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Dietary supplement

Durian Ingredients & Drug Interactions

by Hawaii Pharm

Durian label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Durian against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Durian is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for general nutrition and energy, traditional tonic or aphrodisiac, digestive support.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Durio zibethinus Fruit Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Durian by Hawaii Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Durian by Hawaii Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Durian by Hawaii Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 23, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This is a one-ingredient liquid extract of durian fruit. Durian is a tropical fruit high in sugar and calories, and this product delivers it in concentrated form rather than as whole fruit.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Durian product and its label doesn't state a use — see Durian's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness ratings for durian extract in the data we have, so we can't say what research supports its use or whether it's been studied for any particular purpose.

The evidence, ingredient by ingredient Durian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Durian is generally well tolerated as a food in moderate amounts, but the facts note it's high in sugar and calories — something to keep in mind if you're watching either. The safety data on durian supplements specifically is limited; the facts advise caution with supplement forms and large amounts, and suggest talking with your provider about whether it fits your health situation.

Adverse effects are rare but documented: a small number of case reports describe abdominal discomfort and bloating, diarrhea and vomiting, and allergic reactions (hives, nasal congestion, runny nose, and throat discomfort with hoarseness) after eating durian fruit. We don't have specific data on pregnancy or breastfeeding safety — talk with your doctor or pharmacist if you're pregnant, nursing, or planning either.

Side effects, ingredient by ingredient Durian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Durian.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The only medication type you should double-check before taking this product is alcohol — whether in drinks, cough syrups, or other sources. A traditional concern and a single case report link the combination to severe illness, though modern reports are extremely rare.

If you drink, confirm with your doctor or pharmacist that this product is appropriate for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Durian extract is a concentrated tropical fruit supplement with no established effectiveness in our data. If you drink alcohol, the combination carries a documented but very rare historical risk — worth discussing with your doctor or pharmacist before you start.

The biggest caution is the sugar and calorie load, especially in supplement form.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Durian, straight from the product label.

Brand Hawaii Pharm
Barcode (UPC) 840253619396
Net contents 4 Fluid Ounce(s); 120 mL
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 301558
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Durian by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
1 mL
Servings per container
120
UPC/BARCODE
840253619396
IngredientAmount% DV
Durio zibethinus Fruit Extract, Dry983 mg--

Other ingredients: Alcohol, Water, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Hawaii Pharm Herbal Extract Highest quality since 2008

Suggested/Recommended/Usage/Directions

Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.

Precautions

Warning: We recommend to seek expert medical advice before taking.

Do not use if you are allergic to any ingredients.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.

May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.

Keep out of the reach of children!

Storage

Store in a cool dry place.

Seals/Symbols

cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.

Organic Alcohol Based USA Made in United States of America

FDA Disclaimer Statement

This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Scan this QR-code to get 15% discount on your next purchase. Limited time deal.

Formula

Durio zibethinus

Organic Alcohol Based

Formulation

Only natural ingredients Purity is laboratory tested and verified

All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives

Not tested on animals

Organic Alcohol Based

Made in USA, Hawaii

FDA Statement of Identity

Herbal Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Durian by Hawaii Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Durian label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Durian by Hawaii Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.

Durio zibethinus Fruit Extract, Dry

Interacts with
1 drug
983 mg per serving

Durian is a popular tropical fruit valued mainly as a nutritious food rich in carbohydrates, fiber, vitamins, and antioxidants. While it has many trad...

Durio zibethinus Fruit Extract, Dry monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Durian by Hawaii Pharm Drug Interactions

Want to check YOUR meds against Durian?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Durio zibethinus Fruit Extract, Dry 1

Individual Drug Interactions

The ingredients in Durian interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Durian interact with drugs. Each result below shows which ingredient is responsible. Durio zibethinus Fruit Extract, Dry

Each ingredient & the kinds of drugs it affects

For each ingredient in Durian with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Durio zibethinus Fruit Extract, Dry1 drug type · 1 drug

Alcohol (Ethanol)

There is a traditional belief that ingestion of alcohol with durian can be fatal. A case report from 1941 describes an adult in India who developed acute hemorrhagic pancreatitis and died after drinking alcohol with durian, but there have been no other published reports since. A study in mice given homogenized durian fruit flesh in 10% ethanol did not demonstrate any toxicity. However, evidence from in vitro research shows that durian extract can inhibit alcohol dehydrogenase. This activity is similar to the effects of disulfiram. In theory, concomitant use might cause effects similar to disulfiram-ethanol reactions. Until more is known, avoid concomitant use of durian and alcohol.

Likelihood Possible Evidence D
Durio zibethinus Fruit Extract, Dry full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Durian, from the product label.

Hawaii Pharm

See all Hawaii Pharm products
Name
Hawaii Pharm LLC
Street Address
510 Sumner St. Ste. 613
City
Honolulu
State
HI
ZipCode
96817
Phone Number
888-854-2924
Web Address
www.hawaiipharm.com
Pharmacist Counseling Corner

Durian by Hawaii Pharm: Common Questions

Does Durian by Hawaii Pharm interact with any medications?
Yes. Based on its ingredients, Durian has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Durian contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is durian and why is it in a supplement?
Durian is a tropical fruit native to Southeast Asia, and this product is a concentrated liquid extract of it. The facts don't explain what health purpose it's intended for, so we can't tell you what to expect it to do.
Is durian safe to take if I don't drink alcohol?
Durian is generally well tolerated as a food in normal amounts, though the supplement form has less safety data. It's high in sugar and calories, so if that's a concern for you — like if you're managing blood sugar or weight — mention it to your doctor or pharmacist before starting.
Can I take this while pregnant or breastfeeding?
We don't have specific safety data for durian supplements during pregnancy or breastfeeding. Talk with your doctor or pharmacist to figure out whether it's right for you in that situation.
What are the side effects of durian?
Most people tolerate it without trouble, but a small number of case reports describe abdominal discomfort and bloating, diarrhea and vomiting, and allergic reactions including hives and throat irritation after eating durian fruit. These are uncommon.
Does this product contain alcohol?
Yes — the inactive ingredients list includes alcohol, water, and glycerin. That matters especially if you're avoiding alcohol for medical or personal reasons, so check the label and talk with your pharmacist if you have concerns.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Durian is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Durian label
Go deeper

The Full Monographs Behind Durian’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Durian

Interacts with 1 drug

Durian is a popular tropical fruit valued mainly as a nutritious food rich in carbohydrates, fiber, vitamins, and antioxidants. While it has many traditional medicinal uses, there is little...

Read the full Durian monograph →
Sources

Sources & How We Checked

Durian's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Durian 5 references
  1. Singh, P. Journal of the Malaya Branch British Medical Association 1941;5(1):62-63.
  2. Olivieri, J., Quiliquini-Chambard, A. M., and Hauser, C. Allergy to durian. Allergy 2002;57(3):263.
  3. Ogle, C. W. and Teh, Y. F. Durian and alcohol. A preliminary report. Singapore Med J 1969;10(4):288-290.
  4. Maninang JS, Lizada, MCC, Gemma, H. Inhibition of aldehyde dehydrogenase enzyme by Durian (Durio zibethinus Murray) fruit extract. Food Chem 2009;117(2):352-355. DOI
  5. Husin NA, Rahman S, Karunakaran R, Bhore SJ. A review on the nutritional, medicinal, molecular and genome attributes of Durian (Durio zibethinus L.) the king of fruits in Malaysia. Bioinformation 2018;14(6):265-70. PubMed

See these in context on the Durian monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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