Organic Flax Oil Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Organic Flax Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Organic Flax Oil is a dietary supplement by Nature's Way EfaGold with 1 active ingredient. Its ingredients are commonly taken for source of omega-3 (ala) fatty acids, heart and cholesterol health, dry skin and inflammation.Based on those ingredients, 379 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Flax seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Organic Flax Oil by Nature's Way EfaGold
Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Flax Oil by Nature's Way EfaGold — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Organic Flax Oil by Nature's Way EfaGold
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Nature's Way EfaGold is a liquid flax oil supplement with five active ingredients: polyunsaturated fat, linoleic acid, oleic acid, alpha-linolenic acid, and organic flax seed oil. It also contains FreshGuard Blend as an inactive ingredient.
Flax oil is a source of omega-3 and omega-6 fatty acids, which are essential fats your body cannot make on its own.
Does it work?
Moderate evidence
Oleic acid in this product is rated possibly effective for high cholesterol (hypercholesterolemia) and possibly effective for coronary heart disease. We hold no effectiveness data on file for the other active ingredients in this formula.
How safe is it?
Some data gaps
Oleic acid is generally recognized as safe in the amounts you'd get from food sources like olive oil. However, concentrated supplement doses haven't been well studied — food amounts are considered safe, but we don't have solid safety data for supplement-level amounts in pregnancy or while breastfeeding.
Because safety data is limited for high-dose supplement use, talk with your doctor or pharmacist before taking this product if you're pregnant or nursing.
Meds to double-check
Moderate interaction found
Check your antidiabetes drugs (blood sugar medications) with your doctor or pharmacist before adding this product — oleic acid may increase how strongly they work, potentially lowering blood sugar more than intended.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and some safety-information gaps remain.
If you take antidiabetes drugs, this product needs a conversation with your doctor or pharmacist first — it may strengthen your medication's effect. If your blood sugar is stable and you're not on diabetes medication, you can use the checker below to confirm your other medications aren't affected.
Either way, run your full list through before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Organic Flax Oil, straight from the product label.
| Brand | Nature's Way EfaGold |
|---|---|
| Barcode (UPC) | 033674154274 |
| Net contents | 24 fl. Oz.; 720 mL |
| Market status | On market |
| Date entered into DSLD | Feb 25, 2019 |
| DSLD ID | 200045 |
| Product type | Fat/fatty Acid |
| Supplement form | Liquid |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Organic Flax Oil by Nature's Way EfaGold, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Calories | 130 Calorie(s) | -- |
| Saturated Fat | 1 Gram(s) | 5% |
| Trans Fat | 0 Gram(s) | -- |
| Cholesterol | 0 mg | -- |
| Total Fat | 14 Gram(s) | 18% |
| Polyunsaturated Fat | 10 Gram(s) | -- |
| Linoleic Acid | 2.1 Gram(s) | -- |
| Oleic Acid | 2.4 Gram(s) | -- |
| Alpha-Linolenic Acid | 8 Gram(s) | -- |
| Monounsaturated Fat | 2.5 Gram(s) | -- |
| organic Flax seed Oil | 14 Gram(s) | -- |
Other ingredients: FreshGuard Blend
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Premium Organic Flax Oil 57% Omega-3 (alpha-linolenic acid) 17% Omega-9 (oleic acid) 15% Omega-6 (linoleic acid)
FreshGuard blend
57% Omega-3
General Statements
Superior Freshness & Flavor
Light protective bottles Nitrogen-flushed packaging
Please recycle this container. 1
Cold Pressed Unrefined
Product of Canada
Formulation
Cold Pressed & Unrefined Hexane free, no chemical solvents
Gluten Free. No sugar, salt, yeast, wheat, corn, soy, dairy products, artificial colors, or flavors.
Vegetarian
No Solvents
Certified Organic by Pro-Cert
Precautions
Keep out of reach of children.
Safety sealed with outer shrink-wrap seal and inner seal. Do not use if either seal is broken or missing.
If pregnant, nursing, or taking any medications, consult a healthcare professional before use.
Seals/Symbols
Pro-cert Organic Vegetarian
USDA Organic
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommendation: Shake well before use. Take 1 Tablespoon (15 mL) 1 to 2 times daily.
Storage
Refrigerate after opening.
Brand IP Statement(s)
2018 Distributed by Nature's Way Brands, LLC
General
LN15427.A04 BLQ7647A
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Organic Flax Oil by Nature's Way EfaGold label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Organic Flax Oil by Nature's Way EfaGold
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tbsp Dosage formLiquid Servings per container48 Amounts shown are per serving.
Organic Flax seed Oil
Interacts with293 drugs
Flaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help s...
Organic Flax seed Oil monograph & interactions- › Linoleic Acid
- › Oleic Acid
- › Alpha-Linolenic Acid
Other (inactive) ingredients: FreshGuard Blend. These complete the product’s ingredient list but are not active constituents.
Organic Flax Oil by Nature's Way EfaGold Drug Interactions
HelloPharmacist Interaction Report
Nature's Way EfaGold Organic Flax Oil contains oleic acid, which has documented interactions with medications.
The most serious concern is with antidiabetes drugs (blood sugar medications) — oleic acid may increase their effects, potentially lowering blood sugar more than expected.
Read the full breakdown — every affected drug type, severity by severity
Altogether, these interactions span 86 individual medications. The affected drug type is antidiabetes drugs, where the interaction is rated Moderate in severity.
Research in people with type 2 diabetes suggests that diets rich in oleic acid lower fasting blood glucose levels compared to diets higher in other oils, which means your blood sugar medication might work more strongly than usual.
We could not check three other ingredients in this product — polyunsaturated fat, linoleic acid, and alpha-linolenic acid — because we hold no interaction data for them. Use the medication checker on this page to search your exact medications against the full list.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Organic Flax Oil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Organic Flax Oil interact with 379 drugs. Click any drug to see the details.
1 of the 1 ingredient in Organic Flax Oil interact with drugs. Each result below shows which ingredient is responsible. organic Flax seed Oil
AbciximabReoPro
How Abciximab interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Acetaminophen, Ibuprofen interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Albiglutide interactionAliskirenTekturna
How Aliskiren interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Aliskiren interactionAlogliptinNesina
How Alogliptin interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Oleic AcidAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, oleic acid might increase the effects of antidiabetes drugs.
Read the full Oleic Acid + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Ambrisentan interactionAmilorideAmilamont, Midamor
How Amiloride interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amiloride interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amiloride, Hydrochlorothiazide interactionAmlodipineNorliqva
How Amlodipine interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Amlodipine, Celecoxib interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Read the full Organic Flax Seed Oil + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Organic Flax Oil — through 1 ingredient. Tap an ingredient for the detail:
Organic Flax Seed OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Read the full Organic Flax Seed Oil + Anacaulase-bcdb interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Organic Flax Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
organic Flax seed Oil
Anticoagulant/Antiplatelet Drugs
Theoretically, using flaxseed oil in combination with anticoagulant or antiplatelet drugs might have additive effects and increase the risk of bleeding.
Small clinical studies show that consuming flaxseed oil might decrease platelet aggregation and increase bleeding time.
Antihypertensive Drugs
Theoretically, combining flaxseed oil with other antihypertensive drugs might have additive effects and increase the risk of hypotension.
Some clinical evidence suggests that long-term consumption of flaxseed oil can modestly lower systolic and diastolic blood pressure, while other clinical research shows no effect.
Ezetimibe (Zetia)
Concomitant use of flaxseed oil and ezetimibe reduces the absorption of alpha-linolenic acid from flaxseed oil.
In one clinical study, concomitant consumption of ezetimibe 10 mg daily with flaxseed oil 2 grams providing 1 gram of alpha-linolenic acid daily blocked the absorption of alpha-linolenic acid, resulting in an overall reduction in alpha-linolenic plasma levels from baseline.
Brand information
Manufacturer and brand details for Organic Flax Oil, from the product label.
Nature's Way EfaGold
See all Nature's Way EfaGold products- Name
- Nature's Way Brands, LLC
- City
- Green Bay
- State
- WI
- ZipCode
- 54311
- Phone Number
- 1-800-962-8873
- Web Address
- naturesway.com
Organic Flax Oil by Nature's Way EfaGold: Common Questions
Does Organic Flax Oil by Nature's Way EfaGold interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this help my cholesterol?
Can I take this if I'm on diabetes medication?
Is it safe to take while pregnant or breastfeeding?
What's in this besides the flax oil?
Are there any side effects from flax oil?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Organic Flax Oil is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Organic Flax Oil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Flaxseed Oil
Interacts with 293 drugsFlaxseed oil is a plant-based source of the omega-3 fatty acid ALA, which the body can partly convert to the omega-3s found in fish oil. It may help support heart health and provide healthy...
Read the full Flaxseed Oil monograph → Herb & supplement monographOleic Acid
Interacts with 86 drugsOleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...
Read the full Oleic Acid monograph →Sources & How We Checked
Organic Flax Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Oleic Acid 19 references
- Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
- Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
- Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
- Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
- Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
- Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
- FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
- Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
- Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
- Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
- Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
- Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
- Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
- Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
- Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
- de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
- Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
- Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
- Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed
Flaxseed Oil 21 references
- Kolonel LN, Nomura AM, Cooney RV. Dietary fat and prostate cancer: current status. J Natl Cancer Inst 1999;91:414-28. PubMed
- Ramon JM, Bou R, Romea S, et al. Dietary fat intake and prostate cancer risk: a case-control study in Spain. Cancer Causes Control 2000;11:679-85. PubMed
- Nordstrom DC, Honkanen VE, Nasu Y, et al. Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed. Rheumatol Int 1995;14:231-4. PubMed
- De Stefani E, Deneo-Pellegrini H, Boffetta P, et al. Alpha-linolenic acid and risk of prostate cancer: a case-control study in Uruguay. Cancer Epidemiol Biomarkers Prev 2000;9:335-8.
- Giovannucci E, Rimm EB, Colditz GA, et al. A prospective study of dietary fat and risk of prostate cancer. J Natl Cancer Inst 1993;85:1571-9. PubMed
- Bloedon LT, Szapary PO. Flaxseed and cardiovascular risk. Nutr Rev 2004;62:18-27. DOI
- Laaksonen DE, Laukkanen JA, Niskanen L, et al. Serum linoleic and total polyunsaturated fatty acids in relation to prostate and other cancers: a population-based cohort study. Int J Cancer 2004;111:444-50.. PubMed
- Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22.
- Paschos GK, Magkos F, Panagiotakos DB, et al. Dietary supplementation with flaxseed oil lowers blood pressure in dyslipidaemic patients. Eur J Clin Nutr 2007;61:1201-6. PubMed
- Harper CR, Edwards MC, Jacobson TA. Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjects. J Nutr 2006;136:2844-8. PubMed
- University of Montreal. Pregnant Women Consuming Flaxseed Oil Have High Risk Of Premature Birth.ScienceDaily, October 29, 2008. Available at: www.sciencedaily.com/releases/2008/10/081027140817.htm (Accessed May 14, 2009).
- Allman, M. A., Pena, M. M., and Pang, D. Supplementation with flaxseed oil versus sunflowerseed oil in healthy young men consuming a low fat diet: effects on platelet composition and function. Eur.J Clin.Nutr. 1995;49(3):169-178.
- Ursoniu S, Sahebkar A, Andrica F, Serban C, Banach M; Lipid and Blood Pressure Meta-analysis Collaboration Group. Effects of flaxseed supplements on blood pressure: a systematic review and meta-analysis of controlled clinical trial. Clin Nutr. 2016 Jun;3 PubMed
- Taghizadeh M, Jamilian M, Mazloomi M, Sanami M, Asemi Z. A randomized-controlled clinical trial investigating the effect of omega-3 fatty acids on vitamin E co-supplementation on markers of insulin metabolism and lipid profiles in gestational diabetes. J
- Blackwood DP, LaVallee RK, Al Busaidi A, Jassal DS, Pierce GN. A randomized trial of the effects of ezetimibe on the absorption of omega-3 fatty acids in cardiac disease patients: a pilot study. Clin Nutr ESPEN. 2015 Oct;10(5):e155-e159. PubMed
- Morshedzadeh N, Shahrokh S, Aghdaei HA, et al. Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complement Ther Med. 2019;46:36-43. PubMed
- Downie LE, Hom MM, Berdy GJ, et al. An artificial tear containing flaxseed oil for treating dry eye disease: A randomized controlled trial. Ocul Surf. 2020;18(1):148-157. PubMed
- Saleh-Ghadimi S, Kheirouri S, Golmohammadi A, Moludi J, Jafari-Vayghan H, Alizadeh M. Effect of flaxseed oil supplementation on anthropometric and metabolic indices in patients with coronary artery disease: A double-blinded randomized controlled trial. J PubMed
- Jamilian M, Tabassi Z, Reiner Z, et al. The effects of n-3 fatty acids from flaxseed oil on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2020;123(7):792-799
- Li L, Li H, Gao Y, Vafaei S, Zhang X, Yang M. Effect of flaxseed supplementation on blood pressure: a systematic review, and dose-response meta-analysis of randomized clinical trials. Food Funct 2023;14(2):675-690. PubMed
- Mahmudiono T, Jasim SA, Karim YS, et al. The effect of flaxseed oil consumption on blood pressure among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized clinical trials. Phytother Res 2022;36(10):
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