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Dietary supplement

Formula 498 Ingredients & Drug Interactions

by DC

Formula 498 label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Formula 498 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Formula 498 is a dietary supplement by DC with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart health support, blood sugar support.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Barley Grass. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Formula 498 by DC

Ask about any prescription or over-the-counter medication and we check it for interactions with Formula 498 by DC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Formula 498 by DC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Formula 498 contains one active ingredient: barley grass. Barley grass is the young shoot of the barley plant and is used in this product for its potential effects on cholesterol and heart health.

The capsule also contains kosher gelatin as an inactive ingredient.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Barley's overall clinical evidence instead.

Strong

Strong clinical evidence supports Barley for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Likely Effective" (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Likely Effective" (Natural Medicines).

Barley grass is likely effective for lowering cholesterol (hypercholesterolemia) and supporting heart health in coronary heart disease. The evidence comes from established research on barley's cardiovascular benefits.

The evidence, ingredient by ingredient Barley

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Barley grass is generally well tolerated when taken by mouth. The most common side effects are mild: bloating, gas, abdominal distension, and an unpleasant taste.

Some people may have allergic reactions, especially those sensitive to grains — symptoms can range from tingling around the mouth to more serious reactions like swelling, hives, chest tightness, shortness of breath, or in rare cases, anaphylaxis. Barley contains gluten, so it's not suitable if you have celiac disease or gluten sensitivity.

For pregnancy, concentrated barley grass supplements haven't been well studied — there isn't enough data to know if they're safe. The same goes for breastfeeding: safety data is limited.

Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while nursing.

Side effects, ingredient by ingredient Barley

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Barley.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take triclabendazole (Egaten) for a parasitic infection, check with your doctor or pharmacist before starting this product — barley may reduce how well your body uses the medication. No other interactions are documented for the ingredients we hold data on.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Formula 498 may help with cholesterol and heart health, but barley grass does interact with triclabendazole (a parasitic infection medication), so check with your doctor before taking it if you're on that drug. If you're sensitive to grains or have celiac disease, avoid this product — it contains gluten.

For pregnancy or breastfeeding, confirm with your own doctor or pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Formula 498, straight from the product label.

Brand DC
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 265766
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Formula 498 by DC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
90
IngredientAmount% DV
Barley Grass460 mg--

Other ingredients: kosher Gelatin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Dee Cee's Barley Grass is grown in the United States on the midwestern plains. Immediately after harvest it is dried by a special process that uses dehumidified air rather than heat to remove the moisture. Barley Grass is an excellent source of chlorophyll and contains many nutrients found in dark green leafy vegetables. It is grown on farms that use no chemical sprays or pesticides.

100% whole leaf barley grass powder.

Barley grass

Ko Kosher Service

Formulation

Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs)

No additives or dilutents. Gluten free

Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability. Made in USA

Made in USA

Precautions

Tamper Evident: Do not use this product if imprinted foil seal under cap is broken or missing.

Keep out of reach of children.

Caution: If you are pregnant or nursing do not take this product.

Storage

Keep tightly closed. Store at room temperature: 59 degrees - 86 degrees F (15 degrees to 30 degrees C).

Seals/Symbols

Quali Pure

Ko Kosher Service

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 1 to 3 capsules three times daily.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Formula 498 by DC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Formula 498 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Formula 498 by DC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Barley Grass

Interacts with
1 drug
460 mg per serving

Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad...

Barley Grass monograph & interactions

Other (inactive) ingredients: Kosher Gelatin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Formula 498 by DC Drug Interactions

Want to check YOUR meds against Formula 498?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Barley Grass 1

Individual Drug Interactions

The ingredients in Formula 498 interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Formula 498 interact with drugs. Each result below shows which ingredient is responsible. Barley Grass

Each ingredient & the kinds of drugs it affects

For each ingredient in Formula 498 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Barley Grass1 drug type · 1 drug

Triclabendazole (Egaten)

Theoretically, barley might decrease the clinical effects of triclabendazole.
Animal research suggests that a diet supplemented with barley can reduce the bioavailability of triclabendazole when taken concomitantly. This effect has not been shown in humans.

Likelihood Possible Evidence D
Barley Grass full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Formula 498, from the product label.

DC

See all DC products
Name
Dee Cee Laboratories, Inc.
Street Address
304 Dee Cee Rd.
City
White House
State
TN
ZipCode
37188
Pharmacist Counseling Corner

Formula 498 by DC: Common Questions

Does Formula 498 by DC interact with any medications?
Yes. Based on its ingredients, Formula 498 has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Formula 498 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does barley grass contain gluten?
Yes. Barley is a grain that contains gluten, so if you have celiac disease or gluten sensitivity, this product is not for you.
What are the most common side effects?
Most people tolerate barley grass well. The most common side effects are bloating, gas, abdominal distension, and an unpleasant taste. Some people with grain sensitivity may have allergic reactions, which can range from mild (tingling around the mouth) to severe (swelling, shortness of breath, or in rare cases, anaphylaxis).
Is barley grass safe during pregnancy?
Concentrated barley grass supplements haven't been well studied in pregnancy, so there isn't enough data to know either way. Talk with your doctor or pharmacist for personalized advice.
Can I take this while breastfeeding?
There's limited safety data on barley grass supplements during breastfeeding. Check with your doctor or pharmacist before taking it.
What is barley grass used for in this product?
Barley grass is included because research shows it's likely effective at helping lower cholesterol and supporting heart health in people with coronary heart disease.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Formula 498 is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Formula 498 label
Go deeper

The Full Monographs Behind Formula 498’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Barley

Interacts with 1 drug

Barley is a nutritious whole grain that is a good source of soluble fiber called beta-glucan, which has solid evidence for modestly lowering LDL ('bad') cholesterol when eaten regularly. It...

Read the full Barley monograph →
Sources

Sources & How We Checked

Formula 498's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Barley 15 references
  1. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  2. Fernandez-Anaya S, Crespo JF, Rodriguez JR, et al. Beer anaphylaxis. J Allergy Clin Immunol 1999;103:959-60.
  3. Lembo A, Camilleri M. Chronic constipation. N Engl J Med 2003;349:1360-8. . PubMed
  4. Ferre, I., Giraldez, F. J., Alvarez-Bujidos, M. L., and Mantecon, A. R. Influence of barley supplement on plasma concentration of triclabendazole metabolites in sheep. Vet.Rec. 11-22-1997;141(21):549-551. PubMed
  5. Curioni, A., Santucci, B., Cristaudo, A., Canistraci, C., Pietravalle, M., Simonato, B., and Giannattasio, M. Urticaria from beer: an immediate hypersensitivity reaction due to a 10- kDa protein derived from barley. Clin Exp Allergy 1999;29(3):407-413. PubMed
  6. Fernandez-Anaya, S., Crespo, J. F., Rodriguez, J. R., Daroca, P., Carmona, E., Herraez, L., and Lopez-Rubio, A. Beer anaphylaxis. J Allergy Clin Immunol. 1999;103(5 Pt 1):959-960.
  7. Cronin, E. Contact dermatitis from barley dust. Contact Dermatitis 1979;5(3):196. PubMed
  8. Block, G., Tse, K. S., Kijek, K., Chan, H., and Chan-Yeung, M. Baker's asthma. Studies of the cross-antigenicity between different cereal grains. Clin Allergy 1984;14(2):177-185.
  9. van Ketel, W. G. Immediate type allergy to malt in beer. Contact Dermatitis 1980;6(4):297-298. PubMed
  10. Ellis, H. J., Doyle, A. P., Day, P., Wieser, H., and Ciclitira, P. J. Demonstration of the presence of coeliac-activating gliadin-like epitopes in malted barley. Int Arch Allergy Immunol. 1994;104(3):308-310. PubMed
  11. Vidal, C. and Gonzalez-Quintela, A. Food-induced and occupational asthma due to barley flour. Ann Allergy Asthma Immunol. 1995;75(2):121-124.
  12. Gutgesell, C. and Fuchs, T. Contact urticaria from beer. Contact Dermatitis 1995;33(6):436-437. PubMed
  13. Baker, P. G. and Read, A. E. Oats and barley toxicity in coeliac patients. Postgrad.Med J 1976;52(607):264-268. PubMed
  14. Nakase, M., Usui, Y., Alvarez-Nakase, A. M., Adachi, T., Urisu, A., Nakamura, R., Aoki, N., Kitajima, K., and Matsuda, T. Cereal allergens: rice-seed allergens with structural similarity to wheat and barley allergens. Allergy 1998;53(46 Suppl):55-57. PubMed
  15. Pereira, F., Rafael, M., and Lacerda, M. H. Contact dermatitis from barley. Contact Dermatitis 1998;39(5):261-262. PubMed

See these in context on the Barley monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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