Essiac Tonic Ingredients & Drug Interactions
by Herbs, Etc.
What is this page for?
First and foremost: checking Essiac Tonic against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Essiac Tonic is a dietary supplement by Herbs, Etc. with 4 active ingredients. Its ingredients are commonly taken for skin conditions like acne and eczema, digestive support, diuretic ('detox') and blood purifier.Based on those ingredients, 2,130 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm Inner Bark Extract, Chinese Rhubarb Root Extract, Sheep Sorrel herb extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Essiac Tonic by Herbs, Etc.
Ask about any prescription or over-the-counter medication and we check it for interactions with Essiac Tonic by Herbs, Etc. — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Essiac Tonic by Herbs, Etc.
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Essiac Tonic contains 4 active ingredients, all delivered as extracts in a softgel capsule. The blend includes burdock root, sheep sorrel herb, slippery elm inner bark, and Chinese rhubarb root—each selected for traditional use, though modern evidence for most of these purposes remains limited.
The capsule itself is made from gelatin, glycerin, and water, with added carob, chlorophyll, olive oil, sunflower lecithin, and beeswax as inactive ingredients that help deliver and preserve the formula.
Does it work?
Moderate evidence
The evidence supporting Essiac Tonic's ingredients is sparse. Rhubarb shows possibly effective ratings for menopausal symptoms and pancreatitis, but the other three ingredients—burdock, sheep sorrel, and slippery elm—lack reliable evidence for the conditions they're traditionally used for, including acne, eczema, cough, bronchitis, and inflammatory bowel disease.
The data we hold does not establish effectiveness for most claimed uses of this product.
How safe is it?
Well-documented data
Burdock is generally well tolerated as a food and for short-term medicinal use, though serious allergic reactions including anaphylaxis are rare, and contact dermatitis has been reported. A case of liver injury was reported in someone taking a herbal blend containing burdock, though it's unclear whether burdock alone was responsible.
Sheep sorrel is generally safe in food amounts, but its high oxalate content can be a concern at concentrated medicinal doses; a case of acute kidney inflammation was reported in a child who consumed wild sorrel. Slippery elm is generally well tolerated short-term, though contact dermatitis and allergic reactions to its pollen can occur.
Rhubarb root commonly causes cramping, diarrhea, and gastrointestinal upset, and chronic use can lead to electrolyte loss, particularly potassium, and kidney damage. For pregnancy, burdock and rhubarb should be avoided at medicinal doses.
Sheep sorrel and slippery elm have insufficient safety data in pregnancy; talk with your doctor or pharmacist for personalized advice. During breastfeeding, burdock, rhubarb, and slippery elm carry cautions due to limited safety data; sheep sorrel is possibly safe but at food amounts only.
Meds to double-check
Moderate interaction found
Before taking Essiac Tonic, double-check your medications against these types, worst severity first: blood thinners and antiplatelet drugs (warfarin, aspirin, clopidogrel), diuretics, corticosteroids, stimulant laxatives, cyclosporine or other transplant medications, digoxin (a heart medication), and any other oral drugs (since slippery elm may slow their absorption). If you take fexofenadine (Allegra), this product may reduce its effectiveness.
Use the medication checker below to confirm your exact drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Essiac Tonic is built on traditional herbal ingredients with limited modern evidence for effectiveness. If you take any prescription medication—especially blood thinners, diuretics, corticosteroids, or immunosuppressants—you need to check this product against your exact medications before starting.
The formula can also cause digestive side effects and carries rare risks of allergic or liver reactions. Talk with your doctor or pharmacist about whether this product is right for you and your current health situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Essiac Tonic, straight from the product label.
| Brand | Herbs, Etc. |
|---|---|
| Barcode (UPC) | 765704604717 |
| Net contents | 120 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 300020 |
| Product type | Botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Essiac Tonic by Herbs, Etc., sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Extract Blend | 200 mg | -- |
| Burdock Root Extract | 0 NP | -- |
| Sheep Sorrel herb extract | 0 NP | -- |
| Slippery Elm Inner Bark Extract | 0 NP | -- |
| Chinese Rhubarb Root Extract | 0 NP | -- |
Other ingredients: Gelatin, Glycerin, Water, Purified, Carob, Chlorophyll, Extra Virgin Olive Oil, Sunflower Lecithin, Beeswax
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Value size
We apply our company philosophy to Essiac Tonic, as we do to all of our herbal medicines. That philosophy is to do what's right, which extends to choosing the right herbs, using the right processes and making the right formulations that support your health needs.
Formulation
Herbal medicine
Gluten free
Made in Santa Fe, NM.
No artificial preservatives.
Formula
Traditional four herb Ojibwa cleanse
Essiac Tonic stays true to the traditional four herb Ojibwa cleanse formula.
FDA Statement of Identity
Herbal Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take one softgel with water twice a day on an empty stomach.
Precautions
Caution: Do not use during pregnancy.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brand IP Statement(s)
We do all of this to bring you herbal medicines made right.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Essiac Tonic by Herbs, Etc. label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Essiac Tonic by Herbs, Etc.
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Extract Blend
Other (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Carob, Chlorophyll, Extra Virgin Olive Oil, Sunflower Lecithin, Beeswax. These complete the product’s ingredient list but are not active constituents.
Essiac Tonic by Herbs, Etc. Drug Interactions
HelloPharmacist Interaction Report
Essiac Tonic by Herbs, Etc. does interact with medications through its burdock root, sheep sorrel, slippery elm, and rhubarb root content.
The most serious concern is rhubarb's potential to increase bleeding risk when combined with warfarin (a blood thinner), a Moderate-severity interaction. Rhubarb's laxative effects can also compound potassium loss if you're taking diuretics (water pills), corticosteroids, or other stimulant laxatives—all Moderate-severity risks.
Additionally, rhubarb may reduce levels of cyclosporine, a transplant and autoimmune medication.
Read the full breakdown — every affected drug type, severity by severity
Burdock and sheep sorrel both carry a Moderate risk with blood thinners and antiplatelet drugs (such as aspirin or clopidogrel), as lab work shows they may slow clotting, though this hasn't been reported in people. Sheep sorrel also may reduce the absorption and effectiveness of fexofenadine (an antihistamine), and more broadly might interfere with absorption of other OATP substrate drugs—a group of medications that depends on a specific transport system in your gut.
Slippery elm carries a Moderate risk with oral medications in general; its mucilage content may slow the absorption of drugs you swallow, potentially lowering their levels in your blood.
Altogether, these interactions span 2,131 individual medications. Use the medication checker on this page to see if any of yours are affected, and talk with your doctor or pharmacist before starting Essiac Tonic.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Essiac Tonic?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Essiac Tonic interact with 2,130 drugs. Click any drug to see the details.
4 of the 4 ingredients in Essiac Tonic interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm Inner Bark Extract Chinese Rhubarb Root Extract Sheep Sorrel herb extract Burdock Root Extract
"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Essiac Tonic — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + 6-mercaptopurine interactionChinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + 6-mercaptopurine interactionAbacavirZiagen
How Abacavir interacts with Essiac Tonic — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Abacavir, Lamivudine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Essiac Tonic — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abciximab interactionSheep Sorrel Herb ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel Herb Extract + Abciximab interactionBurdock Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock Root Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Essiac Tonic — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abiraterone interactionChinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Abiraterone Acetate interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Essiac Tonic — through 3 ingredients. Tap an ingredient for the detail:
Burdock Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock Root Extract + Abrocitinib interactionSheep Sorrel Herb ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel Herb Extract + Abrocitinib interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Essiac Tonic — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Essiac Tonic — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acarbose interactionChinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acebutolol interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Essiac Tonic — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acenocoumarol interactionSheep Sorrel Herb ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel Herb Extract + Acenocoumarol interactionBurdock Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock Root Extract + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Essiac Tonic — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen interactionChinese Rhubarb Root ExtractNephrotoxic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Chinese Rhubarb Root Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Essiac Tonic — through 4 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Aspirin interactionBurdock Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock Root Extract + Acetaminophen, Aspirin interactionSheep Sorrel Herb ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel Herb Extract + Acetaminophen, Aspirin interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Essiac Tonic — through 4 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Aspirin, Caffeine interactionSheep Sorrel Herb ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
Read the full Sheep Sorrel Herb Extract + Acetaminophen, Aspirin, Caffeine interactionChinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Aspirin, Caffeine interactionBurdock Root ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
Read the full Burdock Root Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractNephrotoxic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Butalbital interactionChinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractNephrotoxic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Butalbital, Caffeine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionChinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractNephrotoxic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Butalbital, Codeine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Caffeine, Codeine interactionChinese Rhubarb Root ExtractNephrotoxic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Chinese Rhubarb Root ExtractHepatotoxic Drugs, Nephrotoxic Drugs Moderate
Interaction Summary
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionSlippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Essiac Tonic — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm Inner Bark ExtractOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm Inner Bark Extract + Acetaminophen, Caffeine, Isometheptene interactionChinese Rhubarb Root ExtractNephrotoxic Drugs, Hepatotoxic Drugs Moderate
Interaction Summary
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
Read the full Chinese Rhubarb Root Extract + Acetaminophen, Caffeine, Isometheptene interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Essiac Tonic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Slippery Elm Inner Bark Extract
Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
Chinese Rhubarb Root Extract
Corticosteroids
Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.
Cyclosporine (Neoral, Sandimmune)
Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.
Digoxin (Lanoxin)
Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.
Diuretic Drugs
Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.
Hepatotoxic Drugs
Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.
Nephrotoxic Drugs
Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.
Stimulant Laxatives
Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.
Sheep Sorrel herb extract
Anticoagulant/Antiplatelet Drugs
Theoretically, sorrel might cause additive effects and side effects when used with anticoagulant or antiplatelet drugs.
In vitro, sorrel has been shown to inhibit platelet aggregation. However, this effect has not been reported in humans.
Fexofenadine (Allegra)
Sorrel might reduce the effectiveness of fexofenadine by reducing its absorption from the gut.
In vitro research shows that an ethanol extract of sorrel inhibits organic anion-transporting polypeptide 1A2 (OATP1A2), which transports fexofenadine from the intestine into cells. In rats, concomitant administration of sorrel extract with fexofenadine reduces oral absorption of fexofenadine and the area under the plasma concentration-time curve (AUC).
Organic Anion-Transporting Polypeptide Substrates (Oatp)
Sorrel might reduce the effectiveness of OATP substrates by reducing their absorption from the gut.
In vitro research shows that sorrel inhibits OATP1A2. Theoretically it may inhibit other OATPs. The OATPs are expressed in the small intestine and liver and transport drugs into cells. Inhibition of OATP may reduce the bioavailability of oral drugs that are substrates of OATP.
Burdock Root Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, taking burdock with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lignans from burdock reduce rabbit platelet aggregation by inhibiting platelet activating factor. This interaction has not been reported in humans.
Brand information
Manufacturer and brand details for Essiac Tonic, from the product label.
Herbs, Etc.
See all Herbs, Etc. products- Name
- Herbs Etc., Inc.
- Street Address
- 1340 Rufina Circle
- City
- Sante Fe
- State
- NM
- ZipCode
- 87507
- Web Address
- www.herbsetc.com
Essiac Tonic by Herbs, Etc.: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Essiac Tonic’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Burdock
Interacts with 122 drugsBurdock is a traditional herb most often used for skin problems and as a so-called 'blood purifier,' but high-quality human studies are lacking and most claims are not well proven. It is wid...
Read the full Burdock monograph → Herb & supplement monographSorrel
Interacts with 169 drugsSorrel is a tangy, leafy herb used in cooking and traditional medicine, often for congestion, digestion, and inflammation. Solid human evidence for any health benefit is limited, and its hig...
Read the full Sorrel monograph → Herb & supplement monographSlippery Elm
Interacts with 2,022 drugsSlippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...
Read the full Slippery Elm monograph → Herb & supplement monographRhubarb
Interacts with 658 drugsRhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...
Read the full Rhubarb monograph →Sources & How We Checked
Essiac Tonic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 42 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Burdock 11 references
- Iwakami S, Wu JB, Ebizuka Y, Sankawa U. Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. Chem Pharm Bull (Tokyo) 1992;40:1196-8. PubMed
- Sasaki Y, Kimura Y, Tsunoda T, Tagami H. Anaphylaxis due to burdock. Int J Dermatol 2003;42:472-3. PubMed
- Rhoads PM, Tong TG, Banner W Jr, Anderson R. Anticholinergic poisonings associated with commercial burdock root tea. J Toxicol Clin Toxicol 1984-85;22:581-4. PubMed
- Rodriguez P, Blanco J, Juste S, et al. Allergic contact dermatitis due to burdock (Arctium lappa). Contact Dermatitis 1995;33:134-5.
- Kassler, W. J., Blanc, P., and Greenblatt, R. The use of medicinal herbs by human immunodeficiency virus-infected patients. Arch Intern Med 1991;151(11):2281-2288. DOI
- Chan, Y. S., Cheng, L. N., Wu, J. H., Chan, E., Kwan, Y. W., Lee, S. M., Leung, G. P., Yu, P. H., and Chan, S. W. A review of the pharmacological effects of Arctium lappa (burdock). Inflammopharmacology. 2011;19(5):245-254. PubMed
- Breed, F. B. and Kuwabara, T. Burdock ophthalmia. Arch Ophthalmol 1966;75(1):16-20.
- Bryson, P. D., Watanabe, A. S., Rumack, B. H., and Murphy, R. C. Burdock root tea poisoning. Case report involving a commercial preparation. JAMA 5-19-1978;239(20):2157. DOI
- <p>Fletcher GF<span>, </span>Cantwell JD. Burdock root tea poisoning. JAMA <span>1978 Oct 6;240(15):1586.</span></p> DOI
- Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed
- Niazi B, Ahmed K, Ahmed M, Ali S, Song K, Elias S. Drug-Induced Liver Injury from Herbal Liver Detoxification Tea. Case Rep Gastroenterol 2022;16(3):612-617. PubMed
Sorrel 8 references
- Neubauer N, Marz RW. Placebo-controlled, randomized, double-blind, clincal trial with Sinupret sugar coated tablets on the basis of a therapy with antibiotics and decongestant nasal drops in acute sinusitis. Phytomedicine 1994;1:177-81.
- Marz RW, Ismail C, Popp MA. Action profile and efficacy of a herbal combination preparation for the treatment of sinusitis. Wien Med Wochenschr 1999;149:202-8.
- Zick, S. M., Sen, A., Feng, Y., Green, J., Olatunde, S., and Boon, H. Trial of Essiac to ascertain its effect in women with breast cancer (TEA-BC). J Altern Complement Med 2006;12(10):971-980. PubMed
- Sanz, P. and Reig, R. Clinical and pathological findings in fatal plant oxalosis. A review. Am J Forensic Med Pathol. 1992;13(4):342-345. PubMed
- Gniazdowska, B., Doroszewska, G., and Doroszewski, W. [Hypersensitivity to weed pollen allergens in the region of Bygdoszcz]. Pneumonol.Alergol.Pol. 1993;61(7-8):367-372.
- Selçuk SN, Gülhan B, Düzova A, Teksam Ö. Acute tubulointerstitial nephritis due to large amount of sorrel (Rumex acetosa) intake. Clin Toxicol (Phila) 2015;53(5):497. PubMed
- Ahn JH, Kim J, Rehman NU, Kim HJ, Ahn MJ, Chung HJ. Effect of Rumex Acetosa Extract, a Herbal Drug, on the Absorption of Fexofenadine. Pharmaceutics. 2020;12(6):E547. PubMed
- Jeong D, Irfan M, Lee DH, Hong SB, Oh JW, Rhee MH. Rumex acetosa modulates platelet function and inhibits thrombus formation in rats. BMC Complement Med Ther. 2020;20(1):98. PubMed
Slippery Elm 3 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Czarnecki D, Nixon R, Bekhor P, and et al. Delayed prolonged contact urticaria from the elm tree. Contact Dermatitis 1993;28:196-197. PubMed
Rhubarb 20 references
- Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Kwan TH, Tong MK, Leung KT, et al. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Hong Kong Med J 2006;12:394-7.
- Fairbairn JW. The anthraquinone laxatives. Biological assay and its relation to chemical structure. Pharmacology 1976;14:48-61. PubMed
- Siegers, C. P., Hertzberg-Lottin, E., Otte, M., and Schneider, B. Anthranoid laxative abuse--a risk for colorectal cancer? Gut 1993;34(8):1099-1101. PubMed
- Fan, J. G. Evaluating the efficacy and safety of Danning Pian in the short-term treatment of patients with non-alcoholic fatty liver disease: a multicenter clinical trial. Hepatobiliary.Pancreat.Dis.Int 2004;3(3):375-380.
- Yan, M., Zhang, L. Y., Sun, L. X., Jiang, Z. Z., and Xiao, X. H. Nephrotoxicity study of total rhubarb anthraquinones on Sprague Dawley rats using DNA microarrays. J Ethnopharmacol. 4-15-2006; PubMed
- Zhang, J. H., Li, L. S., and Zhang, M. Clinical effects of rheum and captopril on preventing progression of chronic renal failure. Chin Med J (Engl.) 1990;103(10):788-793.
- Mitsuma, T., Yokozawa, T., Oura, H., and Terasawa, K. [Rhubarb therapy in patients with chronic renal failure (Part 2)]. Nippon Jinzo Gakkai Shi 1987;29(2):195-207.
- Wu, C. X. [A preliminary study on the effect of a single Rheum officinale in heavy doses in the treatment of acute icteric hepatitis]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(2):88-89.
- Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Zhong.Xi.Yi.Jie.He.Za Zhi.(Chinese Journal of Modern Developments in Traditional Medicine) 1984;4(10):597-600, 579.
- Jiao, D. H., Ma, Y. H., Chen, S. J., Liu, C. T., Shu, H. N., and Chu, C. M. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Pharmacology 1980;20 Suppl 1:128-130.
- Zhang, JH, Yao, XD, Song, Y, and et al. [Long-term treating effects of rhubarb and captopril in delaying the progression of renal failure]. Chinese Kidney Disease Journal 1993;9(4):197-201.
- Rehman H, Begum W, Anjum F, Tabasum H, Zahid S. Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial. J Complement Integr Med. 2015 Mar;12(1):61-9.
- Yu CP, Lin HJ, Lin SP, Shia CS, Chang PH, Hou YC, Hsieh YW. Rhubarb decreased the systemic exposure of cyclosporine, a probe substrate of P-glycoprotein and CYP 3A. Xenobiotica. 2016 Aug;46(8):677-82. PubMed
- Byeon JH, Kil JH, Ahn YC, Son CG. Systematic review of published data on herb induced liver injury. J Ethnopharmacol 2019;233:190-6. PubMed
- Zhao D, Feng SX, Zhang HJ, et al. Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale. Xenobiotica. 2021;51(8):916-925. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC