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Dietary supplement

Fermented Maitake 500 mg Ingredients & Drug Interactions

by Solaray

Fermented Maitake 500 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fermented Maitake 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fermented Maitake 500 mg is a dietary supplement by Solaray with 1 active ingredient. Its ingredients are commonly taken for immune support, blood sugar support in diabetes, high blood pressure.Based on those ingredients, 260 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic fermented Maitake Mushroom. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Fermented Maitake 500 mg by Solaray

Ask about any prescription or over-the-counter medication and we check it for interactions with Fermented Maitake 500 mg by Solaray — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fermented Maitake 500 mg by Solaray

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic fermented maitake mushroom at 500 mg per capsule. Maitake is a medicinal mushroom traditionally used in Asian cuisines and supplements.

The capsule itself is made from vegetable cellulose, a plant-based filler.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Maitake Mushroom product and its label doesn't state a use — see Maitake Mushroom's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold shows insufficient reliable evidence to rate maitake mushroom for allergic rhinitis (hay fever), chemotherapy-related anemia, laryngeal cancer, chemotherapy-related diarrhea, chemotherapy-related low white blood cells (leukopenia), or chronic fatigue syndrome. That doesn't mean it doesn't work — it means the studies so far haven't been robust enough to make a firm claim.

If you're considering it for one of these uses, talk it over with your doctor or pharmacist to see whether the emerging research fits your situation.

The evidence, ingredient by ingredient Maitake Mushroom

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maitake mushroom from food sources is generally well tolerated, but concentrated supplements haven't been fully studied for safety. The most common side effects reported in clinical trials were gastrointestinal: a small number of participants experienced diarrhea, nausea, or stomach pain.

One person reported a rash and itching after two doses, though it cleared on its own without treatment. Because safety data during pregnancy and breastfeeding is insufficient, concentrated maitake supplements are not recommended at those times — talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.

Side effects, ingredient by ingredient Maitake Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maitake Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 260 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take warfarin or other blood thinners (Moderate risk of increased blood-thinning effect), antihypertensive drugs for high blood pressure (Moderate risk of blood pressure dropping too low), or antidiabetes medications (Moderate risk of blood sugar dropping too low).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Maitake mushroom is generally well tolerated as a food, but as a concentrated supplement it may interact with blood thinners, blood pressure medications, and diabetes drugs. If you take any of those, or any prescription medication at all, check your exact drugs with your pharmacist or doctor before starting.

This isn't a product to add without confirming it won't affect how your medicines work.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fermented Maitake 500 mg, straight from the product label.

Brand Solaray
Barcode (UPC) 076280908473
Net contents 60 Veg Cap(s)
Market status On market
Date entered into DSLD Mar 24, 2017
DSLD ID 71556
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fermented Maitake 500 mg by Solaray, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veg Cap(s)
Maximum serving Sizes:
2 Veg Cap(s)
Servings per container
30
UPC/BARCODE
076280908473
IngredientAmount% DV
organic fermented Maitake Mushroom1000 mg--

Other ingredients: Vegetable Cellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Formulation

Organically grown

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Discussion: Solaray organically grown mushrooms are 100% vegan, excipient-free and contain no fillers or additional ingredients.

Formula

Grifola frondosa 500 mg per capsule Mushroom

Seals/Symbols

Lab verified

Precautions

Warning: Do not use if safety seal is broken or missing.

Keep out of reach of children.

Keep you licensed health care practitioner informed when using this product.

Suggested/Recommended/Usage/Directions

Directions: Use only as directed. Take two VegCaps daily with a meal or glass of water.

Storage

Store in a cool, dry place.

General Statements

The organic mushroom mycelium biomass is cultured on organic gluten-free whole oats and then fermented. A mycelium is the vegetative portion of a fungus. It is through this root-like substance that the fungus absorbs nutrients.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General

7649822 0716

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fermented Maitake 500 mg by Solaray label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fermented Maitake 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fermented Maitake 500 mg by Solaray

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Veg Cap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Organic fermented Maitake Mushroom

Interacts with
260 drugs
1000 mg per serving

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and bl...

Organic fermented Maitake Mushroom monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fermented Maitake 500 mg by Solaray Drug Interactions

Want to check YOUR meds against Fermented Maitake 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
260Drugs
260 Moderate

Ingredients driving the most interactions

organic fermented Maitake Mushroom 260

Individual Drug Interactions

The ingredients in Fermented Maitake 500 mg interact with 260 drugs. Click any drug to see the details.

1 of the 1 ingredient in Fermented Maitake 500 mg interact with drugs. Each result below shows which ingredient is responsible. organic fermented Maitake Mushroom

Each ingredient & the kinds of drugs it affects

For each ingredient in Fermented Maitake 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic fermented Maitake Mushroom3 drug types · 260 drugs

Antidiabetes Drugs

Theoretically, combining maitake mushroom with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking maitake mushroom polysaccharide (MMP) can lower blood glucose levels in patients with types 2 diabetes.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, combining maitake mushroom with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that maitake mushroom can lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that maitake mushroom may increase the anticoagulant effects of warfarin.
In a case report, a patient previously stabilized on warfarin developed an elevated international normalized ratio (INR) of 5.1 after taking maitake mushroom (Grifron-Pro Maitake D-Fraction) 1 drop/kg daily in three divided doses for one week. The elevated INR resolved after holding warfarin for two days, then reducing the dose by 11%. It is thought that the beta-glucan constituent of maitake mushroom might cause warfarin dissociation from proteins, resulting in increased free warfarin levels and increased warfarin effects.

Likelihood Possible Evidence D
organic fermented Maitake Mushroom full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fermented Maitake 500 mg, from the product label.

Solaray

See all Solaray products
Name
Nutraceutical Corp.
Web Address
www.nutrafamily.com
Pharmacist Counseling Corner

Fermented Maitake 500 mg by Solaray: Common Questions

Does Fermented Maitake 500 mg by Solaray interact with any medications?
Yes. Based on its ingredients, Fermented Maitake 500 mg has a known interaction with 260 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fermented Maitake 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data for concentrated maitake supplements during pregnancy and breastfeeding isn't enough to know either way, so they're not recommended at those times. Talk with your doctor or pharmacist about whether it's right for you.
What side effects might I notice?
Maitake is generally well tolerated, but some people in clinical trials experienced stomach upset — diarrhea, nausea, or pain in the upper belly. One person reported a rash and itching after two doses, though it went away on its own.
Does maitake mushroom actually work?
The evidence we have isn't strong enough yet to say whether it's effective for hay fever, cancer-related side effects, or chronic fatigue syndrome. If you're thinking about it for one of those reasons, chat with your doctor about what the research shows so far.
Why do I need to check with my doctor if I take blood pressure or diabetes medication?
Maitake can lower blood pressure and blood sugar on its own, so combining it with medications that do the same thing might push them too low. Your doctor or pharmacist can tell you if it's safe to take together or if your doses need adjusting.
What is maitake mushroom?
Maitake is a medicinal mushroom used in Asian cooking and traditional medicine for centuries. This product is fermented, which is a process meant to make it easier for your body to absorb.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fermented Maitake 500 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fermented Maitake 500 mg label
Go deeper

The Full Monographs Behind Fermented Maitake 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maitake Mushroom

Interacts with 260 drugs

Maitake is an edible mushroom long used as food and in traditional Japanese medicine, and it is being studied for possible immune, blood sugar, and blood pressure effects. The human evidence...

Read the full Maitake Mushroom monograph →
Sources

Sources & How We Checked

Fermented Maitake 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 8 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maitake Mushroom 8 references
  1. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. PubMed
  2. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. PubMed
  3. Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. PubMed
  4. Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Compl
  5. Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. PubMed
  6. Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. PubMed
  7. Deng, G., Lin, H., Seidman, A., Fornier, M., D'Andrea, G., Wesa, K., Yeung, S., Cunningham-Rundles, S., Vickers, A. J., and Cassileth, B. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: i
  8. Wesa KM, Cunningham-Rundles S, Klimek VM, et al. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 2015;64(2):237-47. PubMed

See these in context on the Maitake Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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