Thyraid Ingredients & Drug Interactions
by Advanced Nutrition by Zahler
What is this page for?
First and foremost: checking Thyraid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Thyraid is a dietary supplement by Advanced Nutrition by Zahler with 8 active ingredients. Its ingredients are commonly taken for mental focus and alertness, coping with stress, fatigue and sleep loss.Based on those ingredients, 1,503 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sensoril, Forskohlii root extract, Guggul Oleo-Gum Resin Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Thyraid by Advanced Nutrition by Zahler
Ask about any prescription or over-the-counter medication and we check it for interactions with Thyraid by Advanced Nutrition by Zahler — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Thyraid by Advanced Nutrition by Zahler
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Thyraid contains eight active ingredients: L-Tyrosine, Zinc, Iodine, Forskohlii root extract (coleus), Copper, Manganese, Sensoril (ashwagandha), and Guggul Oleo-Gum Resin Extract. These are formulated to support thyroid function — tyrosine and iodine are building blocks for thyroid hormones, zinc and manganese are needed for thyroid enzyme activity, and the plant extracts (coleus, ashwagandha, guggul) have been traditionally used or studied for metabolic and thyroid support.
The capsules also contain inactive ingredients: hypromellose (the capsule material) and rice hull concentrate.
Does it work?
Moderate evidence
The ingredients in Thyraid have varying levels of evidence. L-Tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognition and memory; evidence for athletic performance is limited.
Zinc is effective for zinc deficiency and likely effective for Wilson disease. Iodine is likely effective for radiation exposure and iodine deficiency.
Coleus, ashwagandha, and guggul all have insufficient evidence in our data to rate them for their potential thyroid or metabolic effects. Copper is likely effective for copper deficiency.
Manganese is effective for manganese deficiency. Overall, the evidence for this product as a thyroid-support formula is not established in the data we hold.
How safe is it?
Well-documented data
Most ingredients here are generally well tolerated at recommended doses, but some cautions apply. L-Tyrosine may cause fatigue, headache, heartburn, and nausea; higher doses can worsen these.
Zinc is well tolerated below 40 mg daily but can cause abdominal cramps, diarrhea, a metallic taste, nausea, and vomiting at higher doses; long-term high-dose use raises concern for copper deficiency. Iodine at normal dietary amounts is safe, but excess can cause thyroid problems, goiter, nausea, and metallic taste.
Coleus may cause constipation, diarrhea, nausea, or vomiting and can lower blood pressure. Ashwagandha may cause diarrhea, gastrointestinal upset, nausea, and vomiting at higher doses, and rare reports link it to liver problems and hyperthyroidism.
Guggul can cause digestive upset, headache, and allergic or non-allergic skin reactions. Manganese is safe at normal dietary amounts, but high doses pose a risk of serious nerve damage similar to Parkinson disease.
Copper is safe in food and standard supplement amounts; high doses can be harmful.
Meds to double-check
Major interaction found
Before taking Thyraid, check with your pharmacist if you use nitrates or calcium channel blockers (major risk of dangerous blood pressure drop), blood pressure medications, blood thinners (anticoagulants or antiplatelet drugs), diabetes drugs, sedatives or psychiatric medications, thyroid hormones, antibiotics (especially quinolones, tetracyclines, or cephalexin), levodopa for Parkinson's disease, penicillamine, lithium, antithyroid drugs, or amiodarone. Also check if you take HIV medications (ritonavir, integrase inhibitors), immunosuppressants, liver-metabolized drugs, estrogen or oral contraceptives, or tamoxifen.
These are the main areas where this product's ingredients interact with medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
Thyraid is designed to provide nutrients and plant extracts that support thyroid function. It's most appropriate for someone without major medical conditions who wants nutritional thyroid support — but if you take any prescription medications, especially for your heart, blood pressure, diabetes, mood, blood clotting, or infections, you need to check your specific drugs before starting.
Talk to your pharmacist or doctor first, particularly if you're on thyroid hormone replacement or any psychiatric or cardiac medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 8 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Thyraid, straight from the product label.
| Brand | Advanced Nutrition by Zahler |
|---|---|
| Barcode (UPC) | 848998081706 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 14, 2023 |
| DSLD ID | 301149 |
| Product type | Botanical With Nutrients |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Thyraid by Advanced Nutrition by Zahler, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| L-Tyrosine | 500 mg | -- |
| Zinc | 10 mg | 91% |
| Iodine | 100 mcg | 67% |
| Forskohlii root extract | 100 mg | -- |
| Copper | 0.1 mg | 11% |
| Manganese | 0.25 mg | 11% |
| Sensoril | 125 mg | -- |
| Guggul Oleo-Gum Resin Extract | 100 mg | -- |
Other ingredients: Hypromellose, Rice Hull Concentrate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Thyroid support formula A critical gland in the endocrine system, the thyroid regulates and affects metabolism, energy, as well as overall wellbeing. Zahler Thyraid is a comprehensive nutritional formula designed to support the thyroid gland.
Non-GMO Dairy free Soy free
Vegetarian friendly
Maintains thyroid health & metabolism
General Statements
You may need additional supplements to support a healthy diet; consult your nutritionist for a formula that is right for you or contact us at 877-ASK-ZAHLER (877-275-9245) or [email protected].
Advanced health
Precautions
Keep out of reach of children. Warning: For adult use only.
Do not use if safety seal is damaged or missing.
If pregnant, nursing, or on medication, consult with your healthcare practitioner.
Do not exceed recommended dose. Discontinue use two weeks prior to surgery.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Kosher Pareve OU (Kosher) Under the strict supervision of Rabbi SH. Stern & The Orthodox Union
Seals/Symbols
Kosher Pareve OU (Kosher) Under the strict supervision of Rabbi SH. Stern & The Orthodox Union This product is manufactured in a GMP Certified Facility Manufactured in the USA
Storage
Store tightly close in a cool, dry place.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Feel Better, Everyday
Thyraid is a trademark of Advanced Nutrition by Zahler.
Sensoril is a registered trademark Natreon, Inc.
Suggested/Recommended/Usage/Directions
Directions: Take 2 capsules daily, preferably 1 capsule twice a day with food, or as directed by a healthcare practitioner.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Thyraid by Advanced Nutrition by Zahler label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Thyraid by Advanced Nutrition by Zahler
These are the 8 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
L-Tyrosine
Interacts with21 drugs
L-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performan...
L-Tyrosine monograph & interactionsZinc
Interacts with67 drugs
Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...
Zinc monograph & interactionsIodine
Interacts with7 drugs
Iodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements...
Iodine monograph & interactionsForskohlii root extract
Interacts with915 drugs
Coleus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. Whil...
Forskohlii root extract monograph & interactionsCopper
Interacts with31 drugs
Copper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes wor...
Copper monograph & interactionsManganese
Interacts with83 drugs
Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...
Manganese monograph & interactionsSensoril
Interacts with1,372 drugs
Ashwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evid...
Sensoril monograph & interactionsGuggul Oleo-Gum Resin Extract
Interacts with757 drugs
Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...
Guggul Oleo-Gum Resin Extract monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Hull Concentrate. These complete the product’s ingredient list but are not active constituents.
Thyraid by Advanced Nutrition by Zahler Drug Interactions
HelloPharmacist Interaction Report
Thyraid by Advanced Nutrition by Zahler contains eight active ingredients, and several of them interact with medications.
The most serious interactions involve Forskohlii root extract (coleus), which has major-severity interactions with nitrates and calcium channel blockers — both can cause excessive widening of blood vessels in the heart when combined with the forskolii, potentially causing dangerous drops in blood pressure or heart problems.
Read the full breakdown — every affected drug type, severity by severity
The product also carries moderate-severity interactions across multiple medication types. L-Tyrosine may interfere with levodopa (a Parkinson's medication) and add to the effects of thyroid hormones.
Zinc can reduce absorption of several antibiotics (quinolones, tetracyclines, cephalexin), as well as penicillamine and some HIV drugs (ritonavir, integrase inhibitors). Iodine may intensify the thyroid-suppressing effects of lithium, alter how antithyroid drugs work, or cause problems when combined with amiodarone (which is already high in iodine).
Coleus also interacts with blood pressure medications, blood thinners (anticoagulants and antiplatelet drugs), and drugs metabolized by liver enzymes (CYP2C9, CYP3A4). Ashwagandha (Sensoril) may increase the effects of sedatives, blood pressure medications, diabetes drugs, and thyroid hormones, and it carries a theoretical risk with immunosuppressants and drugs that stress the liver.
Manganese may reduce the absorption of certain antibiotics (quinolones and tetracyclines) and interact with antipsychotic drugs. Guggul can reduce the effects of beta-blockers like propranolol and diltiazem, interfere with hormonal contraceptives and estrogen therapy, increase bleeding risk with anticoagulants, and affect drugs metabolized by liver enzymes.
Copper has minor interactions with penicillamine and oral contraceptives. We could not check interactions for one ingredient, Sensoril, beyond what ashwagandha monograph data provides.
Altogether, these interactions span 1,482 individual medications.
Check your exact medications with the search tool on this page before starting Thyraid.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Thyraid?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Thyraid interact with 1,503 drugs. Click any drug to see the details.
8 of the 8 ingredients in Thyraid interact with drugs. Each result below shows which ingredient is responsible. Sensoril Forskohlii root extract Guggul Oleo-Gum Resin Extract Manganese Zinc Copper L-Tyrosine Iodine
AmlodipineNorliqva
How Amlodipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Amlodipine interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Amlodipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Amlodipine interactionAmlodipine BenzoateKaterzia
How Amlodipine Benzoate interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Amlodipine Benzoate interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Amlodipine Benzoate interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Amlodipine Benzoate interactionAmlodipine BesilateIstin
How Amlodipine Besilate interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Amlodipine Besilate interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Amlodipine Besilate interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Amlodipine Besilate interactionAmlodipine BesylateNorvasc
How Amlodipine Besylate interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Amlodipine Besylate interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Amlodipine Besylate interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Amlodipine Besylate interactionAmlodipine Besylate, BenazeprilLotrel
How Amlodipine Besylate, Benazepril interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forskohlii Root Extract + Amlodipine Besylate, Benazepril interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Amlodipine Besylate, Benazepril interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Amlodipine Besylate, Benazepril interactionAmlodipine, CelecoxibConsensi
How Amlodipine, Celecoxib interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Calcium Channel Blockers +2 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Amlodipine, Celecoxib interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Amlodipine, Celecoxib interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Amlodipine, Celecoxib interactionBepridilVascor
How Bepridil interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Bepridil interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Bepridil interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Bepridil interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Diltiazem interactionGuggul Oleo-gum Resin ExtractDiltiazem (cardizem, Others), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Guggul might reduce the effects of diltiazem.
Read the full Guggul Oleo-gum Resin Extract + Diltiazem interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forskohlii Root Extract + Diltiazem, Enalapril interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Diltiazem, Enalapril interactionGuggul Oleo-gum Resin ExtractDiltiazem (cardizem, Others), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Guggul might reduce the effects of diltiazem.
Read the full Guggul Oleo-gum Resin Extract + Diltiazem, Enalapril interactionEnalapril Maleate, FelodipineLexxel
How Enalapril Maleate, Felodipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Enalapril Maleate, Felodipine interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Enalapril Maleate, Felodipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Enalapril Maleate, Felodipine interactionFelodipinePlendil, Renedil
How Felodipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Felodipine interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Felodipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Felodipine interactionGlyceryl TrinitrateNitronal
How Glyceryl Trinitrate interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Glyceryl Trinitrate interactionIsosorbide DinitrateAngitak, Cedocard Retard, Isoket, Isoket Retard, Isordil
How Isosorbide Dinitrate interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Isosorbide Dinitrate interactionIsosorbide Dinitrate, HydralazineBiDil
How Isosorbide Dinitrate, Hydralazine interacts with Thyraid — through 2 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates, Antihypertensive Drugs Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Isosorbide Dinitrate, Hydralazine interactionSensorilAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Isosorbide Dinitrate, Hydralazine interactionIsosorbide MononitrateAngeze, Angeze SR, Chemydur 60XL, Dynamin, Elantan, Elantan LA +13 more
How Isosorbide Mononitrate interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Isosorbide Mononitrate interactionIsradipineDynacirc CR
How Isradipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Isradipine interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Isradipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Isradipine interactionLercanidipine HydrochlorideZanidip
How Lercanidipine Hydrochloride interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Lercanidipine Hydrochloride interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Lercanidipine Hydrochloride interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Lercanidipine Hydrochloride interactionLevamlodipineConjupri
How Levamlodipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forskohlii Root Extract + Levamlodipine interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Levamlodipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Levamlodipine interactionNicardipineCardene, Cardene IV, Cardene SR
How Nicardipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forskohlii Root Extract + Nicardipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Nicardipine interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Nicardipine interactionNicorandilAprior, Dancor, Ikorel, Sigmart, Zynicor
How Nicorandil interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Nicorandil interactionNifedipineAdalat, Adalat CC, Adalat LA, Adalat PA, Adalat Retard, Adalat XL +15 more
How Nifedipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Calcium Channel Blockers +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Nifedipine interactionSensorilHepatotoxic Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + Nifedipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Nifedipine interactionNisoldipineSular
How Nisoldipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Nisoldipine interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Nisoldipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Nisoldipine interactionNitrendipineCardif
How Nitrendipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCalcium Channel Blockers, Cytochrome P450 3a4 (cyp3a4) Substrates Major
Interaction Summary
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Nitrendipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Nitrendipine interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates Minor
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Nitrendipine interactionNitroglycerinGonitro, Nitro Time, Nitro-Bid, Nitrocine Timecaps, Nitrogard, Nitrogard SR +7 more
How Nitroglycerin interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Nitroglycerin interactionPentaerythritol TetranitratePeritrate, Peritrate SA
How Pentaerythritol Tetranitrate interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
Forskohlii Root ExtractNitrates Major
Interaction Summary
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Read the full Forskohlii Root Extract + Pentaerythritol Tetranitrate interactionPerindopril Arginine, AmlodipinePrestalia
How Perindopril Arginine, Amlodipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forskohlii Root Extract + Perindopril Arginine, Amlodipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Perindopril Arginine, Amlodipine interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Perindopril Arginine, Amlodipine interactionTelmisartan, AmlodipineTwynsta
How Telmisartan, Amlodipine interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Telmisartan, Amlodipine interactionSensorilAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Telmisartan, Amlodipine interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Telmisartan, Amlodipine interactionTrandolapril, VerapamilTarka
How Trandolapril, Verapamil interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Antihypertensive Drugs +1 Major
Interaction Summary
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
Read the full Forskohlii Root Extract + Trandolapril, Verapamil interactionSensorilAntihypertensive Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Read the full Sensoril + Trandolapril, Verapamil interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Trandolapril, Verapamil interactionVerapamilCalan, Calan SR, Covera HS, Isoptin, Isoptin SR, Veramil +3 more
How Verapamil interacts with Thyraid — through 3 ingredients. Tap an ingredient for the detail:
Forskohlii Root ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Major
Interaction Summary
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Read the full Forskohlii Root Extract + Verapamil interactionSensorilCytochrome P450 3a4 (cyp3a4) Substrates, Hepatotoxic Drugs +2 Moderate
Interaction Summary
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Sensoril + Verapamil interactionGuggul Oleo-gum Resin ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul Oleo-gum Resin Extract + Verapamil interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Thyraid — through 1 ingredient. Tap an ingredient for the detail:
SensorilHepatotoxic Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Read the full Sensoril + 6-mercaptopurine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Thyraid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Sensoril
Antidiabetes Drugs
Theoretically, taking ashwagandha with antidiabetes drugs might increase the risk of hypoglycemia.
There is preliminary clinical evidence suggesting that ashwagandha might lower blood glucose levels. Theoretically, ashwagandha might have additive effects when used with antidiabetes drugs and increase the risk of hypoglycemia.
Antihypertensive Drugs
Theoretically, taking ashwagandha with antihypertensive drugs might increase the risk of hypotension.
Animal research suggests that ashwagandha might lower systolic and diastolic blood pressure. Theoretically, ashwagandha might have additive effects when used with antihypertensive drugs and increase the risk of hypotension.
Benzodiazepines
Theoretically, taking ashwagandha might increase the sedative effects of benzodiazepines.
There is preliminary evidence that ashwagandha might have an additive effect with diazepam (Valium) and clonazepam (Klonopin). This may also occur with other benzodiazepines.
Cns Depressants
Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.
Ashwagandha seems to have sedative effects. Theoretically, this may potentiate the effects of barbiturates, other sedatives, and anxiolytics.
Hepatotoxic Drugs
Theoretically, taking ashwagandha with hepatotoxic drugs might increase the risk of liver damage.
Ashwagandha has been linked to cases of acute hepatitis, liver failure, hepatic encephalopathy, autoimmune hepatitis, the need for liver transplantation, and death due to liver failure.
Immunosuppressants
Theoretically, taking ashwagandha might decrease the effects of immunosuppressants.
Ashwagandha has demonstrated immunostimulant effects in humans. Animal research has shown that ashwagandha can attenuate the immunosuppression caused by cyclophosphamide.
Thyroid Hormone
Ashwagandha might increase the effects and adverse effects of thyroid hormone.
Concomitant use of ashwagandha with thyroid hormones may cause additive therapeutic and adverse effects. Preliminary clinical research and animal studies suggest that ashwagandha boosts thyroid hormone synthesis and secretion. In one clinical study, ashwagandha increased triiodothyronine (T3) and thyroxine (T4) levels by 41.5% and 19.6%, respectively, and reduced serum TSH levels by 17.4% from baseline in adults with subclinical hypothyroidism.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that ashwagandha extract induces CYP1A2 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, ashwagandha might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that ashwagandha extract induces CYP3A4 enzymes.
Serotonergic Drugs
Some animal studies have reported that ashwagandha can enhance serotonergic transmission by altering certain serotonin (5-HT) receptors. However, there is no evidence to suggest that ashwagandha increases the risk of serotonin-related effects, and there have been no published case reports of serotonin syndrome when combined with other serotonergic drugs. Nevertheless, due to the lack of extensive studies on the matter and the fact that ashwagandha appears to affect serotonergic pathways, it would be prudent to exercise caution when combining it with drugs that affect serotonin. [References: - Effects of Withania somnifera (Ashwaga ndha) on Stress and the Stress-Related Neuropsychiatric Disorders Anxiety, Depression, and Insomnia. Curr Neuropharmacol. 2021 Sep 14; 19: 1468–1495. - A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3573577/]
Forskohlii root extract
Calcium Channel Blockers
Theoretically, combining coleus with calcium channel blockers might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and calcium channel blockers both cause coronary vasodilatory effects.
Nitrates
Theoretically, combining coleus with nitrates might increase the coronary vasodilatory effects.
Forskolin, a constituent of coleus, and nitrates both cause coronary vasodilatory effects.
Anticoagulant/Antiplatelet Drugs
Theoretically, concomitant use of coleus and anticoagulant or antiplatelet drugs might increase the risk of bruising and bleeding.
In vitro and animal research shows that forskolin, a constituent of coleus, can inhibit platelet aggregation and adhesion.
Antihypertensive Drugs
Theoretically, combining coleus with antihypertensive drugs might cause additive blood pressure lowering effects and increase the risk of hypotension.
Animal research shows that forskolin, a constituent of coleus, may lower blood pressure.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, taking coleus may affect drugs metabolized by CYP2C9 and increase the risk of adverse effects or reduce the effectiveness.
Research on the effect of coleus on CYP2C9 is conflicting. Some animal research shows that coleus extract can induce CYP2C9, while in vitro research shows that coleus can inhibit CYP2C9. Until more is known, advise patients that taking coleus might increase or decrease levels of drugs metabolized by CYP2C9.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, taking coleus might decrease serum levels of drugs metabolized by CYP3A4.
In vitro research shows that coleus can activate the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of coleus and other drugs affected by these enzymes.
Warfarin (Coumadin)
Theoretically, taking coleus may affect the metabolism of warfarin and increase the risk of adverse effects or reduce the effectiveness.
Some animal research shows that coleus extract can induce cytochrome P450 2C9 (CYP2C9), an enzyme that metabolizes warfarin. However, other in vitro research shows that coleus can inhibit CYP2C9. Theoretically, taking coleus with drugs metabolized by CYP2C9 might affect drug levels and the risk of adverse effects. Until more is known, advise patients that taking coleus might increase or decrease levels of warfarin.
Guggul Oleo-Gum Resin Extract
Anticoagulant/Antiplatelet Drugs
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.
Contraceptive Drugs
Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.
Diltiazem (Cardizem, Others)
Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.
Estrogens
Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.
Propranolol (Inderal)
Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.
Rosuvastatin (Crestor)
Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.
Tamoxifen (Nolvadex)
Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Thyroid Hormone
Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.
Manganese
Antipsychotic Drugs
Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.
Quinolone Antibiotics
Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.
Tetracycline Antibiotics
Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.
Zinc
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.
Cephalexin (Keflex)
Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.
Cisplatin (Platinol-Aq)
Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.
Integrase Inhibitors
Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.
Penicillamine (Cuprimine, Depen)
Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.
Quinolone Antibiotics
Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.
Ritonavir (Norvir)
Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.
Tetracycline Antibiotics
Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.
Amiloride (Midamor)
Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.
Atazanavir (Reyataz)
Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.
Copper
Penicillamine (Cuprimine, Depen)
Theoretically, taking copper with penicillamine might decrease the absorption of penicillamine; separate dosing by at least 2 hours.
Copper chelates penicillamine, which decreases its absorption and may reduce its clinical effects.
Contraceptive Drugs
Theoretically, taking copper with contraceptive drugs might increase the levels and toxic effects of copper.
A meta-analysis of clinical studies suggests that chronic use of oral contraceptives increases serum copper levels by a mean of 57 mcg/dL. In most people, this resulted in levels above the normal reference range for copper.
L-Tyrosine
Levodopa
Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.
Thyroid Hormone
Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.
Iodine
Amiodarone (Cordarone)
Combining iodine with amiodarone might cause excessively high iodine levels.
Amiodarone contains 37.3% iodine and can increase iodine levels. Concomitant use with iodine might increase the risk of having excessive iodine levels and adversely affecting thyroid function. Monitor thyroid function.
Antithyroid Drugs
Iodine might alter the effects of antithyroid drugs.
Iodine in high doses has been reported to cause both hyperthyroidism and hypothyroidism, depending on the individual's past medical history. Taking iodine while using antithyroid drugs could alter the effects of the antithyroid drugs.
Lithium
Combining iodine with lithium might have additive hypothyroid effects.
Lithium can inhibit thyroid function. Several case reports suggest that concomitant use of lithium and potassium iodide can reduce thyroid function in otherwise healthy adults. Monitor thyroid function.
Brand information
Manufacturer and brand details for Thyraid, from the product label.
Advanced Nutrition by Zahler
See all Advanced Nutrition by Zahler products- Name
- Advanced Nutrition by Zahler
- City
- Brooklyn
- State
- NY
- ZipCode
- 11230
- Phone Number
- 877-275-9245
- Web Address
- www.zahlers.com
Thyraid by Advanced Nutrition by Zahler: Common Questions
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Thyraid’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Tyrosine
Interacts with 21 drugsL-tyrosine is an amino acid your body uses to make brain chemicals like dopamine and norepinephrine. Some studies suggest it may help mental performance during short-term stress, sleep loss,...
Read the full Tyrosine monograph → Herb & supplement monographZinc
Interacts with 67 drugsZinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...
Read the full Zinc monograph → Herb & supplement monographIodine
Interacts with 7 drugsIodine is an essential mineral your body needs to make thyroid hormones, and most people get enough from iodized salt, dairy, and seafood. Supplements help when you are truly deficient, but...
Read the full Iodine monograph → Herb & supplement monographColeus
Interacts with 915 drugsColeus is a plant from the mint family whose root contains a compound called forskolin, often marketed for weight loss, asthma, and heart health. While early lab and small human studies are...
Read the full Coleus monograph → Herb & supplement monographCopper
Interacts with 31 drugsCopper is an essential trace mineral your body needs in small amounts for making red blood cells, supporting nerves and bones, and helping enzymes work. Most people get enough copper from fo...
Read the full Copper monograph → Herb & supplement monographManganese
Interacts with 83 drugsManganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...
Read the full Manganese monograph → Herb & supplement monographAshwagandha
Interacts with 1,372 drugsAshwagandha is an Ayurvedic herb most often taken to help with stress, anxiety, and sleep, and some small studies suggest it may help, though the evidence is still limited. It is generally w...
Read the full Ashwagandha monograph → Herb & supplement monographGuggul
Interacts with 757 drugsGuggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...
Read the full Guggul monograph →Sources & How We Checked
Thyraid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 219 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Tyrosine 4 references
- Meyer JS, Welch KM, Deshmukh VD, et al. Neurotransmitter precursor amino acids in the treatment of multi-infarct dementia and Alzheimer's disease. J Amer Geriat Soc 1977;25:289-98.
- DiPiro JT, Talbert RL, Yee GC, et al; eds. Pharmacotherapy: A pathophysiologic approach. 4th ed. Stamford, CT: Appleton & Lange, 1999.
- Wood DR, Reimherr FW, Wender PH. Amino acid precursors for the treatment of attention deficit disorder, residual type. Psychopharmacol Bull 1985;21:146-9.
- van Spronsen FJ, van Rijn M, Bekhof J. Phenylketonuria: tyrosine supplementation in phenylalanine-restricted diets. Am J Clin Nutr 2001;73:153-7. PubMed
Zinc 88 references
- Barceloux DG. Zinc. J Toxicol Clin Toxicol 1999;37:279-92.
- Eby GA, Davis DR, Halcomb WW. Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study. Antimicrob Agents Chemother 1984;25:20-4. DOI
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