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Dietary supplement

Enzyme Packet Ingredients & Drug Interactions

by Nature's Sunshine

Enzyme Packet label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Oct 7, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Enzyme Packet against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Enzyme Packet is a dietary supplement by Nature's Sunshine with 7 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Enzyme Packet by Nature's Sunshine

Ask about any prescription or over-the-counter medication and we check it for interactions with Enzyme Packet by Nature's Sunshine — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Enzyme Packet by Nature's Sunshine

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Oct 1, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 7 active ingredients.
  • “Proprietary Enzyme Blend” is a proprietary blend — the label gives one combined amount (800 mg) without saying how much of each component you get.

This packet contains 7 active ingredients: bromelain (a pineapple enzyme), protease (a protein-digesting enzyme), cellulase, hemicellulase, biotin (a B vitamin), amylase, and glucoamylase (starch-digesting enzymes). Together they're meant to support digestive breakdown of proteins, carbohydrates, and fiber.

The inactive ingredients are gelatin, water, cellulose, rice bran, and medium-chain triglyceride—these are the capsule shell and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: digestive enzyme and metabolic support.
  • We looked for evidence on: Exercise-induced muscle soreness, Postoperative pain, Postoperative swelling, Rhinosinusitis, Wound healing, inflammation — and 1 related terms.
  • The closest evidence on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Bromelain is rated "Insufficient Reliable Evidence To Rate" for Postoperative pain, Rhinosinusitis, Wound healing, Postoperative swelling.

The data we hold shows bromelain's effectiveness is not established for most uses people try it for—hay fever, burns, cancer prevention, nerve pain, circulation, and diabetes all have insufficient evidence. Biotin, on the other hand, is likely effective for biotin deficiency and possibly ineffective for multiple sclerosis and seborrheic dermatitis.

For protease and the other digestive enzymes in this blend, we have no effectiveness ratings on file.

The evidence, ingredient by ingredient Biotin Bromelain Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain is generally well tolerated short-term, but long-term safety data is limited. The most common side effects orally are diarrhea, flatulence, stomach upset, and headache.

Allergic reactions are possible—if you're sensitive to pineapple or have a history of enzyme allergies, be cautious. Protease may cause digestive upset or allergic reactions in some people.

Biotin is generally safe even at higher doses because your body removes excess through urine; high-dose bromelain is not recommended during pregnancy or breastfeeding. For biotin during pregnancy, dietary amounts and prenatal vitamins are fine, but high-dose supplements should be cleared with your doctor first.

Breastfeeding safety with protease hasn't been well studied.

Side effects, ingredient by ingredient Biotin Bromelain Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (such as warfarin, aspirin, or clopidogrel)—bromelain may increase bleeding risk. Also check if you take tetracycline antibiotics, where bromelain may theoretically raise drug levels.

No other interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This is an enzyme blend for digestive support. If you take blood thinners, antiplatelet drugs, tetracycline antibiotics, or any prescription medication, check with your doctor or pharmacist before starting—some ingredients have documented interactions.

If you're pregnant or breastfeeding, talk it over with your healthcare provider first, since safety data for most of these enzymes in those periods is limited or unknown.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Enzyme Packet, straight from the product label.

Brand Nature's Sunshine
Net contents 42 Packet(s); 84 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2024
DSLD ID 313078
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Enzyme Packet by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Packet(s)
Maximum serving Sizes:
1 Packet(s)
Servings per container
42
IngredientAmount% DV
Bromelain0 NP--
Protease0 NP--
Cellulase0 NP--
Hemicellulase0 NP--
Biotin300 mcg1000%
Amylase0 NP--
Glucoamylase0 NP--
Proprietary Enzyme Blend800 mg--

Other ingredients: Gelatin, Water, Cellulose, Rice Bran, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommended use: Take contents of one Enzyme Packet three times daily on an empty stomach.

Dietary recommendations while taking Candida Clear Foods to avoid: sugary foods, foods high in simple carbohydrates, alcohol, starchy foods, high-glycemic fruits, fermented foods, mushrooms, vinegar, foods high in gluten, foods that contain yeast and mold, cheese, and most other dairy products. Foods to eat: vegetables, foods high in protein, meats, plain yogurt, nuts (almonds), berries (strawberries, raspberries), grains low in gluten (quinoa, chia, flax), and green foods. Complement Candida Clear with Nature's Sunshine's NutriBiome line of probiotics which will help populate the gut with friendly bacteria.

Precautions

Notice: Consult your health care provider prior to using this product if you are taking blood thinning medications, or have a bleeding disorder. Pregnant or lactating should consult their health care provider prior to taking this supplement.

Inner packets not intended or labeled for individual sale. This carton was sealed for your protection. Do not use if seal is missing or damaged.

Formulation

Nature's Sunshine uses natural source materials that are subject to color variation.

Targeted intestinal and immune support 14 day program

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Please recycle this carton. We are committed to you and our planet. Scan QR code to learn more.

New look! Same great product

Improper diet, refined foods, low-fiber foods and fast foods can cause an imbalance in the gut and digestive system. This imbalance can limit the body's ability to fully absorb vital nutrients needed for optimal health.

Enzyme Packet 2 Enzyme capsules

84 Packets (42 combo, 42 enzyme)

Formula

Biotin Supports enzymes that play a role in important metabolic processes.

Candida Clear with Pau D'arco, Caprylic Acid and Enzymes

Brand IP Statement(s)

Nature's Sunshine Herbal experts since 1972

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Guaranteed Pure

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Enzyme Packet by Nature's Sunshine label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Enzyme Packet label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Enzyme Packet by Nature's Sunshine

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Packet(s) Dosage formCapsule Servings per container42 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
300 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Proprietary Enzyme Blend

800 mg per serving
  • › Bromelain
  • › Protease
  • › Cellulase
  • › Hemicellulase
  • › Amylase
  • › Glucoamylase

Other (inactive) ingredients: Gelatin, Water, Cellulose, Rice Bran, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Enzyme Packet by Nature's Sunshine Drug Interactions

Want to check YOUR meds against Enzyme Packet?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Individual Drug Interactions

The ingredients in Enzyme Packet interact with 141 drugs. Click any drug to see the details.

1 of the 7 ingredients in Enzyme Packet interact with drugs. Each result below shows which ingredient is responsible. Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Enzyme Packet with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Enzyme Packet, from the product label.

Nature's Sunshine

See all Nature's Sunshine products
Name
Nature's Sunshine Products, Inc
City
Spanish Fork
State
Utah
ZipCode
84660
Phone Number
1-800-223-8225
Web Address
www.naturessunshine.com
Pharmacist Counseling Corner

Enzyme Packet by Nature's Sunshine: Common Questions

Does Enzyme Packet by Nature's Sunshine interact with any medications?
Yes. Based on its ingredients, Enzyme Packet has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Enzyme Packet contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my digestion?
These are digestive enzymes designed to support breakdown of proteins and carbohydrates. We don't have effectiveness ratings on file for most of them, so the evidence to support their digestive benefit isn't established in our data.
Can I take this if I'm pregnant?
Safety data for bromelain and protease in pregnancy is limited or absent, so they're best avoided. Biotin at dietary levels is likely safe, but high-dose supplements should be cleared with your doctor. Talk with your healthcare provider before taking this product while pregnant.
What are the side effects?
Bromelain most commonly causes diarrhea, flatulence, stomach upset, and headache when taken by mouth. Allergic reactions including asthma are rare but possible if you're sensitive to pineapple or enzymes. Protease may cause digestive upset or allergic reactions in some people.
Is biotin in here safe?
Yes—biotin is generally well tolerated, even at higher doses, because excess is removed in your urine. The only caution is high-dose biotin has rarely caused mild diarrhea, and you should check with your doctor before taking high-dose supplements if you're pregnant or breastfeeding.
Can I take this long-term?
Bromelain is generally well tolerated short-term, but evidence on long-term safety is limited. If you're thinking of taking this regularly, discuss it with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Enzyme Packet is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Enzyme Packet label
Go deeper

The Full Monographs Behind Enzyme Packet’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Enzyme Packet's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Biotin 4 references
  1. Debourdeau PM, Djezzar S, Estival JL, et al. Life-threatening eosinophilic pleuropericardial effusion related to vitamins B5 and H. Ann Pharmacother 2001;35:424-6. DOI
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  3. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9. PubMed
  4. Sedel F, Papeix C, Bellanger A, Touitou V, Lebrun-Frenay C, Galanaud D, et al. High doses of biotin in chronic progressive multiple sclerosis: a pilot study.Mult Scler Relat Disord. 2015;4(2):159-69. doi: 10.1016/j.msard.2015.01.005. PubMed

See these in context on the Biotin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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