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Dietary supplement

Fermented Vitamin B12 1000 mcg Ingredients & Drug Interactions

by New Chapter

Fermented Vitamin B12 1000 mcg label
See full label image
Tablet Or Pill Category: Botanical With Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fermented Vitamin B12 1000 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fermented Vitamin B12 1000 mcg is a dietary supplement by New Chapter with 4 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 815 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Schizandra, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fermented Vitamin B12 1000 mcg by New Chapter

Ask about any prescription or over-the-counter medication and we check it for interactions with Fermented Vitamin B12 1000 mcg by New Chapter — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Fermented Vitamin B12 1000 mcg by New Chapter

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 5 active ingredients.
  • “Vitamin B12” is listed as a grouped ingredient — the label gives one combined amount (1,000 mcg) without saying how much of each component you get.
  • “Energy and Digestion Support Blend” is a proprietary blend — the label gives one combined amount (45 mg) without saying how much of each component you get.

This tablet contains 5 active ingredients. The two main forms of vitamin B12 — cyanocobalamin and methylcobalamin — are the workhorses here; your body uses B12 to make red blood cells and maintain your nervous system.

The product also includes cardamom (a spice), schisandra (an herbal adaptogen), and maca (a root vegetable used in traditional medicine), grouped together as an "Energy and Digestion Support Blend." You'll also find inactive ingredients like probiotics (Lactobacillus and Bifidobacterium), digestive enzymes (papain and bromelain), and standard tablet binders and flow agents.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • The label markets general wellness (“energy and B12 nutritional support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Imerslund-Grasbeck disease — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Vitamin B12 deficiency — rated "Effective" (Vitamin B12) (Natural Medicines).
  • On file: Cyanide poisoning — rated "Likely Effective" (Vitamin B12) (Natural Medicines).
  • On file: Hyperhomocysteinemia — rated "Possibly Effective" (Vitamin B12) (Natural Medicines).
  • On file: Postherpetic neuralgia — rated "Possibly Effective" (Vitamin B12) (Natural Medicines).

The B12 in this product is effective for treating B12 deficiency and a rare condition called Imerslund-Grasbeck disease, and it's likely effective for cyanide poisoning. It's possibly effective for canker sores and nerve pain after shingles (postherpetic neuralgia).

The other ingredients — cardamom, schisandra, and maca — don't have enough reliable evidence in our data to rate their effectiveness for the conditions they're traditionally used for, like energy, digestion, or athletic performance.

The evidence, ingredient by ingredient Vitamin B12 Cardamom Schisandra Maca

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

B12 is generally very safe; your body removes excess in the urine, so there's no established upper limit. It's safe at normal recommended doses during pregnancy and breastfeeding, and you should follow your provider's advice on dosing.

B12 is generally well tolerated when taken by mouth, though rarely some people develop allergic reactions like rash or hives — theoretically linked to the cobalt in the B12 molecule. Cardamom in food amounts is well tolerated, but safety of larger supplement doses isn't well studied.

Schisandra is generally well tolerated short term in healthy adults, though it can cause heartburn, decreased appetite, stomach upset, or hives in some people; avoid it during pregnancy (it may stimulate the uterus) and while breastfeeding. Maca is well tolerated as a food but hasn't been studied long term as a supplement; avoid it during pregnancy and breastfeeding due to insufficient safety data.

Fresh, uncooked maca may cause stomach pain.

Side effects, ingredient by ingredient Vitamin B12 Cardamom Schisandra Maca

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Schisandra, Vitamin B12.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs.
  • For scale: 816 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this, check with your pharmacist if you're on tacrolimus (an immune-suppressor), voriconazole or other antifungals, midazolam or other sedatives, warfarin or other blood thinners, or any drugs that your liver metabolizes via CYP3A4, CYP2C9, or CYP2C19 pathways — schisandra can raise or lower their levels. Also flag metformin, a diabetes drug, since the B12 here might interact with how your body handles it, though it's a Minor interaction.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement makes sense if you have a documented B12 deficiency or take metformin long term and want to support your B12 levels — but talk to your pharmacist first, especially if you take medications for transplants, seizures, sedation, blood thinning, or fungal infections. Schisandra in here affects a lot of drugs, so checking your exact medications is essential before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fermented Vitamin B12 1000 mcg, straight from the product label.

Brand New Chapter
Barcode (UPC) 727783902597
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 288198
Product type Botanical With Nutrients
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fermented Vitamin B12 1000 mcg by New Chapter, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
60
UPC/BARCODE
727783902597
IngredientAmount% DV
Vitamin B121000 mcg41667%
Cyanocobalamin600 mcg--
Methylcobalamin400 mcg--
Cardamom0 NP--
Schizandra0 NP--
Maca0 NP--
Energy and Digestion Support Blend45 mg--

Other ingredients: Gum Acacia, Soy Flour, Saccharomyces cerevisiae, Papain, Bromelain, Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus rhamnosus, Brown Rice, Silica, Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: One tablet daily. Can be taken anytime, even on an empty stomach.

Formulation

Certified gluten-free by NSF; certified Vegan; no artificial flavors or colors.

Certified gluten-free by NSF; certified Vegan; no artificial flavors or colors.

Formulated for absorption Nutrition crafted for: Energy & healthy blood cell support

100% Vegan

USDA Organic

Non GMO Project Verified nongmoproject.org NSF Certified Gluten-Free

Certified Vegan Vegan.org

Certified Organic by Where Food Comes From Organic, Castle Rock, CO, USA

Manufactured in the US from globally sourced ingredients

General Statements

Please refer to newchapter.com for more information about this product and its benefits.

Please recycle this bottle after use.

The New Chapter money-back guarantee We proudly stand behind every product we make. However, if you are not satisfied, please visit www.newchapter.com/guarantee for refund details.

Precautions

Caution: As with any dietary supplements, advise your healthcare professional of the use of this product if you have a medical condition or are taking medication. If you are nursing, pregnant, or considering pregnancy, you should consult your healthcare professional prior to using this product.

Keep out of reach of children.

Contains: Fermented soy.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

New Chapter Est. 1982

Brand IP Statement(s)

Copyright 2021 New Chapter, Inc.

Formula

The magic inside: Bioactive B12 with whole-food herbs

OU (Kosher)

Seals/Symbols

USDA Organic Non GMO Project Verified nongmoproject.org NSF Certified Gluten-Free OU (Kosher) Certified Vegan Vegan.org

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fermented Vitamin B12 1000 mcg by New Chapter label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fermented Vitamin B12 1000 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fermented Vitamin B12 1000 mcg by New Chapter

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Energy and Digestion Support Blend

45 mg per serving

Other (inactive) ingredients: Gum Acacia, Soy Flour, Saccharomyces cerevisiae, Papain, Bromelain, Lactobacillus acidophilus, Bifidobacterium bifidum, Lactobacillus rhamnosus, Brown Rice, Silica, Tapioca Maltodextrin, Sunflower Lecithin, Palm Oil, Guar Gum. These complete the product’s ingredient list but are not active constituents.

Interaction report

Fermented Vitamin B12 1000 mcg by New Chapter Drug Interactions

Want to check YOUR meds against Fermented Vitamin B12 1000 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
815Drugs
803 Moderate 12 Minor

Ingredients driving the most interactions

Schizandra 803
Vitamin B12 20

Individual Drug Interactions

The ingredients in Fermented Vitamin B12 1000 mcg interact with 815 drugs. Click any drug to see the details.

2 of the 4 ingredients in Fermented Vitamin B12 1000 mcg interact with drugs. Each result below shows which ingredient is responsible. Schizandra Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Fermented Vitamin B12 1000 mcg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Schizandra12 drug types · 803 drugs

Cyclophosphamide

Theoretically, schisandra might increase the levels and clinical effects of cyclophosphamide.
In vitro research shows that schisandra increases the concentration of cyclophosphamide, likely through inhibition of cytochrome P450 3A4. After multiple doses of the schisandra constituents schisandrin A and schisantherin A, the maximum concentration of cyclophosphamide was increased by 7% and 75%, respectively, while the overall exposure to cyclophosphamide was increased by 29% and 301%, respectively.

Likelihood Probable Evidence D
Cyclosporine (Neoral, Sandimmune)

Schisandra can increase the levels and clinical effects of cyclosporine.
A small observational study in children with aplastic anemia found that taking schisandra with cyclosporine increased cyclosporine trough levels by 93% without increasing the risk of adverse events. However, the dose of cyclosporine was reduced in 9% of children to maintain appropriate cyclosporine blood concentrations.

Likelihood Probable Evidence B
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, schisandra might increase the levels and clinical effects of CYP2C19 substrates.
In vitro research shows that schisandra inhibits CYP2C19, and animal research shows that schisandra increases the concentration of voriconazole, a CYP2C19 substrate. Theoretically, schisandra may also inhibit the metabolism of other CYP2C19 substrates. This effect has not been reported in humans.

Likelihood Probable Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, schisandra might decrease the levels and clinical effects of CYP2C9 substrates.
In vitro and animal research suggests that schisandra induces CYP2C9 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Schisandra can increase the levels and clinical effects of drugs metabolized by CYP3A4.
Most clinical and laboratory research shows that schisandra, administered either as a single dose or up to twice daily for 14 days, inhibits CYP3A4 and increases the concentration of CYP3A4 substrates such as cyclophosphamide, midazolam, tacrolimus, and talinolol. Although one in vitro and animal study shows that schisandra may induce CYP3A4 metabolism, this effect appears to be overpowered by schisandra's CYP3A4 inhibitory activity and has not been reported in humans.

Likelihood Probable Evidence D
Midazolam (Versed)

Schisandra can increase the levels and clinical effects of midazolam.
A small pharmacokinetic study in healthy adults shows that taking schisandra extract (Hezheng Pharmaceutical Co.) containing deoxyschizandrin 33.75 mg twice daily for 8 days and a single dose of midazolam 15 mg on day 8 increases the overall exposure to midazolam by about 119%, increases the peak plasma level of midazolam by 86%, and decreases midazolam clearance by about 52%. This effect has been attributed to inhibition of CYP3A4 by schisandra.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Schisandra might increase the levels and clinical effects of P-glycoprotein substrates.
In vitro research shows that schisandra extracts and constituents such as schisandrin B inhibit P-glycoprotein mediated efflux in intestinal cells and in P-glycoprotein over-expressing cell lines. Additionally, a small clinical study shows that schisandra increases the peak concentration and overall exposure to talinolol, a P-glycoprotein probe substrate. Theoretically, schisandra might inhibit the efflux of other P-glycoprotein substrates.

Likelihood Possible Evidence D
Sirolimus (Rapamune)

Schisandra can increase the levels and clinical effects of sirolimus.
A small pharmacokinetic study in healthy volunteers shows that taking 3 capsules of schisandra (Hezheng Pharmaceutical Company) containing a total of 33.75 mg deoxyschizandrin twice daily for 13 days and then taking a single dose of sirolimus 2 mg increases the overall exposure and peak level of sirolimus by two-fold. This effect is thought to be due to inhibition of cytochrome P450 3A4 by schisandra, as well as possible inhibition of the P-glycoprotein drug transporter.

Likelihood Probable Evidence B
Tacrolimus (Prograf)

Schisandra can increase the levels and clinical effects of tacrolimus.
Clinical research in healthy children and adults, transplant patients, and patients with nephrotic syndrome and various rheumatic immunologic disorders shows that taking schisandra with tacrolimus increases tacrolimus peak levels by 183% to 268%, prolongs or delays time to peak tacrolimus concentrations, increases overall exposure to tacrolimus by 126% to 343%, and decreases tacrolimus clearance by 19% to 73%. This effect is thought to be due to inhibition of P-glycoprotein drug transporter and CYP3A4 and CYP3A5 by schisandra. Some clinical and observational studies suggest that schisandra increases tacrolimus levels similarly in both expressors and non-expressors of CYP3A5, while other studies suggest it does so to a greater degree in CYP3A5 expressors than non-expressors. Animal research suggests that the greatest increase in tacrolimus levels occurs when schisandra is taken either concomitantly or up to 2 hours before tacrolimus, and clinical and observational research in humans suggests that schisandra may increase whole blood levels of tacrolimus and decrease clearance of tacrolimus in a dose-dependent manner.

Likelihood Probable Evidence B
Talinolol

Schisandra can increase the levels and clinical effects of talinolol.
A small pharmacokinetic study in healthy volunteers shows that taking schisandra extract 300 mg twice daily for 14 days with a single dose of talinolol 100 mg on day 14 increases the peak talinolol level by 51% and the overall exposure to talinolol by 47%. This effect is thought to be due to the possible inhibition of cytochrome P450 3A4 and P-glycoprotein by schisandra. tly.

Likelihood Probable Evidence B
Voriconazole (Vfend)

Theoretically, schisandra might increase the levels and clinical effects of voriconazole.
Animal research shows that oral schisandra given daily for 1 or 14 days increases levels of intravenously administered voriconazole, a cytochrome P450 (CYP) 2C19 substrate. This effect is thought to be due to inhibition of CYP2C19 by schisandra. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, schisandra might decrease the levels and clinical effects of warfarin.
Animal research suggests that oral schisandra extract, given daily for 6 days, reduces levels of intravenously administered warfarin. This effect might be due to the induction of cytochrome P450 (CYP) 2C9 metabolism by schisandra. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Schizandra full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fermented Vitamin B12 1000 mcg, from the product label.

New Chapter

See all New Chapter products
Name
New Chapter, Inc.
Street Address
90 Technology Drive
City
Brattleboro
State
VT
ZipCode
05301
Phone Number
888-874-4461
Web Address
www.newchapter.com/guarantee
Pharmacist Counseling Corner

Fermented Vitamin B12 1000 mcg by New Chapter: Common Questions

Does Fermented Vitamin B12 1000 mcg by New Chapter interact with any medications?
Yes. Based on its ingredients, Fermented Vitamin B12 1000 mcg has a known interaction with 815 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fermented Vitamin B12 1000 mcg contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help if I'm on metformin?
Metformin can lower your B12 levels over time, especially with long-term use, so a B12 supplement may help. But it's a Minor interaction and worth discussing with your doctor or pharmacist to make sure the dose and timing work for you.
Is B12 safe during pregnancy?
Yes, B12 is needed during pregnancy and is considered safe at normal recommended amounts. Follow your provider's advice on dosing. However, schisandra in this blend is best avoided during pregnancy — it may stimulate the uterus — and there isn't enough safety data on maca to recommend it, so talk with your doctor before using this product if you're pregnant.
Can I take this while breastfeeding?
B12 is important during breastfeeding and is safe at recommended amounts. Cardamom is generally safe in food amounts. But schisandra and maca lack reliable safety data while breastfeeding, so discuss this product with your doctor or pharmacist before using it if you're nursing.
What does schisandra in here do?
Schisandra is an herbal adaptogen traditionally used to support energy and digestion, but we don't have reliable evidence that it works for these purposes. What we do know is it can change how your liver processes many medications, so it's important to check your drugs against it before starting this supplement.
Does this tablet have fillers?
Yes, it contains inactive ingredients like gum acacia, silica, tapioca maltodextrin, and several probiotics and enzymes to support digestion — these are standard tablet binders and additives that help the tablet hold together and break down in your stomach.
What are the side effects?
B12 is generally well tolerated by mouth, though allergic reactions like rash or hives are rare. Schisandra can cause heartburn, decreased appetite, stomach upset, or hives in some people. Maca and cardamom in food amounts are usually well tolerated, but fresh uncooked maca may cause stomach pain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fermented Vitamin B12 1000 mcg label
Go deeper

The Full Monographs Behind Fermented Vitamin B12 1000 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Cardamom

Cardamom is a popular cooking spice that has long been used in traditional medicine for digestion and fresh breath. As a food, it is generally safe for most people, but high-dose supplements...

Read the full Cardamom monograph → Herb & supplement monograph

Schisandra

Interacts with 803 drugs

Schisandra is a traditional Chinese medicine berry used as an adaptogen for stress, fatigue, and liver support. Human evidence is limited and most claims are not well proven, but it appears...

Read the full Schisandra monograph → Herb & supplement monograph

Maca

Maca is a nutrient-rich Andean root often used for energy, libido, and menopause symptoms. Early studies suggest it may modestly help sexual desire and some menopause symptoms, but the evide...

Read the full Maca monograph →
Sources

Sources & How We Checked

Fermented Vitamin B12 1000 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 59 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
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Cardamom 2 references
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Schisandra 26 references
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See these in context on the Schisandra monograph →

Maca 1 reference
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See these in context on the Maca monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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