposure to airborne proteolytic enzymes has caused respiratory allergic reactions in some people.

Betaine HCl may irritate the stomach and is not safe for people with ulcers, gastritis, or acid reflux—it can theoretically worsen existing ulcers. Papain is possibly unsafe in pregnancy; concentrated papain and unripe papaya products should be avoided.

Betaine HCl should be avoided during pregnancy, and safety while breastfeeding has not been established. For protease, pepsin, lipase, and pancreatin, there is little safety data in pregnancy and lactation—discuss use with your doctor before taking if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Papain Proteolytic Enzymes (proteases) Betaine Hydrochloride Pancreatic Enzyme Products Lipase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Papain, Pancreatic Enzyme Products, Betaine Hydrochloride.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 39 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting DuoZyme, double-check with your doctor or pharmacist if you take warfarin or other blood thinners (papain may increase their effects), acarbose or other blood-sugar-controlling medications (pancreatin may reduce their effectiveness), or acid-reducing drugs including H2-blockers, antacids, or proton pump inhibitors (betaine HCl may decrease their effects). Altogether, these interactions span 39 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

DuoZyme is a multi-enzyme digestive supplement designed for people who may have difficulty breaking down food—particularly those with pancreatic insufficiency (where pancreatin is proven effective). If you take blood thinners like warfarin, diabetes medications like acarbose, or acid-reducing drugs like H2-blockers, PPIs, or antacids, talk with your doctor or pharmacist before starting this product, as the interactions are real and could affect how your medications work.

Similarly, if you're pregnant, breastfeeding, or have a history of stomach ulcers or acid reflux, check with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about DuoZyme, straight from the product label.

Brand Karuna
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2013
DSLD ID 24362
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for DuoZyme by Karuna, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
IngredientAmount% DV
Amylase45000 USP Unit(s)--
Papain100 mg--
Protease45000 USP Unit(s)--
Lipase7500 USP Unit(s)--
Pepsin40 mg--
Glutamic Acid Hydrochloride300 mg--
Betaine HCl300 mg--
Pancreatin300 mg--
Ox Bile extract120 mg--
Providing at least the following0 NP--

Other ingredients: Capsule, Silica, Stearic Acid, Vegetable Stearate, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

KARUNA(R) RESPONSIBLE NUTRITION(TM)

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use for adults: Two or more capsules, taken with meals, or as directed by your health care practitioner.

Precautions

Patients with active peptic ulcer should use HCl products with caution.

General Statements

This product is intended for professional use and is manufactured under strict quality control to ensure the optimum in purity, potency and reliability.

Fast-acting, Full Range Digestive Enzymes

Storage

Keep in a cool, dry place, tightly capped.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

DuoZyme by Karuna label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

DuoZyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in DuoZyme by Karuna

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Papain

Interacts with
2 drugs
100 mg per serving

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Pepsin

No known
interactions
40 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Pepsin monograph & interactions

Glutamic Acid Hydrochloride

300 mg per serving

Betaine HCl

Interacts with
36 drugs
300 mg per serving

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is l...

Betaine HCl monograph & interactions

Pancreatin

Interacts with
1 drug
300 mg per serving

Pancreatic enzyme products supply the digestive enzymes (lipase, protease, and amylase) that some people cannot make enough of, helping them break dow...

Pancreatin monograph & interactions

Ox Bile extract

120 mg per serving

Providing at least the following

0 NP per serving

Other (inactive) ingredients: Capsule, Silica, Stearic Acid, Vegetable Stearate, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

DuoZyme by Karuna Drug Interactions

Want to check YOUR meds against DuoZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
39Drugs
3 Moderate 36 Minor

Ingredients driving the most interactions

Betaine HCl 36
Papain 2
Pancreatin 1

Individual Drug Interactions

The ingredients in DuoZyme interact with 39 drugs. Click any drug to see the details.

3 of the 9 ingredients in DuoZyme interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl Papain Pancreatin

Each ingredient & the kinds of drugs it affects

For each ingredient in DuoZyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions

Pancreatin1 drug type · 1 drug

Acarbose (Precose, Prandase)

Theoretically, pancreatic enzyme products may reduce the effects of acarbose.
The digestive enzymes present in pancreatic enzyme products may break down acarbose, reducing its effects.

Likelihood Possible Evidence D
Pancreatin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for DuoZyme, from the product label.

Karuna

See all Karuna products
Name
Karuna Corporation
Street Address
42 Digital Drive #7
City
Novato
State
CA
ZipCode
94949
Pharmacist Counseling Corner

DuoZyme by Karuna: Common Questions

Does DuoZyme by Karuna interact with any medications?
Yes. Based on its ingredients, DuoZyme has a known interaction with 39 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
DuoZyme contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is papain safe if I have allergies?
Papain can trigger allergic reactions in people sensitive to it—including itchy eyes, sneezing, abdominal cramps, and diarrhea. If you have a known papaya allergy or are prone to allergic reactions, check with your doctor before taking this product.
Can I take this if I have an ulcer or acid reflux?
No. Betaine HCl, one of the ingredients in DuoZyme, increases stomach acid and is not safe for people with ulcers, gastritis, or true acid reflux—it may irritate your stomach or worsen an existing ulcer. Avoid this product and talk with your doctor about safer alternatives.
Is DuoZyme safe during pregnancy?
Papain is possibly unsafe during pregnancy, and concentrated papain or unripe papaya products should be avoided. Betaine HCl should also be avoided during pregnancy. There isn't enough safety data for the other ingredients in pregnancy either, so discuss this product with your doctor before taking it if you're pregnant.
Does this product actually help with digestion?
Pancreatin is proven effective for pancreatic insufficiency, a condition where the pancreas doesn't produce enough enzymes. For general digestive complaints or other uses, the evidence is insufficient to say whether DuoZyme's ingredients actually work—the data we hold doesn't establish that.
What are the most common side effects?
The enzymes in DuoZyme—papain, protease, pepsin, and pancreatin—may cause allergic reactions in sensitive people and can trigger digestive upset like abdominal pain, constipation, diarrhea, nausea, flatulence, and vomiting. At high doses, papain may cause more serious effects.
Can I take this with my diabetes medication?
If you take acarbose (a diabetes medication), talk with your doctor first—pancreatin in this product may reduce acarbose's effectiveness by breaking it down. Do not start DuoZyme without checking with your healthcare provider.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if DuoZyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

DuoZyme label
Go deeper

The Full Monographs Behind DuoZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Pancreatic Enzyme Products

Interacts with 1 drug

Pancreatic enzyme products supply the digestive enzymes (lipase, protease, and amylase) that some people cannot make enough of, helping them break down and absorb food. Prescription versions...

Read the full Pancreatic Enzyme Products monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph →
Sources

Sources & How We Checked

DuoZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 57 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Pancreatic Enzyme Products 40 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  3. Smyth RL, van Velzen D, Smyth AR, et al. Strictures of ascending colon in cystic fibrosis and high-strength pancreatic enzymes. Lancet 1994;343:85-6. PubMed
  4. Bergner A, Bergner RK. Pulmonary hypersensitivity associated with pancreatin powder exposure. Pediatrics 1975;55:814-7. DOI
  5. Wiessmann KJ, Baur X. Occupational lung disease following long-term inhalation of pancreatic extracts. Eur J Respir Dis 1985;66:13-20.
  6. Bragelmann, R., Armbrecht, U., Rosemeyer, D., Schneider, B., Zilly, W., and Stockbrugger, R. W. The effect of pancreatic enzyme supplementation in patients with steatorrhoea after total gastrectomy. Eur.J Gastroenterol.Hepatol. 1999;11(3):231-237. PubMed
  7. Halm, U., Loser, C., Lohr, M., Katschinski, M., and Mossner, J. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment.Pharmacol.Ther. PubMed
  8. O'Keefe, S. J., Cariem, A. K., and Levy, M. The exacerbation of pancreatic endocrine dysfunction by potent pancreatic exocrine supplements in patients with chronic pancreatitis. J Clin Gastroenterol. 2001;32(4):319-323. PubMed
  9. Shin, S. Y., Hur, G. Y., Ye, Y. M., and Park, H. S. A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma. J Korean Med Sci. 2008;23(2):347-349. PubMed
  10. Andersen, H. O., Hjelt, K., Waever, E., and Overgaard, K. The age-related incidence of meconium ileus equivalent in a cystic fibrosis population: the impact of high-energy intake. J Pediatr Gastroenterol.Nutr 1990;11(3):356-360. DOI
  11. Ramo, O. J., Puolakkainen, P. A., Seppala, K., and Schroder, T. M. Self-administration of enzyme substitution in the treatment of exocrine pancreatic insufficiency. Scand.J Gastroenterol. 1989;24(6):688-692. PubMed
  12. Aparisi, L., Rodrigo, J. M., Serra, M. A., Del Olmo, J., Bisquert, M., and Raga, F. [Efficacy of a new microencapsulated pancreatin versus a conventional preparation, in the treatment of steatorrhea of pancreatic origin]. Rev.Esp.Enferm.Apar.Dig. 1989;76
  13. Ansaldi-Balocco, N., Santini, B., and Sarchi, C. Efficacy of pancreatic enzyme supplementation in children with cystic fibrosis: comparison of two preparations by random crossover study and a retrospective study of the same patients at two different ages DOI
  14. Beverley, D. W., Kelleher, J., Macdonald, A., Littlewood, J. M., Robinson, T., and Walters, M. P. Comparison of four pancreatic extracts in cystic fibrosis. Arch Dis.Child 1987;62(6):564-568. PubMed
  15. Silber, W. Pankreoflat in benign diseases of the oesophagus: a blind therapeutic trial. S.Afr.Med J 7-7-1973;47(26):1137-1138.
  16. Sack, J., Blau, H., Goldfarb, D., Ben-Zaray, S., and Katznelson, D. Hyperuricosuria in cystic fibrosis patients treated with pancreatic enzyme supplements. A study of 16 patients in Israel. Isr.J Med Sci. 1980;16(6):417-419.
  17. Oades, P. J., Bush, A., Ong, P. S., and Brereton, R. J. High-strength pancreatic enzyme supplements and large-bowel stricture in cystic fibrosis. Lancet 1-8-1994;343(8889):109. DOI
  18. Mac Sweeney, E. J., Oades, P. J., Buchdahl, R., Rosenthal, M., and Bush, A. Relation of thickening of colon wall to pancreatic-enzyme treatment in cystic fibrosis. Lancet 3-25-1995;345(8952):752-756. PubMed
  19. Jones, R., Franklin, K., Spicer, R., and Berry, J. Colonic strictures in children with cystic fibrosis on low-strength pancreatic enzymes. Lancet 8-19-1995;346(8973):499. DOI
  20. Taylor, C. J. and Steiner, G. M. Fibrosing colonopathy in a child on low-dose pancreatin. Lancet 10-21-1995;346(8982):1106-1107. PubMed
  21. Ong, P. S., Oades, P. J., Bush, A., and Brereton, R. J. Colonic stricture in a boy with cystic fibrosis. Postgrad.Med J 1995;71(835):309-312. PubMed
  22. Milla, C. E., Wielinski, C. L., and Warwick, W. J. High-strength pancreatic enzymes. Lancet 3-5-1994;343(8897):599. DOI
  23. McHugh, K., Thomson, A., and Tam, P. Case report: colonic stricture and fibrosis associated with high-strength pancreatic enzymes in a child with cystic fibrosis. Br.J Radiol. 1994;67(801):900-901. PubMed
  24. Nouisa-Arvanitakis, S., Stapleton, F. B., Linshaw, M. A., and Kennedy, J. Therapeutic approach to pancreatic extract-induced hyperuricosuria in cystic fibrosis. J Pediatr 1977;90(2):302-305. PubMed
  25. Lancellotti, L., Cabrini, G., Zanolla, L., and Mastella, G. High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. J Pediatr.Gastroenterol.Nutr. 1996;22(1):73-78. DOI
  26. FitzSimmons, S. C., Burkhart, G. A., Borowitz, D., Grand, R. J., Hammerstrom, T., Durie, P. R., Lloyd-Still, J. D., and Lowenfels, A. B. High-dose pancreatic-enzyme supplements and fibrosing colonopathy in children with cystic fibrosis. N.Engl.J Med 5-1- PubMed
  27. Stapleton, F. B., Kennedy, J., Nousia-Arvanitakis, S., and Linshaw, M. A. Hyperuricosuria due to high-dose pancreatic extract therapy in cystic fibrosis. N.Engl.J Med 7-29-1976;295(5):246-248. PubMed
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See these in context on the Pancreatic Enzyme Products monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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