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Dietary supplement

Essiac Gold with AHCC Ingredients & Drug Interactions

by Rene's Naturals

Essiac Gold with AHCC label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Essiac Gold with AHCC against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Essiac Gold with AHCC is a dietary supplement by Rene's Naturals with 5 active ingredients. Its ingredients are commonly taken for sore throat and cough, heartburn and acid reflux, digestive upset and ibs.Based on those ingredients, 2,203 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm bark extract, Turkey Rhubarb Root Extract, ACHH. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Essiac Gold with AHCC by Rene's Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Essiac Gold with AHCC by Rene's Naturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Essiac Gold with AHCC by Rene's Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Essiac Gold with AHCC contains five active ingredients: slippery elm bark extract, burdock root extract, AHCC (an extract from shiitake mushroom), sheep sorrel whole herb extract, and turkey rhubarb root extract. The product also contains inactive ingredients—hypromellose, microcrystalline cellulose, carnauba wax, dextrin, and magnesium stearate—which are fillers and binders used to form and preserve the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Immune system support and white blood cell activity.
  • We looked for evidence on: Common cold, Influenza, Bronchitis, Pharyngitis, Cough, Rhinosinusitis — and 4 related terms.
  • The closest evidence on file: Burdock is rated "Insufficient Reliable Evidence To Rate" for Breast cancer (Natural Medicines).
  • Also on file: Burdock is rated "Insufficient Reliable Evidence To Rate" for Common cold.
  • Also on file: Rhubarb is rated "Insufficient Reliable Evidence To Rate" for Nasopharyngeal cancer, Sepsis.

The effectiveness evidence for these ingredients is not established in our data. Rhubarb root has a "Possibly Effective" rating for menopausal symptoms and pancreatitis, but slippery elm, burdock, shiitake mushroom, and sorrel all carry "Insufficient Reliable Evidence To Rate" for the conditions they're traditionally used for—including digestive complaints, skin health, immune support, and respiratory issues.

This means there isn't enough solid research to confirm whether they work for their intended uses.

The evidence, ingredient by ingredient Slippery Elm Burdock Shiitake Mushroom Sorrel Rhubarb

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Slippery elm is generally well tolerated for short-term use, but long-term safety data are limited; the pollen and extracts can cause contact dermatitis or allergic reactions in some people. Burdock is likely safe as a food and for brief use, though serious allergic reactions including anaphylaxis are rare; a single case of drug-induced liver damage has been reported, though it's unclear whether burdock alone was responsible.

Shiitake mushroom (AHCC) is generally safe as food but concentrated supplements can cause abdominal discomfort, bloating, diarrhea, nausea, and vomiting; raw mushrooms may cause shiitake dermatitis, a distinctive skin eruption. Sorrel is safe in normal food amounts but contains high oxalates; concentrated doses have caused kidney damage in rare cases.

Rhubarb root is well tolerated at food levels but should not be used long-term as a laxative; chronic use can cause electrolyte loss, kidney problems, and dehydration. During pregnancy, burdock and rhubarb are rated possibly unsafe and should be avoided at medicinal doses; sorrel is rated possibly safe; data for slippery elm and shiitake mushroom during pregnancy are insufficient, so discuss with your doctor.

During breastfeeding, avoid medicinal amounts of slippery elm, burdock, sorrel, and rhubarb; data for shiitake mushroom are insufficient.

Side effects, ingredient by ingredient Slippery Elm Burdock Shiitake Mushroom Sorrel Rhubarb

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Burdock, Rhubarb, Shiitake Mushroom, Sorrel, Slippery Elm.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 2,204 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (burdock, sorrel, and rhubarb increase bleeding risk), corticosteroids or diuretics (rhubarb may worsen low potassium), digoxin (rhubarb raises toxicity risk), cyclosporine or other immunosuppressants (rhubarb may lower cyclosporine levels; shiitake may weaken immune therapy), any oral medication (slippery elm may slow absorption), drugs metabolized by liver enzyme CYP2D6 (shiitake may reduce levels), nephrotoxic drugs (rhubarb may increase kidney damage), hepatotoxic drugs (rhubarb may increase liver damage), or fexofenadine/Allegra (sorrel may reduce its effectiveness).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Essiac Gold with AHCC is a multi-ingredient herbal product with several moderate interactions affecting a large number of medications—particularly blood thinners, immunosuppressants, digoxin, cyclosporine, and several other drug classes. Effectiveness for any of its traditional uses is not well established in the research we hold.

If you take any prescription medication or have kidney or liver disease, check your specific medications with the tool on this page before starting, and discuss it with your doctor or pharmacist to see whether it's appropriate for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Essiac Gold with AHCC, straight from the product label.

Brand Rene's Naturals
Barcode (UPC) 623326018995
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 290185
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Essiac Gold with AHCC by Rene's Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
623326018995
IngredientAmount% DV
Slippery Elm bark extract27.4 mg--
Burdock Root Extract360.76 mg--
ACHH500 mg--
Sheep Sorrel Whole Herb Extract71.76 mg--
Turkey Rhubarb Root Extract12.2 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Carnauba Wax, Dextrin, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Do not use if safety seal under cap is broken.

For prolonged use, consult a healthcare practitioner.

Caution: Not to be taken by pregnant women or nursing mothers.

Keep out of reach of children.

Suggested/Recommended/Usage/Directions

Directions for use (adults): Take 2 capsules twice daily for daily use, one hour before or after meals. For prolonged use, consult a healthcare practitioner.

Formulation

Supports activity of white blood cells

Immune system support

100% Vegan

GMO free 100% natural product Non-irradiated Gluten free

Proprietary formula

Made in USA

General Statements

Supported by over 30 human studies

Authorized by Rene M. Caisse Trusted worldwide since 1922

Exported worldwide.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

AHCC is a standardized extract of cultured Lentinula edodes mycelia AHCC is a registered trademark of Amino Up Co,, Ltd., Japan

Copyright 2016. All rights reserved.

Seals/Symbols

cGMP registered good manufacturing practice

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Essiac Gold with AHCC by Rene's Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Essiac Gold with AHCC label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Essiac Gold with AHCC by Rene's Naturals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Slippery Elm bark extract

Interacts with
2,022 drugs
27.4 mg per serving

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...

Slippery Elm bark extract monograph & interactions

Burdock Root Extract

Interacts with
122 drugs
360.76 mg per serving

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and mo...

Burdock Root Extract monograph & interactions

ACHH

Interacts with
312 drugs
500 mg per serving Form: Shiitake Mushroom Mycelium Extract

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have b...

ACHH monograph & interactions

Sheep Sorrel Whole Herb Extract

Interacts with
169 drugs
71.76 mg per serving

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for an...

Sheep Sorrel Whole Herb Extract monograph & interactions

Turkey Rhubarb Root Extract

Interacts with
658 drugs
12.2 mg per serving

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal clai...

Turkey Rhubarb Root Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Carnauba Wax, Dextrin, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Essiac Gold with AHCC by Rene's Naturals Drug Interactions

Want to check YOUR meds against Essiac Gold with AHCC?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,203Drugs
2,203 Moderate

Ingredients driving the most interactions

Slippery Elm bark extract 2,022
Turkey Rhubarb Root Extract 658
ACHH 312
Sheep Sorrel Whole Herb Extract 169
Burdock Root Extract 122

Individual Drug Interactions

The ingredients in Essiac Gold with AHCC interact with 2,203 drugs. Click any drug to see the details.

5 of the 5 ingredients in Essiac Gold with AHCC interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm bark extract Turkey Rhubarb Root Extract ACHH Sheep Sorrel Whole Herb Extract Burdock Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Essiac Gold with AHCC with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Slippery Elm bark extract1 drug type · 2,022 drugs

Oral Drugs

Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.

Likelihood Possible Evidence D
Slippery Elm bark extract full monograph & interactions

Turkey Rhubarb Root Extract8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Turkey Rhubarb Root Extract full monograph & interactions

ACHH2 drug types · 312 drugs

Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.
In vitro studies suggest that the shiitake mushroom extract AHCC might induce the CYP2D6 enzyme. This effect has not been reported in humans.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, taking shiitake mushroom might decrease the effects of immunosuppressive therapy.
In vitro evidence suggests that shiitake mushroom extracts stimulate immune function.

Likelihood Possible Evidence D
ACHH full monograph & interactions

Sheep Sorrel Whole Herb Extract3 drug types · 169 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.

Likelihood Possible Evidence D
Fexofenadine (Allegra)

Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).

Likelihood Likely Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.

Likelihood Possible Evidence D
Sheep Sorrel Whole Herb Extract full monograph & interactions

Burdock Root Extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.

In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Burdock Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Essiac Gold with AHCC, from the product label.

Rene's Naturals

See all Rene's Naturals products
Name
ESSIAC FROM CANADA INT'L
City
Ottawa
State
Ontario
ZipCode
K1P 5P6
Phone Number
(561) 223-6003
Pharmacist Counseling Corner

Essiac Gold with AHCC by Rene's Naturals: Common Questions

Does Essiac Gold with AHCC by Rene's Naturals interact with any medications?
Yes. Based on its ingredients, Essiac Gold with AHCC has a known interaction with 2,203 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Essiac Gold with AHCC contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my blood thinner or aspirin?
No—not without checking first. Burdock, sorrel, and rhubarb root in this product all carry a moderate risk of increasing bleeding when combined with blood thinners like warfarin or antiplatelet drugs like aspirin or clopidogrel. Talk to your doctor or pharmacist about whether it's safe for you.
What are the side effects?
The most common side effects reported for these ingredients are gastrointestinal—abdominal discomfort, bloating, diarrhea, nausea, and vomiting, especially from the shiitake mushroom (AHCC). Slippery elm, burdock, sorrel, and rhubarb can each trigger allergic reactions including contact dermatitis in sensitive people. Rhubarb can also cause cramping and is not meant for long-term use as a laxative.
Is this safe to take while pregnant?
The safety data vary by ingredient. Burdock and rhubarb are rated possibly unsafe and should be avoided at medicinal doses during pregnancy. Sorrel is rated possibly safe, but slippery elm and shiitake mushroom have insufficient data to say either way. Talk with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
There isn't enough safety data to recommend medicinal amounts of slippery elm, burdock, sorrel, or rhubarb while nursing—the safety notes advise against them. Data for shiitake mushroom are insufficient. Discuss this with your doctor or pharmacist to decide what's safest for you and your baby.
Does this actually work for what it claims?
The evidence is limited. Rhubarb has a "Possibly Effective" rating for menopausal symptoms and pancreatitis, but slippery elm, burdock, shiitake mushroom, and sorrel don't have enough solid research to confirm they work for the conditions they're traditionally used for. There's simply not enough data to know.
What are the inactive ingredients, and are there fillers?
The product contains five inactive ingredients: hypromellose, microcrystalline cellulose, carnauba wax, dextrin, and magnesium stearate. These are standard fillers, binders, and capsule materials used in supplement manufacturing.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Essiac Gold with AHCC is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Essiac Gold with AHCC label
Go deeper

The Full Monographs Behind Essiac Gold with AHCC’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Slippery Elm

Interacts with 2,022 drugs

Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...

Read the full Slippery Elm monograph → Herb & supplement monograph

Burdock

Interacts with 122 drugs

Burdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...

Read the full Burdock monograph → Herb & supplement monograph

Shiitake Mushroom

Interacts with 312 drugs

Shiitake is a popular edible mushroom that is nutritious and safe to eat as food for most people. Some of its extracts (like lentinan and AHCC) have been studied as immune support, mainly al...

Read the full Shiitake Mushroom monograph → Herb & supplement monograph

Sorrel

Interacts with 169 drugs

Sorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...

Read the full Sorrel monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph →
Sources

Sources & How We Checked

Essiac Gold with AHCC's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 109 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Slippery Elm 3 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  3. Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed

See these in context on the Slippery Elm monograph →

Burdock 11 references
  1. Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
  2. Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
  3. Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
  4. Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
  5. Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
  6. Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
  7. Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
  8. Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
  9. <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
  10. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
  11. Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed

See these in context on the Burdock monograph →

Shiitake Mushroom 67 references
  1. Hitosugi M, Kitamura O, Takatsu A, Yoshino Y. Autopsy case of duodenal obstruction from impacted mushroom. J Gastroenterol 1998;33:562-5. PubMed
  2. Hanada K, Hashimoto I. Flagellate mushroom (Shiitake) dermatitis and photosensitivity. Dermatol 1998;197:255-7. PubMed
  3. Levy AM, Kita H, Phillips SF, et al. Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms. J Allergy Clin Immunol 1998;101:613-20. PubMed
  4. Murakami M, Kawabe K, Hosoi Y, et al. Decreased pulmonary perfusion in hypersensitivity pneumonitis caused by Shiitake mushroom spores. J Intern Med 1997;241:85-8. PubMed
  5. Matsui S, Nakazawa T, Umegae Y, Mori M. Hypersensitivity pneumonitis induced by Shiitake mushroom spores. Intern Med 1992;31:1204-6.
  6. Nakamura T. Shiitake (Lentinus edodes) dermatitis. Contact Dermatitis 1992;27:65-70.
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Sorrel 8 references
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Rhubarb 20 references
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