Forskolin Lean & Tone Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Forskolin Lean & Tone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Forskolin Lean & Tone is a dietary supplement by BioGenetic Laboratories with 1 active ingredient. Its ingredients are commonly taken for weight management, asthma and breathing, high blood pressure.Based on those ingredients, 915 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are ForsLean Coleus forskohlii extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Forskolin Lean & Tone by BioGenetic Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Forskolin Lean & Tone by BioGenetic Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Forskolin Lean & Tone by BioGenetic Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Forskolin Lean & Tone contains one active ingredient: ForsLean Coleus forskohlii extract, which supplies forskolin, a compound thought to work on cellular signaling. The capsule also holds inactive ingredients — hypromellose, vegetable magnesium stearate, and silicon dioxide — which are standard binding and flow agents.
Does it work?
Not established
The evidence we hold doesn't establish whether coleus works for any of the conditions listed on the label — angina, asthma, cancer, congestive heart failure, atopic dermatitis (eczema), or dry eye. All of these carry a rating of insufficient reliable evidence, meaning the research either isn't there or isn't solid enough to say whether it helps.
If you're thinking about this for a specific health concern, talk with your pharmacist or doctor about what the current science actually supports.
How safe is it?
Well-documented data
Coleus is generally well tolerated when taken by mouth, but there are real side effects to know about. The most common are constipation, diarrhea, nausea, and vomiting.
In one clinical trial, about 1 in 15 people reported increased bowel movements or loose stools, and other reports suggest roughly 1 in 10 people experience gastrointestinal upset — mostly diarrhea. The safety notes also flag that coleus may lower blood pressure and is not well studied for long-term use, so professional guidance is wise.
The data advises against use during pregnancy and while breastfeeding because there isn't enough safety information.
Meds to double-check
Major interaction found
Before taking this product, double-check if you use nitrates or calcium channel blockers for your heart — these carry the most serious interaction risk. Also ask your pharmacist about blood pressure medications, blood thinners, antiplatelet drugs (like aspirin), warfarin, and any drugs your liver metabolizes through the CYP2C9 or CYP3A4 system.
Use the medication checker on this page with your exact prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.
Forskolin Lean & Tone is worth a conversation with your pharmacist, especially if you take heart medications, blood pressure drugs, blood thinners, or warfarin. The evidence for what it's marketed to treat is not established in our data.
If you do consider it, watch for digestive side effects and monitor your blood pressure, and plan to check in with your pharmacist or doctor about long-term use.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Forskolin Lean & Tone, straight from the product label.
| Brand | BioGenetic Laboratories |
|---|---|
| Net contents | 60 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 24, 2020 |
| DSLD ID | 228235 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Forskolin Lean & Tone by BioGenetic Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| ForsLean Coleus forskohlii extract | 250 mg | -- |
Other ingredients: Hypromellose, Vegetable Magnesium Stearate, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Patented weight-loss potency!
It increases cAMP (Cyclic Adenosine Monophosphate) to help increase lean body tissue and break down fat tissue. ForsLean has been extensively tested for purity and potency. Forskolin Lean & Tone with ForsLean extract offers the only patented 10 and 20% extract with published studies showing a decrease in body fat and body weight and an increase in lean tissue.
The conclusion? ForsLean has been shown to increase important metabolism-boosting lean tissue as it reduces body fat, helping our bodies become more efficient fat-fighting machines. If your goal is to look leaner and more toned, Forskolin Lean & Tone with patented ForsLean may help you tip the scales in your favor so you can reach your goals faster.
12-Week clinical studies showed support for: Improved fat-burning metabolism Enhanced lean, toned muscle Decreased body fat Improved BMI
Stimulant free
Vegetarian
Made in the USA from International and Domestic ingredients.
General Statements
Do you want a lean and toned body? This new breakthrough can be the key to both!
In one study, ForsLean subjects lost 4.02% of their total body weight while the placebo group actually gained weight (0.29%). In a subsequent 12-week, randomized, double-blind, placebo controlled study, ForsLean subjects lost 9.9 lbs of fat mass and gained 8.1 lbs of lean body mass (vs. fat loss of 1.1 lbs and gain of 3.45 lbs lean body mass for the placebo group).
Quality and results!
"ForsLean shifts the proportion between lean body mass and adipose, or fatty, tissue in favor of lean body mass, which improves overall health," explains N. Kalyanam, Ph.D, Sabinsa Corporation's president of Research and Development. "The effect can be measured by decreases in the waist/hip ratio and the body mass index."
Look for real ForsLean, listed by name, rather than a generic form of forskohlii to ensure quality and results.
Scientific references: Badmaev V, Majeed M, Conte A, Parker JE. (2002). Diterpene forskolin (Coleus forskohlii, Benth): A possible new compound for reduction of body weight by increasing lean body mass. NutraCos. March/April, 6-7 Asano Tsuguyoshi. (2001). Clinical report on root extract of perilla plant (Coleus forskohlii) ForsLean in reducing body fat. Asano Institute. Tokyo, Japan. Krieder R et al. (2002). Effects of Coleus forskohlii extract supplementation on body composition and markers of health in sendentary overweight female. Memphis TN: Exercise and Sports Nutrition Laboratory, Department of Human Movement Science and Education, University of Memphis Bhagwat, A.M. et al. (2004). A Randomized Double-Blind Clinical Trial to investigate the Efficacy and Safety of ForsLean in increasing Lean Body Mass Shri C.B. Patel Research Center for Chemistry and Biological Sciences, Mumbai, India Godard, M. P. et al. (2004). Body composition and hormonal adaptations associated with Forskolin consumption in overweight and obese Men. Obesity Res. 13: 1335-1343 Kamath, M.S. et al. (2004). Efficacy and safety of ForsLean in increasing Lean Body Mass. Department of Ayurvedic Medicine, Kasturba Medical College, Manipal, India Dr. Pankaj Gandhi, Dr. J.R. Parekh. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese women. Clinworld (P) Ltd.
Facebook Come join the thousands of others who are enjoying their new, thinner, lighter, and more energetic bodies, and see them sharing their successful weight-loss stories: Facebook.com/BioGeneticLabs
New look
30 Day supply
Free diet plan inside
(Stock Symbol: FTLF)
Formula
Coleus forskohlii is an herb originating from India. Yet not all Coleus forskohliis are the same. Recent breakthroughs credit a special extract as the key to looking leaner. Here's the skinny on how it works and why this patented extract may help you sculpt a leaner, sleeker body: ForsLean is the proprietary extract of Coleus forskohlli's active ingredient, Forskolin.
With patented ForsLean including 20% Forskolin
ForsLean With patented 10 and 20 % Forskolin 250 mg per serving
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Brand IP Statement(s)
ForsLean is a proprietary ingredient, patented for use and composition in promoting lean body mass, reduction of adipose tissue (fat) and weight loss (US Patent # 5,804,596).
ForsLean is a registered trademark of Sabinsa Corporation. US Patent #5,804,596
2018 FitLife Brands, Inc.
Precautions
Individual results may and will differ. Always consult a physician prior to any diet or exercise program.
Notice: Keep out of reach of children.
For adult use only. Do not exceed recommended dose.
Consult a physician prior to using this product if you are pregnant, nursing, taking medication of have a medical condition.
Discontinue use two weeks prior to surgery. Seek the advice of a health care professional before beginning any supplement or exercise program. If you or your doctor has any questions about this product, please call 1-888-752-6615. Improper use of this product will not improve results and is not advised. Only follow a reduced calorie diet under the supervision of a doctor.
Consult with your primary physician prior to use if you have any pre-existing medical conditions including high blood pressure, thyroid problems, nervous disorders, or if you are using MAO inhibitors or taking any prescription drugs.
Warning for California residents only: This product contains substances known to the state of California to cause cancer and birth defects and other reproductive harm.
Do not use if packaging has been tampered with.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions for use: As a dietary supplement, take one serving (1 veggie capsule) twice daily with a full glass of water, preferably on an empty stomach, about 30 minutes prior to meals. Take one serving upon waking (before breakfast), and take a second serving between lunch and dinner. Please read the entire label carefully before use, and follow the diet plan (included free).
Storage
Store in a cool, dry place. Avoid excessive heat.
Seals/Symbols
Made in the USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Forskolin Lean & Tone by BioGenetic Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Forskolin Lean & Tone by BioGenetic Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
ForsLean Coleus forskohlii extract
Interacts with915 drugs
Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...
ForsLean Coleus forskohlii extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Vegetable Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Forskolin Lean & Tone by BioGenetic Laboratories Drug Interactions
HelloPharmacist Interaction Report
Forskolin Lean & Tone contains a single active ingredient, ForsLean Coleus forskohlii extract, and it does interact with several important medication types.
The most serious concerns are with nitrates and calcium channel blockers (drugs used for heart conditions and blood pressure). Coleus and these medications both widen blood vessels in the heart; using them together could theoretically boost that effect too much and cause problems.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check if you take blood pressure medications (antihypertensives), blood thinners or antiplatelet drugs, or warfarin. Coleus may lower blood pressure on its own, so combining it with blood pressure drugs risks your pressure dropping too far.
Similarly, research suggests coleus might interfere with how your blood clots or how warfarin works — either making bleeding more likely or changing how well the drug controls clotting.
Lastly, coleus may affect how your liver processes a broad group of medications metabolized through the cytochrome P450 system (CYP2C9 and CYP3A4). The evidence is mixed — it might speed up or slow down clearance of these drugs — but either way, your medication levels could shift.
Altogether, these interactions span 904 individual medications. Before you start this product, use the medication checker below with your exact prescriptions.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Forskolin Lean & Tone?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Forskolin Lean & Tone interact with 915 drugs. Click any drug to see the details.
1 of the 1 ingredient in Forskolin Lean & Tone interact with drugs. Each result below shows which ingredient is responsible. ForsLean Coleus forskohlii extract
AmlodipineNorliqva
How Amlodipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forslean Coleus Forskohlii Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 2c9 (cyp2c9) Substrates +2 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Amlodipine, Celecoxib interactionBepridilVascor
How Bepridil interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Bepridil interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Diltiazem, Enalapril interactionEnalapril Maleate, FelodipineLexxel
How Enalapril Maleate, Felodipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Enalapril Maleate, Felodipine interactionFelodipinePlendil, Renedil
How Felodipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Felodipine interactionGlyceryl TrinitrateNitronal
How Glyceryl Trinitrate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Glyceryl Trinitrate interactionIsosorbide DinitrateAngitak, Cedocard Retard, Isoket, Isoket Retard, Isordil
How Isosorbide Dinitrate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Isosorbide Dinitrate interactionIsosorbide Dinitrate, HydralazineBiDil
How Isosorbide Dinitrate, Hydralazine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates, Antihypertensive Drugs Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Isosorbide Dinitrate, Hydralazine interactionIsosorbide MononitrateAngeze, Angeze SR, Chemydur 60XL, Dynamin, Elantan, Elantan LA +13 more
How Isosorbide Mononitrate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Isosorbide Mononitrate interactionIsradipineDynacirc CR
How Isradipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Isradipine interactionLercanidipine HydrochlorideZanidip
How Lercanidipine Hydrochloride interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Lercanidipine Hydrochloride interactionLevamlodipineConjupri
How Levamlodipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forslean Coleus Forskohlii Extract + Levamlodipine interactionNicardipineCardene, Cardene IV, Cardene SR
How Nicardipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forslean Coleus Forskohlii Extract + Nicardipine interactionNicorandilAprior, Dancor, Ikorel, Sigmart, Zynicor
How Nicorandil interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Nicorandil interactionNifedipineAdalat, Adalat CC, Adalat LA, Adalat PA, Adalat Retard, Adalat XL +15 more
How Nifedipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Nifedipine interactionNisoldipineSular
How Nisoldipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Nisoldipine interactionNitrendipineCardif
How Nitrendipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Nitrendipine interactionNitroglycerinGonitro, Nitro Time, Nitro-Bid, Nitrocine Timecaps, Nitrogard, Nitrogard SR +7 more
How Nitroglycerin interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Nitroglycerin interactionPentaerythritol TetranitratePeritrate, Peritrate SA
How Pentaerythritol Tetranitrate interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forslean Coleus Forskohlii Extract + Pentaerythritol Tetranitrate interactionPerindopril Arginine, AmlodipinePrestalia
How Perindopril Arginine, Amlodipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forslean Coleus Forskohlii Extract + Perindopril Arginine, Amlodipine interactionTelmisartan, AmlodipineTwynsta
How Telmisartan, Amlodipine interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Telmisartan, Amlodipine interactionTrandolapril, VerapamilTarka
How Trandolapril, Verapamil interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forslean Coleus Forskohlii Extract + Trandolapril, Verapamil interactionVerapamilCalan, Calan SR, Covera HS, Isoptin, Isoptin SR, Veramil +3 more
How Verapamil interacts with Forskolin Lean & Tone — through 1 ingredient. Tap an ingredient for the detail:
Forslean Coleus Forskohlii ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forslean Coleus Forskohlii Extract + Verapamil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Forskolin Lean & Tone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
ForsLean Coleus forskohlii extract
Calcium Channel Blockers
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.
Nitrates
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.
Antihypertensive Drugs
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.
Warfarin (Coumadin)
Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.
Brand information
Manufacturer and brand details for Forskolin Lean & Tone, from the product label.
BioGenetic Laboratories
See all BioGenetic Laboratories products- Name
- BioGenetic Laboratories A Division of FitLife Brands
- Street Address
- 5214 South 136th Street
- City
- Omaha
- State
- NE
- ZipCode
- 68137
- Phone Number
- 1-888-752-6615
- Web Address
- BioGeneticLabs.com
Forskolin Lean & Tone by BioGenetic Laboratories: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Forskolin Lean & Tone’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Forskolin Lean & Tone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 16 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Coleus 16 references
- Baumann G, Felix S, Sattelberger U, Klein G. Cardiovascular effects of forskolin (HL-362) in patients with idiopathic congestiv cardiomyopathy. A comparative study with dobutamine and sodium nitroprusside. J Cardiovasc Pharmacol 1990;16:93-100.
- Kramer W, Thormann J, Kindler M, Schlepper M. Effects of forskolin on left ventricular function in dilated cardiomyopathy. Arzneimittelforschung 1987;37:364-7.
- Bauer K, Dietersdorfer F, Kaspar S, et al. Pharmacodynamic effects of inhaled dry powder formulations of fenoterol and colforsin in asthma. Clin Pharmacol Ther 1993;53:76-83. PubMed
- Christenson JT, Thulesius O, Nazzal MM. The effect of forskolin on blood flow, platelet metabolism, aggregation and ATP release. Vasa 1995;24:56-61.
- Agarwal KC, Zielinski BA, Maitra RS. Significance of plasma adenosine in the antiplatelet activity of forskolin: potentiation by dipyridamole and dilazep. Thromb Haemost 1989;61:106-10. DOI
- Agarwal KC, Parks RE. Forskolin: a potential antimetastatic agent. Int J Cancer 1983;32:801-4. PubMed
- Almeida, F. C. and Lemonica, I. P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. J Ethnopharmacol 2000;73(1-2):53-60. PubMed
- Ding, X. and Staudinger, J. L. Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway. J Pharmacol Exp Ther 2005;312(2):849-856. PubMed
- Staudinger, J. L., Ding, X., and Lichti, K. Pregnane X receptor and natural products: beyond drug-drug interactions. Expert.Opin Drug Metab Toxicol 2006;2(6):847-857. PubMed
- van Hecke, E., Hindryckx, P., Geuns, J. M., and Devriese, E. Airborne contact dermatitis from coleus in a housewife. Contact Dermatitis 1991;25(2):128-129. PubMed
- Schlepper, M., Thormann, J., and Mitrovic, V. Cardiovascular effects of forskolin and phosphodiesterase-III inhibitors. Basic Res Cardiol 1989;84 Suppl 1:197-212. PubMed
- Dooms-Goossens, A., Borghijs, A., Degreef, H., Devriese, E. G., and Geuns, J. M. Airborne contact dermatitis to Coleus. Contact Dermatitis 1987;17(2):109-110. PubMed
- Lindner, E., Dohadwalla, A. N., and Bhattacharya, B. K. Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohli: Forskolin. Arzneimittelforschung 1978;28(2):284-289.
- Loftus HL, Astell KJ, Mathai ML, et al. Coleus forskohlii Extract Supplementation in Conjunction with a Hypocaloric Diet Reduces the Risk Factors of Metabolic Syndrome in Overweight and Obese Subjects: A Randomized Controlled Trial. Nutrients. 2015;7(11): PubMed
- Yokotani K, Chiba T, Sato Y, et al. Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol. 2012;64(12):1793-801.
- Nishijima C, Chiba T, Sato Y, Umegaki K. Nationwide Online Survey Enables the Reevaluation of the Safety of Coleus forskohlii Extract Intake Based on the Adverse Event Frequencies. Nutrients. 2019;11(4). pii: E866. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC