Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Flex Mobility Ingredients & Drug Interactions

by NOW

Flex Mobility label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Flex Mobility against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Flex Mobility is a dietary supplement by NOW with 5 active ingredients. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 876 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Devil's Claw extract, Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Flex Mobility by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Flex Mobility by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Flex Mobility by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Flex Mobility contains 5 active ingredients. Bromelain is an enzyme from pineapple that may have anti-inflammatory properties.

Regenasure Glucosamine HCl is a compound that supports joint structure. FlavanFlex is a plant-derived ingredient.

Boswellin is an extract of frankincense resin, traditionally used in joint and mobility support. Devil's claw extract comes from a southern African plant root, also used for joint comfort.

The capsules also contain inactive ingredients (cellulose, rice flour, stearic acid, magnesium stearate, silica, and maltodextrin) that serve as fillers and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: joint health and healthy inflammatory response.
  • We looked for evidence on: Osteoarthritis, Back pain, Knee pain, Rheumatoid arthritis (RA), Exercise-induced muscle soreness, Postoperative swelling — and 4 related terms.
  • The strongest evidence on file: Devil's Claw is rated "Possibly Effective" for Back pain (Natural Medicines).
  • Also on file: Devil's Claw is rated "Possibly Effective" for Osteoarthritis.
  • Also on file: Frankincense is rated "Insufficient Reliable Evidence To Rate" for Back pain, Osteoarthritis, Rheumatoid arthritis (RA).

The evidence is sparse for most uses in this product. Bromelain has insufficient reliable evidence for hay fever, burns, cancer, chemotherapy nerve damage, vein insufficiency, and diabetes.

Boswellin also shows insufficient evidence for acne, aging skin, back pain, cancer fatigue, and radiation skin damage. Devil's claw is possibly effective for back pain and osteoarthritis, but shows insufficient evidence for atherosclerosis.

The evidence, ingredient by ingredient Bromelain Frankincense Devil's Claw

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bromelain and devil's claw are generally well tolerated for short-term use, though long-term safety data is limited for both. The most common side effects from bromelain are diarrhea, flatulence, stomach upset, and headache when taken by mouth.

Devil's claw may cause allergic skin reactions, diarrhea, and indigestion—8 to 18% of users report digestive complaints, especially at higher doses. Rarely, devil's claw has caused gastrointestinal bleeding and neurological symptoms like headache, dizziness, and sleep disturbance in case reports.

Both bromelain and devil's claw may trigger allergic reactions, including asthma or throat swelling if inhaled. Bromelain is not recommended during pregnancy and should be avoided while breastfeeding.

Devil's claw is possibly unsafe in pregnancy because it may affect the uterus, and safety while breastfeeding is not established. Data on Boswellin and pregnancy or breastfeeding advises against use.

We hold no pregnancy or breastfeeding data for Regenasure Glucosamine HCl and FlavanFlex.

Side effects, ingredient by ingredient Bromelain Frankincense Devil's Claw

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Bromelain, Devil's Claw.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 877 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before using this product if you take blood thinners or antiplatelet drugs (like warfarin or aspirin)—bromelain may increase bleeding risk. Also clear it if you use warfarin or other medications metabolized by CYP2C19, CYP2C9, or CYP3A4 enzymes (a very broad category including many heart, blood pressure, and psychiatric drugs), or if you take acid-reflux medications like H2-blockers or proton pump inhibitors.

Devil's claw may theoretically raise levels of these drugs or interfere with acid control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Flex Mobility may be worth considering if you're interested in joint and mobility support and have no contraindications—but you'll want to be careful if you take blood thinners, antiplatelet drugs, warfarin, or medications your liver breaks down (especially via the CYP2C9, CYP2C19, or CYP3A4 pathways), or if you use acid-reflux medications. Talk with your doctor or pharmacist about whether this product is right for your medications and health before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Flex Mobility, straight from the product label.

Brand NOW
Barcode (UPC) 733739034304
Net contents 120 Vcap(s)(R)
Market status On market
Date entered into DSLD Nov 21, 2012
DSLD ID 15229
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Flex Mobility by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Vegetarian Capsule(s)
Maximum serving Sizes:
2 Vegetarian Capsule(s)
Servings per container
60
UPC/BARCODE
733739034304
IngredientAmount% DV
Bromelain250 mg--
Regenasure Glucosamine HCl750 mg--
FlavanFlex(TM)125 mg--
Boswellin100 mg--
Devil's Claw extract100 mg--

Other ingredients: Cellulose, Rice Flour, Stearic Acid, Magnesium Stearate, Silica, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

NOW Foods developed the glucosamine test method chosen as the official AOACI industry standard method.

ACTUAL SIZE

JOINT HEALTH Supports a Healthy Inflammatory Response*

Made in the U.S.A.

Please Recycle.

Formulation

Vegetarian

The Glucosamine in this product is derived from a vegetarian, Non-GMO fungal source.

Vegetarian/Vegan Product.

Contains no sugar, salt, yeast, wheat, gluten, soy, milk, egg, shellfish or preservatives.

FDA Statement of Identity

A Dietary Supplement

Suggested/Recommended/Usage/Directions

SUGGESTED USAGE: As a dietary supplement, take 2 Vcaps(R) 2 times daily with meals or on an empty stomach. Consider taking this product in combination with NOW(R) Hyaluronic Acid, MSM and Serrazimes(R).

Seals/Symbols

GMP QUALITY ASSURED

Brand IP Statement(s)

Regenasure(R) is a registered trademark of Cargill; Boswellin(R) is a registered trademark of Sabinsa Corporation; Vcaps(R) is a registered trademark of Capsugel. FlavanFlex(TM) is covered by US Patent Nos. 7,108,868 and 7,192,611, and additional patents pending.

NOW(R) Flex Mobility(TM) is a 100% vegetarian joint support formula with Regenasure(R), the only non-shellfish, non-animal derived Glucosamine. Glucosamine is naturally produced in the human body and is an important constituent of connective tissues, such as joints. Flex Mobility(TM) also contains FlavanFlex(TM), a patented herbal extract that has been scientifically shown to support a healthy inflammatory response through its effects on COX and LOX enzyme activity. COX and LOX enzymes help to regulate activity of signaling molecules that are critical for the maintenance of normal immune and inflammatory function. In addition, Boswellin(R) and Devil's Claw have been included for their ability to support healthy inflammatory responses through these and other mechanisms. With Glucosamine and complementary herbal extracts, NOW(R) Flex Mobility(TM) provides comprehensive support for joint structure, as well as joint comfort.*

Precautions

Do Not Eat Freshness Packet. Keep in Bottle.

Storage

Store in a cool, dry place.

General

CODE 3430 V1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Flex Mobility by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Flex Mobility label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Flex Mobility by NOW

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bromelain

Interacts with
141 drugs
250 mg per serving

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Regenasure Glucosamine HCl

750 mg per serving

FlavanFlex(TM)

125 mg per serving Form: Acacia catechu, Scutellaria baicalensis

Boswellin

No known
interactions
100 mg per serving

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. E...

Boswellin monograph & interactions

Devil's Claw extract

Interacts with
804 drugs
100 mg per serving

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort....

Devil's Claw extract monograph & interactions

Other (inactive) ingredients: Cellulose, Rice Flour, Stearic Acid, Magnesium Stearate, Silica, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Flex Mobility by NOW Drug Interactions

Want to check YOUR meds against Flex Mobility?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
876Drugs
799 Moderate 77 Minor

Ingredients driving the most interactions

Devil's Claw extract 804
Bromelain 141

Individual Drug Interactions

The ingredients in Flex Mobility interact with 876 drugs. Click any drug to see the details.

2 of the 5 ingredients in Flex Mobility interact with drugs. Each result below shows which ingredient is responsible. Devil's Claw extract Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Flex Mobility with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Devil's Claw extract7 drug types · 804 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that devil's claw might inhibit CYP2C19, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that devil's claw might inhibit CYP2C9, although this has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, devil's claw might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that devil's claw might inhibit CYP3A4, although this has not been reported in humans.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, Devil's claw might increase the activity of warfarin.
In one case report, purpura occurred in a patient taking warfarin and devil's claw concurrently. This might indicate over-anticoagulation. It is unclear if this was due to Devil's claw or other contributing factors.

Likelihood Possible Evidence D
H2-Blockers

Theoretically, devil's claw might decrease the effectiveness of H2-blockers.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of H2-blockers.

Likelihood Possible Evidence D
P-Glycoprotein Substrates

Theoretically, devil's claw might increase levels of P-glycoprotein substrates.
In vitro research shows that devil's claw inhibits P-glycoprotein, which transports many drugs out of cells. This might increase intracellular levels of P-glycoprotein substrates, although it is unclear if this effect would be clinically important.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Theoretically, devil's claw might decrease the effectiveness of PPIs.
Devil's claw has been reported to increase stomach acid, which might interfere with the effects of PPIs.

Likelihood Possible Evidence D
Devil's Claw extract full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Flex Mobility, from the product label.

NOW

See all NOW products
Name
NOW FOODS
City
BLOOMINGDALE
State
IL
ZipCode
60108
Web Address
www.nowfoods.com
Pharmacist Counseling Corner

Flex Mobility by NOW: Common Questions

Does Flex Mobility by NOW interact with any medications?
Yes. Based on its ingredients, Flex Mobility has a known interaction with 876 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Flex Mobility contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take Flex Mobility if I'm pregnant?
No. Bromelain is not recommended in pregnancy, and devil's claw is possibly unsafe because it may affect the uterus. Talk with your doctor or pharmacist about your options.
Can I take this while breastfeeding?
Safety data for bromelain and devil's claw while breastfeeding is not established or advises against use. Check with your doctor or pharmacist before taking it.
Does devil's claw really help with back pain?
Evidence suggests devil's claw is possibly effective for back pain and osteoarthritis. The other ingredients in this product lack reliable evidence for their claimed uses.
What are the most common side effects?
Bromelain may cause diarrhea, flatulence, stomach upset, and headache. Devil's claw may cause allergic skin reactions, diarrhea, and indigestion in 8 to 18% of users at standard doses.
Can this trigger an allergic reaction?
Yes. Both bromelain and devil's claw may cause allergic reactions. If you inhale bromelain dust, it can trigger asthma, throat swelling, and other respiratory symptoms—a concern mainly for factory workers. Skin reactions have been reported with both ingredients.
Is there anything else in these capsules besides the active ingredients?
Yes. The capsules contain inactive ingredients: cellulose, rice flour, stearic acid, magnesium stearate, silica, and maltodextrin, which are fillers and binders.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Flex Mobility is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Flex Mobility label
Go deeper

The Full Monographs Behind Flex Mobility’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Frankincense

Frankincense is the aromatic resin of the Boswellia tree and is best known for its boswellic acids, which may help with inflammation and joint pain. Early research is promising for condition...

Read the full Frankincense monograph → Herb & supplement monograph

Devil's Claw

Interacts with 804 drugs

Devil's claw is a southern African plant used mainly for arthritis and back pain, and some studies suggest it may help ease these types of discomfort. The evidence is moderate at best, and p...

Read the full Devil's Claw monograph →
Sources

Sources & How We Checked

Flex Mobility's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Frankincense 2 references
  1. Acebo, E., Raton, J. A., Sautua, S., Eizaguirre, X., Trebol, I., and Perez, J. L. Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream. Contact Dermatitis 2004;51(2):91-92.
  2. Buonomo M, Hylwa S. Allergic contact dermatitis from Boswellia carterii (frankincense) oil. Contact Dermatitis 2021;85(4):465-467.

See these in context on the Frankincense monograph →

Devil's Claw 18 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Chantre P, Cappelaere A, Leblan D, et al. Efficacy and tolerance or Harpagophytum procumbens versus diacerhein in treatment of osteoarthritis. Phytomedicine 2000;7:177-83.
  4. Chrubasik S, Thanner J, Kunzel O, et al. Comparison of outcome measures during treatment with the proprietary Harpagophytum extract doloteffin in patients with pain in the lower back, knee or hip. Phytomedicine 2002;9:181-94. PubMed
  5. Circosta C, Occhiuto F, Ragusa S, et al. A drug used in traditional medicine: Harpagophytum procumbens DC. II. Cardiovascular activity. J Ethnopharmacol 1984;11:259-74. PubMed
  6. Grahame R, Robinson BV. Devils's claw (Harpagophytum procumbens): pharmacological and clinical studies. Ann Rheum Dis 1981;40:632. PubMed
  7. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  8. Wegener T, Lupke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC). Phytother Res 2003;17:1165-72.
  9. Chrubasik S, Kunzel O, Thanner J, et al. A 1-year follow-up after a pilot study with Doloteffin for low back pain. Phytomedicine 2005;12:1-9. PubMed
  10. Romiti N, Tramonti G, Corti A, Chieli E. Effects of Devil's Claw (Harpagophytum procumbens) on the multidrug transporter ABCB1/P-glycoprotein. Phytomedicine 2009;16:1095-100. PubMed
  11. Chrubasik, S., Junck, H., Breitschwerdt, H., Conradt, C., and Zappe, H. Effectiveness of Harpagophytum extract WS 1531 in the treatment of exacerbation of low back pain: a randomized, placebo-controlled, double- blind study. Eur.J Anaesthesiol. 1999;16(2 DOI
  12. Laudahn, D. and Walper, A. Efficacy and tolerance of Harpagophytum extract LI 174 in patients with chronic non-radicular back pain. Phytother.Res. 2001;15(7):621-624.
  13. Belaiche P. Etude clinique de 630 cas d'artrose traites par le nebulisat aqueux d'Harpagophytum procumbens (Radix). Phytotherapy 1982;1:22-28.
  14. Chrubasik S, Model A, Black A, and et al. A randomized double-blind pilot study comparing Doloteffin® and Vioxx® in the treatment of low back pain. Rheumatology 2003;42:141-148.
  15. Cuspidi C, Sala C, Tadic M, et al. Systemic hypertension induced by Harpagophytum procumbens (devil's claw): a case report. J Clin Hypertens (Greenwich) 2015;17(11):908-10.
  16. Mahomed IM, Ojewole JAO. Oxytocin-like effect of Harpagophytum procumbens [Pedaliacae] secondary root aqueous extract on rat isolated uterus. Afr J Trad CAM 2006;3(1):82-89.
  17. Carvalho RR, Donadel CD, Cortez AF, Valviesse VR, Vianna PF, Correa BB. J Bras Nefrol. 2017 Mar;39(1):79-81.
  18. Anon. Devil's claw root: ulcers and gastrointestinal bleeding. Prescrire Int 2013;22(144):296.

See these in context on the Devil's Claw monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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