Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Folic Acid 5 mg Ingredients & Drug Interactions

by Vitamatic

Folic Acid 5 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Folic Acid 5 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Folic Acid 5 mg is a dietary supplement by Vitamatic with 1 active ingredient. Its ingredients are commonly taken for preventing neural tube birth defects, treating or preventing folate deficiency, supporting pregnancy health.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Folic Acid 5 mg by Vitamatic

Ask about any prescription or over-the-counter medication and we check it for interactions with Folic Acid 5 mg by Vitamatic — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Folic Acid 5 mg by Vitamatic

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (8,333 mcg DFE) without saying how much of each component you get.

This product contains 1 active ingredient: folic acid 5 mg per tablet. Folic acid is a B vitamin that your body needs to make new cells and maintain DNA.

It's the synthetic form of the naturally occurring folate found in foods like leafy greens and legumes. The tablet also contains several inactive ingredients — dicalcium phosphate, microcrystalline cellulose, stearic acid, beet powder, croscarmellose sodium, magnesium stearate, and silicon dioxide — which help bind and deliver the folic acid.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports healthy prenatal development.
  • We looked for evidence on: Neural tube birth defects, Abdominal wall defects, Oral clefts, Low birth weight, Fetal and premature infant mortality, Folate deficiency — and 4 related terms.
  • The strongest evidence on file: Folic Acid is rated "Effective" for Folate deficiency (Natural Medicines).
  • Also on file: Folic Acid is rated "Likely Effective" for Neural tube birth defects.
  • Also on file: Folic Acid is rated "Possibly Ineffective" for Fetal and premature infant mortality.

The evidence behind folic acid is strong for some uses and weaker for others. It's effective for treating folate deficiency and likely effective for preventing methotrexate toxicity and neural tube birth defects (like spina bifida) during pregnancy.

It's possibly effective for depression, phenytoin-induced gum overgrowth, and cognitive impairment, meaning the research is promising but not yet conclusive.

The evidence, ingredient by ingredient Folic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Folic acid at this 5 mg dose is generally well tolerated in most adults. At this amount, the most common side effects are abdominal cramps, diarrhea, and rash; these are not common but possible.

It's recommended at standard prenatal doses to help prevent birth defects during pregnancy and is considered safe while breastfeeding at normal recommended doses. One caution: if you have undiagnosed anemia, folic acid can mask the symptoms of pernicious anemia (a vitamin B12 deficiency disorder), which can lead to nerve damage if left untreated.

Don't self-treat suspected anemia; have your doctor check first. Large doses can also worsen symptoms in people who are deficient in vitamin B12.

Side effects, ingredient by ingredient Folic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Folic Acid.
  • The most serious interaction on file is rated Moderate.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check with your doctor or pharmacist if you take seizure medications (phenobarbital, phenytoin, primidone), cancer treatments (methotrexate, capecitabine, 5-fluorouracil), or pyrimethamine for parasitic infections. All carry moderate-severity interactions with folic acid that can reduce how well they work or increase their toxicity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Folic acid is a solid choice if you're pregnant, deficient in folate, or dealing with certain other conditions — but the seizure and cancer medication interactions are significant. If you take phenobarbital, phenytoin, primidone, methotrexate, capecitabine, 5-fluorouracil, or pyrimethamine, you need to talk this over with your doctor or pharmacist before starting.

Even if you're not on those, run your full medication list through the checker to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Folic Acid 5 mg, straight from the product label.

Brand Vitamatic
Barcode (UPC) 810078470625
Net contents 120 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 283027
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Folic Acid 5 mg by Vitamatic, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
120
UPC/BARCODE
810078470625
IngredientAmount% DV
Folic Acid5000 mcg--
Folate8333 mcg DFE2083%

Other ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Beet, Powder, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Consult with your healthcare provider if you are pregnant, nursing, taking any medications or planning any medical procedures.

Do not use if the safety seal is broken or missing.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formulation

Free of sugar, starch, yeast, soy, corn, wheat, egg, artificial colors, flavors & preservatives.

Supports healthy prenatal development

Non GMO

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Essential B-vitamin

Seals/Symbols

GMP Good Manufacturing Practice Certified Made in U.S.A.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 tablet daily with meal or as directed by your qualified health care provider.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Folic Acid 5 mg by Vitamatic label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Folic Acid 5 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Folic Acid 5 mg by Vitamatic

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container120 Amounts shown are per serving.

Folate

8333 mcg DFE per serving

Other (inactive) ingredients: Dicalcium Phosphate, Microcrystalline Cellulose, Stearic Acid, Beet, Powder, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Folic Acid 5 mg by Vitamatic Drug Interactions

Want to check YOUR meds against Folic Acid 5 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Moderate

Ingredients driving the most interactions

Folic Acid 40

Individual Drug Interactions

The ingredients in Folic Acid 5 mg interact with 40 drugs. Click any drug to see the details.

1 of the 1 ingredient in Folic Acid 5 mg interact with drugs. Each result below shows which ingredient is responsible. Folic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Folic Acid 5 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Folic Acid 5 mg, from the product label.

Vitamatic

See all Vitamatic products
Name
Vitamatic
Street Address
PO Box 406
City
Raritan
State
NJ
ZipCode
08869
Phone Number
1-973-400-9165
Web Address
www.vitamaticusa.com
Pharmacist Counseling Corner

Folic Acid 5 mg by Vitamatic: Common Questions

Does Folic Acid 5 mg by Vitamatic interact with any medications?
Yes. Based on its ingredients, Folic Acid 5 mg has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Folic Acid 5 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take folic acid if I'm pregnant?
Yes — folic acid is recommended at standard prenatal doses during pregnancy to help prevent birth defects like spina bifida. It's considered safe for this use. If you're already taking a prenatal vitamin, check its folic acid content to avoid taking too much.
Can I take this if I'm breastfeeding?
Yes, folic acid is considered safe at normal recommended doses while breastfeeding.
What are the most common side effects at this dose?
At 5 mg daily, folic acid can cause abdominal cramps, diarrhea, and rash, though these aren't common. Higher doses bring a different set of side effects like nausea and sleep disturbances.
Will this help my depression?
Folic acid is possibly effective for depression based on current research, meaning the evidence is promising but not definitive. Talk to your doctor about whether it makes sense for your situation.
Can folic acid help if I have anemia?
It depends on what kind. Don't self-treat for anemia — folic acid can hide the symptoms of pernicious anemia, a serious B12 deficiency that can cause nerve damage if it goes untreated. Have your doctor figure out what's going on first.
Is this product just folic acid, or are there other ingredients?
It's folic acid plus several inactive ingredients that help bind and deliver the tablet — like cellulose, magnesium stearate, and silicon dioxide. These are standard tablet fillers and don't add active effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Folic Acid 5 mg label
Go deeper

The Full Monographs Behind Folic Acid 5 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph →
Sources

Sources & How We Checked

Folic Acid 5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 56 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
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  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
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  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
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  36. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
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  39. van Wijngaarden JP, Swart KM, Enneman AW, et al. Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial. Am J Clin
  40. Qin X, Fan F, Cui Y, Chen F, Chen Y, Cheng X, Li Y, Wang B, Xu X, Xu X, Huo Y, Wang X. Folic acid supplementation with and without vitamin B6 and revascularization risk: a meta-analysis of randomized controlled trials. Clin Nutr. 2014;33(4):603-12. PubMed
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  47. Van Der Woude DA, De Vries J, Van Wijk EM, Verzijl JM, Pijnenborg JM. A randomized controlled trial examining the addition of folic acid to iron supplementation in the treatment of postpartum anemia. Int J Gynaecol Obstet. 2014;126(2):101-5. PubMed
  48. Vila-Nova C, Wehby GL, Queirós FC, Chakraborty H, Félix TM, Goco N, Moore J, Gewehr EV, Lins L, Affonso CM, Murray JC. Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. J Perinat Med. 201 PubMed
  49. Vollset SE, Clarke R, Lewington S, Ebbing M, Halsey J, Lonn E, Armitage J, Manson JE, Hankey GJ, Spence JD, Galan P, Bønaa KH, Jamison R, Gaziano JM, Guarino P, Baron JA, Logan RF, Giovannucci EL, den Heijer M, Ueland PM, Bennett D, Collins R, Peto R; B-V
  50. Wehby GL, Félix TM, Goco N, Richieri-Costa A, Chakraborty H, Souza J, Pereira R, Padovani C, Moretti-Ferreira D, Murray JC. High dosage folic acid supplementation, oral cleft recurrence and fetal growth. Int J Environ Res Public Health. 2013 4;10(2):590-6 PubMed
  51. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  52. Liu J, Li Z, Ye R, Liu J, Ren A. Periconceptional folic acid supplementation and risk of parent-reported asthma in children at 4-6 years of age. ERJ Open Res. 2020;6(1):00250-2019. PubMed
  53. Houghton LA, Sherwood KL, Pawlosky R, Ito S, O'Connor DL. [6S]-5-Methyltetrahydrofolate is at least as effective as folic acid in preventing a decline in blood folate concentrations during lactation. Am J Clin Nutr. 2006 Apr;83(4):842-50. PubMed
  54. Houghton LA, Yang J, O'Connor DL. Unmetabolized folic acid and total folate concentrations in breast milk are unaffected by low-dose folate supplements. Am J Clin Nutr. 2009 Jan;89(1):216-20. PubMed
  55. Chan SL, Chan AWH, Mo F, et al. Association Between Serum Folate Level and Toxicity of Capecitabine During Treatment for Colorectal Cancer. Oncologist. 2018 Dec;23(12):1436-1445. PubMed
  56. Sarris J, Ravindran A, Yatham LN, et al. Clinician guidelines for the treatment of psychiatric disorders with nutraceuticals and phytoceuticals: The World Federation of Societies of Biological Psychiatry (WFSBP) and Canadian Network for Mood and Anxiety T

See these in context on the Folic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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