Enzyme Advantage Ingredients & Drug Interactions
by Purium
What is this page for?
First and foremost: checking Enzyme Advantage against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Enzyme Advantage is a dietary supplement by Purium with 9 active ingredients. Its ingredients are commonly taken for lactose intolerance, gas and bloating after dairy, diarrhea from dairy foods.Based on those ingredients, 891 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sea Kelp. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Enzyme Advantage by Purium
Ask about any prescription or over-the-counter medication and we check it for interactions with Enzyme Advantage by Purium — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Enzyme Advantage by Purium
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Enzyme Advantage contains nine ingredients, including several digestive enzymes: lactase (which breaks down milk sugar), lipase (fat digestion), protease (protein digestion), cellulase, amylase (starch digestion), maltase (malt sugar digestion), and sucrase (table sugar digestion). It also includes sea kelp and what the label calls an "Assimilating Enhancing System." The only inactive ingredient listed is cellulose, a binding agent.
Does it work?
Strong evidence
Lactase is rated effective for lactose intolerance, so if you struggle to digest milk products, this enzyme may help. The other active ingredients — lipase, protease, and the rest — don't have established effectiveness ratings in our data for their intended uses like digestive upset or inflammatory bowel disease.
The evidence for them isn't firm enough to rate.
How safe is it?
Well-documented data
Lactase is generally well tolerated, though a rare occupational allergy to powdered lactase has been reported. Lipase and protease are generally well tolerated in supplement form for most adults, though protease may rarely cause digestive upset or allergic reactions, and occupational airborne exposure to proteolytic enzymes has triggered allergic rhinitis and asthma in some workers.
Sea kelp is the ingredient with the most caution: its high iodine content can disrupt thyroid function, cause goiter, or shift you between overactive and underactive thyroid depending on your health history. A rare case of thyroid cancer has been reported.
Because of iodine and possible heavy metal concentration, sea kelp is rated possibly unsafe in pregnancy and should be avoided while breastfeeding.
Meds to double-check
Moderate interaction found
Before taking Enzyme Advantage, double-check with your doctor or pharmacist if you take lithium, antithyroid drugs, thyroid hormone, or amiodarone — these have Moderate-severity documented interactions with sea kelp. Also clear it if you use blood thinners (anticoagulants) or antiplatelet drugs.
Several enzyme systems in your liver may theoretically be affected by sea kelp, though this hasn't been seen in people yet.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you have lactose intolerance, the lactase in this product is worth considering. However, if you take lithium, any thyroid medication, antithyroid drugs, or amiodarone, sea kelp makes this product risky for you — talk with your doctor or pharmacist before taking it.
The same goes if you take any blood thinner. For anyone else considering it, check your exact medications with the tool on this page to be sure.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Enzyme Advantage, straight from the product label.
| Brand | Purium |
|---|---|
| Barcode (UPC) | 764934026108 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 296263 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Enzyme Advantage by Purium, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lactase | 0 NP | -- |
| Lipase | 0 NP | -- |
| Protease | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Sea Kelp | 100 mg | -- |
| Amylase | 0 NP | -- |
| Maltase | 0 NP | -- |
| Proprietary Enzyme Blend | 420 mg | -- |
| Sucrase | 0 NP | -- |
| Assimilating Enhancing System | 0 NP | -- |
Other ingredients: Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
Peel back for more info
Pure + Premium We create Purium products using 6 core values as our foundation. By living these each day, we believe great change is possible in our humanity. Core Value No. 4 Responsibility Taking ownership for behaviors and decisions.
Committed to freeing our planet from plastic pollution, our new packaging is home compostable, for non-edible gardens and soil. Remove the label prior to home composting.
Formulation
Gluten-free
Vegetarian
Suggested/Recommended/Usage/Directions
Suggested Use: Take one capsule with each meal.
Storage
Store in a cool, dry place.
Precautions
Caution: Keep out of reach of children.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Enzyme Advantage by Purium label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Enzyme Advantage by Purium
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Lactase
No knowninteractions
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can red...
Lactase monograph & interactionsLipase
No knowninteractions
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy fo...
Lipase monograph & interactionsProtease
No knowninteractions
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...
Protease monograph & interactionsCellulase
Sea Kelp
Interacts with891 drugs
Fucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is l...
Sea Kelp monograph & interactionsAmylase
Maltase
Proprietary Enzyme Blend
- › Assimilating Enhancing System
Sucrase
Other (inactive) ingredients: Cellulose. These complete the product’s ingredient list but are not active constituents.
Enzyme Advantage by Purium Drug Interactions
HelloPharmacist Interaction Report
Enzyme Advantage by Purium has interactions documented for one of its nine ingredients: sea kelp.
The most serious concern is a Moderate-severity interaction with lithium, a mood-stabilizer medication, which has caused overactive thyroid (hyperthyroidism) in at least one patient. Sea kelp's high iodine content is the culprit.
Read the full breakdown — every affected drug type, severity by severity
Sea kelp also carries Moderate-severity interactions with antithyroid drugs, amiodarone (a heart rhythm medication), and thyroid hormone replacements — all because iodine can shift how your thyroid behaves, and high doses can push it either way depending on your history. Additionally, Minor-severity theoretical interactions exist with several enzyme systems in your liver (CYP2D6, CYP2C9, and CYP3A4 substrates) and with blood thinners (anticoagulants) and antiplatelet drugs, though these have not been confirmed in humans.
We could not check cellulase, amylase, maltase, sucrase, or the assimilating enhancing system — we hold no data for those ingredients. Altogether, these interactions span 892 individual medications.
Before you start, run your exact medications through the interaction checker on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Enzyme Advantage?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Enzyme Advantage interact with 891 drugs. Click any drug to see the details.
1 of the 9 ingredients in Enzyme Advantage interact with drugs. Each result below shows which ingredient is responsible. Sea Kelp
AmiodaroneCordarone, Pacerone
How Amiodarone interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 2c8 (cyp2c8) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Amiodarone interactionCarbimazoleNeo-Mercazole
How Carbimazole interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Sea Kelp + Carbimazole interactionConjugated EstrogensCenestin, Enjuvia, Premarin, Premarin Vaginal Cream
How Conjugated Estrogens interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Conjugated Estrogens interactionDesiccated Thyroid ExtractWesthroid, WP Thyroid
How Desiccated Thyroid Extract interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Desiccated Thyroid Extract interactionDesiccated Thyroid Extract (prescription Drug)Nature-Throid, Thyrar
How Desiccated Thyroid Extract (prescription Drug) interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Desiccated Thyroid Extract (prescription Drug) interactionDextrothyroxineCholoxin
How Dextrothyroxine interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Dextrothyroxine interactionHuman Chorionic Gonadotropin (hcg)Pregnyl
How Human Chorionic Gonadotropin (hcg) interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Human Chorionic Gonadotropin (hcg) interactionLevothyroxineEltroxin, Estre, Euthyrox, Levo-T, Levolet, Levothroid +5 more
How Levothyroxine interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Levothyroxine interactionLevothyroxine SodiumErmez, Thyquidity, Tirosint-Sol
How Levothyroxine Sodium interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Levothyroxine Sodium interactionLevothyroxine, LiothyronineArmour Thyroid
How Levothyroxine, Liothyronine interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Levothyroxine, Liothyronine interactionLiothyronineCytomel
How Liothyronine interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Liothyronine interactionLiotrixEuthroid 1, Euthroid 1/2, Euthroid 3
How Liotrix interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Liotrix interactionLiotrix, T4/t3Euthroid 2
How Liotrix, T4/t3 interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Liotrix, T4/t3 interactionLithium Carbonate (prescription Drug)Eskalith, Lithium Carbonate
How Lithium Carbonate (prescription Drug) interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpLithium Moderate
Interaction Summary
Concomitant use of Fucus vesiculosus and lithium has resulted in hyperthyroidism.
Read the full Sea Kelp + Lithium Carbonate (prescription Drug) interactionMenotropinsMenopur, Repronex
How Menotropins interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Menotropins interactionMethenamine MandelateMandelamine, Methimazole
How Methenamine Mandelate interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Sea Kelp + Methenamine Mandelate interactionMethimazoleTapazole
How Methimazole interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Sea Kelp + Methimazole interactionOspemifeneOsphena
How Ospemifene interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Ospemifene interactionPotassium Iodide (prescription Drug)Thyro-Block
How Potassium Iodide (prescription Drug) interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Sea Kelp + Potassium Iodide (prescription Drug) interactionPropylthiouracil, PtuPropylthiouracil
How Propylthiouracil, Ptu interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAntithyroid Drugs Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Read the full Sea Kelp + Propylthiouracil, Ptu interactionTestosterone UndecanoateAndriol, Aveed, Jatenzo, Kyzatrex
How Testosterone Undecanoate interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates, Thyroid Hormone Moderate
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Testosterone Undecanoate interactionThyroglobulinProloid
How Thyroglobulin interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Thyroglobulin interactionThyroid HormoneEtwon
How Thyroid Hormone interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpThyroid Hormone Moderate
Interaction Summary
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Read the full Sea Kelp + Thyroid Hormone interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAnticoagulant/antiplatelet Drugs Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Sea Kelp + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpAnticoagulant/antiplatelet Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates Minor
Interaction Summary
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Read the full Sea Kelp + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Enzyme Advantage — through 1 ingredient. Tap an ingredient for the detail:
Sea KelpCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
Read the full Sea Kelp + Acalabrutinib interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Enzyme Advantage with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sea Kelp
Amiodarone (Cordarone)
Theoretically, combining Fucus vesiculosus with amiodarone might cause excessively high iodine levels.
Fucus vesiculosus contains high concentrations of iodine. Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.
Antithyroid Drugs
Due to its iodine content, Fucus vesiculosus might alter the effects of antithyroid drugs.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using antithyroid drugs could alter the effects of the antithyroid drugs.
Lithium
Concomitant use of Fucus vesiculosus and lithium has resulted in hyperthyroidism.
There is a case of hyperthyroidism occurring in a patient taking Fucus vesiculosus and lithium. Monitor thyroid hormones closely in patients taking lithium and Fucus vesiculosus concomitantly.
Thyroid Hormone
Due to its iodine content, Fucus vesiculosus might alter the effects of thyroid hormone.
Fucus vesiculosus contains high concentrations of iodine. Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking Fucus vesiculosus while using thyroid hormone could alter the effects of thyroid hormone.
Anticoagulant/Antiplatelet Drugs
Theoretically, taking Fucus vesiculosus with antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
In vitro evidence suggests that a constituent of Fucus vesiculosus, known as fucoidan, has anticoagulant effects. However, in clinical research, fucoidan does not seem to have significant anticoagulant activity when taken orally, possibly due to poor absorption.
Cytochrome P450 2C8 (Cyp2C8) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2C8 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C8. This interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2C9 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP2C9. This interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP2D6 substrates might alter the effects of these substrates.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, both inhibits and induces CYP2D6. This interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, concomitant use of Fucus vesiculosus with CYP3A4 substrates might increase the risk for adverse effects.
In vitro research shows that fucoidan, a constituent of Fucus vesiculosus, inhibits CYP3A4. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Enzyme Advantage, from the product label.
Purium
See all Purium products- Name
- Purium
- Street Address
- 2610 Homestead Place
- City
- Rancho Dominguez
- State
- CA
- ZipCode
- 90220
- Phone Number
- 1-888-747-6733
- Web Address
- ishoppurium.com
Enzyme Advantage by Purium: Common Questions
Does Enzyme Advantage by Purium interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this product safe during pregnancy?
Can I use this while breastfeeding?
What does lactase do, and does it actually work?
What's the sea kelp for, and why should I worry about it?
Can I take this if I have celiac disease or a food sensitivity?
Are there any reported side effects from taking these enzymes?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Enzyme Advantage is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Enzyme Advantage’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lactase
Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...
Read the full Lactase monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographFucus Vesiculosus
Interacts with 891 drugsFucus vesiculosus (bladderwrack) is a brown seaweed rich in iodine that has been used traditionally for thyroid concerns, weight, and skin. There is little solid human evidence to support mo...
Read the full Fucus Vesiculosus monograph →Sources & How We Checked
Enzyme Advantage's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 20 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lactase 1 reference
- Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Fucus Vesiculosus 15 references
- Goodman GA, Rall TW, Nies AS, Taylor P. The Pharmacological Basis of Therapeutics, 9th ed.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
- Phaneuf D, Cote I, Dumas P, et al. Evaluation of the contamination of marine algae (Seaweed) from the St. Lawrence River and likely to be consumed by humans. Environ Res 1999;80:S175-S182. PubMed
- Durig J, Bruhn T, Zurborn KH, et al. Anticoagulant fucoidan fractions from Fucus vesiculosus induce platelet activation in vitro. Thromb Res 1997;85:479-91. PubMed
- Conz PA, La Greca G, Benedetti P, et al. Fucus vesiculosus: a nephrotoxic alga? Nephrol Dial Transplant 1998;13:526-7.
- Ohye H, Fukata S, Kanoh M, et al. Thyrotoxicosis caused by weight-reducing herbal medicines. Arch Intern Med 2005;165:831-4. PubMed
- Okamura K, Inoue K, Omae T. A case of Hashimoto's thyroiditis with thyroid immunological abnormality manifested after habitual ingestion of seaweed. Acta Endocrinol (Copenh) 1978;88:703-12. PubMed
- Agarwal SC, Crook JR, Pepper CB. Herbal remedies -- how safe are they? A case report of polymorphic ventricular tachycardia/ventricular fibrillation induced by herbal medication used for obesity. Int J Cardiol 2006;106:260-1. PubMed
- Sterling JB, Heymann WR. Potassium iodide in dermatology: a 19th century drug for the 21st century-uses, pharmacology, adverse effects, and contraindications. J Am Acad Dermatol 2000;43:691-7. PubMed
- Catania, M. A., Oteri, A., Caiello, P., Russo, A., Salvo, F., Giustini, E. S., Caputi, A. P., and Polimeni, G. Hemorrhagic cystitis induced by an herbal mixture. South.Med.J. 2010;103(1):90-92. PubMed
- Cumashi, A., Ushakova, N. A., Preobrazhenskaya, M. E., D'Incecco, A., Piccoli, A., Totani, L., Tinari, N., Morozevich, G. E., Berman, A. E., Bilan, M. I., Usov, A. I., Ustyuzhanina, N. E., Grachev, A. A., Sanderson, C. J., Kelly, M., Rabinovich, G. A., I
- Irhimeh, M. R., Fitton, J. H., and Lowenthal, R. M. Pilot clinical study to evaluate the anticoagulant activity of fucoidan. Blood Coagul.Fibrinolysis 2009;20(7):607-610. PubMed
- Arbaizar, B. and Llorca, J. [Fucus vesiculosus induced hyperthyroidism in a patient undergoing concomitant treatment with lithium]. Actas Esp.Psiquiatr. 2011;39(6):401-403.
- Church FC, Meade JB, Treanor RE, and et al. Antithrombin activity of fucoidan. The interaction of fucoidan with heparin cofactor II, antithrombin III, and thrombin. J Biol Chem 2-25-1989;264(6):3618-3623. DOI
- Mathew L, Burney M, Gaikwad A, et al. Preclinical evaluation of safety of fucoidan extracts from Undaria pinnatifida and Fucus vesiculosus for use in cancer treatment. Integr Cancer Ther 2017;16(4):572-84.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC