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Dietary supplement

Feverfew Leaf Extract Ingredients & Drug Interactions

by Solgar

Feverfew Leaf Extract label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Feverfew Leaf Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Feverfew Leaf Extract is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for migraine prevention, headache, fever (traditional).Based on those ingredients, 929 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are standardized Feverfew extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Feverfew Leaf Extract by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with Feverfew Leaf Extract by Solgar — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Feverfew Leaf Extract by Solgar

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients: a standardized feverfew extract and raw feverfew powder. Both deliver the same plant material—the feverfew leaf—in different forms.

The inactive ingredients include vegetable cellulose (the capsule), vegetable magnesium stearate (a lubricant), and a PhytO2X antioxidant blend.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: migraine and headache prevention.
  • We looked for evidence on: Tension headache, Migraine, Headache, Fever.
  • The closest evidence on file: Feverfew is rated "Insufficient Reliable Evidence To Rate" for Tension headache (Natural Medicines).

The evidence for feverfew's effectiveness is currently insufficient to rate for the conditions studied—tension headache, prurigo nodularis (a skin condition), psoriasis, and rheumatoid arthritis. We don't have reliable data showing it works for these uses.

The evidence, ingredient by ingredient Feverfew

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Feverfew is generally well tolerated in the short term, but some people experience allergic reactions or mouth irritation. The most common side effects are gastrointestinal: abdominal pain, bloating, constipation, diarrhea, flatulence, heartburn, and nausea.

Skin rash can occur in sensitive individuals. Chewing fresh feverfew leaves (rather than taking the capsule form) carries a higher risk of mouth ulceration, swelling of the lips, and inflamed mouth tissues.

You should avoid feverfew during pregnancy because it may stimulate the uterus and its safety is not established. There isn't enough reliable safety information to recommend it while breastfeeding either.

If you've taken feverfew long-term and plan to stop, be aware that discontinuation may cause anxiety, headaches, and insomnia.

Side effects, ingredient by ingredient Feverfew

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Feverfew.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 930 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—feverfew may increase bleeding risk. Also verify any medications your liver metabolizes, especially those broken down by CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, or CYP3A4 pathways, as feverfew may raise their levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Feverfew Leaf Extract is generally well tolerated for short-term use, but it interacts with a very large number of medications—especially blood thinners and drugs your liver breaks down. If you take any prescription medications, blood thinners, or antiplatelet drugs, check your exact list with your doctor or pharmacist before starting.

Avoid it in pregnancy and breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Feverfew Leaf Extract, straight from the product label.

Brand Solgar
Barcode (UPC) 033984041288
Net contents 60 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2020
DSLD ID 219034
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Feverfew Leaf Extract by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegetable Capsule(s)
Maximum serving Sizes:
1 Vegetable Capsule(s)
UPC/BARCODE
033984041288
IngredientAmount% DV
standardized Feverfew extract200 mg--
raw Feverfew powder150 mg--

Other ingredients: Vegetable Cellulose, Vegetable Magnesium Stearate, PhytO2X Antioxidant Blend

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Solgar's Full Potency (SFP) Herbs are developed through a unique process that integrates the ideologies of both traditional herbalism and standardized herbal technology.

Solgar's Feverfew Leaf Extract Vegetable Capsules are free of sugar, salt, corn, yeast, wheat, soy, gluten, dairy and animal products and are formulated without the use of artificial preservatives, flavors or colors.

Standardized Full potency

Suitable for vegetarians

Formula

To ensure consistent and reliable phytonutrient levels, we isolate a controlled amount of these important active plant compounds. Then, we blend these enhanced, "standardized" compounds with all of the components that occur naturally in the whole raw herb. The result is a potent, premium-quality standardized herbal extract with all of the synergistic and beneficial qualities found in nature.

PHYTO2X SYSTEM

(Tanacetum parthenium)

PhytO2X is a special blend of antioxidants, the purpose of which is to maintain the freshness of the ingredients.

Solgar's KOF-K certification #K-1250

Storage

To assure freshness and potency, store at room temperature 59 degrees-86 degrees F (15 degrees-30 degrees C). Store away from heat, light and moisture.

Precautions

Do not use if outer bottle seal is missing, torn or damaged in any way.

If you are pregnant, nursing, taking any medication or have a medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Keep out of reach of children.

General Statements

Solgar since 1947

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

K Parve (Kosher)

Suggested/Recommended/Usage/Directions

Suggested Use: As an herbal dietary supplement for adults, take one (1) vegetable capsule, up to three (3) times daily, preferably at mealtime, or as directed by a healthcare practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Feverfew Leaf Extract by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Feverfew Leaf Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Feverfew Leaf Extract by Solgar

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegetable Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Standardized Feverfew extract

Interacts with
929 drugs
200 mg per serving Form: Parthenolides

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Standardized Feverfew extract monograph & interactions

Raw Feverfew powder

Interacts with
929 drugs
150 mg per serving

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though...

Raw Feverfew powder monograph & interactions

Other (inactive) ingredients: Vegetable Cellulose, Vegetable Magnesium Stearate, PhytO2X Antioxidant Blend. These complete the product’s ingredient list but are not active constituents.

Interaction report

Feverfew Leaf Extract by Solgar Drug Interactions

Want to check YOUR meds against Feverfew Leaf Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
929Drugs
929 Moderate

Ingredients driving the most interactions

standardized Feverfew extract 929

Individual Drug Interactions

The ingredients in Feverfew Leaf Extract interact with 929 drugs. Click any drug to see the details.

1 of the 2 ingredients in Feverfew Leaf Extract interact with drugs. Each result below shows which ingredient is responsible. standardized Feverfew extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Feverfew Leaf Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

standardized Feverfew extract7 drug types · 929 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, feverfew might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Laboratory research suggests that feverfew may inhibit platelet aggregation. Additionally, in one case report, a 36-year-old patient taking feverfew 2400 mg daily for 3 months experienced vaginal bleeding and a prolonged menstrual cycle, with a modest increase in partial thromboplastin time (PTT) and prothrombin time (PT).

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP1A2.
Laboratory research shows that feverfew might inhibit CYP1A2. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C19.
Laboratory research shows that feverfew might inhibit CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C8.
Laboratory research shows that feverfew might inhibit CYP2C8. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2C9.
Laboratory research shows that feverfew might inhibit CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP2D6.
Laboratory research shows that feverfew might inhibit CYP2D6. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, feverfew might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that feverfew might inhibit CYP3A4. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
standardized Feverfew extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Feverfew Leaf Extract, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

Feverfew Leaf Extract by Solgar: Common Questions

Does Feverfew Leaf Extract by Solgar interact with any medications?
Yes. Based on its ingredients, Feverfew Leaf Extract has a known interaction with 929 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Feverfew Leaf Extract contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is feverfew safe to take if I'm pregnant or breastfeeding?
No. The safety data advises against feverfew in pregnancy because it may stimulate the uterus. There also isn't enough reliable safety information to recommend it while breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you if you're pregnant, planning to become pregnant, or nursing.
What are the most common side effects?
Gastrointestinal symptoms are the most frequent: abdominal pain, bloating, constipation, diarrhea, flatulence, heartburn, and nausea. Some people also experience skin rash. Mouth irritation and ulceration are more likely if you chew fresh feverfew leaves rather than take the capsule form.
Can I stop taking feverfew whenever I want?
If you've been taking it long-term, stopping abruptly may trigger "post-feverfew syndrome," which includes anxiety, headaches, and insomnia. If you've been on it for a while and want to stop, discuss it with your doctor or pharmacist first.
Does feverfew actually help with tension headaches?
The evidence isn't established in our data. We have insufficient reliable evidence to say whether feverfew works for tension headaches or the other conditions it's sometimes used for.
What's the difference between the standardized extract and the raw powder in this product?
Both deliver feverfew leaf, just in different forms—one is standardized for consistent potency, the other is raw powder. Both carry the same interaction and safety profile.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Feverfew Leaf Extract label
Go deeper

The Full Monographs Behind Feverfew Leaf Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Feverfew

Interacts with 929 drugs

Feverfew is a daisy-family herb best known for migraine prevention, where some studies suggest it may modestly lower how often migraines occur, though the evidence is mixed. It is generally...

Read the full Feverfew monograph →
Sources

Sources & How We Checked

Feverfew Leaf Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Feverfew 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Awang DVC. Prescribing therapeutic feverfew (Tancetum pathrnium (L.) Schultz Bip., syn. Chrysanthemumparthenium (L.) Bernh). Int Med 1998;1:11-3.
  3. Heptinstall S, Groenewegen WA, Spangenberg P, Loesche W. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. J Pharm Pharmacol 1987;39:459-65. PubMed
  4. Heptinstall S, White A, Williamson L, Mitchell JR. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet 1985;1:1071-4. PubMed
  5. Makheja AN, Bailey JM. A platelet phospholipase inhibitor from the medicinal herb feverfew (Tanacetum parthenium). Prostaglandins Leukot Med 1982;8:653-60.
  6. Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol 1990;42:553-7. PubMed
  7. Heptinstall S, Groenewegen WA, Spangenberg P, Losche W. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:447-9.
  8. Biggs MJ, Johnson ES, Persaud NP, Ratcliffe DM. Platelet aggregation in patients using feverfew for migraine. Lancet 1982;2:776. PubMed
  9. Lamminpaa A, Estlander T, Jolanki R, Kanerva L. Occupational allergic contact dermatitis caused by decorative plants. Contact Dermatitis 1996;34:330-5. PubMed
  10. Johnson ES, Kadam NP, Hylands DM, Hylands PJ. Efficacy of feverfew as prophylactic treatment of migraine. Br Med J (Clin Res Ed) 1985;291:569-73. PubMed
  11. Pittler MH, Ernst E. Feverfew for preventing migraine. Cochrane Database Syst Rev 2004;(1):CD002286. PubMed
  12. Ernst E, Pittler MH. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutr 2000;3:509-14.
  13. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  14. Sil'vestrov VP, Kinitin AV, and Chesnokova, IV. [Immunological and metabolic disorders and the means for their correction in patients with chronic bronchitis]. Ter.Arkh. 1991;63:7-11.
  15. Cady RK, Goldstein J, Nett R, et al. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic M) in the treatment of migraine. Headache 2011;51:1078-86.
  16. Jovanovic, M. and Poljacki, M. [Compositae dermatitis]. Med Pregl. 2003;56(1-2):43-49. PubMed
  17. Burry, J. N. Compositae dermatitis in South Australia: contact dermatitis from Chrysanthemum parthenium. Contact Dermatitis 1980;6(6):445.
  18. Alenzi KA, Alharbi FH, Tawhari FM, Fradees GS. Alteration of Coagulation Test Results and Vaginal Bleeding Associated With the Use of Feverfew (Tanacetum parthenium). J Med Cases 2021;12(1):9-12.

See these in context on the Feverfew monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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