P-5-P 50 mg Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking P-5-P 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
P-5-P 50 mg is a dietary supplement by Solgar with 1 active ingredient. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pyridoxal 5-Phosphate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against P-5-P 50 mg by Solgar
Ask about any prescription or over-the-counter medication and we check it for interactions with P-5-P 50 mg by Solgar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of P-5-P 50 mg by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: pyridoxal 5-phosphate, a form of vitamin B6 at 50 mg per tablet. Pyridoxal 5-phosphate is the active form your body uses directly, so it doesn't need conversion like some other B6 sources do.
The tablet also contains inactive ingredients — dicalcium phosphate, microcrystalline cellulose, vegetable cellulose, vegetable magnesium stearate, methacrylic acid, riboflavin, titanium dioxide, glyceryl triacetate, and vegetable glycerin — which are fillers, binders, and coating materials.
Does it work?
Strong evidence
Solgar's P-5-P is effective for sideroblastic anemia and vitamin B6 deficiency. It's likely effective for high homocysteine levels (hyperhomocysteinemia), a cardiovascular risk factor.
For pregnancy-induced nausea and vomiting, the evidence suggests it possibly works, though it's typically used only under a doctor's guidance for that purpose. For other uses, the evidence we hold doesn't establish effectiveness.
How safe is it?
Well-documented data
Vitamin B6 at doses under 100 mg daily is generally well tolerated. At this product's 50 mg dose, common side effects are uncommon but can include headache, nausea, abdominal pain, heartburn, or loss of appetite.
The main safety concern is that high doses over time — especially totals exceeding 1,000 grams or daily doses above 1,000 mg — can damage nerves (sensory neuropathy), causing tingling and numbness. Nerve damage can happen at lower doses too, though it's rarer.
In pregnancy, the safety picture is mixed: some data suggest vitamin B6 is likely safe, while other data suggest it's possibly unsafe. If you're pregnant or thinking about it, talk with your doctor or pharmacist about whether this dose is right for you.
Vitamin B6 is likely safe during breastfeeding.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take blood pressure medications (since vitamin B6 may lower pressure further), amiodarone for heart rhythm, seizure medications like phenobarbital or phenytoin, or levodopa for Parkinson's disease without carbidopa. These are the main medication types our data shows interact with vitamin B6.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This B6 form works well for B6 deficiency and certain anemias and may help with high homocysteine. If you take blood pressure drugs, heart rhythm medications, or seizure medications, check with your doctor or pharmacist before starting — vitamin B6 can interact with them.
For pregnancy-related nausea, only use it under medical guidance. At 50 mg, this dose is low-risk for most people, but anyone on the medications listed should confirm it's okay first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2016.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about P-5-P 50 mg, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984023086 |
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Jul 25, 2016 |
| DSLD ID | 63232 |
| Product type | Vitamin |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for P-5-P 50 mg by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pyridoxal 5-Phosphate | 50 mg | -- |
Other ingredients: Dicalcium Phosphate, Methacrylic Acid, Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Magnesium Stearate, Riboflavin, Titanium Dioxide, Glyceryl Triacetate, Vegetable Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
The body converts Vitamin B6 into P-5-P (pyridoxal-5-phosphate) before it can be used. This biologically active, coenzyme form of B6 promotes the metabolism of carbohydrates, proteins and amino acids.
Since 1947
Supports a healthy nervous system
Formula
P-5-P is one of Solgar’s premium-quality Vitamin B products and is specially coated to protect against degradation from stomach acids.
Solgar’s KOF-K certification #K-1250
Active coenzyme form of B6
Brand IP Statement(s)
2016 Solgar, Inc.
General
SOLGB72307 02D
Formulation
Gluten, Wheat & Dairy free
Suitable for vegans
Free of: Gluten, Wheat, Dairy, Soy, Yeast, Sugar, Sodium, Artificial Flavor, Sweetener and Preservatives.
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
Certified GF Gluten free
K Parve
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement for adults, take one (1) tablet daily, preferably with a meal or as directed by a healthcare practitioner.
Precautions
If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.
Discontinue use and consult your healthcare practitioner if any adverse reactions occur.
Keep out of reach of children.
Do not use if outer bottle seal is missing or damaged.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
P-5-P 50 mg by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in P-5-P 50 mg by Solgar
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
Pyridoxal 5-Phosphate
Interacts with210 drugs
Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...
Pyridoxal 5-Phosphate monograph & interactionsOther (inactive) ingredients: Dicalcium Phosphate, Methacrylic Acid, Microcrystalline Cellulose, Vegetable Cellulose, Vegetable Magnesium Stearate, Riboflavin, Titanium Dioxide, Glyceryl Triacetate, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.
P-5-P 50 mg by Solgar Drug Interactions
HelloPharmacist Interaction Report
Solgar's P-5-P 50 mg contains pyridoxal 5-phosphate (a form of vitamin B6) that does interact with several medication types.
The most serious concern is with blood pressure medications (antihypertensives) — vitamin B6 may add to their effects and lower your blood pressure further than intended.
Read the full breakdown — every affected drug type, severity by severity
Vitamin B6 may also worsen the light sensitivity (photosensitivity) caused by amiodarone, a heart rhythm medication. Additionally, at high doses, vitamin B6 can reduce how well your body uses seizure medications like phenobarbital and phenytoin, potentially weakening their control of seizures.
If you take levodopa alone for Parkinson's disease, vitamin B6 might reduce its effectiveness — though this doesn't happen if you're taking it with carbidopa (Sinemet).
Although this product contains 50 mg per tablet, most of the drug interactions noted in our data involve high doses. Still, check your exact medications with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against P-5-P 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in P-5-P 50 mg interact with 210 drugs. Click any drug to see the details.
1 of the 1 ingredient in P-5-P 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pyridoxal 5-Phosphate
AcebutololRhotral, Sectral
How Acebutolol interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amiloride, Hydrochlorothiazide interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Read the full Pyridoxal 5-phosphate + Amiodarone interactionAmlodipineNorliqva
How Amlodipine interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Ammonium Chloride interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Aprobarbital, Butabarbital, Phenobarbital interactionAprocitentanTryvio
How Aprocitentan interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Aprocitentan interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Aspirin, Codeine Phosphate, Phenobarbital interactionAtenololAtenix, Tenormin
How Atenolol interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Atenolol interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Atenolol, Chlorthalidone interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Atropine, Phenobarbital interactionAzilsartanEdarbi
How Azilsartan interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Azilsartan interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphateAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Read the full Pyridoxal 5-phosphate + Azilsartan, Chlorthalidone interactionBelladona Extract, PhenobarbitalChardonna-2
How Belladona Extract, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Belladona Extract, Phenobarbital interactionBelladonna Alkaloids, Ergotamine Tartrate, PhenobarbitalBel Tabs, Bellamine-S, Bellaphen-S, Duragal S, Phenarbal S, Spastrin
How Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Belladonna Alkaloids, Ergotamine Tartrate, Phenobarbital interactionBelladonna Alkaloids, PhenobarbitalBarbidonna, Donnatal
How Belladonna Alkaloids, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Belladonna Alkaloids, Phenobarbital interactionBelladonna Extract, PhenobarbitalBelap
How Belladonna Extract, Phenobarbital interacts with P-5-P 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pyridoxal 5-phosphatePhenobarbital (luminal) Moderate
Interaction Summary
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Read the full Pyridoxal 5-phosphate + Belladonna Extract, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in P-5-P 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pyridoxal 5-Phosphate
Amiodarone (Cordarone)
Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.
Antihypertensive Drugs
Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.
Phenobarbital (Luminal)
High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.
Phenytoin (Dilantin)
High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.
Levodopa
Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.
Brand information
Manufacturer and brand details for P-5-P 50 mg, from the product label.
Solgar
See all Solgar products- Name
- Solgar, Inc.
- Street Address
- 500 Willow Tree Road
- City
- Leonia
- State
- NJ
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
P-5-P 50 mg by Solgar: Common Questions
Does P-5-P 50 mg by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this form of B6 better than regular pyridoxine?
Can I take this if I'm pregnant?
What does this product actually treat?
Are there side effects at this 50 mg dose?
Can I breastfeed while taking this?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if P-5-P 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind P-5-P 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
P-5-P 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 32 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin B6 32 references
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
- Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
- Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
- South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
- Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
- Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
- Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
- Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
- Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
- Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
- Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
- Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
- Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
- Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
- Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
- Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
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