Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Fractionated Pectin Powder Ingredients & Drug Interactions

by Thorne

Fractionated Pectin Powder label
See full label image
Powder Category: Fiber And Other Nutrients
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Fractionated Pectin Powder against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Fractionated Pectin Powder is a dietary supplement by Thorne with 1 active ingredient. Its ingredients are commonly taken for diarrhea relief, constipation and digestive health, cholesterol support.Based on those ingredients, 23 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Modified Citrus Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Fractionated Pectin Powder by Thorne

Ask about any prescription or over-the-counter medication and we check it for interactions with Fractionated Pectin Powder by Thorne — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Fractionated Pectin Powder by Thorne

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains a single active ingredient: modified citrus pectin, a soluble fiber extracted from citrus fruit. It's the type of fiber that dissolves in water and has been studied for its effects on cholesterol levels and blood sugar.

There are no inactive ingredients (fillers, binders, or capsule materials) listed in the formulation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Pectin's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: liver detoxification and digestive health.
  • We looked for evidence on: Diarrhea, Gastroesophageal reflux disease (GERD), Irritable bowel syndrome (IBS), Mercury toxicity, Radiation exposure, Constipation — and 2 related terms.
  • The closest evidence on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Gastroesophageal reflux disease (GERD), Irritable bowel syndrome (IBS), Radiation exposure, Mercury toxicity.

Modified citrus pectin is possibly effective for high cholesterol (hypercholesterolemia) according to the evidence we hold. For blood sugar control and prediabetes, there isn't enough reliable evidence yet to know whether it works.

The research on radiation exposure is also too limited to make a claim.

The evidence, ingredient by ingredient Pectin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pectin from food and typical supplement doses is generally well tolerated for most people. The most common side effects are mild — diarrhea, gas, loose stools, and gentle cramping.

Rarely, sensitive individuals may have allergic reactions, including a severe reaction called anaphylaxis; occupational exposure to pectin dust can also trigger asthma in workers. In pregnancy, pectin from food is fine, but concentrated supplement amounts haven't been well studied — talk with your doctor about whether it's right for you.

The same goes for breastfeeding: dietary amounts are likely okay, but supplement safety data is thin.

Side effects, ingredient by ingredient Pectin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pectin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 23 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this product before taking it alongside digoxin (a heart medication), lovastatin or other cholesterol-lowering statins, or tetracycline antibiotics. Pectin may reduce how much of these drugs your body absorbs, making them less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Fractionated pectin may help with cholesterol levels, but it can interfere with the absorption of several important medications, especially digoxin and certain antibiotics. If you take any prescription drugs — particularly heart or antibiotic medications — check with us before starting this supplement.

Most people tolerate it well, though mild digestive side effects are common.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Fractionated Pectin Powder, straight from the product label.

Brand Thorne
Barcode (UPC) 693749778028
Net contents 5.3 Ounce(s); 150 Gram(s)
Market status On market
Date entered into DSLD Jun 23, 2021
DSLD ID 251233
Product type Fiber And Other Nutrients
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Fractionated Pectin Powder by Thorne, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
30
UPC/BARCODE
693749778028
IngredientAmount% DV
Modified Citrus Pectin5 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Liver/Detox

Gluten free

Suggested/Recommended/Usage/Directions

Suggested Use: Mix 1 scoop one to three times daily or as recommended by your health-care practitioner. Mix with a small amount of warm water in a blender or shaker, then dilute with juice of choice.

Precautions

Tamper Evident: Use only if bottle is sealed.

If pregnant, consult your health-care practitioner before using this product.

Warning for California Residents Only: Consuming this product can expose you to chemicals, including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food. See also www.thorne.com/prop65.

Storage

Store tightly sealed in a cool, dry place.

Formula

Modified Citrus Pectin

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

This product uses PectaSol-C. PectaSol-C is a registered trademark of EcoNugenics.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Fractionated Pectin Powder by Thorne label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Fractionated Pectin Powder label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Fractionated Pectin Powder by Thorne

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container30 Amounts shown are per serving.

Modified Citrus Pectin

Interacts with
23 drugs
5 Gram(s) per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Modified Citrus Pectin monograph & interactions
Interaction report

Fractionated Pectin Powder by Thorne Drug Interactions

Want to check YOUR meds against Fractionated Pectin Powder?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
23Drugs
23 Moderate

Ingredients driving the most interactions

Modified Citrus Pectin 23

Individual Drug Interactions

The ingredients in Fractionated Pectin Powder interact with 23 drugs. Click any drug to see the details.

1 of the 1 ingredient in Fractionated Pectin Powder interact with drugs. Each result below shows which ingredient is responsible. Modified Citrus Pectin

Each ingredient & the kinds of drugs it affects

For each ingredient in Fractionated Pectin Powder with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Modified Citrus Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
Modified Citrus Pectin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Fractionated Pectin Powder, from the product label.

Thorne

See all Thorne products
Name
Thorne Research, Inc.
Phone Number
1-800-228-1966
Pharmacist Counseling Corner

Fractionated Pectin Powder by Thorne: Common Questions

Does Fractionated Pectin Powder by Thorne interact with any medications?
Yes. Based on its ingredients, Fractionated Pectin Powder has a known interaction with 23 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Fractionated Pectin Powder contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
Pectin from food is considered likely safe in pregnancy, but concentrated supplement amounts haven't been well studied. Dietary pectin while breastfeeding is probably fine, but supplement safety isn't established. Talk with your doctor to decide what's right for your situation.
What side effects should I expect?
Most people experience mild, temporary digestive effects like diarrhea, gas, loose stools, or gentle cramping. Rarely, sensitive individuals may have allergic reactions. If you notice swelling, difficulty breathing, or severe symptoms, seek help right away.
Does this product really lower cholesterol?
Modified citrus pectin is possibly effective for high cholesterol based on available evidence — meaning there's some evidence it may help, but it's not yet proven conclusively. It works best as part of a broader approach, not on its own.
Will it help my blood sugar or prediabetes?
We don't have enough reliable evidence to say whether it helps with blood sugar or prediabetes. If that's your goal, ask your doctor or pharmacist what the research supports for you.
How is this different from regular pectin?
This product uses modified citrus pectin — a processed, more concentrated form of the soluble fiber found in citrus fruits. It's designed to be absorbed differently in your digestive tract than regular whole fruit pectin, though both come from citrus sources.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Fractionated Pectin Powder is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Fractionated Pectin Powder label
Go deeper

The Full Monographs Behind Fractionated Pectin Powder’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pectin

Interacts with 23 drugs

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...

Read the full Pectin monograph →
Sources

Sources & How We Checked

Fractionated Pectin Powder's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team