Exxstane Ingredients & Drug Interactions
by Vaxxen Labs
What is this page for?
First and foremost: checking Exxstane against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Exxstane is a dietary supplement by Vaxxen Labs with 2 active ingredients. Its ingredients are commonly taken for lowering estrogen levels, post-cycle therapy after steroid or prohormone use, reducing gynecomastia ('gyno').Based on those ingredients, 4 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Androsta-3,5-Diene-7,17-Dione. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Exxstane by Vaxxen Labs
Ask about any prescription or over-the-counter medication and we check it for interactions with Exxstane by Vaxxen Labs — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Exxstane by Vaxxen Labs
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Exxstane contains 2 active ingredients: Androsta-3,5-Diene-7,17-Dione (also called Arimistane) and Safed musli. Arimistane is a hormone-altering compound believed to work via the aromatase enzyme.
Safed musli is a plant-based ingredient traditionally used in herbal formulations. The remaining ingredients—rice powder, gelatin, magnesium stearate, silicon dioxide, and food colorings—are inactive excipients that give the capsule its form and stability.
Does it work?
Not established
The evidence we hold shows insufficient reliable data to rate either ingredient for athletic performance, muscle strength, erectile dysfunction, sexual arousal, or obesity. In other words, the science backing these uses isn't established in the sources we have on file.
If you're considering this product for one of those purposes, talk it over with your doctor about what the current research actually supports.
How safe is it?
Some data gaps
Arimistane carries serious safety concerns. Regulators warn against aromatase inhibitor supplements because the safety data are thin and it's a hormone-altering drug.
It is possibly unsafe in pregnancy—lowering estrogen during pregnancy could be harmful, so do not use it if you're pregnant. There's no safety data for breastfeeding, so avoid it unless your doctor advises otherwise.
Safed musli is generally well tolerated in traditional use, but high-quality human safety studies are limited. It's best avoided in pregnancy due to insufficient safety information, and its safety while breastfeeding is unknown, so check with your doctor or pharmacist before using it if you're nursing.
Meds to double-check
Moderate interaction found
Before you take Exxstane, double-check any aromatase inhibitors you're on—the Moderate-severity interaction here could raise your risk of low-estrogen side effects or liver stress. If you take other prescription drugs, run them through the checker on this page or confirm with your pharmacist that they're safe to combine with this product.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.
This is a hormone-altering product with limited safety data and significant cautions around pregnancy and breastfeeding. If you take any aromatase inhibitors or other medications, check them against this product's interactions before starting.
Anyone pregnant, breastfeeding, or managing a hormone-sensitive condition should talk with their doctor or pharmacist first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Exxstane, straight from the product label.
| Brand | Vaxxen Labs |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 22, 2019 |
| DSLD ID | 210065 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Exxstane by Vaxxen Labs, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Androsta-3,5-Diene-7,17-Dione | 75 mg | -- |
| Safed musli | 500 mg | -- |
Other ingredients: Rice powder, Gelatin, Magnesium Stearate, Silicon Dioxide, FD&C Red #40, FD&C Yellow #5
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
30 full dosage servings
Aromatase Inhibitor
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Exxstane by Vaxxen Labs label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Exxstane by Vaxxen Labs
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Androsta-3,5-Diene-7,17-Dione
Interacts with4 drugs
Arimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone,...
Androsta-3,5-Diene-7,17-Dione monograph & interactionsSafed musli
No knowninteractions
Safed Musli is an Ayurvedic herb traditionally used as a tonic and aphrodisiac, especially for male sexual health and energy. Human evidence is limite...
Safed musli monograph & interactionsOther (inactive) ingredients: Rice powder, Gelatin, Magnesium Stearate, Silicon Dioxide, FD&C Red #40, FD&C Yellow #5. These complete the product’s ingredient list but are not active constituents.
Exxstane by Vaxxen Labs Drug Interactions
HelloPharmacist Interaction Report
Exxstane by Vaxxen Labs contains an ingredient—Androsta-3,5-Diene-7,17-Dione (Arimistane)—that interacts with aromatase inhibitors, a class of drugs used mainly in hormone-related conditions.
The interaction is Moderate in severity; combining them may raise the risk of side effects tied to low estrogen levels or additive liver stress. Safed musli, the product's other active ingredient, has no interactions documented in our data.
Read the full breakdown — every affected drug type, severity by severity
Alterations to hormone levels are the main concern here. Because Arimistane itself works by inhibiting the aromatase enzyme, using it alongside prescription aromatase inhibitors could intensify that effect.
Altogether, these interactions span 4 individual medications. Before you start Exxstane, run any aromatase inhibitors or other prescription medications through the checker on this page, and talk it over with your doctor or pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Exxstane?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Exxstane interact with 4 drugs. Click any drug to see the details.
1 of the 2 ingredients in Exxstane interact with drugs. Each result below shows which ingredient is responsible. Androsta-3,5-Diene-7,17-Dione
AnastrozoleArimidex
How Anastrozole interacts with Exxstane — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Anastrozole interactionExemestaneAromasin
How Exemestane interacts with Exxstane — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Exemestane interactionLetrozoleFemara
How Letrozole interacts with Exxstane — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Letrozole interactionLetrozole, Ribociclib SuccinateKisqali Femara Co-Pack
How Letrozole, Ribociclib Succinate interacts with Exxstane — through 1 ingredient. Tap an ingredient for the detail:
Androsta-3,5-diene-7,17-dioneAromatase Inhibitors Moderate
Interaction Summary
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors.
Read the full Androsta-3,5-diene-7,17-dione + Letrozole, Ribociclib Succinate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Exxstane with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Androsta-3,5-Diene-7,17-Dione
Aromatase Inhibitors
It is believed that Arimistane inhibits the aromatase enzyme, which may interact with other aromatase inhibitors. This interaction could potentially increase the risk of side effects associated with low estrogen levels or from additive side effects, such as an increased risk of liver toxicity. It is recommended to consult with a healthcare provider before combining Arimistane with other aromatase inhibitors to assess the potential risks and benefits.
Brand information
Manufacturer and brand details for Exxstane, from the product label.
Exxstane by Vaxxen Labs: Common Questions
Does Exxstane by Vaxxen Labs interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Exxstane if I'm pregnant or breastfeeding?
Is Safed musli safe to take?
What does Arimistane do in this product?
Does this product actually work for muscle strength or athletic performance?
What medications interact with Exxstane?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Exxstane is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Exxstane’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Arimistane
Interacts with 4 drugsArimistane (sometimes sold as Estrovade) is a synthetic aromatase inhibitor marketed as a dietary supplement to lower estrogen and raise testosterone, often during or after steroid or prohor...
Read the full Arimistane monograph → Herb & supplement monographSafed Musli
Safed Musli is an Ayurvedic herb traditionally used as a tonic and aphrodisiac, especially for male sexual health and energy. Human evidence is limited and mostly preliminary, so its benefit...
Read the full Safed Musli monograph →Sources & How We Checked
Exxstane's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 2 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Arimistane 1 reference
- Joseph JF, Parr MK. Synthetic androgens as designer supplements. Curr Neuropharmacol. 2015;13(1):89-100. PubMed
Safed Musli 1 reference
- Tripathi RK, Dethe PD, Bhojne SK, Raut AA, Rege NN. A prospective, randomized, placebo-controlled, double-blind comparative pilot study to evaluate the efficacy of Chlorophytum borivilianum on physical performance. Indian J Pharmacol 2019;51(3):150-6. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC